当前位置： SCI文献检索 > BRITISH JOURNAL OF HAEMATOLOGY期刊下所有文献 > Thrombopoietin levels in cord blood plasma and amniotic fluid in fetuses with alloimmune thrombocytopenia and healthy controls.

Thrombopoietin levels in cord blood plasma and amniotic fluid in fetuses with alloimmune thrombocytopenia and healthy controls.

Abstract：

:To extend our knowledge of the kinetics of fetal thrombopoietin (TPO), we studied TPO levels in cord blood plasma and amniotic fluid collected from 15 fetuses considered to be at risk of fetomaternal alloimmune thrombocytopenia and also from 10 healthy controls at caesarean delivery. In the plasma of all 25 fetuses and newborn infants studied, TPO was detected above the lower limit of detection (7 pg/ml) and correlated inversely with platelet counts (r = -0.53, P = 0.006). At term, TPO detected in amniotic fluid was at significantly lower levels (7 pg/ml; range 0-22 pg/ml) than simultaneously obtained cord plasma TPO (114 pg/ml; range 43-201 pg/ml; P < 0.001). There was no correlation between levels of TPO in amniotic fluid and cord plasma or platelet counts. In the serial samples collected from the five fetuses with HPA-1a alloimmunization before 37 weeks' gestation, the TPO levels in amniotic fluid were significantly higher than at term (P = 0.013): from 22 to 28 weeks' gestation, 42 pg/ml (30-78 pg/ml); from 32 weeks', 24 pg/ml (17-33 pg/ml); at term, 8 pg/ml (4-13 pg/ml), correlating inversely with gestational age (r = -0.81, P = 0.003). Thus, TPO is present in amniotic fluid at levels apparently inversely related to gestational age. Whether these high levels seen early in pregnancy are normal or are associated with the HPA-1 alloimmunization remains to be shown.

journal_name

Br J Haematol

journal_title

British journal of haematology

authors

Sainio S,Javela K,Kekomäki R,Teramo K

doi

10.1046/j.1365-2141.2000.02031.x

subject

Has Abstract

pub_date

2000-05-01 00:00:00

pages

330-5

issue

2

eissn

0007-1048

issn

1365-2141

pii

bjh2031

journal_volume

109

pub_type

杂志文章

相关文献

BRITISH JOURNAL OF HAEMATOLOGY文献大全
  • Membrane proteins synthesized by human reticulocytes and their precursors.

    abstract：:Membrane protein synthesis in human immature erythroid cells was studied by incubating the cells with 35S-methionine in vitro. The radioactive precursor amino acid was incorporated into membrane protein in a linear fashion for approximately 60 min, after which there was only a slight increase in incorporation. Intrace...

    journal_title：British journal of haematology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2141.1981.tb02777.x

    authors： Krasnow SH,Pielichowski HJ,Caro J,Burka ER,Ballas SK

    更新日期：1981-02-01 00:00:00

  • RUNX1 gene mutation in primary myelodysplastic syndrome--the mutation can be detected early at diagnosis or acquired during disease progression and is associated with poor outcome.

    abstract：:Mutations of Runt-related transcription factor 1 (RUNX1) have been detected in patients with myelodysplastic syndrome (MDS). However, the prognostic implication of RUNX1 mutations in primary MDS is limited. The stage of the disease at which the mutations are acquired and whether they persist during the disease course ...

    journal_title：British journal of haematology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2141.2007.06811.x

    authors： Chen CY,Lin LI,Tang JL,Ko BS,Tsay W,Chou WC,Yao M,Wu SJ,Tseng MH,Tien HF

    更新日期：2007-11-01 00:00:00

  • Combination of a mitogen-activated protein kinase inhibitor with the tyrosine kinase inhibitor pacritinib combats cell adhesion-based residual disease and prevents re-expansion of FLT3-ITD acute myeloid leukaemia.

    abstract：:Minimal residual disease (MRD) in acute myeloid leukaemia (AML) poses a major challenge due to drug insensitivity and high risk of relapse. Intensification of chemotherapy and stem cell transplantation are often pivoted on MRD status. Relapse rates are high even with the integration of first-generation FMS-like tyrosi...

    journal_title：British journal of haematology

    pub_type： 杂志文章

    doi：10.1111/bjh.16665

    authors： Zabkiewicz J,Lazenby M,Edwards G,Bygrave CA,Omidvar N,Zhuang L,Knapper S,Guy C,Hills RK,Burnett AK,Alvares CL

