Ferritin synthesis in inflammation. I. Pathogenesis of impaired iron release.

abstract：:To determine the effects of L-arginine (L-Arg) supplementation on nitric oxide metabolite (NOx) production, oral L-Arg was given to normal controls, sickle cell disease (SCD) patients at steady state and SCD patients hospitalized with a vaso-occlusive crisis (VOC). L-Arg (0.1 g/kg) increased NOx formation by 18.8 +/- ...

journal_title：British journal of haematology

authors： Morris CR,Kuypers FA,Larkin S,Sweeters N,Simon J,Vichinsky EP,Styles LA

更新日期：2000-11-01 00:00:00

abstract：:We tested whether parvovirus B19 (PVB19) is involved in benign lymph node swelling as a causative agent. The serum specimens from 13 patients with lymph node swelling of unidentified cause were tested for IgM and IgG antibody against PVB19 by Western blot analysis. Five patients had IgM antibody, and PVB19 DNA was det...

journal_title：British journal of haematology

authors： Tsuda H,Maeda Y,Nakagawa K

更新日期：1993-11-01 00:00:00

abstract：:This report describes a case of chronic myelomonocytic leukaemia (CMML) in whom a complete remission was achieved and sustained 15 months after treatment with 25-OH vitamin D3. No side-effects were observed. Although vitamin D1 has been used in the treatment of myelodysplastic syndromes, to our knowledge this is the f...

journal_title：British journal of haematology

authors： Mellibovsky L,Díez A,Aubia J,Nogues X,Pérez-Vila E,Serrano S,Recker RR

更新日期：1993-12-01 00:00:00

abstract：:Serum erythropoietin (Epo) was measured in 23 patients before, during and after intensive cytostatic treatment courses for acute leukaemia or before bone marrow transplantation. A marked increase was seen in all patients, starting 1 or 2 d after initiation of treatment. A peak was reached after about 7 d, at levels as...

journal_title：British journal of haematology

authors： Birgegård G,Wide L,Simonsson B

更新日期：1989-07-01 00:00:00

abstract：:Previous studies report conflicting results concerning the potential significance of thrombophilic genotypes in postarthroplasty venous thromboembolism (VTE). This study assessed thrombophilic genotypes, haemostatic and clinical variables as independent risk factors for VTE postarthroplasty. A total number of 569 pati...

journal_title：British journal of haematology

authors： Joseph JE,Low J,Courtenay B,Neil MJ,McGrath M,Ma D

更新日期：2005-04-01 00:00:00

abstract：:A recombinant bispecific single-chain fragment variable antibody (bsscFv), directed against the B-cell antigen CD19 and the low affinity Fc-receptor FcgammaRIII (CD16), was designed for use in the treatment of patients with leukaemias and lymphomas. The Fc-portions of whole antibodies were deliberately eliminated in t...

journal_title：British journal of haematology

authors： Bruenke J,Barbin K,Kunert S,Lang P,Pfeiffer M,Stieglmaier K,Niethammer D,Stockmeyer B,Peipp M,Repp R,Valerius T,Fey GH

更新日期：2005-07-01 00:00:00

abstract：:High-dose chemotherapy with autologous stem cell transplantation (SCT) is widely used as a treatment for systemic AL amyloidosis, but its efficacy has not been proved and it has substantial toxicity in this setting. We report here the outcome of 92 patients evaluated at the UK National Amyloidosis Centre who underwent...

journal_title：British journal of haematology

authors： Goodman HJ,Gillmore JD,Lachmann HJ,Wechalekar AD,Bradwell AR,Hawkins PN

更新日期：2006-08-01 00:00:00

abstract：:Patients with aplastic anaemia (AA) frequently develop paroxysmal nocturnal haemoglobinuria (PNH) as a late complication. We investigated the frequency of the development of PNH features including a glycosyl phosphatidylinositol (GPI) anchoring defect in 73 Japanese patients with AA. A deficient expression of CD59 was...

