Abstract:
:We studied a 2-year-old boy with a phenotype of combined hypo- and dysprothrombinaemia. Sequencing of polymerase-chain-reaction-amplified genomic DNA revealed three different mutations in heterozygosity, a G to A transition at position 7312, resulting in the replacement of arginine 271 by histidine, an A to G transition at position 20058, resulting in the replacement of histidine 562 by arginine, and a 2-bp deletion at 20062-20063, causing a frameshift and a premature stop codon in exon 14. The first two mutations are compatible with the dysprothrombinaemia phenotype, whereas the small deletion is thought to be the cause of hypoprothrombinaemia.
journal_name
Br J Haematoljournal_title
British journal of haematologyauthors
Akhavan S,Luciani M,Lavoretano S,Mannucci PMdoi
10.1046/j.1365-2141.2003.03986.xsubject
Has Abstractpub_date
2003-01-01 00:00:00pages
142-4issue
1eissn
0007-1048issn
1365-2141pii
3986journal_volume
120pub_type
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