    更新日期：2020-10-01 00:00:00

  • Lack of association of soluble endothelial protein C receptor and PROCR 6936A/G polymorphism with the risk of venous thromboembolism in a prospective study.

    abstract：:Prior case-control studies reported that levels of the soluble form of the endothelial protein C receptor (sEPCR) were strongly controlled by the PROCR 6963A/G polymorphism and higher levels were a risk factor for venous thromboembolism (VTE). We sought to prospectively examine the association of sEPCR and the 6963A/G...

    journal_title：British journal of haematology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2141.2009.07612.x

    authors： Yamagishi K,Cushman M,Heckbert SR,Tsai MY,Folsom AR

    更新日期：2009-04-01 00:00:00

  • A phase II study of Givinostat in combination with hydroxycarbamide in patients with polycythaemia vera unresponsive to hydroxycarbamide monotherapy.

    abstract：:Givinostat, a histone-deacetylase inhibitor (HDACi), inhibits proliferation of cells bearing the JAK2 V617F mutation and has shown significant activity with good tolerability in patients with chronic myeloproliferative neoplasms (MPN). In this multicentre, open-label, phase II study, 44 patients with polycythaemia ver...

    journal_title：British journal of haematology

    pub_type： 杂志文章,多中心研究,随机对照试验

    doi：10.1111/bjh.12332

    authors： Finazzi G,Vannucchi AM,Martinelli V,Ruggeri M,Nobile F,Specchia G,Pogliani EM,Olimpieri OM,Fioritoni G,Musolino C,Cilloni D,Sivera P,Barosi G,Finazzi MC,Di Tollo S,Demuth T,Barbui T,Rambaldi A

    更新日期：2013-06-01 00:00:00

  • Beneficial effect of exogenous platelet factor 4 for detecting pathogenic heparin-induced thrombocytopenia antibodies.

    abstract：:The laboratory diagnosis of heparin-induced thrombocytopenia (HIT) is based on an enzyme immunoassay combined with a functional test, and serotonin release assay (SRA) is the gold standard for detecting activating HIT antibodies. However, a recent atypical history of HIT prompted us to evaluate whether addition of pla...

    journal_title：British journal of haematology

    pub_type： 杂志文章

    doi：10.1111/bjh.14955

    authors： Vayne C,Guery EA,Kizlik-Masson C,Rollin J,Bauters A,Gruel Y,Pouplard C

    更新日期：2017-12-01 00:00:00

  • Erythropoietin synthesis by tumour tissues in a patient with uterine myoma and erythrocytosis.

    abstract：:We report a patient with uterine myoma (leiomyoma) and erythrocytosis in whom erythropoietin (Epo) production in the leiomyoma tissue was identified by reverse transcription polymerase chain reaction (RT-PCR) and enzyme-linked immunosorbent assay (ELISA). A 48-year-old Japanese woman with uterine myoma showed marked e...

    journal_title：British journal of haematology

    pub_type： 杂志文章

    doi：10.1046/j.1365-2141.2001.02682.x

    authors： Suzuki M,Takamizawa S,Nomaguchi K,Suzu S,Yamada M,Igarashi T,Sato I

    更新日期：2001-04-01 00:00:00

  • Progress in central nervous system lymphomas.

    abstract：:Until recently, primary central nervous system lymphoma (PCNSL) was associated with a uniformly dismal prognosis. It is now reasonable to anticipate long-term survival and possibly cure for a significant proportion of patients diagnosed with PCNSL. Accumulated data generated over the past 10 years has provided evidenc...

    journal_title：British journal of haematology

    pub_type： 杂志文章,评审

    doi：10.1111/bjh.12938

    authors： Wang CC,Carnevale J,Rubenstein JL

    更新日期：2014-08-01 00:00:00

  • Allogeneic peripheral stem cell transplantation in a case of hereditary sideroblastic anaemia.

    abstract：:We report on a case of pyridoxine refractory hereditary sideroblastic anaemia (HSA) in a 19-year-old man who underwent peripheral blood stem cell transplantation (PBSCT) from his HLA-identical brother. By using short tandem repeat polymorphism, 100% donor cells were observed in peripheral blood on day +21; bone marrow...

    journal_title：British journal of haematology

    pub_type： 杂志文章

    doi：10.1046/j.1365-2141.2000.02050.x

    authors： González MI,Caballero D,Vázquez L,Cañizo C,Hernández R,López C,Izarra A,Arroyo JL,González M,García R,San Miguel JF

    更新日期：2000-06-01 00:00:00

  • The correlation of cold agglutinin titrations in saline and albumin with haemolytic anaemia.

