Plasma levels and production of soluble stem cell factor by marrow stromal cells in patients with aplastic anaemia.

abstract：:We describe a simple approach for molecular characterization and locus assignment of structural mutants by direct sequencing of enzymatically amplified DNA selective to alpha 1 and alpha 2 globin gene regions. Nucleotide substitution of two structural variants (Stanleyville II alpha 2(78Lys) and J Mexico alpha 2(54Glu...

journal_title：British journal of haematology

authors： Dodé C,Rochette J,Krishnamoorthy R

更新日期：1990-10-01 00:00:00

abstract：:The availability of a preparation of recombinant human erythropoietin (rEp) prompted us to investigate the role of Ep in the regulation of megakaryocytopoiesis in mice, using experimental procedures by which the effects on the mitotic and post-mitotic compartment of megakaryocytes could be evaluated separately. In aga...

journal_title：British journal of haematology

authors： Grossi A,Vannucchi AM,Rafanelli D,Rossi Ferrini P

更新日期：1989-04-01 00:00:00

abstract：:There are no accepted methods to predict the development of platelet transfusion refractoriness (PTR) due to human leucocyte antigen (HLA)-alloimmunization. Hence, matched platelets are usually given only to patients demonstrating PTR, necessarily resulting in some ineffective random donor platelets (RDPLT) transfusio...

journal_title：British journal of haematology

authors： Beligaswatte A,Tsiopelas E,Humphreys I,Bennett G,Robinson K,Davis K,Bardy P

更新日期：2013-08-01 00:00:00

abstract：:Aspergillus terreus, a less common pathogen, appears to be an emerging cause of infection at our institution, the Medical University Hospital of Innsbruck. Thus the epidemiology and outcome of A. terreus infections over the past 10 years was assessed. We analysed 67 cases of proven invasive aspergillosis (IA) accordin...

journal_title：British journal of haematology

authors： Lass-Flörl C,Griff K,Mayr A,Petzer A,Gastl G,Bonatti H,Freund M,Kropshofer G,Dierich MP,Nachbaur D

更新日期：2005-10-01 00:00:00

abstract：:To extend our knowledge of the kinetics of fetal thrombopoietin (TPO), we studied TPO levels in cord blood plasma and amniotic fluid collected from 15 fetuses considered to be at risk of fetomaternal alloimmune thrombocytopenia and also from 10 healthy controls at caesarean delivery. In the plasma of all 25 fetuses an...

journal_title：British journal of haematology

authors： Sainio S,Javela K,Kekomäki R,Teramo K

更新日期：2000-05-01 00:00:00

abstract：:Crude barium chloride eluates prepared from 12 unrelated patients with cross-reacting material positive (CRM+) haemophilia B were activated with celite eluate, the reaction products resolved after reduction by 13% SDS-PAGE, and factor IX antigenic material detected by probing with radiolabelled immunopurified rabbit a...

journal_title：British journal of haematology

authors： Liddell MB,Peake IR,Taylor SA,Lillicrap DP,Giddings JC,Bloom AL

更新日期：1989-08-01 00:00:00

abstract：:Ethnic variations in red blood cell (RBC) antigens can be a source of alloimmunization, especially in migrant populations. To improve transfusion safety in continental Africa and countries with African migrants, we performed RBC genotyping to determine allele frequencies coding for high- and low-prevalence antigens. A...

journal_title：British journal of haematology

authors： Silvy M,Beley S,Granier T,Ba A,Chiaroni J,Bailly P

更新日期：2013-11-01 00:00:00

abstract：:The erythrocyte chemokine receptor, a receptor for Plasmodium vivax, carries the antigens of the Duffy blood group system. Sequence analysis of reticulocyte RNA from individuals of known Duffy phenotype showed that the Fya antigen differs from the Fyb antigen as a result of a single nucleotide difference (A131 or G) e...

