Increased concentration of the fast-acting plasminogen activator inhibitor in plasma associated with familial venous thrombosis.

abstract：:Relapse of childhood acute lymphoblastic leukaemia (ALL) involving the eye is a rare but challenging problem. Twenty cases occurred in patients treated on the Medical Research Council United Kingdom Acute Lymphoblastic Leukaemia XI and ALL97 trials between 1991 and 2001, representing 2.2% of ALL relapses. Seventeen oc...

journal_title：British journal of haematology

authors： Somervaille TC,Hann IM,Harrison G,Eden TO,Gibson BE,Hill FG,Mitchell C,Kinsey SE,Vora AJ,Lilleyman JS,MRC Childhood Leukaemia Working Party.

更新日期：2003-04-01 00:00:00

abstract：:The response to 0.8 ml of D-positive (ccDEE) red cells injected i.v., together with 1 microgram anti-D i.m., was studied in 13 D-negative male volunteers (test subjects); the red cells were labelled with 51Cr and were found to have a mean survival time of 24 d, after correction for Cr elution. Within the following 5 m...

journal_title：British journal of haematology

authors： Contreras M,Mollison PL

更新日期：1983-01-01 00:00:00

abstract：:The effect of parenteral administration of IL-11 on gastrointestinal iron absorption was evaluated. A significant increase in the absorption of 59Fe-tagged food iron fed to fasting rats was observed when two subcutaneous injections of IL-11 were given 48 and 24 h prior to testing. Relatively similar increases of 25% w...

journal_title：British journal of haematology

authors： Baynes RD,Cook JD,Keith J

更新日期：1995-09-01 00:00:00

abstract：:Parental longevity is associated with an increased life expectancy; results with regard to specific diseases are conflicting. There are limited data focusing on host characteristics and their effect on survival among multiple myeloma (MM) patients and individuals with monoclonal gammopathy of undetermined significance...

journal_title：British journal of haematology

authors： Sverrisdóttir IS,Lund SH,Turesson I,Björkholm M,Goldin LR,Landgren O,Kristinsson SY

更新日期：2019-07-01 00:00:00

abstract：:This study shows a marked and protracted activation of HbF synthesis in homozygous beta.-thalassaemia patients transplanted from HLA identical siblings heterozygous for beta-thalassaemia, as compared to patients transplanted from normal donors. HbF synthesis in recipients was much higher in relation to the correspondi...

journal_title：British journal of haematology

authors： Galanello R,Barella S,Maccioni L,Paglietti E,Melis MA,Rosatelli MC,Argiolu F,Cao A

更新日期：1989-08-01 00:00:00

abstract：:Four children with acute lymphoblastic leukaemia (ALL) who relapsed after allogeneic bone marrow transplantation (BMT) were treated with donor lymphocyte infusion (DLI) without prior conditioning. Three patients had previously received a non-T-cell-depleted matched sibling BMT and the fourth had a T-cell-depleted matc...

journal_title：British journal of haematology

authors： Atra A,Millar B,Shepherd V,Shankar A,Wilson K,Treleaven J,Pritchard-Jones K,Meller ST,Pinkerton CR

更新日期：1997-04-01 00:00:00

abstract：:This report describes a case of chronic myelomonocytic leukaemia (CMML) in whom a complete remission was achieved and sustained 15 months after treatment with 25-OH vitamin D3. No side-effects were observed. Although vitamin D1 has been used in the treatment of myelodysplastic syndromes, to our knowledge this is the f...

journal_title：British journal of haematology

authors： Mellibovsky L,Díez A,Aubia J,Nogues X,Pérez-Vila E,Serrano S,Recker RR

更新日期：1993-12-01 00:00:00

abstract：:Mantle cell lymphoma (MCL), a malignancy of B-lymphocytes, has a poor prognosis. It is thus necessary to improve the understanding of the pathobiology of MCL and identify factors contributing to its aggressiveness. Our studies, based on Affymetrix data from 17 MCL biopsies, real-time quantitative polymerase chain reac...