    abstract：:Cold agglutinin syndrome (CAS) is usually associated with IgM cold agglutinins with titres exceeding 1000 at 4 degrees C and a thermal amplitude of 30-32 degrees C. Occasionally patients are encountered who although having clinical and laboratory findings compatible with CAS do not have the characteristic serological ...

    journal_title：British journal of haematology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2141.1977.tb00623.x

    authors： Garratty G,Petz LD,Hoops JK

    更新日期：1977-04-01 00:00:00

  • Dehydrated hereditary stomatocytosis is associated with neonatal hepatitis.

    abstract：:Dehydrated hereditary stomatocytosis (DHSt) is an inherited haemolytic anaemia associated with increased red cell membrane permeability to Na(+) and K(+). It is increasingly recognized that a syndrome of self-limiting perinatal ascites can accompany the haemolysis. The cause of the perinatal ascites is unknown, and it...

    journal_title：British journal of haematology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2141.2004.05037.x

    authors： Rees DC,Portmann B,Ball C,Mieli-Vergani G,Nicolaou A,Chetty MC,Stewart GW

    更新日期：2004-07-01 00:00:00

  • Partial response or better at six months is prognostic of superior progression-free survival in Waldenström macroglobulinaemia patients treated with ibrutinib.

    abstract：:Ibrutinib is associated with durable responses in patients with Waldenström macroglobulinaemia (WM). We hypothesized that response depth is predictive of progression-free survival (PFS) in WM patients treated with ibrutinib. Using landmark analyses, we evaluated response depth in two cohorts of WM patients treated wit...

    journal_title：British journal of haematology

    pub_type： 杂志文章

    doi：10.1111/bjh.17225

    authors： Castillo JJ,Abeykoon JP,Gustine JN,Zanwar S,Mein K,Flynn CA,Demos MG,Guerrera ML,Kofides A,Liu X,Munshi M,Tsakmaklis N,King R,Yang G,Hunter ZR,Advani RH,Palomba ML,Ansell SM,Gertz MA,Kapoor P,Treon SP

    更新日期：2020-11-18 00:00:00

  • Increased leucocyte apoptosis in transfused β-thalassaemia patients.

    abstract：:This exploratory study assessed apoptosis in peripheral blood leucocytes (PBL) from β-thalassaemia patients receiving chronic transfusions and chelation therapy (deferasirox or deferoxamine) at baseline, 1, 6, and 12 months. At baseline, thalassaemic PBLs presented 50% greater levels of Bax (BAX), 75% higher caspase-3...

    journal_title：British journal of haematology

    pub_type： 杂志文章

    doi：10.1111/bjh.12076

    authors： Walter PB,Porter J,Evans P,Kwiatkowski JL,Neufeld EJ,Coates T,Giardina PJ,Grady RW,Vichinsky E,Olivieri N,Trachtenberg F,Alberti D,Fung E,Ames B,Higa A,Harmatz P,Thalassemia Clinical Research Network.

    更新日期：2013-02-01 00:00:00

  • Evaluation of a tissue factor dependent factor V assay to detect factor V Leiden: demonstration of high sensitivity and specificity for a generally applicable assay for activated protein C resistance.

    abstract：:Resistance to the anticoagulant effects of activated protein C (APC) is now considered the most prevalent cause of inherited thrombophilia. The great majority of patients with activated protein C resistance (APCR) have a missense mutation in the factor V molecule (factor V Leiden, FVR506Q) resulting in defective inact...

    journal_title：British journal of haematology

    pub_type： 杂志文章

    doi：10.1046/j.1365-2141.1996.d01-1937.x

    authors： Liebman HA,Sutherland D,Bacon R,McGehee W

    更新日期：1996-12-01 00:00:00

  • Erythropoiesis and mean red-cell lifespan in normal subjects and in patients with the anaemia of active rheumatoid arthritis.

    abstract：:Recently developed ferrokinetic methods offer a tool to measure effective and ineffective erythropoiesis and mean red-cell lifespan (Ricketts et al, 1975). We have used this tool to investigate erythropoiesis in normal subjects and in patients with the anaemia of active rheumatoid arthritis. In normal subjects the res...

    journal_title：British journal of haematology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2141.1978.tb01114.x

    authors： Dinant HJ,de Maat CE

    更新日期：1978-07-01 00:00:00

  • Development of a prognostic model for overall survival in multiple myeloma using the Connect® MM Patient Registry.

    abstract：:Median overall survival (OS) has improved for patients with newly diagnosed multiple myeloma (NDMM), but prognosis varies depending on baseline patient characteristics. Current models use data from selected clinical trial populations, which prevent application to patients in an unselected community setting that reflec...

    journal_title：British journal of haematology

    pub_type： 杂志文章,多中心研究

    doi：10.1111/bjh.16139

    authors： Terebelo HR,Abonour R,Gasparetto CJ,Toomey K,Durie BGM,Hardin JW,Jagannath S,Wagner L,Narang M,Flick ED,Srinivasan S,Yue L,Kitali A,Agarwal A,Rifkin RM,CONNECT MM Registry Investigators.