journal_title：British journal of haematology

authors： Mallinson G,Soo KS,Schall TJ,Pisacka M,Anstee DJ

更新日期：1995-08-01 00:00:00

abstract：:We report on a case of pyridoxine refractory hereditary sideroblastic anaemia (HSA) in a 19-year-old man who underwent peripheral blood stem cell transplantation (PBSCT) from his HLA-identical brother. By using short tandem repeat polymorphism, 100% donor cells were observed in peripheral blood on day +21; bone marrow...

journal_title：British journal of haematology

authors： González MI,Caballero D,Vázquez L,Cañizo C,Hernández R,López C,Izarra A,Arroyo JL,González M,García R,San Miguel JF

更新日期：2000-06-01 00:00:00

abstract：:The levels of platelet-associated Igs (PAIgs) and plasma circulating antiplatelet antibodies were evaluated by a flow cytometric immunofluorescence assay (FCIFA), an enzyme-linked immunoassay (ELISA), and a platelet radioactive antiglobulin test (PRAT), in a group of 45 human immunodeficiency virus (HIV)-infected intr...

journal_title：British journal of haematology

authors： Gonzalez-Conejero R,Rivera J,Rosillo MC,Cano A,Rodriguez T,Vicente V

更新日期：1996-05-01 00:00:00

abstract：:A patient with apparent anaemia and thrombocytopenia caused by a monoclonal paraprotein is described. The patient's serum contained a monoclonal IgM kappa, a cryoglobulin and a cold agglutinin. The cryoglobulin, similar to the serum paraprotein, was a monoclonal IgM kappa. Serum was studied to determine the relationsh...

journal_title：British journal of haematology

authors： Pujol M,Ribera JM,Jimenez C,Ribera A,Abad E,Feliu E

更新日期：1998-03-01 00:00:00

abstract：:The anti-cancer drug arsenic trioxide (AT) induces apoptosis in a variety of transformed or proliferating cells. However, little is known regarding its ability to induce apoptosis in terminally differentiated cells, such as neutrophils. Because neutropenia has been reported in some cancer patients after AT treatment, ...

journal_title：British journal of haematology

authors： Binet F,Cavalli H,Moisan E,Girard D

更新日期：2006-02-01 00:00:00

abstract：:A significant number of patients diagnosed with beta-thalassaemia develop clinical and histopathological manifestations similar to those of an inherited disorder called Pseudoxanthoma elasticum (PXE). The inherited PXE is caused by mutations in the ATP-binding cassette, subfamily C (CFTR/MRP), member 6 (ABCC6) gene an...

journal_title：British journal of haematology

authors： Hamlin N,Beck K,Bacchelli B,Cianciulli P,Pasquali-Ronchetti I,Le Saux O

更新日期：2003-09-01 00:00:00

abstract：:A novel colony stimulating factor-1 (CSF-1) binding factor present in the serum from a patient in remission from lymphoma is described. Radioimmunoassay (RIA) repeatedly failed to detect circulating levels of CSF-1 in the peripheral blood system of this patient. Molecular analysis showed a normal CSF-1 gene structure ...

journal_title：British journal of haematology

authors： Baker AH,Cachia PG,Tennant GB,Whittaker JA,White D,Stanley ER,Burnett AK,Padua RA

更新日期：1995-01-01 00:00:00

abstract：:Conflicting evidence exists on the epidemiology of type 2 diabetes mellitus (T2DM) among patients with sickle cell disease (SCD). This study measured the prevalence, incidence and clinical outcomes associated with T2DM in a large US population of commercially-insured adults aged ≥20 years with SCD between 2009 and 201...

journal_title：British journal of haematology

authors： Zhou J,Han J,Nutescu EA,Galanter WL,Walton SM,Gordeuk VR,Saraf SL,Calip GS

更新日期：2019-04-01 00:00:00

abstract：:We describe and compare five assay systems for Protein C (PC) in human plasma; a functional assay for PC activity, Laurell electroimmunoassay with EDTA or calcium (EDTA-Laurell or Ca-Laurell), radioimmunoassay (RIA) and immunoradiometric assay (IRMA). The lower limit of sensitivity of PC in normal reference plasma was...

