Effects of oxidative stress on red blood cell rheology in sickle cell patients.

abstract：:Non-haemolytic transfusion reactions are the most common type of transfusion reaction and include transfusion-related acute lung injury, transfusion-associated circulatory overload, allergic reactions, febrile reactions, post-transfusion purpura and graft-versus- host disease. Although life-threatening anaphylaxis occ...

journal_title：British journal of haematology

authors： Hirayama F

更新日期：2013-02-01 00:00:00

abstract：:A patient with Jo-1 antibody-associated polymyositis (Jo-1 PM) had a Karnofsky score of 40% and severe muscle, liver and lung damage that was refractory to standard therapy. The female patient received an autologous T-cell-depleted haematopoietic stem cell transplant (HSCT) after myeloablative conditioning. The transp...

journal_title：British journal of haematology

authors： Baron F,Ribbens C,Kaye O,Fillet G,Malaise M,Beguin Y

更新日期：2000-08-01 00:00:00

abstract：:Cooley's original description of beta-thalassaemia major included marked bone deformities as a characteristic feature. These were thought to be due to expansion of haemopoiesis attempting to compensate for the congenital anaemia. Regular blood transfusions from infancy prevents these skeletal problems. Nevertheless, s...

journal_title：British journal of haematology

authors： Jensen CE,Tuck SM,Agnew JE,Koneru S,Morris RW,Yardumian A,Prescott E,Hoffbrand AV,Wonke B

更新日期：1998-12-01 00:00:00

abstract：:Aplastic anaemia (AA) is considered as an immune-mediated bone marrow failure syndrome. The mechanism is involved with a variety of immune molecules including interferon-γ (IFN-γ), tumour necrosis factor-α (TNF-α) and interleukins (ILs). IL-27 is a novel member of the IL-12 family, which mediates T cell response and e...

journal_title：British journal of haematology

authors： Li J,Zhao Q,Xing W,Feng J,Wu H,Li H,Ge M,Tian K,Li X,Zhou J,Liu B,Zhang L,Zheng Y,Han ZC

更新日期：2011-06-01 00:00:00

abstract：:Myeloid-derived suppressor cells (MDSCs) are a heterogeneous population of immature myeloid cells at different stages of maturation that play a role in cancer tolerance and function as an immune-suppressive cell subpopulation. They utilize different mechanisms to block both innate and adaptive arms of anti-tumour immu...

journal_title：British journal of haematology

authors： Tadmor T,Attias D,Polliack A

更新日期：2011-06-01 00:00:00

abstract：:The efficiency of stored platelet transfusion was evaluated in terms of clinical status in 141 thrombocytopenic patients. In a paired prospective study in which fresh platelets were used as controls, clinical efficiency was assessed on the basis of the ability to increase platelet count (recovery) and the time to the ...

journal_title：British journal of haematology

authors： Norol F,Kuentz M,Cordonnier C,Beaujean F,Haioun C,Vernant JP,Duédari N

更新日期：1994-01-01 00:00:00

abstract：:We have treated 17 refractory or relapsed multiple myeloma patients resistant to chemotherapy with thalidomide at a dose of 200-800 mg/day. Eleven patients responded, five of whom had a very good partial response (> 75% decline in M protein) and another five exhibited a partial response (> 50% decline in M protein). E...

journal_title：British journal of haematology

authors： Kneller A,Raanani P,Hardan I,Avigdor A,Levi I,Berkowicz M,Ben-Bassat I

更新日期：2000-02-01 00:00:00

abstract：:Ibrutinib is associated with durable responses in patients with Waldenström macroglobulinaemia (WM). We hypothesized that response depth is predictive of progression-free survival (PFS) in WM patients treated with ibrutinib. Using landmark analyses, we evaluated response depth in two cohorts of WM patients treated wit...