journal_title：British journal of haematology

authors： Mundt F,Merrien M,Nygren L,Sutton LA,Christensson B,Wahlin BE,Rosenquist R,Sander B,Wasik AM

更新日期：2019-05-01 00:00:00

abstract：:An 'artificial' plasma for one-stage factor-VIII assays is made by incubating human plasma with EDTA, to destroy factor VIII, and afterwards removing the anticoagulant by dialysis. Bovine factor V is then added to a given level. In the assay, contact activation is controlled by adding contact product. It was confirmed...

journal_title：British journal of haematology

authors： Chantarangkul V,Ingram GI,Thorn MB,Darby SC

更新日期：1978-11-01 00:00:00

abstract：:A robust method for obtaining chromosome preparations from individual haemopoietic colonies in semi-solid media is described. The accumulation of metaphases and the hypotonic treatment of cells were carried out in the culture dish and individual colonies were transferred onto poly-L-lysine-treated slides and fixed ste...

journal_title：British journal of haematology

authors： Kadhim MA,Pocock DA,Lorimore SA,Wright EG

更新日期：1999-06-01 00:00:00

abstract：:Systemic inflammation activates the tissue factor/factor VIIa complex (TF/FVIIa), leading to a procoagulant state, which may be enhanced by impairment of physiological anticoagulant pathways, such as the protein C system. Besides impaired protein C activation, resistance to activated protein C (APC) may occur. We stud...

journal_title：British journal of haematology

authors： de Pont AC,Bakhtiari K,Hutten BA,de Jonge E,Vlasuk GP,Rote WE,Levi M,Büller HR,Meijers JC

更新日期：2006-07-01 00:00:00

abstract：:The continued improvement in the prognosis of childhood acute myeloid leukaemia (AML) has been paralleled by the use of increasingly intensive therapy. This has led to attempts to develop risk-directed strategies in which the most intensive treatment is reserved for those at highest risk of relapse. Unfortunately, cur...

journal_title：British journal of haematology

authors： Goulden N,Virgo P,Grimwade D

更新日期：2006-08-01 00:00:00

abstract：:During the past years, several authors have used labelled leucocytes to detect inflammatory foci. However, before routine use in man. It is necessary to control the viability of labelled cells. Five leucocyte labelling techniques (111In-oxine, 111In-oxine without extraction, 99mTc oxine, pyrophosphate 99mTc, 51Cr) wer...

journal_title：British journal of haematology

authors： Colas-Linhart N,Barbu M,Gougerot MA,Bok B

更新日期：1983-01-01 00:00:00

abstract：:Little is known about the impact of cytomegalovirus (CMV) infections that occur after human leucocyte antigen (HLA)-matched unrelated donor (MUD) non-myleoablative haematopoietic stem cell transplantation (HCT). We analysed the incidence, onset and outcomes of CMV infections in 59 recipients of MUD and in 109 recipien...

journal_title：British journal of haematology

authors： Junghanss C,Storb R,Maris MB,Carter RA,Sandmaier BM,Maloney DG,McSweeney PA,Corey L,Boeckh M

更新日期：2003-11-01 00:00:00

abstract：:Fetal haemoglobin levels have been measured prospectively in 135 autopsy cases of sudden, unexpected infant deaths (31 pre-term, 104 full term) using standard laboratory methods. These results have been compared with Hb F values from a normal control group of 570 living infants (145 pre-term, 425 full-term) with a pos...

journal_title：British journal of haematology

authors： Fagan DG,Walker A

更新日期：1992-10-01 00:00:00

abstract：:Human IgG monoclonal antibodies (mabs) against the Rh D antigen have considerable potential for the prophylaxis of haemolytic disease of the newborn. We have carried out in vitro testing for cross-reactions with tissue components by screening two such mabs against animal tissues and a wide panel of human organs from n...

