Purine analogues kill resting lymphocytes by p53-dependent and -independent mechanisms.

abstract：:A highly sensitive Y-microsatellite amplification system was developed for the detection of post bone marrow transplantation (BMT) chimaerism. The system is able to detect the DNA equivalent of a single male cell in a background of 10(5) female cells. For clinical applications it has the distinct advantage that the po...

journal_title：British journal of haematology

authors： Lo YM,Noakes L,Roux E,Jeannet M,Chapuis B,Fleming KA,Wainscoat JS

更新日期：1995-03-01 00:00:00

abstract：:A 33-year-old man presented with hepatosplenomegaly and lymphadenopathy. Bone marrow findings were consistent with Philadelphia-positive accelerated-phase chronic granulocytic leukaemia (CGL). Lymph node histology and immunhistochemistry were diagnostic of T lymphoblastic lymphoma. Molecular studies on lymph node DNA ...

journal_title：British journal of haematology

authors： Jacob A,Rowlands DC,Patton N,Holmes JA

更新日期：1994-10-01 00:00:00

abstract：:We prospectively studied presentation biological differences and the response to therapy in patients with thrombotic thrombocytopenic purpura (TTP) associated with, or unrelated to human immunodeficiency virus (HIV) infection. TTP patients underwent standard evaluations and were treated with prednisone 1 mg/kg in addi...

journal_title：British journal of haematology

authors： Novitzky N,Thomson J,Abrahams L,du Toit C,McDonald A

更新日期：2005-02-01 00:00:00

abstract：:We assessed the clinical utility of next-generation sequencing (NGS)-based monitoring of minimal residual disease (MRD) in a uniformly treated cohort of 79 patients with paediatric B-cell acute lymphoblastic leukaemia. Bone marrow samples were collected at the time of diagnosis, days 33 and 80, pre- (4-5 months) and p...

journal_title：British journal of haematology

authors： Sekiya Y,Xu Y,Muramatsu H,Okuno Y,Narita A,Suzuki K,Wang X,Kawashima N,Sakaguchi H,Yoshida N,Hama A,Takahashi Y,Kato K,Kojima S

更新日期：2017-01-01 00:00:00

abstract：:In myeloproliferative neoplasms (MPN), JAK2V617F allele burden measurement has an impact on prognosis that helps in patient monitoring. Less is known about its usefulness in CALR-mutated cases. Additional mutations found by next-generation sequencing have also shown an impact on prognosis that may drive therapeutic ch...

journal_title：British journal of haematology

authors： Cottin L,Riou J,Orvain C,Ianotto JC,Boyer F,Renard M,Truchan-Graczyk M,Murati A,Jouanneau-Courville R,Allangba O,Mansier O,Burroni B,Rousselet MC,Quintin-Roué I,Martin A,Sadot-Lebouvier S,Delneste Y,Chrétien JM,Hunaul

更新日期：2020-03-01 00:00:00

abstract：:The E4BP4 basic leucine zipper (bZIP) transcription factor is regulated by interleukin-3 (IL-3) in pro-B cells and has been reported to promote survival of the murine IL-3-dependent pro-B cell lines, FL5.12 and Baf-3. The E2A-HLF oncoprotein arises from a t(17;19) translocation in childhood pro-B cell acute lymphoblas...

journal_title：British journal of haematology

authors： Yeung J,O'Sullivan E,Hubank M,Brady HJ

更新日期：2004-06-01 00:00:00

abstract：:In the positron emission tomography (PET) era, traditional prognostic factors may not apply for patients with relapsed/refractory (R/R) diffuse large B cell lymphoma (DLBCL) undergoing autologous stem cell transplantation (ASCT). Moreover, little is known about prognostic factors in patients transplanted for transform...

journal_title：British journal of haematology

authors： Armand P,Welch S,Kim HT,LaCasce AS,Jacobsen ED,Davids MS,Jacobson C,Fisher DC,Brown JR,Coughlin E,Freedman AS,Chen YB