journal_title：British journal of haematology

authors： Mikami S,Tuddenham EG

更新日期：1986-01-01 00:00:00

abstract：:This study compared the diagnostic value of Whole-Body Ultra Low-Dose computed tomography (WBULDCT) with that of Spinal Magnetic Resonance Imaging (SMRI) in identification of spinal bone marrow involvement in patients with Multiple Myeloma (MM). Thirty-five patients with histologically proven MM underwent WBULDCT and ...

journal_title：British journal of haematology

authors： Ippolito D,Talei Franzesi C,Spiga S,Besostri V,Pezzati S,Rossini F,Sironi S

更新日期：2017-05-01 00:00:00

abstract：:Hydroxyurea increases fetal haemoglobin in many patients with sickle cell anaemia, but its effectiveness in thalassaemia appears to be less consistent. We describe the response to hydroxyurea in an adult male with homozygous beta thalassaemia, symptomatic paraspinal extramedullary haemopoiesis, bone pain, and progress...

journal_title：British journal of haematology

authors： Saxon BR,Rees D,Olivieri NF

更新日期：1998-06-01 00:00:00

abstract：:Comparative genomic hybridization (CGH) was used to analyse 34 follicular lymphoma (FL) samples. 27 samples showed DNA sequence copy number changes of at least one genomic region (26 samples with at least one gain and nine with at least one loss). Some chromosomes or chromosomal regions were preferentially involved. T...

journal_title：British journal of haematology

authors： Avet-Loiseau H,Vigier M,Moreau A,Mellerin MP,Gaillard F,Harousseau JL,Bataille R,Milpied N

更新日期：1997-04-01 00:00:00

abstract：:To identify and treat patients at high risk of cytomegalovirus (CMV) pneumonia after bone marrow transplantation (BMT), we tested for CMV viraemia weekly, and performed broncho-alveolar lavage (BAL) on day 35 post-transplant in 63 recipients. 36 allogeneic BMT recipients were at a high risk of CMV pneumonia (25 CMV-se...

journal_title：British journal of haematology

authors： Ibrahim A,Gautier E,Roittmann S,Bourhis JH,Fajac A,Charnoz I,Terrier P,Salord JM,Tancrède C,Hayat M,Bernaudin JF,Pico JL

更新日期：1997-07-01 00:00:00

abstract：:During definitive erythropoiesis, erythroid precursors undergo differentiation through multiple nucleated states to an enucleated reticulocyte, which loses its residual RNA/organelles to become a mature erythrocyte. Over the course of these transformations, continuous changes in membrane proteins occur, including shif...

journal_title：British journal of haematology

authors： Kodippili GC,Spector J,Kang GE,Liu H,Wickrema A,Ritchie K,Low PS

更新日期：2010-09-01 00:00:00

abstract：:Multiple myeloma (MM) is a disease with known immune dysregulation. Natural killer (NK) cells have shown preclinical activity in MM. We conducted a first-in-human study of umbilical cord blood-derived (CB) NK cells for MM patients undergoing high dose chemotherapy and autologous haematopoietic stem cell transplantatio...

journal_title：British journal of haematology

authors： Shah N,Li L,McCarty J,Kaur I,Yvon E,Shaim H,Muftuoglu M,Liu E,Orlowski RZ,Cooper L,Lee D,Parmar S,Cao K,Sobieiski C,Saliba R,Hosing C,Ahmed S,Nieto Y,Bashir Q,Patel K,Bollard C,Qazilbash M,Champlin R,Rezvani

更新日期：2017-05-01 00:00:00

abstract：:We have studied the surface expression of the Toll-like receptor family member CD 180 on cells from 78 patients with B-chronic lymphocytic leukaemia (B-CLL). B-CLL cells had variable levels of CD 180 expression, but this was always less than that expressed by normal blood B cells and was stable for 24 months. Signific...

