Endogenous production of carbon monoxide as measured simultaneously in blood and gas phase.

abstract：:In the positron emission tomography (PET) era, traditional prognostic factors may not apply for patients with relapsed/refractory (R/R) diffuse large B cell lymphoma (DLBCL) undergoing autologous stem cell transplantation (ASCT). Moreover, little is known about prognostic factors in patients transplanted for transform...

journal_title：British journal of haematology

authors： Armand P,Welch S,Kim HT,LaCasce AS,Jacobsen ED,Davids MS,Jacobson C,Fisher DC,Brown JR,Coughlin E,Freedman AS,Chen YB

更新日期：2013-03-01 00:00:00

abstract：:Children with Down syndrome (DS) have a greater risk for developing both acute lymphoblastic leukaemia (ALL) and significant adverse effects of chemotherapy. We investigated their outcome with, and tolerance of, treatment protocols for relapsed ALL optimized in the paediatric population without DS. Probability of surv...

journal_title：British journal of haematology

authors： Meyr F,Escherich G,Mann G,Klingebiel T,Kulozik A,Rossig C,Schrappe M,Henze G,von Stackelberg A,Hitzler J

更新日期：2013-07-01 00:00:00

abstract：:Allele alphaLELY is a common low-expression allele of the erythroid spectrin SPTA1 gene. It results in the aggravated expression of hereditary elliptocytosis due to SPTA1 gene mutations occurring in trans. Allele alphaLELY contains, in particular, mutations in introns 45 and 46, both in polypyrimidine tracts, and caus...

journal_title：British journal of haematology

authors： Wilmotte R,Marechal J,Delaunay J

更新日期：1999-03-01 00:00:00

abstract：:Reversible aggregation of red blood cells (RBC) plays an important role in determining blood flow properties, and it is this aggregation which increases blood viscosity at low shear rates. The structure and sites of venous thrombi, as well as the fact that stasis is a major predisposing factor in venous thrombosis, su...

journal_title：British journal of haematology

authors： Chabanel A,Horellou MH,Conard J,Samama MM

更新日期：1994-09-01 00:00:00

abstract：:The polymerase chain reaction (PCR) assay was used to detect human parvovirus B19 DNA in 38 blood products and start plasma pools from five different manufacturers. The products examined were albumin, factor VIII, intravenous (i.v.) and intramuscular (i.m) immunoglobulin batches. The majority of pools from all the man...

journal_title：British journal of haematology

authors： Saldanha J,Minor P

更新日期：1996-06-01 00:00:00

abstract：:Post-transplantation lymphoproliferative disorders (PTLDs) are a well-recognized and potentially life-threatening complication of solid organ transplantation. While the vast majority of PTLDs are B-cell lymphoproliferations, T-cell PTLDs are rarely seen. Among 898 patients receiving cardiac transplants between 1990 an...

journal_title：British journal of haematology

authors： Draoua HY,Tsao L,Mancini DM,Addonizio LJ,Bhagat G,Alobeid B

更新日期：2004-11-01 00:00:00

abstract：:Ninety consecutive patients with acute promyelocytic leukaemia were investigated for promoter methylation of CDKN2B (alias p15) and CDKN2A (alias p16) in disease relapse and progression. CDKN2B methylation was significantly more frequent at first relapse (30/36, 83%) than at presentation (48/77, 62%) (P=0.025), while ...

journal_title：British journal of haematology

authors： Au WY,Fung AT,Ma ES,Chan CH,Wong KF,Chim CS,Liang RH,Kwong YL

更新日期：2005-12-01 00:00:00

abstract：:Culture medium was harvested after co-incubation of mononuclear cells collected and pooled from the peripheral blood of two different normal donors and was tested for colony-stimulating activity (CSA) in agar culture. With bone marrow from normal donors or peripheral blood from patients with chronic granulocytic leuka...

journal_title：British journal of haematology

authors： Hellmann A,Th'ng KH,Goldman JM

更新日期：1980-06-01 00:00:00

abstract：:There is a discrepancy in the results of reported studies of levels of vitamin K dependent coagulation factors in patients on warfarin therapy. This may have arisen partly because of the problem of assuring compliance with therapy in outpatients. The plasma concentrations of the vitamin K dependent clotting factors II...

journal_title：British journal of haematology

authors： Kumar S,Haigh JR,Tate G,Boothby M,Joanes DN,Davies JA,Roberts BE,Feely MP

更新日期：1990-01-01 00:00:00

abstract：:The blood-related cancer leukaemias were the first diseases where human cancer stem cells, or leukaemic stem cells (LSC), were isolated. The haematopoietic system is one of the best tissues for investigating cancer stem cells, because the developmental hierarchy of normal blood formation is well defined. Leukaemias ca...

journal_title：British journal of haematology

authors： Bonnet D

更新日期：2005-08-01 00:00:00

abstract：:Lymphoproliferative diseases of large granular lymphocytes (LDGL) may arise from either CD3+ T cells or CD3- natural killer (NK) cells. LDGL with clonal proliferation of large granular lymphocytes (LGL) is defined as LGL leukaemia. The number of patients with NK-LGL leukaemia reported is limited and the pathogenesis o...

