Variables to predict engraftment of umbilical cord blood into immunodeficient mice: usefulness of the non-obese diabetic--severe combined immunodeficient assay.

abstract：:Routine testing on plasma from a patient due to undergo a coronary artery bypass graft operation revealed a prolonged thrombin clotting time associated with a normal plasma fibrinogen level when this was determined by a method not dependent upon the rate of fibrin formation. Fibrinogen purified from the patient's plas...

journal_title：British journal of haematology

authors： Lane DA,Cuddigan B,VanRoss M,Kakkar VV

更新日期：1980-03-01 00:00:00

abstract：:This study systematically reviewed and meta-analysed the prognostic value of complete remission status at end-of-treatment (18) F-fluoro-2-deoxy-d-glucose positron emission tomography (FDG-PET) in diffuse large B-cell lymphoma (DLBCL) patients treated with rituximab, cyclophosphamide, doxorubicin, vincristine and pred...

journal_title：British journal of haematology

authors： Adams HJ,Nievelstein RA,Kwee TC

更新日期：2015-07-01 00:00:00

abstract：:Approximately 31 patients with chronic myelogenous leukaemia (CML) are documented in the literature who survived more than 10 years after diagnosis. We present a CML-patient whose survival of 27 years is probably the longest reported so far. The analysis of the course of disease in these patients revealed that the dur...

journal_title：British journal of haematology

authors： Prischl FC,Haas OA,Lion T,Eyb R,Schwarzmeier JD

更新日期：1989-03-01 00:00:00

abstract：:The reasons why some patients with multiple myeloma (MM) do not develop severe bone loss, or even develop sclerotic bone lesions, remain unclear. In order to answer this question at the cellular and tissue level, we evaluated the histological bone condition of 10 patients with MM who never developed lytic bone lesions...

journal_title：British journal of haematology

authors： Bataille R,Chappard D,Marcelli C,Rossi JF,Dessauw P,Baldet P,Sany J,Alexandre C

更新日期：1990-12-01 00:00:00

abstract：:The clonalities in white blood cells (WBC) of blood and nucleated bone marrow cells from patients with refractory anaemia and aplastic anaemia were examined by polymerase chain reaction (PCR) methods using the polymorphic short tandem repeat (STR) on the human androgen-receptor gene (HUMARA). Peripheral blood samples ...

journal_title：British journal of haematology

authors： Anan K,Ito M,Misawa M,Ohe Y,Kai S,Kohsaki M,Hara H

更新日期：1995-04-01 00:00:00

abstract：:The F5 G1691A (Factor V Leiden) and F2 G20210A (prothrombin) mutations are linked to an increase in the incidence rate of venous thromboembolism (VTE), but their effects are highly variable. We investigated whether the effects of smoking and obesity might explain this variability. In a case-cohort study including the ...

journal_title：British journal of haematology

authors： Severinsen MT,Overvad K,Johnsen SP,Dethlefsen C,Madsen PH,Tjønneland A,Kristensen SR

更新日期：2010-04-01 00:00:00

abstract：:Ineffective erythropoiesis was quantitated in a series of patients with pernicious anaemia at different times in relation to vitamin B12 therapy by measuring the incorporation of [15N]delta aminolaevulinic acid and [15N]glycine into early labelled bilirubin. Prior to therapy ineffective erythropoiesis was grossly incr...

journal_title：British journal of haematology

authors： Samson D,Halliday D,Chanarin I

更新日期：1977-02-01 00:00:00

abstract：:The thiol isomerase enzymes protein disulphide isomerase (PDI) and endoplasmic reticulum protein 5 (ERp5) are released by resting and activated platelets. These re-associate with the cell surface where they modulate a range of platelet responses including adhesion, secretion and aggregation. Recent studies suggest the...

journal_title：British journal of haematology

authors： Holbrook LM,Watkins NA,Simmonds AD,Jones CI,Ouwehand WH,Gibbins JM

更新日期：2010-02-01 00:00:00

abstract：:In agreement with a recently published manuscript, this present study demonstrated that CD38+ sub-populations had increased proliferative activity as evidenced by higher Ki-67 expression (P < 0.0001). This raised the possibility that the CD38+ fraction is exposed to an increased risk of clonal evolution. However, seri...

journal_title：British journal of haematology

authors： Lin TT,Hewamana S,Ward R,Taylor H,Payne T,Pratt G,Baird D,Fegan C,Pepper C

更新日期：2008-08-01 00:00:00

abstract：:Summary Previous findings of megakaryocytic hypogranulation and dysmegakaryocytopoietic features in acute myeloid leukaemia (AML) strongly indicate defects in platelet production. The bleeding tendency of these patients may result from dysregulated platelet production, resulting in thrombocytopenia as well as qualitat...

journal_title：British journal of haematology

authors： Leinoe EB,Hoffmann MH,Kjaersgaard E,Johnsen HE

更新日期：2004-10-01 00:00:00

abstract：:The past decade has seen an explosion of interest in the epigenetics of cancer, with an increasing understanding that this form of genomic modification plays a critical role in pathogenesis. The malignant phenotype results from a step-wise increase of both genetic abnormalities and epigenetic modifications, leading to...

