Expression of functional interleukin-21 receptor on adult T-cell leukaemia cells.

abstract：:High-dose chemotherapy (HDT) with autologous stem cell transplantation is the standard of care for relapsed/refractory (RR) Hodgkin lymphoma (HL). Given that HDT may cure a sizeable proportion of patients refractory to first salvage, development of newer conditioning regimens remains a priority. We present the results...

journal_title：British journal of haematology

authors： Musso M,Messina G,Di Renzo N,Di Carlo P,Vitolo U,Scalone R,Marcacci G,Scalzulli PR,Moscato T,Matera R,Crescimanno A,Santarone S,Orciuolo E,Merenda A,Pavone V,Pastore D,Donnarumma D,Carella AM,Ciochetto C,Cascavilla

更新日期：2016-01-01 00:00:00

abstract：:We report on the generation and functional characterization of a humanized immunoenzyme comprising a stable humanized single chain Fv (scFv) with grafted specificity of the anti-CD22 murine monoclonal antibody RFB4 and the human ribonuclease angiogenin (ANG). The fusion protein produced from transiently transfected ma...

journal_title：British journal of haematology

authors： Krauss J,Arndt MA,Vu BK,Newton DL,Rybak SM

更新日期：2005-03-01 00:00:00

abstract：:Adhesive interactions between haemopoietic progenitor cells and bone marrow sinusoidal endothelium are potentially important in the homing of these cells back to the extravascular compartment of the marrow to re-establish haemopoiesis following stem cell transplantation. A simple method for the isolation and culture o...

journal_title：British journal of haematology

authors： Masek LC,Sweetenham JW

更新日期：1994-12-01 00:00:00

abstract：:Therapeutic options for treatment of recurrence of leukaemia after allogeneic bone marrow transplantation (BMT) are limited. A beneficial effect of donor lymphocyte infusions (DLI) has not previously been described in acute myeloid leukaemia (AML) relapse. We report a case of AML with t(8;21), relapsing 3 months after...

journal_title：British journal of haematology

authors： Buzyn-Veil A,Belanger C,Audat F,Hermine O,Bodemer C,Ribrag V,Radford I,Poirel H,Chane C,Valensi F,Macintyre E,Varet B

更新日期：1996-02-01 00:00:00

abstract：:Immune-mediated pathways have been recognized to be of importance in the pathogenesis of chronic lymphocytic leukaemia (CLL). We assessed a broad variety of immune-related and inflammatory conditions and subsequent CLL development among 4 million adult male veterans admitted to VA hospitals. We identified 3,680 CLL ca...

journal_title：British journal of haematology

authors： Landgren O,Gridley G,Check D,Caporaso NE,Morris Brown L

更新日期：2007-12-01 00:00:00

abstract：:Accumulating evidence indicates that a graft-vs.-myeloma effect (GVM) and its associated clinical remission of the disease can be induced by donor lymphocyte infusion in myeloma patients who have relapsed after allogeneic bone marrow transplantation. Although it is believed that GVM is induced by allospecific T cells,...

journal_title：British journal of haematology

authors： Chiriva-Internati M,Du J,Cannon M,Barlogie B,Yi Q

更新日期：2001-02-01 00:00:00

abstract：:The prognostic relevance of karyotype has been established in adult acute lymphoblastic leukaemia (ALL) patients treated with chemotherapy but not definitively evaluated in an allogeneic bone marrow transplantation (BMT) setting. To determine the factors affecting the outcome of allogeneic BMT for adults with precurso...

journal_title：British journal of haematology

authors： Lee S,Kim DW,Kim YJ,Park YH,Min CK,Lee JW,Min WS,Kim CC

更新日期：2002-04-01 00:00:00

abstract：:Peripheral T-cell lymphomas (PTCL) have suboptimal outcomes using conventional CHOP (cyclophosphamide, doxorubicin, vincristine, prednisone) chemotherapy. The anti-folate pralatrexate, the first drug approved for patients with relapsed/refractory PTCL, provided a rationale to incorporate it into the front-line setting...

journal_title：British journal of haematology

authors： Advani RH,Ansell SM,Lechowicz MJ,Beaven AW,Loberiza F,Carson KR,Evens AM,Foss F,Horwitz S,Pro B,Pinter-Brown LC,Smith SM,Shustov AR,Savage KJ,Vose JM

更新日期：2016-02-01 00:00:00

abstract：:Five monoclonal antibodies have been tested for their ability to bind to myeloid precursor cells in normal human bone marrow. Indirect immunofluorescence and the fluorescence activated cell sorter was used to separate cells according to their reactivity for trial culture in vitro in order to grow granulocyte-macrophag...

journal_title：British journal of haematology

authors： Crawford DH,Francis GE,Wing MA,Edwards AJ,Janossy G,Hoffbrand AV,Prentice HG,Secher D,McConnell I,Kung PC,Goldstein G

更新日期：1981-10-01 00:00:00

abstract：:The Fanconi anaemia protein FANCD2 suppresses PPARƔ to maintain haematopoietic stem cell's (HSC) function; however, the underlying mechanism is not known. Here we show that FANCD2 acts in concert with the Notch target HES1 to suppress inflammation-induced PPARƔ in HSC maintenance. Loss of HES1 exacerbates FANCD2-KO HS...