journal_title：British journal of haematology

authors： Chou WC,Chiang IP,Tang JL,Su IJ,Huang SY,Chen YC,Liu MC,Lee FY,Wang CH,Shen MC,Chuang SM,Tien HF

更新日期：1998-12-01 00:00:00

abstract：:Children with neutropenia of more than 3 months duration often have evidence of immune-mediated destruction of mature neutrophils and variable abnormalities of myeloid precursors in their bone marrow. These patients often have anti-neutrophil antibodies which persist for several months. To further investigate the aeti...

journal_title：British journal of haematology

authors： McClain K,Estrov Z,Chen H,Mahoney DH Jr

更新日期：1993-09-01 00:00:00

abstract：:Despite the significance of red blood cell (RBC) alloimmunization, the lack of standardized registries in the US has prevented the completion of large studies. Data from 3·5 years of the Recipient Epidemiology and Donor Evaluation Study-III (REDS-III) recipient database, containing information from 12 hospitals, were ...

journal_title：British journal of haematology

authors： Karafin MS,Westlake M,Hauser RG,Tormey CA,Norris PJ,Roubinian NH,Wu Y,Triulzi DJ,Kleinman S,Hendrickson JE,NHLBI Recipient Epidemiology and Donor Evaluation Study-III (REDS-III).

更新日期：2018-06-01 00:00:00

abstract：:Haematopoietic cell transplantation (HCT) survivors are at increased risk for developing congestive heart failure (CHF), primarily due to pre-HCT exposure to anthracyclines. We examined the association between the development of CHF after HCT and polymorphisms in 16 candidate genes involved in anthracycline metabolism...

journal_title：British journal of haematology

authors： Armenian SH,Ding Y,Mills G,Sun C,Venkataraman K,Wong FL,Neuhausen SL,Senitzer D,Wang S,Forman SJ,Bhatia S

更新日期：2013-10-01 00:00:00

abstract：:We report two patients with acute leukaemia who received emetogenic cytotoxic drugs and were on therapeutic doses of sodium valproate for epilepsy. Neither patient reported significant nausea nor vomited at any time during the chemotherapy, at times requiring no anti-emetic treatment whatsoever. We suggest that this a...

journal_title：British journal of haematology

authors： Aiken TC,Collin RC

更新日期：1995-04-01 00:00:00

abstract：:International guidance has recently recommended serial proximal compression ultrasound (CUS) as first line imaging for suspected deep vein thrombosis (DVT). Single whole-leg CUS is a routine alternative diagnostic strategy that can reduce repeated attendances and identify alternative pathology. We conducted a prospect...

journal_title：British journal of haematology

authors： Horner D,Hogg K,Body R,Jones S,Nash MJ,Mackway-Jones K

更新日期：2014-02-01 00:00:00

abstract：:Neutralizing anti-IFN alpha antibodies (nIFN alpha Abs) occur in a significant proportion of patients with hairy cell leukaemia, hepatitis or solid tumours treated with recombinant IFN alpha (IFN alpha 2a or IFN alpha 2b), but information on their incidence in chronic myeloid leukaemia (CML) is scanty and their clinic...

journal_title：British journal of haematology

authors： Russo D,Candoni A,Zuffa E,Minisini R,Silvestri F,Fanin R,Zaja F,Martinelli G,Tura S,Botta G,Baccarani M

更新日期：1996-08-01 00:00:00

abstract：:The sensitivity to cytosine arabinoside (Ara-C) of blast progenitors from 22 acute myeloblastic leukaemia (AML) patients was studied in methylcellulose and suspension cultures. Primary colony-formation (PE1) in methylcellulose reflects the terminal divisions of blast progenitors, while secondary colony formation (PE2)...

journal_title：British journal of haematology

authors： Nara N,Suzuki T,Nagata K,Yamashita Y,Murohashi I,Adachi Y

更新日期：1988-10-01 00:00:00

abstract：:Persistent aplasia is a rare complication with poor prognosis after intensive chemotherapy for acute leukaemia. A 59-year-old man with acute myeloid leukaemia (AML), was treated after 186 d of chemotherapy-induced persistent aplasia with an allogeneic peripheral blood stem cell transplantation (PBSCT) from a matched u...

journal_title：British journal of haematology

authors： Hambach L,Heil G,Hertenstein B,Ganser A

更新日期：2002-08-01 00:00:00

abstract：:Clofarabine was the latest new drug to be approved, in 2004, for relapsed or refractory acute lymphoblastic leukaemia (ALL). To investigate its value in the frontline treatment of ALL we applied clofarabine 5 × 40 mg/m(2) in combination with pegylated asparaginase (PEG-ASP) 1 × 2500 iu/m(2) in high risk ALL patients a...

journal_title：British journal of haematology

authors： Escherich G,Zur Stadt U,Zimmermann M,Horstmann MA,CoALL study group.

