The CD11/CD18 granulocyte adhesion molecules in myelodysplastic syndromes.

abstract：:A 16-year-old boy with a bleeding disorder since infancy has a long bleeding time, normal platelet count and morphology and normal plasma factor-VIII activities. His platelets undergo normal shape change and primary aggregation in response to ADP but show defective 5-hydroxytryptamine (5-HT) secretion and aggregation ...

journal_title：British journal of haematology

authors： Hardisty RM,Machin SJ,Nokes TJ,Rink TJ,Smith SW

更新日期：1983-04-01 00:00:00

abstract：:The phenotypic expression and functional capacity of natural killer (NK) T-lymphocytes (E+, OKT3+) were analysed in a series of untreated patients with B-cell chronic lymphocytic leukaemia (B-CLL). The mean value of NK activity of B-CLL T-lymphocytes, tested against the K562 cell line, was significantly depressed (P l...

journal_title：British journal of haematology

authors： Foa R,Lauria F,Lusso P,Giubellino MC,Fierro MT,Ferrando ML,Raspadori D,Matera L

更新日期：1984-11-01 00:00:00

abstract：:The clinical significance of Aspergillus fungaemia in the setting of a deep-seated aspergillosis has not been clearly established. Among 107 microbiologically documented Aspergillus infections in patients with haematological diseases observed over a 17-year period, blood cultures grew Aspergillus species from 10 cases...

journal_title：British journal of haematology

authors： Girmenia C,Nucci M,Martino P

更新日期：2001-07-01 00:00:00

abstract：:A 29-year-old man in remission from acute myeloblastic leukaemia was treated by chemoradiotherapy and transplantation of bone marrow (BMT) collected from his HLA identical brother. Engraftment was documented on D12. Transient acute GVHD (grade II) appeared from D34. No infection complicated the BMT. Nevertheless sever...

journal_title：British journal of haematology

authors： Bierling P,Cordonnier C,Fromont P,Rodet M,Tanzer J,Vernant JP,Bracq C,Duedari N

更新日期：1985-04-01 00:00:00

abstract：:Seven children (age range 1.8-11 years) with juvenile chronic myelomonocytic leukaemia (JCML) received an allogeneic bone marrow transplantation (BMT), four from an HLA-identical sibling and three from a matched unrelated donor. In the four children transplanted using an HLA-identical sibling, conditioning regimen inc...

journal_title：British journal of haematology

authors： Locatelli F,Pession A,Comoli P,Bonetti F,Giorgiani G,Zecca M,Taibi RM,Mongini ME,Ambroselli F,de Stefano P,Severi F,Paolucci G

更新日期：1996-01-01 00:00:00

abstract：:Homing of transplanted bone marrow cells (BMC) to the host bone marrow (BM) is the first step of engraftment towards durable multilineage haematopoietic reconstitution. We used an in vivo assay to track PKH-labelled cells in the BM of mice after transplantation, using fluorescence microscopy through an optical window ...

journal_title：British journal of haematology

authors： Askenasy N,Farkas DL

更新日期：2003-02-01 00:00:00

abstract：:This study shows a marked and protracted activation of HbF synthesis in homozygous beta.-thalassaemia patients transplanted from HLA identical siblings heterozygous for beta-thalassaemia, as compared to patients transplanted from normal donors. HbF synthesis in recipients was much higher in relation to the correspondi...

journal_title：British journal of haematology

authors： Galanello R,Barella S,Maccioni L,Paglietti E,Melis MA,Rosatelli MC,Argiolu F,Cao A

更新日期：1989-08-01 00:00:00

abstract：:β- thalassaemia is a disorder of globin gene synthesis resulting in reduced or absent production of the β-globin chain in red blood cells. In this study, haematopoietic stem cells were isolated from the peripheral blood of six transfusion dependent β-thalassaemia patients and six healthy controls. Following 7 and 14 d...

journal_title：British journal of haematology

authors： Forster L,McCooke J,Bellgard M,Joske D,Finlayson J,Ghassemifar R

更新日期：2015-07-01 00:00:00

abstract：:Increased osteoclastic bone resorption is the major causal factor of bone disease in multiple myeloma. Recently, non-invasive methods have been developed for the estimation of bone resorptive activity. To evaluate the biological sensitivity and clinical usefulness of five biochemical assays for measuring the C-termina...

journal_title：British journal of haematology

authors： Abildgaard N,Brixen K,Kristensen JE,Eriksen EF,Nielsen JL,Heickendorff L

更新日期：2003-01-01 00:00:00

abstract：:Human megakaryocytes have been isolated from marrow obtained from ribs removed at thoracotomy. All but one of the patients had normal pre-operative platelet and leucocyte counts. Megakaryocytes averaged 0.37% of all cells in marrow cell suspensions from nine consecutive subjects. A 283-fold purification (to 10.3%) was...

journal_title：British journal of haematology

authors： Levine RF

更新日期：1980-07-01 00:00:00

abstract：:Antibodies (Abs) that block factor VIII (FVIII) activity occur in hemophilia A patients treated with FVIII replacement therapy and severely impair treatment. In this work, we designed and synthesized ten peptides whose sequences are found in putative epitopes at the surface of a1 and C2 domains of the FVIII molecule. ...

