Renal and extrarenal erythropoietin production in anaemic rats.

abstract：UNLABELLED:Transplant-related mortality (TRM) remains a major problem in older patients undergoing allogeneic haemopoietic stem cell transplants (HSCTs). We have therefore explored a less intensive conditioning in 33 patients with a median age of 52 years (range 43-60) transplanted from human leucocyte antigen (HLA)-id...

journal_title：British journal of haematology

authors： Raiola AM,Van Lint MT,Lamparelli T,Gualandi F,Mordini N,Berisso G,Bregante S,Frassoni F,Sessarego M,Fugazza G,Di Stefano F,Pitto A,Bacigalupo A

更新日期：2000-06-01 00:00:00

abstract：:In the present study, we aimed to identify distinct structural and numerical chromosomal aberrations in peripheral blood B cells of patients with myeloma and monoclonal gammopathy of undetermined significance (MGUS), which reflect changes thought to occur at different stages of the disease process. Peripheral blood fr...

journal_title：British journal of haematology

authors： Zojer N,Schuster-Kolbe J,Assmann I,Ackermann J,Strasser K,Hübl W,Drach J,Ludwig H

更新日期：2002-06-01 00:00:00

abstract：:Reduced-intensity conditioning (RIC) regimens for allogeneic haematopoietic stem cell transplantation (SCT) have been shown to lead to engraftment of donor stem cells without the severe extra-haematological toxicities of traditional myeloablative transplants. Between December 1998 and December 2000, 76 patients underw...

journal_title：British journal of haematology

authors： Martino R,Caballero MD,Canals C,Simón JA,Solano C,Urbano-Ispízua A,Bargay J,Rayón C,Léon A,Sarrá J,Odriozola J,Conde JG,Sierra J,San Miguel J,ALLOPBSCT Subcommittee of the Spanish Group for Haematopoietic Transplantation (GET

更新日期：2001-12-01 00:00:00

abstract：:Although traditional anticoagulant regimens are highly effective and safe in most patients with venous thromboembolism (VTE), the aggressive natural history of VTE and the high risk of serious bleeding in cancer patients can complicate the management of VTE. In addition, because few clinical trials have focused on the...

journal_title：British journal of haematology

authors： Lee AY

更新日期：2005-02-01 00:00:00

abstract：:Mastocytosis is an uncommon disease characterized by a proliferation of tissue mast cells involving various organs, particularly the bone marrow. Though rare, the association of mastocytosis and haematological malignancies is well established. However, the frequency of mastocytosis reported in patients with essential ...

journal_title：British journal of haematology

authors： Le Tourneau A,Gaulard P,D'Agay MF,Vainchencker W,Cadiou M,Devidas A,Haioun C,Clauvel JP,Audouin J,Diebold J

更新日期：1991-09-01 00:00:00

abstract：:To evaluate the clinical significance of CD21S expression of diffuse large B-cell lymphoma (DLBCL) tumour cells, we compared their clinical features, immunophenotype, response to therapy and outcome in relation to CD21S expression. Between 1987 and 1999, frozen sections from 240 DLBCL cases were examined for CD21S exp...

journal_title：British journal of haematology

authors： Ogawa S,Yamaguchi M,Oka K,Taniguchi M,Ito M,Nishii K,Nakase K,Ohno T,Kita K,Kobayashi T,Shiku H

更新日期：2004-04-01 00:00:00

abstract：:A novel human leukaemia cell line, designated TMD7, was established from blast cells of a patient with de novo acute myeloblastic leukaemia with trilineage myelodysplasia (AML/TLD). As seen in the original blast cells, TMD7 cells expressed CD7, CD13, CD33 and CD34 and showed an abnormal karyotype containing -5, -7, -8...

journal_title：British journal of haematology

authors： Tohda S,Sakano S,Ohsawa M,Murakami N,Nara N

更新日期：2002-05-01 00:00:00

abstract：:Plasma and urine folate fractions were evaluated after ingestion of radioactive N5-methyl-tetrahydrofolic acid by a normal control (subject I), a patient on maintenance haemodialysis for chronic glomerulonephritis (subject 2), and an anephric patient on haemodialysis (subject 3). In subjects 1 and 2 maximal plasma rad...