更新日期：2013-10-01 00:00:00

abstract：:The translocation t(8;16) (p11;p13) was found as the sole deviation from the normal karyotype in three patients with acute monocytic leukaemia. The bone marrow morphology was strikingly similar in the two cases where smears were available for re-evaluation: the leukaemic cells showed signs of differentiation, and acti...

journal_title：British journal of haematology

authors： Heim S,Avanzi GC,Billström R,Kristoffersson U,Mandahl N,Bekassy AN,Garwicz S,Wiebe T,Pegoraro L,Falda M

更新日期：1987-07-01 00:00:00

abstract：:The anti-cancer drug arsenic trioxide (AT) induces apoptosis in a variety of transformed or proliferating cells. However, little is known regarding its ability to induce apoptosis in terminally differentiated cells, such as neutrophils. Because neutropenia has been reported in some cancer patients after AT treatment, ...

journal_title：British journal of haematology

authors： Binet F,Cavalli H,Moisan E,Girard D

更新日期：2006-02-01 00:00:00

abstract：:We report a patient with CML in relapse after a sex-mismatch bone marrow transplant who was treated with donor lymphocyte infusions and developed severe marrow aplasia 3 months later. As cytogenetic analysis at this point was not possible because of the very low number of marrow cells available, we used in situ hybrid...

journal_title：British journal of haematology

authors： Garicochea B,van Rhee F,Spencer A,Chase A,Lin F,Cross NC,Goldman JM

更新日期：1994-10-01 00:00:00

abstract：:We studied the abnormal in vitro polyclonal B-cell activity observed in patients with multiple myeloma and Waldenström's macroglobulinaemia. Numbers of cells spontaneously secreting immunoglobulin (Ig) in freshly isolated suspensions of peripheral blood mononuclear cells and pokeweed mitogen (PWM) stimulated cultures ...

journal_title：British journal of haematology

authors： Levinson AI,Dziarski A,Blankenhorn E,Schreiber AD,Negendank WG

更新日期：1985-07-01 00:00:00

abstract：:We treated 26 patients with hairy cell leukaemia (HCL) with 2-chlorodeoxyadenosine, including nine with abdominal lymphadenopathy and of whom two had HCL-variant; 18 were previously treated. The overall response in 23 evaluable HCL patients was 100% with 87% complete remission (CR). The CR rate was 57% in patients wit...

journal_title：British journal of haematology

authors： Mercieca J,Matutes E,Emmett E,Coles H,Catovsky D

更新日期：1996-05-01 00:00:00

abstract：:Mature (peripheral) T-cell lymphoma (PTCL) other than anaplastic large cell lymphoma is a heterogeneous group of diseases and exceedingly rare in children and adolescents. Survival rates range between 46% and 85%. This study reports the disease characteristics, treatment and outcome of all patients with the diagnosis ...

journal_title：British journal of haematology

authors： Kontny U,Oschlies I,Woessmann W,Burkhardt B,Lisfeld J,Salzburg J,Janda A,Attarbaschi A,Niggli F,Zimmermann M,Reiter A,Klapper W

更新日期：2015-03-01 00:00:00

abstract：:The determinants of steady state haemoglobin levels in sickle cell-haemoglobin C (SC) disease were investigated by measuring routine haematological and biochemical indices, red cell survival, oxygen affinity, pitted erythrocytes, and red cell and plasma volumes in 31 adult patients (15 male; 16 female). Red cell survi...

journal_title：British journal of haematology

authors： Bannerman RM,Serjeant B,Seakins M,England JM,Serjeant GR

更新日期：1979-09-01 00:00:00

abstract：:ATOH8 has previously been shown to be an iron-regulated transcription factor, however its role in iron metabolism is not known. ATOH8 expression in HEK293 cells resulted in increased endogenous HAMP mRNA levels as well as HAMP promoter activity. Mutation of the E-box or SMAD response elements within the HAMP promoter ...

journal_title：British journal of haematology

authors： Patel N,Varghese J,Masaratana P,Latunde-Dada GO,Jacob M,Simpson RJ,McKie AT

更新日期：2014-02-01 00:00:00

abstract：:It is the capacity to generate thrombin, and the enzymatic work that thrombin does, that determines blood coagulability. Therefore, measurement of the enzymatic work potential of thrombin provides a method for quantifying the composite effect of the multiple factors that determine coagulation capacity. The application...

journal_title：British journal of haematology

authors： Baglin T

更新日期：2005-09-01 00:00:00

abstract：:Gaucher disease (GD) is an autosomal recessive inherited defect of the lysosomal enzyme glucocerebrosidase (GluCerase) that leads to glucosylceramide (GluCer) accumulation. We previously demonstrated the existence of imbalances in certain lymphocyte populations in GD patients. We now show that GluCerase-deficient mono...

journal_title：British journal of haematology

authors： Balreira A,Lacerda L,Miranda CS,Arosa FA

更新日期：2005-06-01 00:00:00