Abstract:
:Three male patients (two of whom were brothers) with Shwachman-Diamond (SDS) syndrome presented with acute myeloid leukaemia in adulthood. In all three cases there was trilineage myelodysplasia and the morphology was consistent with FAB subtype M6. SDS is an inherited bone marrow failure syndrome with a high propensity to leukaemic transformation. Since this may not occur until adulthood, SDS should be considered in the differential diagnosis of adults presenting with acute myeloid leukaemia, particularly where features of myelodysplasia are prominent.
journal_name
Br J Haematoljournal_title
British journal of haematologyauthors
Dokal I,Rule S,Chen F,Potter M,Goldman Jdoi
10.1046/j.1365-2141.1997.3673181.xsubject
Has Abstractpub_date
1997-10-01 00:00:00pages
171-3issue
1eissn
0007-1048issn
1365-2141journal_volume
99pub_type
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