journal_title：British journal of haematology

authors： Boultwood J,Wainscoat JS

更新日期：2007-07-01 00:00:00

abstract：:Recently, leukaemia-associated antigens (LAA) recognized by T lymphocytes, such as Wilm's tumour-1 (WT-1) or pathogenesis-related protein-1 (PR-1), have been identified. For immunotherapies that employ antigen peptides, either alone or pulsed on dendritic cells (DC), the expression of human leucocyte antigen (HLA) mol...

journal_title：British journal of haematology

authors： Vollmer M,Li L,Schmitt A,Greiner J,Reinhardt P,Ringhoffer M,Wiesneth M,Döhner H,Schmitt M

更新日期：2003-03-01 00:00:00

abstract：:Cross-species Northern blot hybridization and radioimmunoassay have provided evidence for the expression of an erythropoietin (EPO)-like gene in the rainbow trout. The principal site of EPO-like mRNA and antigen expression in the adult trout appears to be the kidney which also acts as the major erythropoietic organ. T...

journal_title：British journal of haematology

authors： Shiels A,Wickramasinghe SN

更新日期：1995-05-01 00:00:00

abstract：:Mantle cell lymphoma (MCL), a malignancy of B-lymphocytes, has a poor prognosis. It is thus necessary to improve the understanding of the pathobiology of MCL and identify factors contributing to its aggressiveness. Our studies, based on Affymetrix data from 17 MCL biopsies, real-time quantitative polymerase chain reac...

journal_title：British journal of haematology

authors： Mundt F,Merrien M,Nygren L,Sutton LA,Christensson B,Wahlin BE,Rosenquist R,Sander B,Wasik AM

更新日期：2019-05-01 00:00:00

abstract：:In vitro colony formation of bone-marrow erythroid progenitor cells in patients with paroxysmal nocturnal haemoglobinuria (PNH) was examined. The numbers of early and late erythroid progenitors (BFU-E and CFU-E) showed wide variations; two cases out of eight cases of PNH showed decreased erythroid colony formation, bu...

journal_title：British journal of haematology

authors： Urabe A,Fujioka S

更新日期：1982-02-01 00:00:00

abstract：:Type 3 von Willebrand disease, a recessive autosomally inherited bleeding disorder, refers to complete deficiency of von Willebrand factor (VWF). The novel Q1311X mutation was detected in the homozygous state in four Spanish patients from two apparently unrelated families of gypsy origin. The lack of specific amplific...

journal_title：British journal of haematology

authors： Casaña P,Martínez F,Haya S,Lorenzo JI,Espinós C,Aznar JA

更新日期：2000-11-01 00:00:00

abstract：:The variable clinical outcomes of Multiple Myeloma (MM) patients are incompletely defined by current prognostication tools. We examined the clinical utility of high-resolution telomere length analysis as a prognostic marker in MM. Cohort stratification, using a previously determined length threshold for telomere dysfu...

journal_title：British journal of haematology

authors： Hyatt S,Jones RE,Heppel NH,Grimstead JW,Fegan C,Jackson GH,Hills R,Allan JM,Pratt G,Pepper C,Baird DM

更新日期：2017-07-01 00:00:00

abstract：:Membrane protein synthesis in human immature erythroid cells was studied by incubating the cells with 35S-methionine in vitro. The radioactive precursor amino acid was incorporated into membrane protein in a linear fashion for approximately 60 min, after which there was only a slight increase in incorporation. Intrace...

journal_title：British journal of haematology

authors： Krasnow SH,Pielichowski HJ,Caro J,Burka ER,Ballas SK

更新日期：1981-02-01 00:00:00

abstract：:Enteric coated aspirin (ECA) at doses of 325-1300 mg is an effective alternative to regular aspirin for inhibition of platelet activity while avoiding gastric irritation. The objectives of this study were to determine: (1) the lowest chronic dose of ECA providing effective inhibition of platelet activities, (2) the ti...

journal_title：British journal of haematology

authors： Jakubowski JA,Stampfer MJ,Vaillancourt R,Deykin D

更新日期：1985-08-01 00:00:00

abstract：:Based on the morphological appearances of the bone marrow and peripheral blood, 43 patients with dysmyelopoietic syndromes were categorized into four types: refractory anaemia with excess of blasts, chronic myelomonocytic leukaemia, primary acquired sideroblastic anaemia and refractory anaemia with cellular marrow, wi...

journal_title：British journal of haematology

authors： Cazzola M,Barosi G,Berzuini C,Dacco M,Orlandi E,Stefanelli M,Ascari E

更新日期：1982-01-01 00:00:00

abstract：:Defective marrow stroma or microenvironment have been proposed as one of several mechanisms to account for bone marrow failure in aplastic anaemia (AA). Stem cell factor (SCF), the ligand for the c-kit receptor, is produced mainly by marrow stromal cells and seems to reflect the haemopoietic function of bone marrow st...

