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N-RAS mutations in T-cell acute lymphocytic leukaemia: analysis by direct sequencing detects a novel mutation.

Abstract：

:A novel mutation of the N-RAS gene of T-ALL blast cells was detected by a direct sequencing of in vitro amplified exon-1 of the N-RAS gene. Threonine (ACA) was substituted for alanine (GCA) at codon 11. This mutation would have been overlooked by conventional probe hybridization techniques. A search for other mutations in N-RAS exon-1 in T-ALL revealed a codon 13 mutation substituting aspartic acid (GAT) for glycine (GGT) in one of 18 patients. No mutations at codon 12 were detected.

journal_name

Br J Haematol

journal_title

British journal of haematology

authors

Bar-Eli M,Ahuja H,Foti A,Cline MJ

doi

10.1111/j.1365-2141.1989.tb07648.x

subject

Has Abstract

pub_date

1989-05-01 00:00:00

pages

36-9

issue

1

eissn

0007-1048

issn

1365-2141

journal_volume

72

pub_type

杂志文章

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