journal_title：British journal of haematology

authors： Retief FP,Heyns AP,Oosthuizen M,Reenen OR

更新日期：1977-07-01 00:00:00

abstract：:In the positron emission tomography (PET) era, traditional prognostic factors may not apply for patients with relapsed/refractory (R/R) diffuse large B cell lymphoma (DLBCL) undergoing autologous stem cell transplantation (ASCT). Moreover, little is known about prognostic factors in patients transplanted for transform...

journal_title：British journal of haematology

authors： Armand P,Welch S,Kim HT,LaCasce AS,Jacobsen ED,Davids MS,Jacobson C,Fisher DC,Brown JR,Coughlin E,Freedman AS,Chen YB

更新日期：2013-03-01 00:00:00

abstract：:Nd-HPFH are haematological conditions which are natural models to aid understanding of the haemoglobin (Hb) switch. In this paper we describe a new non-deletional hereditary persistence of fetal haemoglobin (nd-HPFH) associated with the highest Hb F level observed to date (up to 49% without haemopoietic stress). Seque...

journal_title：British journal of haematology

authors： Pissard S,M'rad A,Beuzard Y,Roméo PH

更新日期：1996-10-01 00:00:00

abstract：:Comparative expression analysis of wild-typeETV6 in the disease state showed an absence of expression in ETV6-CBFA2 acute lymphoblastic leukaemia (ALL) when compared with non-ETV6-CBFA2 ALL and acute myeloid leukaemia. Fluorescent in-situ hybridization and loss of heterozygosity studies showed that 73% of the ETV6-CBF...

journal_title：British journal of haematology

authors： Patel N,Goff LK,Clark T,Ford AM,Foot N,Lillington D,Hing S,Pritchard-Jones K,Jones LK,Saha V

更新日期：2003-07-01 00:00:00

abstract：:Persistent aplasia is a rare complication with poor prognosis after intensive chemotherapy for acute leukaemia. A 59-year-old man with acute myeloid leukaemia (AML), was treated after 186 d of chemotherapy-induced persistent aplasia with an allogeneic peripheral blood stem cell transplantation (PBSCT) from a matched u...

journal_title：British journal of haematology

authors： Hambach L,Heil G,Hertenstein B,Ganser A

更新日期：2002-08-01 00:00:00

abstract：:Megakaryopoiesis was examined in 10 patients (eight females and two males) with cyclic thrombocytopenia (CT) to investigate the underlying pathogenesis. Numbers of CFU-Meg and megakaryocytes and the mean cytoplasmic area (mean area) of megakaryocytes at the peak, nadir, ascent mid phase, and descent mid phase of the p...

journal_title：British journal of haematology

authors： Nagasawa T,Hasegawa Y,Kamoshita M,Ohtani K,Komeno T,Itoh T,Shinagawa A,Kojima H,Ninomiya H,Abe T

更新日期：1995-09-01 00:00:00

abstract：:Fanconi anaemia (FA) is an autosomal recessive and X-linked disease characterized by severe genetic instability and increased incidence of cancer. One explanation for this instability may be the cellular hypersensitivity to oxidative stress leading to chromosomal breaks. This study explored the possible oxidative dama...

journal_title：British journal of haematology

authors： Uziel O,Reshef H,Ravid A,Fabian I,Halperin D,Ram R,Bakhanashvili M,Nordenberg J,Lahav M

更新日期：2008-07-01 00:00:00

abstract：:Forty female patients with either primary anti-phospholipid syndrome (n = 26) or systemic lupus erythematosus (anti-phospholipid syndrome positive) (n = 14) were investigated for levels of factor XII, the presence of lupus anticoagulant and antibodies to cardiolipin, beta 2-glycoprotein I and factor XII. Twenty-one pa...

journal_title：British journal of haematology

authors： Jones DW,MacKie IJ,Gallimore MJ,Winter M

更新日期：2001-05-01 00:00:00

abstract：:We assessed the clinical utility of next-generation sequencing (NGS)-based monitoring of minimal residual disease (MRD) in a uniformly treated cohort of 79 patients with paediatric B-cell acute lymphoblastic leukaemia. Bone marrow samples were collected at the time of diagnosis, days 33 and 80, pre- (4-5 months) and p...