journal_title：British journal of haematology

authors： Wu L,Li X,Lin Q,Chowdhury F,Mazumder MH,Du W

更新日期：2020-11-22 00:00:00

abstract：:Expression of heat-shock proteins (hsp) was analysed in the leukaemic cells of 12 patients with acute myeloid leukaemia (AML) and nine patients with chronic myeloid leukaemia (CML). Using monoclonal antibodies to hsp70, hsp90 and hsp60 (ML30, a mycobacterial antigen with homology to human hsp60), we measured hsp level...

journal_title：British journal of haematology

authors： Chant ID,Rose PE,Morris AG

更新日期：1995-05-01 00:00:00

abstract：:In a series of 306 cases of myeloproliferative disorders followed over a period of 21 years, 18 cases of well-documented acute leukaemia were encountered. Leukaemias were either acute myeloblastic or myelomonocytic and occurred from 6 months to 20 years after the initial diagnosis. Onset was relatively abrupt and the ...

journal_title：British journal of haematology

authors： Rosenthal DS,Moloney WC

更新日期：1977-07-01 00:00:00

abstract：:We describe three cases of relapsed hairy cell leukaemia (HCL) treated with pentostatin plus rituximab. All three achieved bone marrow complete remission but had persistent splenomegaly and hypersplenism. Because of the clinical uncertainty of its significance, they were all splenectomized. The spleen histology showed...

journal_title：British journal of haematology

authors： Sarid N,Ahmad HN,Wotherspoon A,Dearden CE,Else M,Catovsky D

更新日期：2015-12-01 00:00:00

abstract：:This study assessed the recruitment to an acute myeloid leukaemia (AML) trial (AML15) in a single centre, evaluated whether outcome was influenced by trial entry and whether the trial population could be considered representative of all AML patients by retrospective comparison of patient characteristics, trial entry a...

journal_title：British journal of haematology

authors： Stevens JM,Macdougall F,Jenner M,Oakervee H,Cavenagh J,Lister AT

更新日期：2009-04-01 00:00:00

abstract：:We conducted a study to demonstrate vincristine-induced apoptosis in vivo in peripheral blood mononuclear cells of children with newly diagnosed acute lymphoblastic leukaemia (ALL). In five children, apoptosis was detected by terminal deoxynucleotide transferase-mediated dUTP-digoxigenin nick-end labelling (TUNEL) ass...

journal_title：British journal of haematology

authors： Groninger E,de Graaf SS,Meeuwsen-de Boer GJ,Sluiter WJ,Poppema S

更新日期：2000-12-01 00:00:00

abstract：:The CDKN2 gene, encoding the cyclin-dependent kinase-4 inhibitor p16, is a putative tumour-suppressor gene because it is frequently altered in many malignant tumours. We analysed the CDKN2 gene in 44 cases of adult T-cell leukaemia (ATL) by Southern blot analysis, polymerase chain reaction-mediated single-strand confo...

journal_title：British journal of haematology

authors： Uchida T,Kinoshita T,Watanabe T,Nagai H,Murate T,Saito H,Hotta T

更新日期：1996-09-01 00:00:00

abstract：:We have tested the different mononuclear blood cell populations of seven patients with severe haemophilia and one patient with F VII deficiency for the presence of HBV DNA. These subjects were all polytransfused with non-heated coagulation factors; three were HBsAg positive, five HBsAg negative but anti-HBc and anti-H...

journal_title：British journal of haematology

authors： Lauré F,Chatenoud L,Pasquinelli C,Gazengel C,Beaurain G,Torchet MF,Zagury D,Bach JF,Bréchot C

更新日期：1987-02-01 00:00:00

abstract：:Homing of transplanted bone marrow cells (BMC) to the host bone marrow (BM) is the first step of engraftment towards durable multilineage haematopoietic reconstitution. We used an in vivo assay to track PKH-labelled cells in the BM of mice after transplantation, using fluorescence microscopy through an optical window ...

journal_title：British journal of haematology

authors： Askenasy N,Farkas DL

更新日期：2003-02-01 00:00:00

abstract：:Chronic ITP is due to antibody-induced destruction of platelets by the reticuloendothelial (RE) system. The role of complement in this process is unclear. We measured platelet-associated complement (PAC) components C3, C3bi, C4 and C9 in 16 patients with chronic ITP, in two of these patients prior to and after splenec...

journal_title：British journal of haematology

authors： Kurata Y,Curd JG,Tamerius JD,McMillan R

更新日期：1985-08-01 00:00:00

abstract：:Addition of the inflammatory cytokine interleukin (IL)-6 to the culture medium of human cord blood haematopoietic stem and progenitor cells (HSPCs) has been shown to lead to an altered stromal cell-derived factor-1alpha-dependent migratory phenotype. This study investigated whether this effect was attributed to a diff...