journal_title：British journal of haematology

authors： Azenishi Y,Ueda E,Machii T,Nishimura J,Hirota T,Shibano M,Nakao S,Kinoshita T,Mizoguchi H,Kitani T

更新日期：1999-03-01 00:00:00

abstract：:Rats were rendered anaemic by a single bleeding or by a single injection of phenylhydrazine. At various times after the onset of anaemia they were nephrectomized and challenged with a 6 h exposure to hypoxia. The erythropoietin titre observed at the end of this hypoxic period was corrected for renal erythropoietin ind...

journal_title：British journal of haematology

authors： Erslev AJ,Caro J,Kansu E,Silver R

更新日期：1980-05-01 00:00:00

abstract：:Ineffective erythropoiesis was quantitated in a series of patients with pernicious anaemia at different times in relation to vitamin B12 therapy by measuring the incorporation of [15N]delta aminolaevulinic acid and [15N]glycine into early labelled bilirubin. Prior to therapy ineffective erythropoiesis was grossly incr...

journal_title：British journal of haematology

authors： Samson D,Halliday D,Chanarin I

更新日期：1977-02-01 00:00:00

abstract：:In whole blood from splenectomized subjects (n = 20), red cells showed a significant increase of mean surface area (MSA), mean cell volume (MCV), MSA/MCV-ratio and osmotic resistance, with the mean cell haemoglobin concentration (MCHC) being decreased. Studies on red cell populations of different cell age revealed tha...

journal_title：British journal of haematology

authors： de Haan LD,Werre JM,Ruben AM,Huls HA,de Gier J,Staal GE

更新日期：1988-05-01 00:00:00

abstract：:The records of 121 children presenting with acute lymphoblastic leukaemia between 1969 and 1982 were reviewed. The overall relapse free survival rate was 50%. However, girls presenting with a total white blood cell count of 20 X 10(9)/l or less (35% of all patients) had a particularly favourable prognosis with an 80% ...

journal_title：British journal of haematology

authors： Stockley RJ,Ahlquist PY,Mott MG

更新日期：1983-10-01 00:00:00

abstract：:Many adult T-cell leukaemia/lymphoma (ATLL) patients who respond to induction treatment, then relapse. Knowing the clonality pattern of residual tumourous clones during treatment could help understand disease evolution and aid therapeutic decisions. We developed a sensitive and semi-quantitative molecular analysis of ...

journal_title：British journal of haematology

authors： Leclercq I,Mortreux F,Morschhauser F,Duthilleul P,Desgranges C,Gessain A,Cavrois M,Vernant JP,Hermine O,Wattel E

更新日期：1999-06-01 00:00:00

abstract：:In the present study, we aimed to identify distinct structural and numerical chromosomal aberrations in peripheral blood B cells of patients with myeloma and monoclonal gammopathy of undetermined significance (MGUS), which reflect changes thought to occur at different stages of the disease process. Peripheral blood fr...

journal_title：British journal of haematology

authors： Zojer N,Schuster-Kolbe J,Assmann I,Ackermann J,Strasser K,Hübl W,Drach J,Ludwig H

更新日期：2002-06-01 00:00:00

abstract：:Clinical and laboratory data are presented for two patients with a dyshaematopoietic disorder, and monosomy 7 in their bone marrow cells. The first patient, a 55-year-old woman, had been treated with chlorambucil for an ovarian carcinoma. After 4 years an oligoblastic myeloid leukaemia was diagnosed and she later died...

journal_title：British journal of haematology

authors： Boetius G,Hustinx TW,Smits AP,Scheres JM,Rutten FJ,Haanen C

更新日期：1977-09-01 00:00:00

abstract：:Twenty adult patients with high-risk leukaemia underwent allogeneic haemopoietic stem cell transplantation after melphalan, busulphan and total body irradiation followed by short-term methotrexate and low-dose cyclosporine or tacrolimus. Three patients developed veno-occlusive disease and no patient developed renal dy...

