Abstract:
:Mutations of the DNA mismatch repair (MMR) gene hMLH1 have recently been linked to the development of some hereditary and sporadic cancers which frequently display widespread microsatellite instability (MSI). Conflicting results regarding the extent of MSI in myeloid leukaemias prompted us to perform mutational analysis of all 19 exons of the hMLH1 gene by polymerase chain reaction-single-stranded conformation polymorphism (PCR-SSCP) and sequence analysis in a total of 133 patients with acute and chronic myeloid leukaemia. Apart from one exonic and one intronic polymorphism, no mutations were detected in any of the samples indicating that the major MMR gene hMLH1 is not involved in the pathogenesis or progression of myeloid malignancies.
journal_name
Br J Haematoljournal_title
British journal of haematologyauthors
Auner HW,Olipitz W,Hoefler G,Bodner C,Konrad D,Crevenna R,Linkesch W,Sill Hdoi
10.1046/j.1365-2141.1999.01595.xsubject
Has Abstractpub_date
1999-09-01 00:00:00pages
706-8issue
3eissn
0007-1048issn
1365-2141pii
bjh1595journal_volume
106pub_type
杂志文章abstract::Limited therapies exist for patients with refractory and relapsed (RR) higher-risk myelodysplastic syndromes (HR-MDS) and acute myeloid leukaemia with trilineage dysplasia (AML-TD). High dose (HD) lenalidomide (50 mg) has activity as frontline therapy in elderly AML but there is limited data in the RR setting. This ph...
journal_title:British journal of haematology
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journal_title:British journal of haematology
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journal_title:British journal of haematology
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