更新日期：2013-03-01 00:00:00

abstract：:We treated 26 patients with hairy cell leukaemia (HCL) with 2-chlorodeoxyadenosine, including nine with abdominal lymphadenopathy and of whom two had HCL-variant; 18 were previously treated. The overall response in 23 evaluable HCL patients was 100% with 87% complete remission (CR). The CR rate was 57% in patients wit...

journal_title：British journal of haematology

authors： Mercieca J,Matutes E,Emmett E,Coles H,Catovsky D

更新日期：1996-05-01 00:00:00

abstract：:Iron chelators are increasingly combined clinically but the optimal conditions for cellular iron mobilization and mechanisms of interaction are unclear. Speciation plots for iron(III) binding of paired combinations of the licensed iron chelators desferrioxamine (DFO), deferiprone (DFP) and deferasirox (DFX) suggest co...

journal_title：British journal of haematology

authors： Vlachodimitropoulou Koumoutsea E,Garbowski M,Porter J

更新日期：2015-09-01 00:00:00

abstract：:To determine the effects of L-arginine (L-Arg) supplementation on nitric oxide metabolite (NOx) production, oral L-Arg was given to normal controls, sickle cell disease (SCD) patients at steady state and SCD patients hospitalized with a vaso-occlusive crisis (VOC). L-Arg (0.1 g/kg) increased NOx formation by 18.8 +/- ...

journal_title：British journal of haematology

authors： Morris CR,Kuypers FA,Larkin S,Sweeters N,Simon J,Vichinsky EP,Styles LA

更新日期：2000-11-01 00:00:00

abstract：:The records of 121 children presenting with acute lymphoblastic leukaemia between 1969 and 1982 were reviewed. The overall relapse free survival rate was 50%. However, girls presenting with a total white blood cell count of 20 X 10(9)/l or less (35% of all patients) had a particularly favourable prognosis with an 80% ...

journal_title：British journal of haematology

authors： Stockley RJ,Ahlquist PY,Mott MG

更新日期：1983-10-01 00:00:00

abstract：:Calcium uptake into isolated membrane vesicles from two patients with a grey platelet syndrome has been investigated. An increase in calcium transport appears in both patients when compared to controls. Determination of the kinetic parameters of the calcium transport system gave similar apparent affinity for calcium a...

journal_title：British journal of haematology

authors： Enouf J,Lebret M,Bredoux R,Levy-Toledano S,Caen JP

更新日期：1987-04-01 00:00:00

abstract：:We have identified a tissue kallikrein in polymorphonuclear (PMN) leucocytes of normal human blood and bone marrow by immunocytochemistry, radioimmunoassay and enzymology. Immunoreactive tissue kallikrein was visualized in the mature neutrophil leucocytes and in immature forms such as metamyelocytes and myelocytes. No...

journal_title：British journal of haematology

authors： Figueroa CD,MacIver AG,Bhoola KD

更新日期：1989-07-01 00:00:00

abstract：:Various techniques have been used to assess the flow properties of blood and blood cells in a range of clinical situations. Filtration through microfilters offers a single technique for measuring the flow properties of all cellular components of blood in one experiment but depends on an assumed ability to recognize ce...

journal_title：British journal of haematology

authors： Jones JG,Adams RA,Cook AM,Evans SA

更新日期：1999-01-01 00:00:00

abstract：:Changes in DNA copy number (CN) and DNA methylation represent important aberrations for lymphomas and other cancers. Here, for the first time, we show that the Illumina Infinium Methylation (IIM) assay, although not originally designed for CN profiling, is able to estimate CN changes. We compared the IIM CN profiles t...

journal_title：British journal of haematology

authors： Kwee I,Rinaldi A,Rancoita P,Rossi D,Capello D,Forconi F,Giuliani N,Piva R,Inghirami G,Gaidano G,Zucca E,Bertoni F

