Interleukin 2 enhances cytotoxic cell function in vitro after T-cell depleted marrow transplantation.

Abstract:

:After T-cell depleted marrow transplantation, there is a rapid recovery of cytotoxic effector cells, with activity against targets not susceptible to killing by 'resting' natural killer cells. These targets include Epstein-Barr virus transformed B cells and leukaemic cell lines. Activated killer cell function declines by 3 months after transplantation. We find that when CD3 negative effector cells are obtained from these patients and cultured in vitro with interleukin 2 there is a further enhancement of cytotoxic activity against a range of target cells in the early post-transplant period, and a restoration of high level cytotoxic activity to effector cells obtained 3 months or more after the procedure. These results may have relevance to attempts to reduce the incidence of leukaemic relapse, and EBV + ve lymphoma outgrowth after T-cell depleted BMT.

journal_name

Br J Haematol

authors

Leger O,Drexler HG,Reittie JE,Secker-Walker L,Prentice HG,Brenner MK

doi

10.1111/j.1365-2141.1987.tb02347.x

subject

Has Abstract

pub_date

1987-11-01 00:00:00

pages

273-9

issue

3

eissn

0007-1048

issn

1365-2141

journal_volume

67

pub_type

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