journal_title：British journal of haematology

authors： Murata M,Nishida T,Haneda M,Kanie T,Taji H,Iida H,Suzuki R,Hamaguchi M,Minami S,Kodera Y

更新日期：1999-06-01 00:00:00

abstract：:Isolated trisomy 8 (+8) is a frequent cytogenetic abnormality in the myelodysplastic syndromes (MDS), but its characteristics are poorly reported. We performed a retrospective study of 138 MDS patients with isolated +8, classified or reclassified as MDS (excluding MDS/myeloproliferative neoplasm). Myeloproliferative (...

journal_title：British journal of haematology

authors： Drevon L,Marceau A,Maarek O,Cuccuini W,Clappier E,Eclache V,Cluzeau T,Richez V,Berkaoui I,Dimicoli-Salazar S,Bidet A,Vial JP,Park S,Vieira Dos Santos C,Kaphan E,Berthon C,Stamatoullas A,Delhommeau F,Abermil N,Braun

更新日期：2018-09-01 00:00:00

abstract：:Cord blood (CB) has successfully been used as a stem cell source for haemopoietic reconstitution. However, a significant delay in platelet engraftment is consistently found in CB versus adult peripheral blood (PB) or bone marrow transplants. We sought to determine whether or not CB megakaryocytes have reached terminal...

journal_title：British journal of haematology

authors： Bornstein R,García-Vela J,Gilsanz F,Auray C,Calés C

更新日期：2001-08-01 00:00:00

abstract：:Endogenous carbon monoxide (CO) production rates and total body haemoglobin content were determined simultaneously in blood and gas phase in 15 individuals. At 24% oxygen (O2) concentration in the closed rebreathing system, a correlation was obtained which revealed that a 1 mumole rise in CO in the gas phase of the s...

journal_title：British journal of haematology

authors： Bensinger TA,Brouillard RP,Conrad ME

更新日期：1975-03-01 00:00:00

abstract：:A case of Evans' syndrome with IgM deficiency and lymphopenia was studied before and after splenectomy. The lymphopenia was as a result of profound reduction of CD4 and CD8 cells. Study of cytokine secretion before splenectomy revealed a spontaneous Th1- and Th2-type cytokine production, and complete suppression of tr...

journal_title：British journal of haematology

authors： Karakantza M,Mouzaki A,Theodoropoulou M,Bussel JB,Maniatis A

更新日期：2000-09-01 00:00:00

abstract：:After T-cell depleted marrow transplantation, there is a rapid recovery of cytotoxic effector cells, with activity against targets not susceptible to killing by 'resting' natural killer cells. These targets include Epstein-Barr virus transformed B cells and leukaemic cell lines. Activated killer cell function declines...

journal_title：British journal of haematology

authors： Leger O,Drexler HG,Reittie JE,Secker-Walker L,Prentice HG,Brenner MK

更新日期：1987-11-01 00:00:00

abstract：:The anti-CD30 immunotoxin (IT) Ber-H2/saporin is effective in patients with refractory Hodgkin's disease. However, responses are short and partial, one of the main reasons being the inability to repeat IT doses because of formation of human antibodies against the murine antibody and/or the toxin. To overcome this prob...

journal_title：British journal of haematology

authors： Terenzi A,Bolognesi A,Pasqualucci L,Flenghi L,Pileri S,Stein H,Kadin M,Bigerna B,Polito L,Tazzari PL,Martelli MF,Stirpe F,Falini B

更新日期：1996-03-01 00:00:00

abstract：:Although haematopoietic cell transplantation (HCT) is curative for sickle cell anaemia (SCA), concerns about its short- and long-term toxicities limit its application. A potential toxicity is an adverse effect on growth. To identify an HCT growth effect, serial height and weight measurements from 53 children and adole...