journal_title：British journal of haematology

authors： Sekiya Y,Xu Y,Muramatsu H,Okuno Y,Narita A,Suzuki K,Wang X,Kawashima N,Sakaguchi H,Yoshida N,Hama A,Takahashi Y,Kato K,Kojima S

更新日期：2017-01-01 00:00:00

abstract：:Myeloproliferative disorders (MPD) are reported in 25-65% of patients with splanchnic vein thrombosis (SVT). Diagnostic criteria for MPD have not been fully established in this context. Using clusters of abnormal megakaryocytes in bone marrow (BM) biopsy as a reference standard for Philadelphia negative MPD, we assess...

journal_title：British journal of haematology

authors： Chait Y,Condat B,Cazals-Hatem D,Rufat P,Atmani S,Chaoui D,Guilmin F,Kiladjian JJ,Plessier A,Denninger MH,Casadevall N,Valla D,Brière JB

更新日期：2005-05-01 00:00:00

abstract：:A new putative hepatitis virus has recently been discovered and termed GB virus C (GBV-C). We investigated the prevalence of this virus among 50 haemophiliacs treated with non-virus-inactivated clotting factor concentrates prior to 1985 and 21 haemophiliacs treated exclusively with virus-inactivated clotting factor co...

journal_title：British journal of haematology

authors： Uhle C,Zimmermann R,Goeser T,Seelig R

更新日期：1997-12-01 00:00:00

abstract：:The thrombopoietin receptor agonists (THPO-RAs), romiplostim and eltrombopag, are effective and safe in immune thrombocytopenia (ITP). However, the value of their sequential use when no response is achieved or when adverse events occur with one THPO-RA has not been clearly established. Here we retrospectively evaluate...

journal_title：British journal of haematology

authors： González-Porras JR,Mingot-Castellano ME,Andrade MM,Alonso R,Caparrós I,Arratibel MC,Fernández-Fuertes F,Cortti MJ,Pascual C,Sánchez-González B,Bernat S,Fuertes-Palacio MA,Vázquez-Paganini JA,Olivera PE,Alvarez-Román MT,Jarq

更新日期：2015-04-01 00:00:00

abstract：:We analysed the incidence of graft failure, graft-versus-host disease (GVHD) and relapse of leukaemia in 208 patients undergoing allogeneic bone marrow transplantation (BMT) for chronic myeloid leukaemia in chronic phase in eight transplant centres in Europe and the United States. 106 patients received unmanipulated d...

journal_title：British journal of haematology

authors： Apperley JF,Mauro FR,Goldman JM,Gregory W,Arthur CK,Hows J,Arcese W,Papa G,Mandelli F,Wardle D

更新日期：1988-06-01 00:00:00

abstract：:In a randomized study that compared human leucocyte antigen-identical allogeneic granulocyte colony-stimulating factor (G-CSF)-mobilized peripheral blood stem cell (PBSC) versus bone marrow (BM) transplantation, the expression of activation markers, CD23, CD25 and CD45RO by B cells, was compared in blood before and af...

journal_title：British journal of haematology

authors： Tayebi H,Lapierre V,Saas P,Lienard A,Sutton L,Milpied N,Attal M,Cahn JY,Kuentz M,Blaise D,Hervé P,Tiberghien P,Robinet E,Société Française de Greffe de Moelle et de Therapie Cellulaire.

更新日期：2001-09-01 00:00:00

abstract：:Three patients with familial antithrombin III deficiency underwent a trial of prophylactic antithrombotic therapy with stanozolol. An increase in plasma fibrinolytic activity and antithrombin III was seen. Acute venous thrombosis occurred in two patients; in the first patient thrombosis was precipitated by venography ...

journal_title：British journal of haematology

authors： Winter JH,Fenech A,Bennett B,Douglas AS

更新日期：1984-07-01 00:00:00

abstract：:The myelodysplastic syndromes (MDS) display both haematological and biological heterogeneity with variable leukaemia potential. MicroRNAs play an important role in tumour suppression and the regulation of self-renewal and differentiation of haematopoietic progenitors. Using a microarray platform, we evaluated microRNA...