journal_title：British journal of haematology

authors： Thorpe SJ,Bailey SW

更新日期：1993-02-01 00:00:00

abstract：:The dependence of survival time on a set of prognostic factors was explored by means of Cox's regression model in 137 cases of myelofibrosis with myeloid metaplasia (MMM). The following parameters recorded at diagnosis proved to be important independent indicators of a poor prognosis: a higher value for age, a lower v...

journal_title：British journal of haematology

authors： Barosi G,Berzuini C,Liberato LN,Costa A,Polino G,Ascari E

更新日期：1988-12-01 00:00:00

abstract：:We report the clinical outcome and results of chimaerism analysis in various cell lineages of 30 patients given non-myeloablative conditioning, followed by allogeneic stem cell transplantation (SCT). The commonest diagnoses were chronic myelogenous leukaemia (n = 11) and solid tumours (n = 11). Twenty-one patients rec...

journal_title：British journal of haematology

authors： Mattsson J,Uzunel M,Brune M,Hentschke P,Barkholt L,Stierner U,Aschan J,Ringdén O

更新日期：2001-12-01 00:00:00

abstract：:The treatment of Hodgkin lymphoma (HL) is one of early success. However, disease-free survival (DFS) does not reflect latent organ injury and its impact on health status and well-being beyond 5 years. In fact, we are at a crossroads, in terms of needing individualized approaches to maintain DFS, while minimizing late ...

journal_title：British journal of haematology

authors： Castellino SM,Parsons SK,Kelly KM

更新日期：2019-12-01 00:00:00

abstract：:Accurate clinical staging is crucial for adequate risk-adapted treatment in Hodgkin lymphoma (HL) to prevent patients from under- or over-treatment. Within the latest German Hodgkin Study Group trial generation, diagnostic findings such as histopathology, computerized tomography imaging and clinical risk factors were ...

journal_title：British journal of haematology

authors： Bröckelmann PJ,Goergen H,Fuchs M,Kriz J,Semrau R,Baues C,Kobe C,Behringer K,Eichenauer DA,von Tresckow B,Klimm B,Halbsguth T,Wongso D,Plütschow A,Haverkamp H,Dietlein M,Eich HT,Stein H,Diehl V,Borchmann P,Engert A

更新日期：2015-11-01 00:00:00

abstract：:To investigate the role of retinoblastoma susceptibility (RB) gene inactivation in leukaemogenesis, we evaluated 36 bone marrow specimens of acute leukaemia for RB protein expression by immunoprecipitation and Western blot analysis. 15 patients had no detectable RB protein at initial screening. However, nine of them w...

journal_title：British journal of haematology

authors： Tang JL,Yeh SH,Chen PJ,Lin MT,Tien HF,Chen YC

更新日期：1992-11-01 00:00:00

abstract：:During definitive erythropoiesis, erythroid precursors undergo differentiation through multiple nucleated states to an enucleated reticulocyte, which loses its residual RNA/organelles to become a mature erythrocyte. Over the course of these transformations, continuous changes in membrane proteins occur, including shif...

journal_title：British journal of haematology

authors： Kodippili GC,Spector J,Kang GE,Liu H,Wickrema A,Ritchie K,Low PS

更新日期：2010-09-01 00:00:00

abstract：:Granulocyte colony-stimulating factor (G-CSF)-induced alteration of phosphoprotein during differentiation of HL-60 cells was studied. From the two-dimensional gel electrophoresis analysis of phosphoproteins, a 45 kD phosphoprotein in the cytosolic fraction of DMSO-pretreated HL-60 cells was rapidly dephosphorylated by...