journal_title：British journal of haematology

authors： Castillo JJ,Abeykoon JP,Gustine JN,Zanwar S,Mein K,Flynn CA,Demos MG,Guerrera ML,Kofides A,Liu X,Munshi M,Tsakmaklis N,King R,Yang G,Hunter ZR,Advani RH,Palomba ML,Ansell SM,Gertz MA,Kapoor P,Treon SP

更新日期：2020-11-18 00:00:00

abstract：:Inhibition of apoptosis (genetically programmed active cell death) by p210 BCR-ABL expression is a mechanism that might contribute to clonal expansion in chronic myeloid leukaemia (CML). Since cell death following exposure to ionizing radiation and many chemotherapeutic agents can occur by the apoptotic pathway, inhib...

journal_title：British journal of haematology

authors： Amos TA,Lewis JL,Grand FH,Gooding RP,Goldman JM,Gordon MY

更新日期：1995-10-01 00:00:00

abstract：:We describe two British families with similar, dominantly-inherited, temperature-related variants of hereditary stomatocytosis, consistent with the original description of 'cryohydrocytosis'. The cells show a 5-6-fold increase in passive permeability at 37 degrees C with abnormal intracellular Na and K levels at 15-20...

journal_title：British journal of haematology

authors： Coles SE,Chetty MC,Ho MM,Nicolaou A,Kearney JW,Wright SD,Stewart GW

更新日期：1999-06-01 00:00:00

abstract：:Red blood cells frozen by the low-glycerol fast-freezing technique were thawed, deglycerolized and resuspended in various media. The use of ACD-saline for resuspension markedly reduced in vitro haemolysis such that the red cells could be transfused up to 5 d after thawing. At this time the cells contained satisfactory...

journal_title：British journal of haematology

authors： Amer KA,Pepper DS,Prowse CV

更新日期：1980-04-01 00:00:00

abstract：:A patient with apparent anaemia and thrombocytopenia caused by a monoclonal paraprotein is described. The patient's serum contained a monoclonal IgM kappa, a cryoglobulin and a cold agglutinin. The cryoglobulin, similar to the serum paraprotein, was a monoclonal IgM kappa. Serum was studied to determine the relationsh...

journal_title：British journal of haematology

authors： Pujol M,Ribera JM,Jimenez C,Ribera A,Abad E,Feliu E

更新日期：1998-03-01 00:00:00

abstract：:In emicizumab prophylaxis, the concomitant therapy using bypassing agents (BPAs) is required for breakthrough bleeding and invasive procedures with attention to thrombotic complications. To predict coagulant effects of BPAs in emicizumab-treated patients with haemophilia A (PwHA) with inhibitor (PwHAwI), blood samples...

journal_title：British journal of haematology

authors： Furukawa S,Nogami K,Shimonishi N,Nakajima Y,Matsumoto T,Shima M

更新日期：2020-09-01 00:00:00

abstract：:We studied a 2-year-old boy with a phenotype of combined hypo- and dysprothrombinaemia. Sequencing of polymerase-chain-reaction-amplified genomic DNA revealed three different mutations in heterozygosity, a G to A transition at position 7312, resulting in the replacement of arginine 271 by histidine, an A to G transiti...

journal_title：British journal of haematology

authors： Akhavan S,Luciani M,Lavoretano S,Mannucci PM

更新日期：2003-01-01 00:00:00

abstract：:Post-transplantation lymphoproliferative disorders (PTLDs) are a well-recognized and potentially life-threatening complication of solid organ transplantation. While the vast majority of PTLDs are B-cell lymphoproliferations, T-cell PTLDs are rarely seen. Among 898 patients receiving cardiac transplants between 1990 an...

journal_title：British journal of haematology

authors： Draoua HY,Tsao L,Mancini DM,Addonizio LJ,Bhagat G,Alobeid B

更新日期：2004-11-01 00:00:00

abstract：:Using Southern blot, the restriction digests of genomic DNAs in 11 patients with Glanzmann thrombasthenia from 10 unrelated kindreds were probed with a full-length GPIIb cDNA. An additional 2.3 kb Taq I fragment and two 1.65 kb and 0.65 kb fragments with reduced band intensity were found in the genes of two affected s...