journal_title：British journal of haematology

authors： Eggleston B,Patience M,Edwards S,Adamkiewicz T,Buchanan GR,Davies SC,Dickerhoff R,Donfield S,Feig SA,Giller RH,Haight A,Horan J,Hsu LL,Kamani N,Lane P,Levine JE,Margolis D,Moore TB,Ohene-Frempong K,Redding-Lallinger

更新日期：2007-02-01 00:00:00

abstract：:An open, randomised study was performed to determine whether two doses of influenza vaccine were more effective than one to elicit an immune response in 70 patients with haematological malignancies. The responses were not improved by two doses compared with one (influenza A virus serotypes H1/N1 18% vs. 22% and H3/N2 ...

journal_title：British journal of haematology

authors： Ljungman P,Nahi H,Linde A

更新日期：2005-07-01 00:00:00

abstract：:We report three cases of platelet dysfunction characterized by defective Ca2+ ionophore-induced platelet aggregation without impaired production of thromboxane A2 (TXA2). The patients had mild to moderate bleeding tendencies, and their platelet aggregation and secretion induced by ADP, collagen, arachidonic acid, stab...

journal_title：British journal of haematology

authors： Fuse I,Higuchi W,Uesugi Y,Aizawa Y

更新日期：2001-03-01 00:00:00

abstract：:Platelet function was evaluated in eight patients with chronic granulocytic leukaemia (CGL), seven Ph1 positive and one Ph1 negative. Seven of the eight patients' platelets had an absence of the second wave of adrenaline induced aggregation on at least one occasion, while five had impaired collagen aggregation. The pl...

journal_title：British journal of haematology

authors： Gerrard JM,Stoddard SF,Shapiro RS,Coccia PF,Ramsay NK,Nesbit ME,Rao GH,Krivit W,White JG

更新日期：1978-12-01 00:00:00

abstract：:Peripheral blood stem cell autografts for the treatment of chronic myeloid leukaemia (CML) are currently under evaluation. A patient with CML received intensive chemotherapy followed by granulocyte colony-stimulating factor prior to the collection of peripheral blood derived stem cells. He developed unusually severe, ...

journal_title：British journal of haematology

authors： Clark RE,Lee ES

更新日期：1995-06-01 00:00:00

abstract：:Sixty patients with haematological malignancies received a myeloablative regimen of total body irradiation, cyclophosphamide and fludarabine followed by a T-cell-depleted peripheral blood stem cell transplant from a human leucocyte antigen identical sibling. To improve donor immune function, 1 x 10(7) CD3+ cells/kg we...

journal_title：British journal of haematology

authors： Montero A,Savani BN,Kurlander R,Read EJ,Leitman SF,Childs R,Solomon SR,Barrett AJ

更新日期：2005-09-01 00:00:00

abstract：:Patients with sickle cell disease (SCD) with high fetal haemoglobin (HbF) tend to have a lower incidence of complications and longer survival due to inhibition of deoxyhaemoglobin S (HbS) polymerisation by HbF. HbF-containing cells, namely F cells, are strongly influenced by genetic factors. We measured the percentage...

journal_title：British journal of haematology

authors： Urio F,Nkya S,Rooks H,Mgaya JA,Masamu U,Zozimus Sangeda R,Mmbando BP,Brumat M,Mselle T,Menzel S,Luzzatto L,Makani J

更新日期：2020-10-19 00:00:00

abstract：:A serial study of coagulation activation and whole-blood viscosity was performed on 37 patients with local or systemic bacterial infection, malaria, or a viral infection. Thrombocytopenia, without consumption of coagulation factors, was the main feature of benign tertian malaria and viral infection, whereas in septica...

journal_title：British journal of haematology

authors： Richardson SG,Matthews KB,Cruickshank JK,Geddes AM,Stuart J

更新日期：1979-07-01 00:00:00