journal_title：British journal of haematology

authors： Yamaguchi T,Oshizawa T,Yamaguchi T,Suzuki K,Yamamoto Y,Hayakawa T

更新日期：1998-08-01 00:00:00

abstract：:Epstein-Barr virus-associated haemophagocytic lymphohistiocytosis (EBV-HLH) is one of the most common subtypes of secondary HLH. However, more than 30% of patients do not respond to traditional treatment. Here, we investigated the efficacy and safety of the L-DEP regimen as a salvage therapy for paediatric refractory ...

journal_title：British journal of haematology

authors： Zhao Y,Li Z,Zhang L,Lian H,Ma H,Wang D,Zhao X,Zhang Q,Wang T,Zhang R

更新日期：2020-11-01 00:00:00

abstract：:Marginal zone lymphoma represents about 10% of all non-Hodgkin lymphomas (NHLs). 33% of patients with acquired angioedema (AAE) due to acquired C1-inhibitor (C1-INH) deficiency (C1-INH-AAE) have or will develop NHLs. C1-INH-AAE is a rare condition. We report the follow-up of 72 C1-INH-AAE patients, followed for a medi...

journal_title：British journal of haematology

authors： Castelli R,Wu MA,Arquati M,Zanichelli A,Suffritti C,Rossi D,Cicardi M

更新日期：2016-03-01 00:00:00

abstract：:The Brown Norwegian rat transplanted with promyelocytic leukaemic cells (BNML) has been used as a model for human acute myeloid leukaemia. We have previously shown that both the blood supply to the bone marrow and the metabolic rate decrease in relation to the leukaemic development in these rats. Here we have investig...

journal_title：British journal of haematology

authors： Mortensen BT,Jensen PO,Helledie N,Iversen PO,Ralfkiaer E,Larsen JK,Madsen MT

更新日期：1998-07-01 00:00:00

abstract：:Hypercalcaemia complicating acute myelogenous leukaemia is a rare but well-recognized phenomenon. In most cases the pathogenetic mechanism causing the hypercalcaemia remains poorly understood. We recently studied in detail two patients with acute myelogenous leukaemia who developed hypercalcaemia during the course of ...

journal_title：British journal of haematology

authors： Gewirtz AM,Stewart AF,Vignery A,Hoffman R

更新日期：1983-05-01 00:00:00

abstract：:Thrombosis occurs in 37% of children with acute lymphoblastic leukaemia (ALL) and is related to an L-asparaginase-induced acquired antithrombin (AT) deficiency. The incidence dictates the need for anticoagulant prophylaxis. Direct thrombin inhibitors (DTI) are independent of AT for effect and may thus have advantages ...

journal_title：British journal of haematology

authors： Kuhle S,Lau A,Bajzar L,Vegh P,Halton J,Cherrick I,Anderson R,Desai S,McCusker P,Wu J,Abshire T,Mahoney D,Mitchell L

更新日期：2006-09-01 00:00:00

abstract：:Marginal zone B-cell lymphoma (MZBCL) represents a distinct subtype of B-cell non-Hodgkin's lymphoma (NHL) which has been recently recognized and defined as a disease entity. Cytogenetically, these lymphomas reveal a high prevalence of trisomy 3, and recent data obtained by comparative genomic hybridization indicate t...

journal_title：British journal of haematology

authors： Dierlamm J,Pittaluga S,Stul M,Wlodarska I,Michaux L,Thomas J,Verhoef G,Verhest A,Depardieu C,Cassiman JJ,Hagemeijer A,De Wolf-Peeters C,Van den Berghe H

更新日期：1997-09-01 00:00:00

abstract：:Sickle cell anaemia (SS) and sickle cell-haemoglobin C disease (SC) patients exhibit severe red blood cell (RBC) rheological alterations involved in the development of several complications. The contribution of oxidative stress in these haemorheological abnormalities is still unknown. We compared RBC reactive oxygen s...

journal_title：British journal of haematology

authors： Hierso R,Waltz X,Mora P,Romana M,Lemonne N,Connes P,Hardy-Dessources MD

更新日期：2014-08-01 00:00:00