journal_title：British journal of haematology

authors： Gu JM,Xu WF,Wang XD,Wu QY,Chi CW,Ruan CG

更新日期：1993-03-01 00:00:00

abstract：:This review will focus on the strengths and limitations associated with the current standard of care for primary prevention of ischaemic strokes in children with sickle cell anaemia (SCA) - transcranial Doppler ultrasound (TCD) screening followed by regular blood transfusion therapy when TCD measurement is above a thr...

journal_title：British journal of haematology

authors： Jordan LC,Casella JF,DeBaun MR

更新日期：2012-04-01 00:00:00

abstract：:Three distinct categories of marginal zone lymphomas (MZLs) are currently recognized, principally based on their site of occurrence. They are thought to represent unique entities, but the relationship of one subtype with another is poorly understood. We investigated 17 non-splenic MZLs (seven nodal, 10 extranodal) by ...

journal_title：British journal of haematology

authors： Novak U,Basso K,Pasqualucci L,Dalla-Favera R,Bhagat G

更新日期：2011-11-01 00:00:00

abstract：:Congenital thrombotic thrombocytopenic purpura (cTTP) is a rare, recessively inherited genetic disorder with varying clinical presentation that is caused by ADAMTS13 mutations. Several studies have found limited associations between ADAMTS13 mutations and cTTP phenotype. The use of in silico tools that examine multipl...

journal_title：British journal of haematology

authors： Hing ZA,Schiller T,Wu A,Hamasaki-Katagiri N,Struble EB,Russek-Cohen E,Kimchi-Sarfaty C

更新日期：2013-03-01 00:00:00

abstract：:We performed a retrospective study analysing the effect of sorafenib, an oral fms-Like Tyrosine Kinase 3 (FLT3)/multikinase inhibitor, as post-transplant maintenance in adult patients with FLT3-internal tandem duplication (ITD) acute myeloid leukaemia (AML). We identified consecutive patients with FLT3-ITD AML diagnos...

journal_title：British journal of haematology

authors： Brunner AM,Li S,Fathi AT,Wadleigh M,Ho VT,Collier K,Connolly C,Ballen KK,Cutler CS,Dey BR,El-Jawahri A,Nikiforow S,McAfee SL,Koreth J,Deangelo DJ,Alyea EP,Antin JH,Spitzer TR,Stone RM,Soiffer RJ,Chen YB

更新日期：2016-11-01 00:00:00

abstract：:Three patients with an acute myeloid leukaemia (AML) showed a deletion of the short arm of chromosome 7 with loss of the deleted material. The 7p- anomaly originated from either a terminal or an interstitial deletion and it represented the only karyotypic aberration in all the three cases. According to the clinical, m...

journal_title：British journal of haematology

authors： Mecucci C,Van Orshoven A,Boogaerts M,Michaux JL,Van den Berghe H

更新日期：1989-01-01 00:00:00

abstract：:T-cells from patients with B-cell chronic lymphocytic leukaemia (B-CLL) have abnormal T4/T8 ratios and functions. Previously, we demonstrated that peripheral blood (PB) mononuclear cells from B-CLL patients secrete significant amounts of interleukin 2 (IL2) with an apparent dysregulation of accessory cells controlling...

journal_title：British journal of haematology

authors： Rossi JF,Klein B,Commes T,Jourdan M,Janbon C

更新日期：1988-02-01 00:00:00

abstract：:There are no accepted methods to predict the development of platelet transfusion refractoriness (PTR) due to human leucocyte antigen (HLA)-alloimmunization. Hence, matched platelets are usually given only to patients demonstrating PTR, necessarily resulting in some ineffective random donor platelets (RDPLT) transfusio...

