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2-Chlorodeoxyadenosine in the treatment of hairy cell leukaemia: differences in response in patients with and without abdominal lymphadenopathy.

Abstract：

:We treated 26 patients with hairy cell leukaemia (HCL) with 2-chlorodeoxyadenosine, including nine with abdominal lymphadenopathy and of whom two had HCL-variant; 18 were previously treated. The overall response in 23 evaluable HCL patients was 100% with 87% complete remission (CR). The CR rate was 57% in patients with abdominal lymphadenopathy. Neither of the patients with HCL-variant achieved CR. Of four patients who had become refractory to 2'-deoxycoformycin, two achieved CR and one partial remission (PR). The lower response in HCL with abdominal lymphadenopathy supports the view that this represents a more resistant form of the disease.

journal_name

Br J Haematol

journal_title

British journal of haematology

authors

Mercieca J,Matutes E,Emmett E,Coles H,Catovsky D

doi

10.1046/j.1365-2141.1996.5041045.x

subject

Has Abstract

pub_date

1996-05-01 00:00:00

pages

409-11

issue

2

eissn

0007-1048

issn

1365-2141

journal_volume

93

pub_type

临床试验,杂志文章

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