journal_title：British journal of haematology

authors： Chaves DG,Velloso-Rodrigues C,Moreau V,Nguyen C,Villard S,Belisário AR,Granier C,Santoro MM

更新日期：2008-05-01 00:00:00

abstract：:Blood from five donors, previously shown to be positive for cytomegalovirus (CMV) DNA following polymerase chain reaction (PCR) amplification, was filtered through commercially available leucocyte filters. Analysis of pre- and post-filtration samples by PCR with ethidium bromide staining has shown that filtration was ...

journal_title：British journal of haematology

authors： Smith KL,Cobain T,Dunstan RA

更新日期：1993-04-01 00:00:00

abstract：:The effects of oral contraceptive (OC) usage on platelet responsiveness to arachidonic acid metabolites was investigated. Platelets obtained from women who had been taking oral contraceptives for at least 3 months were compared with those of age-matched controls. Both the basal and prostacyclin (PGI2)-stimulated plate...

journal_title：British journal of haematology

authors： Pan IQ,Hall ER,Wu KK

更新日期：1984-10-01 00:00:00

abstract：:Twelve consecutive adults with severe acute aplastic anaemia, not having a bone marrow transplantation option, were prospectively randomized to receive either cyclosporin A alone or an equivalent amount of this immunosuppressive agent in combination with antilymphocyte serum. The minimum follow-up is 36 months, with h...

journal_title：British journal of haematology

authors： Jacobs P,Wood L,Martell RW

更新日期：1985-10-01 00:00:00

abstract：:Sickle cell disease (SCD) is complicated by silent cerebral infarcts, visible as white matter hyperintensities (WMHs) on magnetic resonance imaging (MRI). Both local vaso-occlusion, elicited by endothelial dysfunction, and insufficiency of cerebral blood flow (CBF) have been proposed to be involved in the aetiology. W...

journal_title：British journal of haematology

authors： van der Land V,Mutsaerts HJ,Engelen M,Heijboer H,Roest M,Hollestelle MJ,Kuijpers TW,Nederkoorn PJ,Cnossen MH,Majoie CB,Nederveen AJ,Fijnvandraat K

更新日期：2016-01-01 00:00:00

abstract：:Thrombopoietin (TPO) is the primary regulator of platelet production and acts through binding its receptor, c-mpl, found on megakaryocyte progenitor cells, megakaryocytes and platelets. Circulating levels of TPO are regulated primarily by the clearance of TPO after it binds to c-mpl receptors on circulating platelets....

journal_title：British journal of haematology

authors： Li J,Xia Y,Kuter DJ

更新日期：1999-08-01 00:00:00

abstract：:The administration of Interleukin-2 (IL-2) causes the release or generation of other cytokines such as tumour necrosis factor (TNF) which, by disturbing the anticoagulant properties of the endothelium, may induce a procoagulant state in patients receiving this drug. We therefore evaluated the effects of IL-2 on coagul...

journal_title：British journal of haematology

authors： Baars JW,de Boer JP,Wagstaff J,Roem D,Eerenberg-Belmer AJ,Nauta J,Pinedo HM,Hack CE

更新日期：1992-10-01 00:00:00

abstract：:The US National Cancer Institute's Surveillance, Epidemiology and End Results program was used to develop aetiological clues for hairy cell leukaemia (HCL). Descriptive techniques (age-adjusted incidence trends, age-specific incidence rates (IR), and age distributions-at-diagnosis) were supplemented with mathematical ...

journal_title：British journal of haematology

authors： Dores GM,Matsuno RK,Weisenburger DD,Rosenberg PS,Anderson WF

更新日期：2008-07-01 00:00:00

abstract：:Chromosomal rearrangements involving the MECOM (MDS1 and EVI1 complex) locus are recurrent genetic events in myeloid leukaemia and are associated with poor prognosis. In this study, we assessed the role of MECOM locus protein EVI1 in the transcriptional regulation of microRNAs (miRNAs) involved in the leukaemic phenot...

journal_title：British journal of haematology

authors： De Weer A,Van der Meulen J,Rondou P,Taghon T,Konrad TA,De Preter K,Mestdagh P,Van Maerken T,Van Roy N,Jeison M,Yaniv I,Cauwelier B,Noens L,Poirel HA,Vandenberghe P,Lambert F,De Paepe A,Sánchez MG,Odero M,Verhasselt

更新日期：2011-08-01 00:00:00

abstract：:To investigate the role of retinoblastoma susceptibility (RB) gene inactivation in leukaemogenesis, we evaluated 36 bone marrow specimens of acute leukaemia for RB protein expression by immunoprecipitation and Western blot analysis. 15 patients had no detectable RB protein at initial screening. However, nine of them w...

journal_title：British journal of haematology

authors： Tang JL,Yeh SH,Chen PJ,Lin MT,Tien HF,Chen YC

更新日期：1992-11-01 00:00:00

abstract：:t(11;18)(q21;q21) has been recognized as a characteristic chromosomal translocation in mucosa-associated lymphoid tissue (MALT)-type lymphoma, and recent studies have demonstrated that this translocation results in the chimaeric transcript of API2 (apoptosis inhibitor 2)-MALT1 (mucosa-associated lymphoid tissue lympho...