journal_title：British journal of haematology

authors： Sokol L,Caceres G,Volinia S,Alder H,Nuovo GJ,Liu CG,McGraw K,Clark JA,Sigua CA,Chen DT,Moscinski L,Croce CM,List AF

更新日期：2011-04-01 00:00:00

abstract：:Interleukin-6 (IL6) plays a central role in multiple myeloma pathogenesis and confers resistance to corticosteroid-induced apoptosis. We therefore evaluated the efficacy and safety of siltuximab, an anti-IL6 monoclonal antibody, alone and in combination with dexamethasone, for patients with relapsed or refractory mult...

journal_title：British journal of haematology

authors： Voorhees PM,Manges RF,Sonneveld P,Jagannath S,Somlo G,Krishnan A,Lentzsch S,Frank RC,Zweegman S,Wijermans PW,Orlowski RZ,Kranenburg B,Hall B,Casneuf T,Qin X,van de Velde H,Xie H,Thomas SK

更新日期：2013-05-01 00:00:00

abstract：:The level of venous thrombosis risk in women who experience spontaneous or induced pregnancy loss has previously been uncertain. However, recent data indicate that the risk of venous thrombosis in women undergoing pregnancy termination in the first trimester is increased two-fold compared to non-pregnant women but red...

journal_title：British journal of haematology

authors： Bagot CN,Pavord S,Hunt BJ,British Society of Haematology Obstetric Haematology Special Interest Group.

更新日期：2020-07-01 00:00:00

abstract：:MYD88 mutations are present in 95% of Waldenstrom Macroglobulinaemia (WM) patients, and support diagnostic discrimination from other IgM-secreting B-cell malignancies. Diagnostic discrimination can be difficult among suspected wild-type MYD88 (MYD88WT ) WM cases. We systematically reviewed the clinical, pathological a...

journal_title：British journal of haematology

authors： Treon SP,Gustine J,Xu L,Manning RJ,Tsakmaklis N,Demos M,Meid K,Guerrera ML,Munshi M,Chan G,Chen J,Kofides A,Patterson CJ,Yang G,Liu X,Severns P,Dubeau T,Hunter ZR,Castillo JJ

更新日期：2018-02-01 00:00:00

abstract：:The combined incidence of classical Philadelphia-negative myeloproliferative neoplasm (MPN) is 6-9/100 000 with a peak frequency between 50 and 70 years. MPN is less frequent in women of reproductive age. However, for essential thrombocythaemia (ET) in particular there is a second peak in women of reproductive age and...

journal_title：British journal of haematology

authors： Robinson SE,Harrison CN

更新日期：2020-05-01 00:00:00

abstract：:Monocytes, lymphocytes and polymorphs were separated from the peripheral blood of normal human subjects. Ferritin concentrations were determined with antibodies to both human spleen and heart ferritins. The heart type ferritin concentration in monocytes was 38.4 +/- 21.6 fg/cell (mean +/- SD), in lymphocytes 8.6 +/- 6...

journal_title：British journal of haematology

authors： Jones BM,Worwood M,Jacobs A

更新日期：1983-09-01 00:00:00

abstract：:Five monoclonal antibodies have been tested for their ability to bind to myeloid precursor cells in normal human bone marrow. Indirect immunofluorescence and the fluorescence activated cell sorter was used to separate cells according to their reactivity for trial culture in vitro in order to grow granulocyte-macrophag...

journal_title：British journal of haematology

authors： Crawford DH,Francis GE,Wing MA,Edwards AJ,Janossy G,Hoffbrand AV,Prentice HG,Secher D,McConnell I,Kung PC,Goldstein G

更新日期：1981-10-01 00:00:00

abstract：:We aimed to identify and classify cases of paediatric myelodysplastic syndromes (MDS) occurring in Britain to estimate the incidence of this rare group of diseases, investigate the results of therapy and identify prognostic risk factors. Patients aged below 15 years at diagnosis were collected from England, Scotland a...

journal_title：British journal of haematology

authors： Passmore SJ,Chessells JM,Kempski H,Hann IM,Brownbill PA,Stiller CA

更新日期：2003-06-01 00:00:00