journal_title：British journal of haematology

authors： Kasenda B,Kassmer SH,Niggemann B,Schiermeier S,Hatzmann W,Zänker KS,Dittmar T

更新日期：2008-09-01 00:00:00

abstract：:Bone mineral content (BMC) of the radius was measured using single photon absorptiometry (SPA) in nine children with congenital neutropenia. Five had normal values. Two children with severe congenital neutropenia (SCN) had low BMC, and two boys with Schwachman syndrome had biochemistry suggestive of rickets. ...

journal_title：British journal of haematology

authors： Fewtrell MS,Kinsey SE,Williams DM,Bishop NJ

更新日期：1997-06-01 00:00:00

abstract：:Colony-forming cells of the granulocytic/macrophage ( CFCGM ) and eosinophilic ( CFCEo ) series were grown from bone marrow and/or peripheral blood of 20 patients with persistent eosinophilia mainly due to helminthic diseases and of 17 patients without eosinophilia. The semi-solid culture technique of haemopoietic cel...

journal_title：British journal of haematology

authors： Kern P,Dietrich M

更新日期：1984-05-01 00:00:00

abstract：:Patients with solid tumours undergoing high-dose chemotherapy with autologous bone marrow transplantation use an average of 10 units of packed red blood cells (PRBC) while awaiting haemopoietic reconstitution. They are also known to have inappropriately low endogenous erythropoietin levels for their degree of anaemia....

journal_title：British journal of haematology

authors： Ayash LJ,Elias A,Hunt M,Demetri G,Wheeler C,Tepler I,Schwartz G,Mazanet R,Reich E,McCauley M

更新日期：1994-05-01 00:00:00

abstract：:We have earlier demonstrated that in a family with a tendency to recurrent venous thrombosis the release of tissue plasminogen activator (t-PA) activity in blood after stimulation was abnormally low. This observation could be related either to an impaired release of t-PA into the blood stream or to a masking of the re...

journal_title：British journal of haematology

authors： Jørgensen M,Bonnevie-Nielsen V

更新日期：1987-02-01 00:00:00

abstract：:Post-transplant lymphoproliferative disorder (PTLD) after haemopoietic stem cell transplantation is a serious complication that occurs in 8-22% of patients with high-risk factors. We retrospectively investigated tolerance and efficacy of humanized anti-CD20 monoclonal antibody (rituximab) as first-line treatment in 12...

journal_title：British journal of haematology

authors： Faye A,Quartier P,Reguerre Y,Lutz P,Carret AS,Dehée A,Rohrlich P,Peuchmaur M,Matthieu-Boué A,Fischer A,Vilmer E

更新日期：2001-10-01 00:00:00

abstract：:Investigations of the purine degradative enzymes adenosine deaminase (ADA), purine nucleoside phosphorylase (PNP), and ecto-5'-nucleotidase (5'NT) have been shown to be of value in defining subsets of lymphoid malignancies. We have studied the activities of these enzymes in the circulating malignant cells of 35 patien...

journal_title：British journal of haematology

authors： Ho AD,Dörken B,Ma DD,Pezzutto A,Hunstein W,Hoffbrand AV

更新日期：1986-03-01 00:00:00

abstract：:The routine methods for estimating erythrocyte size (volume and surface area) are not generally unbiased. Using geometric models introduces a bias determined by the ways in which real red blood corpuscles depart in size and shape from the simplistic ideal. Employing haematocrit and red corpuscle count to estimate mean...

journal_title：British journal of haematology

authors： Mayhew TM,Mwamengele GL,Self TJ,Travers JP

更新日期：1994-02-01 00:00:00

abstract：:ATOH8 has previously been shown to be an iron-regulated transcription factor, however its role in iron metabolism is not known. ATOH8 expression in HEK293 cells resulted in increased endogenous HAMP mRNA levels as well as HAMP promoter activity. Mutation of the E-box or SMAD response elements within the HAMP promoter ...

journal_title：British journal of haematology

authors： Patel N,Varghese J,Masaratana P,Latunde-Dada GO,Jacob M,Simpson RJ,McKie AT

更新日期：2014-02-01 00:00:00

abstract：:Recent studies have suggested the HoxA10, HoxA11 and HoxD11 homeobox genes as candidate loci for the thrombocytopenia with absent radius (TAR) syndrome. For example, targeted disruptions of these Hox genes result in abnormal development of the mouse radius, while overexpression of HoxA10 stimulates mouse megakaryocyte...

journal_title：British journal of haematology

authors： Fleischman RA,Letestu R,Mi X,Stevens D,Winters J,Debili N,Vainchenker W

更新日期：2002-02-01 00:00:00

abstract：:To create immortal mesenchymal cell lines, we transduced primary human bone marrow mesenchymal cells with telomerase reverse transcriptase (TERT). TERT+ mesenchymal cells continued to grow for > 2 years; parallel TERT- cultures underwent senescence after 15 weeks. TERT+ mesenchymal cells did not form foci in soft agar...

journal_title：British journal of haematology

authors： Mihara K,Imai C,Coustan-Smith E,Dome JS,Dominici M,Vanin E,Campana D

更新日期：2003-03-01 00:00:00