journal_title：British journal of haematology

authors： Yonezumi M,Suzuki R,Suzuki H,Yoshino T,Oshima K,Hosokawa Y,Asaka M,Morishima Y,Nakamura S,Seto M

更新日期：2001-12-01 00:00:00

abstract：:The in vitro and in vivo activity of a deoxycytidine analogue, troxacitabine, alone or in combination with imatinib mesylate (IM), was evaluated against human chronic myeloid leukaemia (CML) cell lines both sensitive (KBM5 and KBM7) and resistant (KBM5-R and KBM7-R) to IM. These cell lines differ in their sensitivity ...

journal_title：British journal of haematology

authors： Orsolic N,Giles FJ,Gourdeau H,Golemovic M,Beran M,Cortes J,Freireich EJ,Kantarjian H,Verstovsek S

更新日期：2004-03-01 00:00:00

abstract：:Recently developed ferrokinetic methods offer a tool to measure effective and ineffective erythropoiesis and mean red-cell lifespan (Ricketts et al, 1975). We have used this tool to investigate erythropoiesis in normal subjects and in patients with the anaemia of active rheumatoid arthritis. In normal subjects the res...

journal_title：British journal of haematology

authors： Dinant HJ,de Maat CE

更新日期：1978-07-01 00:00:00

abstract：:Sixty patients with haematological malignancies received a myeloablative regimen of total body irradiation, cyclophosphamide and fludarabine followed by a T-cell-depleted peripheral blood stem cell transplant from a human leucocyte antigen identical sibling. To improve donor immune function, 1 x 10(7) CD3+ cells/kg we...

journal_title：British journal of haematology

authors： Montero A,Savani BN,Kurlander R,Read EJ,Leitman SF,Childs R,Solomon SR,Barrett AJ

更新日期：2005-09-01 00:00:00

abstract：:Folate analogues were added to human bone marrow cells to determine their effect on deoxyuridine utilization in the deoxyuridine suppression test. Formyltetrahydrofolates fully corrected the impairment of dU utilization in pernicious anaemia marrows but tetrahydrofolate was relatively ineffective. All these analogues ...

journal_title：British journal of haematology

authors： Deacon R,Chanarin I,Perry J,Lumb M

更新日期：1980-12-01 00:00:00

abstract：:We treated 21 elderly patients with high-risk myelodysplasia (n = 14) or secondary acute myeloid leukaemia (n = 7) with 2 mg of melphalan orally once a day until a complete peripheral response was obtained or until there was evidence of treatment failure. We observed seven (30%) complete and two (10%) partial peripher...

journal_title：British journal of haematology

authors： Denzlinger C,Bowen D,Benz D,Gelly K,Brugger W,Kanz L

更新日期：2000-01-01 00:00:00

abstract：:Post-transfusion graft-versus-host disease (PTGVHD) is one of the most severe side-effects of blood transfusion. To characterize the effector cells causing this disease, we cloned lymphocytes from a PTGVHD patient's peripheral blood. T-cell and B-cell clones were established, the origins of which were proven to be tra...

journal_title：British journal of haematology

authors： Nishimura M,Uchida S,Mitsunaga S,Tokunaga K,Tadokoro K,Juji T

更新日期：1996-03-01 00:00:00

abstract：:Serum concentrations of the thrombopoiesis-enhancing cytokines thrombopoietin (TPO), erythropoietin (EPO), interleukin (IL)-6 and IL-11 were determined in 119 healthy whole-blood (WBD) and 101 platelet donors (PD) prior to donation. The 90% TPO reference interval in WBD of 64-867 pg/ml (median 163, 100% range 45-7572)...

journal_title：British journal of haematology

authors： Tacke F,Schöffski P,Trautwein C,Martin MU,Stangel W,Seifried E,Manns MP,Ganser A,Petersen D

更新日期：1999-05-01 00:00:00

abstract：:We studied X-chromosome inactivation patterns in blood cells from normal females in three age groups: neonates (umbilical cord blood), 25-32 years old (young women group) and >75 years old (elderly women). Using PCR, the differential allele methylation status was evaluated on active and inactive X chromosomes at the h...

journal_title：British journal of haematology

authors： Tonon L,Bergamaschi G,Dellavecchia C,Rosti V,Lucotti C,Malabarba L,Novella A,Vercesi E,Frassoni F,Cazzola M

更新日期：1998-09-01 00:00:00

abstract：:The Wiskott-Aldrich syndrome (WAS) is a severe disease of platelets (small size, thrombocytopenia) and lymphocytes (immunodeficiency) arising from mutations of the X-chromosome gene WASP. Because of the prominent role of cytoskeletal abnormalities, particularly the paucity of surface microvilli, in the cellular pathol...

journal_title：British journal of haematology

authors： Shcherbina A,Bretscher A,Rosen FS,Kenney DM,Remold-O'Donnell E

更新日期：1999-07-01 00:00:00