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A novel factor-dependent human myelodysplastic cell line, MDS92, contains haemopoietic cells of several lineages.

Abstract：

:A novel long-term cultured interleukin (IL)-3-dependent human myelodysplastic cell line, MDS92, was shown to contain several myeloid-lineage cells such as neutrophils, macrophages, eosinophils, and a small number of megakaryocyte-lineage cells. Therefore this cell line possesses at least bipotential characteristics of myeloid- and megakaryocyte-lineages. Granulocyte colony-stimulating factor clearly promoted the neutrophil alkaline phosphatase activity of MDS92 cells. To the contrary, the incidence and growth of CD41-positive cells were hardly affected by the addition of IL-6, IL-11, c-mpl ligand (thrombopoietin, TPO) or erythropoietin. TPO slightly supported the growth of CD34-positive cell fraction, but not CD41-positive cell fraction of MDS92 cells in combination with IL-3 or Steel factor. This cell line will be a useful tool for the study of MDS stem cells, but the mechanism of commitment of differentiation in MDS stem cells remains unknown.

journal_name

Br J Haematol

journal_title

British journal of haematology

authors

Tohyama K,Tohyama Y,Nakayama T,Ueda T,Nakamura T,Yoshida Y

doi

10.1111/j.1365-2141.1995.tb05391.x

subject

Has Abstract

pub_date

1995-12-01 00:00:00

pages

795-9

issue

4

eissn

0007-1048

issn

1365-2141

journal_volume

91

pub_type

杂志文章

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