更新日期：2012-02-01 00:00:00

abstract：:We studied the abnormal in vitro polyclonal B-cell activity observed in patients with multiple myeloma and Waldenström's macroglobulinaemia. Numbers of cells spontaneously secreting immunoglobulin (Ig) in freshly isolated suspensions of peripheral blood mononuclear cells and pokeweed mitogen (PWM) stimulated cultures ...

journal_title：British journal of haematology

authors： Levinson AI,Dziarski A,Blankenhorn E,Schreiber AD,Negendank WG

更新日期：1985-07-01 00:00:00

abstract：:An immunotoxin containing an anti-CD30 monoclonal antibody (Ber-H2) and saporin, a ribosome-inactivating protein type 1, is described. It specifically inhibits protein synthesis by Hodgkin derived target cell lines with a very high efficiency (IC50 ranging from 5 x 10(-12) M to 5 x 10(-14) M, as saporin), while irrele...

journal_title：British journal of haematology

authors： Tazzari PL,Bolognesi A,de Totero D,Falini B,Lemoli RM,Soria MR,Pileri S,Gobbi M,Stein H,Flenghi L

更新日期：1992-06-01 00:00:00

abstract：:Guidelines on hereditary spherocytosis (HS) published in 2004 (Bolton-Maggs et al, 2004) are here replaced to reflect changes in current opinion on the surgical management, (particularly the indications for concomitant splenectomy with cholecystectomy in children with mild HS, and concomitant cholecystectomy with sple...

journal_title：British journal of haematology

authors： Bolton-Maggs PH,Langer JC,Iolascon A,Tittensor P,King MJ,General Haematology Task Force of the British Committee for Standards in Haematology.

更新日期：2012-01-01 00:00:00

abstract：:Platelets in an infant with Chediak-Higashi (C-H) syndrome without bleeding manifestations and not in the accelerated phase showed abnormal function consistent with storage pool disorder as shown by abnormal aggregation, decreased storage capacity and release of [14C]5-HT, low endogenous 5-HT, reduced ATP and ADP with...

journal_title：British journal of haematology

authors： Boxer GJ,Holmsen H,Robkin L,Bang NU,Boxer LA,Baehner RL

更新日期：1977-04-01 00:00:00

abstract：:Since the description in 1974 of the 5q--syndrome, only 29 cases have been reported. Over a 3 1/2 year period cytogenetic culture of bone marrow submitted from 344 patients being investigated for a blood disorder revealed nine patients with anomalies of chromosome 5. In five of these patients (samples arising from 37 ...

journal_title：British journal of haematology

authors： Tinegate H,Gaunt L,Hamilton PJ

更新日期：1983-05-01 00:00:00

abstract：:A patient with advanced myeloid metaplasia was treated with alpha-interferon (29 months) with a remarkable response. He had anaemia, thrombocytopenia and hepatosplenomegaly with infarction. The initial bone marrow showed replacement with fibrosis with no evident haemopoietic cells. Post-therapy, the patient became asy...

journal_title：British journal of haematology

authors： Dalla KP,Zeigler ZR,Shadduck RK

更新日期：1994-03-01 00:00:00

abstract：:Genetic variation in innate immunity may alter host-pathogen defence mechanisms and promote aberrant immune responses and non-Hodgkin lymphoma (NHL). To test this hypothesis, we investigated polymorphisms in innate immune genes in a pooled analysis of two population-based case-control studies of NHL from the San Franc...

journal_title：British journal of haematology

authors： Forrest MS,Skibola CF,Lightfoot TJ,Bracci PM,Willett EV,Smith MT,Holly EA,Roman E

更新日期：2006-07-01 00:00:00

abstract：:We describe the characterization of a novel 7.9 kb deletion that eliminated one of the duplicated alpha-globin genes, causing an alpha+-thalassaemia phenotype in two independent carriers of Suriname-Indian origin. The molecular characterization of the deletion breakpoint fragment revealed neither involvement of Alu re...