journal_title：British journal of haematology

authors： Porakishvili N,Kulikova N,Jewell AP,Youinou PY,Yong K,Nathwani A,Heelan B,Duke V,Hamblin TJ,Wallace P,Ely P,Clark EA,Lydyard PM

更新日期：2005-11-01 00:00:00

abstract：:The administration of Interleukin-2 (IL-2) causes the release or generation of other cytokines such as tumour necrosis factor (TNF) which, by disturbing the anticoagulant properties of the endothelium, may induce a procoagulant state in patients receiving this drug. We therefore evaluated the effects of IL-2 on coagul...

journal_title：British journal of haematology

authors： Baars JW,de Boer JP,Wagstaff J,Roem D,Eerenberg-Belmer AJ,Nauta J,Pinedo HM,Hack CE

更新日期：1992-10-01 00:00:00

abstract：:The inverse of the difference between rates, called the 'number needed to treat' (NNT), was suggested 20 years ago as a good way to present the results of comparisons of success or failure under different therapies. Such comparisons usually arise in randomised controlled trials and meta-analysis. This article reviews ...

journal_title：British journal of haematology

authors： Hutton JL

更新日期：2009-06-01 00:00:00

abstract：:The combination of interleukin (IL)-4 and IL-10 protects against blood-induced cartilage damage in vitro. It has been hypothesized that the combination of these cytokines is effective if applied early in the process of cartilage damage. The present study investigated whether a single intra-articular injection of IL-4 ...

journal_title：British journal of haematology

authors： van Meegeren ME,Roosendaal G,Coeleveld K,Nieuwenhuizen L,Mastbergen SC,Lafeber FP

更新日期：2013-02-01 00:00:00

abstract：:Total knee replacement (TKR) is a safe treatment for alleviating pain and restoring physical function in end-stage arthropathy of the knee. First reports of TKR in haemophiliacs date back to the mid-1970s, however detailed information on long-term outcome is scarce. This study evaluated factors influencing the outcome...

journal_title：British journal of haematology

authors： Solimeno LP,Mancuso ME,Pasta G,Santagostino E,Perfetto S,Mannucci PM

更新日期：2009-04-01 00:00:00

abstract：:To determine the effects of L-arginine (L-Arg) supplementation on nitric oxide metabolite (NOx) production, oral L-Arg was given to normal controls, sickle cell disease (SCD) patients at steady state and SCD patients hospitalized with a vaso-occlusive crisis (VOC). L-Arg (0.1 g/kg) increased NOx formation by 18.8 +/- ...

journal_title：British journal of haematology

authors： Morris CR,Kuypers FA,Larkin S,Sweeters N,Simon J,Vichinsky EP,Styles LA

更新日期：2000-11-01 00:00:00

abstract：:In an effort to clarify the effect of human T cell leukaemia virus type I (HTLV-I) infection on virus-specific CD8+ cytotoxic T cells, a herpes simplex virus-specific CD8+ cytotoxic T cell clone was infected with HTLV-I in vitro. The cytotoxic activity of the clone was found to have declined early after HTLV-I infecti...

journal_title：British journal of haematology

authors： Inatsuki A,Yasukawa M,Kobayashi Y

更新日期：1991-03-01 00:00:00

abstract：:Data on endogenous thrombopoietin (TPO) levels and their regulation in myelodysplastic syndromes (MDS) are sparse. We examined the plasma TPO level of 85 MDS patients by a sensitive enzyme immunoassay and the platelet expression of TPO receptor (TPO-R) protein, which metabolizes endogenous TPO, in 19 MDS patients with...

journal_title：British journal of haematology

authors： Tamura H,Ogata K,Luo S,Nakamura K,Yokose N,Dan K,Tohyama K,Yoshida Y,Hamaguchi H,Sakamaki H,Kuwaki T,Tahara T,Kato T,Nomura T

更新日期：1998-12-01 00:00:00