journal_title：British journal of haematology

authors： Kojima S,Matsuyama T,Kodera Y

更新日期：1997-11-01 00:00:00

abstract：:The activities of glucose-6-phosphate dehydrogenase (D-glucose-6-phosphate: NADP oxidoreductase, G6PD), 6-phosphogluconate dehydrogenase (6-phospho-D-gluconate: NADP oxidoreductase, 6PGD), hexokinase (ATP: D-hexose 6-phosphotransferase, Hx), lactate dehydrogenase (D-lactate: NAD oxidoreductase, LDH). glutamate oxaloac...

journal_title：British journal of haematology

authors： Brok-Simoni F,Ashkenazi YE,Holtzman F,Ramot B

更新日期：1975-02-01 00:00:00

abstract：:The hepatitis C virus-positive (HCV+) mixed cryoglobulinaemia (MC) is associated with haematological alterations such as monoclonal B-cell lymphocytosis or non-Hodgkin lymphomas (NHLs). Antiviral therapy for MC, based on interferon and ribavirin, has been shown to be able to eliminate the viral replication as well as ...

journal_title：British journal of haematology

authors： Pozzato G,Mazzaro C,Artemova M,Abdurakhmanov D,Grassi G,Crosato I,Mauro E,Ghersetti M,Zorat F,Bomben R,Bulian P,Gattei V

更新日期：2020-08-13 00:00:00

abstract：:Neurological emergencies are frequently catastrophic events in the course of haematological malignancies (HM) that, if not promptly recognized and treated, may lead to lethal outcomes or chronic sequelae. They may occur at any time during the disease course, but are more frequently observed following relapse. Practice...

journal_title：British journal of haematology

authors： de la Fuente MI,Alderuccio JP,Lossos IS

更新日期：2020-06-01 00:00:00

abstract：:Clofarabine was the latest new drug to be approved, in 2004, for relapsed or refractory acute lymphoblastic leukaemia (ALL). To investigate its value in the frontline treatment of ALL we applied clofarabine 5 × 40 mg/m(2) in combination with pegylated asparaginase (PEG-ASP) 1 × 2500 iu/m(2) in high risk ALL patients a...

journal_title：British journal of haematology

authors： Escherich G,Zur Stadt U,Zimmermann M,Horstmann MA,CoALL study group.

更新日期：2013-10-01 00:00:00

abstract：:Parental longevity is associated with an increased life expectancy; results with regard to specific diseases are conflicting. There are limited data focusing on host characteristics and their effect on survival among multiple myeloma (MM) patients and individuals with monoclonal gammopathy of undetermined significance...

journal_title：British journal of haematology

authors： Sverrisdóttir IS,Lund SH,Turesson I,Björkholm M,Goldin LR,Landgren O,Kristinsson SY

更新日期：2019-07-01 00:00:00

abstract：:Plasma iron turnover (PIT) and ferritin synthesis in the liver and spleen were studied in rats within the first 24 h of inflammation produced by turpentine injection. Comparison of the sequential changes in PIT and ferritin synthesis showed that alterations in ferritin synthesis preceded the changes in plasma iron exc...

journal_title：British journal of haematology

authors： Konijn AM,Hershko C

更新日期：1977-09-01 00:00:00

abstract：:When stimulated in vitro, human platelets release matrix metalloproteinase-2 (MMP-2) that, in turn, potentiates platelet activation. The present study investigated if MMP-2 is released from activated platelets in vivo in humans and whether aspirin inhibits this release. MMP-2 levels were measured by zymography, immuno...

journal_title：British journal of haematology

authors： Falcinelli E,Giannini S,Boschetti E,Gresele P

更新日期：2007-07-01 00:00:00

abstract：:We report a case of positive Philadelphia chromosome adult acute lymphoblastic leukaemia with a novel unbalanced translocation t(17;19), leading to trisomy of 17q21-qter. The patient did not obtain complete haematological response and died a few months after diagnosis. The significance of the 17q21-qter trisomy, resul...

journal_title：British journal of haematology

authors： Specchia G,Albano F,Anelli L,Storlazzi CT,Cimino G,Liso A,Zagaria A,Liso V,Rocchi M

更新日期：2002-11-01 00:00:00

abstract：:Ibrutinib is associated with response rate of 90% and median progression-free survival (PFS) in excess of 5 years in Waldenström macroglobulinaemia (WM) patients. CXCR4 mutations are detected in 30-40% of patients with WM and associate with lower rates of response and shorter PFS to ibrutinib therapy. Both frameshift ...

journal_title：British journal of haematology

authors： Castillo JJ,Xu L,Gustine JN,Keezer A,Meid K,Dubeau TE,Liu X,Demos MG,Kofides A,Tsakmaklis N,Chen JG,Munshi M,Guerrera ML,Chan GG,Patterson CJ,Yang G,Hunter ZR,Treon SP

更新日期：2019-11-01 00:00:00