journal_title：British journal of haematology

authors： Harteveld CL,van Delft P,Wijermans PW,Kappers-Klunne MC,Weegenaar J,Losekoot M,Giordano PC

更新日期：2003-01-01 00:00:00

abstract：:Myelofibrosis is characterized by splenomegaly and debilitating constitutional symptoms that negatively impact patients' quality of life. ROBUST, a UK, open-label, phase II study, evaluated the safety and efficacy of ruxolitinib in patients with myelofibrosis (N = 48), including intermediate-1 risk patients. The prima...

journal_title：British journal of haematology

authors： Mead AJ,Milojkovic D,Knapper S,Garg M,Chacko J,Farquharson M,Yin J,Ali S,Clark RE,Andrews C,Dawson MK,Harrison C

更新日期：2015-07-01 00:00:00

abstract：:Risk assessment for patients with sickle cell disease (SCD) remains challenging as it depends on an individual physician's experience and ability to integrate a variety of test results. We aimed to provide a new risk score that combines clinical, laboratory, and imaging data. In a prospective cohort of 600 adult patie...

journal_title：British journal of haematology

authors： Sachdev V,Tian X,Gu Y,Nichols J,Sidenko S,Li W,Beri A,Layne WA,Allen D,Wu CO,Thein SL

更新日期：2021-01-28 00:00:00

abstract：:An 18-month-old child, who had no evidence of liver disease, malabsorption, or chronic ingestion of coumarin compounds, was found to have plasma deficiencies of factors II, VII, IX and X. Assays for factor II and X by immunological techniques (antibody neutralization and immunoelectrophoresis) revealed normal or eleva...

journal_title：British journal of haematology

authors： Johnson CA,Chung KS,McGrath KM,Bean PE,Roberts HR

更新日期：1980-03-01 00:00:00

abstract：:The thiol isomerase enzymes protein disulphide isomerase (PDI) and endoplasmic reticulum protein 5 (ERp5) are released by resting and activated platelets. These re-associate with the cell surface where they modulate a range of platelet responses including adhesion, secretion and aggregation. Recent studies suggest the...

journal_title：British journal of haematology

authors： Holbrook LM,Watkins NA,Simmonds AD,Jones CI,Ouwehand WH,Gibbins JM

更新日期：2010-02-01 00:00:00

abstract：:Mobilised peripheral blood is now the main source of stem cells collected from normal donors. We report our experience of mobilising and collecting 400 normal healthy donors using standardised procedures and techniques. Target recipient doses were reached with one aphaeresis in 63% of donors and with two aphereses in ...

journal_title：British journal of haematology

authors： Ings SJ,Balsa C,Leverett D,Mackinnon S,Linch DC,Watts MJ

更新日期：2006-09-01 00:00:00

abstract：:The addition of rituximab (R) to CHOP (cyclophosphamide, doxorubicin, vincristine, prednisone) chemotherapy was a milestone in the development of front-line therapy for diffuse large B-cell lymphoma (DLBCL). R-CHOP and equivalent rituximab-containing anthracycline-based regimens are now widely accepted as the standard...

journal_title：British journal of haematology

authors： Gisselbrecht C

更新日期：2008-12-01 00:00:00

abstract：:This study was designed to determine the incidence of relapse and factors predictive for relapse in 719 patients with severe aplastic anaemia (SAA) after immunosuppressive treatment (IS). Patients developing myelodysplasia or acute leukaemia after IS, and patients receiving a transplant, were excluded from this analys...

journal_title：British journal of haematology

authors： Schrezenmeier H,Marin P,Raghavachar A,McCann S,Hows J,Gluckman E,Nissen C,van't Veer-Korthof ET,Ljungman P,Hinterberger W

更新日期：1993-10-01 00:00:00