journal_title：British journal of haematology

authors： Beligaswatte A,Tsiopelas E,Humphreys I,Bennett G,Robinson K,Davis K,Bardy P

更新日期：2013-08-01 00:00:00

abstract：:We report a high incidence of subacute, chronic and sometimes occult intracranial subdural haematoma (SDH) occurring during intensive chemotherapy for acute myeloid leukaemia (AML) with a monoblastic component. Between March 1990 and January 1993, 86 AML patients from our institution were randomized in the multicentri...

journal_title：British journal of haematology

authors： Jourdan E,Dombret H,Glaisner S,Micléa JM,Castaigne S,Degos L

更新日期：1995-03-01 00:00:00

abstract：:Prospective studies in children with B-precursor acute lymphoblastic leukaemia (ALL) have shown that polymerase chain reaction (PCR)-based detection of minimal residual disease (MRD) using immunoglobin (Ig) and T-cell receptor (TCR) gene rearrangements as targets can be used to identify patients with a high relapse ri...

journal_title：British journal of haematology

authors： de Haas V,Breunis WB,Dee R,Verhagen OJ,Kroes W,van Wering ER,van Dongen JJ,van den Berg H,van der Schoot CE

更新日期：2002-01-01 00:00:00

abstract：:Asparaginase (ASNase) is an important anti-leukaemic drug in the treatment of childhood acute lymphoblastic leukaemia (ALL) and non-Hodgkin lymphoma (NHL). A substantial proportion of patients develop hypersensitivity reactions with anti-ASNase neutralising antibodies, resulting in allergic reactions or silent inactiv...

journal_title：British journal of haematology

authors： Mondelaers V,Ferster A,Uyttebroeck A,Brichard B,van der Werff Ten Bosch J,Norga K,Francotte N,Piette C,Vandemeulebroecke K,Verbeke C,Schmidt S,Benoit Y,Lammens T,De Moerloose B

更新日期：2020-07-01 00:00:00

abstract：:Critically ill patients with coronavirus disease 2019 (COVID-19) present with hypoxaemia and are mechanically ventilated to support gas exchange. We performed a retrospective, observational study of blood gas analyses (n = 3518) obtained from patients with COVID-19 to investigate changes in haemoglobin oxygen (Hb-O2 )...

journal_title：British journal of haematology

authors： Vogel DJ,Formenti F,Retter AJ,Vasques F,Camporota L

更新日期：2020-11-01 00:00:00

abstract：:Three patients with probable congenital erythrocytosis were studied to determine the role of erythropoietin (ESF) in their disease. In addition, haemoglobin function was measured and ESF excretion determined in response to reduction in the haemoglobin concentration. In two cases ESF excretion was clearly elevated abov...

journal_title：British journal of haematology

authors： Whitcomb WH,Peschle C,Moore M,Nitschke R,Adamson JW

更新日期：1980-01-01 00:00:00

abstract：:Podocalyxin-like protein (PCLP) is a sialomucin-type membrane protein structurally related to CD34 and endoglycan. It was first described in glomerular podocytes and endothelial cells. In mice, PCLP is present in haemangioblasts, and in both chicken and mice it is a marker of early haematopoietic stem cells and lineag...

journal_title：British journal of haematology

authors： Kerosuo L,Juvonen E,Alitalo R,Gylling M,Kerjaschki D,Miettinen A

更新日期：2004-03-01 00:00:00

abstract：:The phenotypic expression and functional capacity of natural killer (NK) T-lymphocytes (E+, OKT3+) were analysed in a series of untreated patients with B-cell chronic lymphocytic leukaemia (B-CLL). The mean value of NK activity of B-CLL T-lymphocytes, tested against the K562 cell line, was significantly depressed (P l...

journal_title：British journal of haematology

authors： Foa R,Lauria F,Lusso P,Giubellino MC,Fierro MT,Ferrando ML,Raspadori D,Matera L

更新日期：1984-11-01 00:00:00