    更新日期：2019-12-01 00:00:00

  • Acute human parvovirus B19 infection and nephrotic syndrome in patients with sickle cell disease.

    abstract：:Acute Human Parvovirus B19 (HPV B19) infection is the major cause of transient red cell aplasia (TRCA) and acute anaemia in patients with sickle cell disease (SCD). We report three cases of patients who developed nephrotic syndrome (NS) with chronic sequelae after initially presenting with HPV B19-associated TRCA. The...

    journal_title：British journal of haematology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2141.2009.08062.x

    authors： Quek L,Sharpe C,Dutt N,Height S,Allman M,Awogbade M,Rees DC,Zuckerman M,Thein SL

    更新日期：2010-04-01 00:00:00

  • Recombinant IL-7/HGFβ hybrid cytokine separates acute graft-versus-host-disease from graft-versus-tumour activity by altering donor T cell trafficking.

    abstract：:Given that donor T cells from a transplant contribute both the desired graft-versus-tumour (GVT) effect and detrimental graft-versus-host disease (GVHD), strategies to separate GVHD and GVT activity are a major clinical goal. We have previously demonstrated that in vivo administration of a recombinant (r)IL-7/HGFβ hyb...

    journal_title：British journal of haematology

    pub_type： 杂志文章

    doi：10.1111/bjh.14268

    authors： Hu R,Liu Y,Song Y,Su M,Lu X,Rood D,Lai L

    更新日期：2016-11-01 00:00:00

  • High levels of lung resistance related protein mRNA in leukaemic cells from patients with acute myelogenous leukaemia are associated with inferior response to chemotherapy and prior treatment with mitoxantrone.

    abstract：:Expression of the mdr1 (multidrug resistance), mrp (multidrug resistance associated protein), and lrp (lung resistance related protein) genes is associated with transport related MDR (multidrug resistance). We quantified mRNA levels of these genes using competitive reverse transcription polymerase chain reaction (RT-P...

    journal_title：British journal of haematology

    pub_type： 杂志文章

    doi：10.1046/j.1365-2141.1999.01611.x

    authors： Xu D,Areström I,Virtala R,Pisa P,Peterson C,Gruber A

    更新日期：1999-09-01 00:00:00

  • Scanning mutations of the 5'UTR regulatory sequence of L-ferritin by denaturing high-performance liquid chromatography: identification of new mutations.

    abstract：:Hereditary hyperferritinaemia cataract syndrome is an autosomal dominant disorder caused by heterogeneous mutations of the iron regulatory element (IRE) in the ferritin l-chain mRNA. The mutations are rare and fast DNA scanning would facilitate diagnosis. The aim of the study was to compare the analytical performances...

    journal_title：British journal of haematology

    pub_type： 杂志文章

    doi：10.1046/j.1365-2141.2003.04253.x

    authors： Cremonesi L,Paroni R,Foglieni B,Galbiati S,Fermo I,Soriani N,Belloli S,Ruggeri G,Biasiotto G,Cazzola M,Ferrari F,Ferrari M,Arosio P

    更新日期：2003-04-01 00:00:00

  • Podocalyxin in human haematopoietic cells.

    abstract：:Podocalyxin-like protein (PCLP) is a sialomucin-type membrane protein structurally related to CD34 and endoglycan. It was first described in glomerular podocytes and endothelial cells. In mice, PCLP is present in haemangioblasts, and in both chicken and mice it is a marker of early haematopoietic stem cells and lineag...

    journal_title：British journal of haematology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2141.2004.04840.x

    authors： Kerosuo L,Juvonen E,Alitalo R,Gylling M,Kerjaschki D,Miettinen A

    更新日期：2004-03-01 00:00:00

  • Role of the cold shock domain protein A in the transcriptional regulation of HBG expression.

    abstract：:Impaired switching from fetal haemoglobin (HbF) to adult globin gene expression leads to hereditary persistence of fetal haemoglobin (HPFH) in adult life. This is of prime interest because elevated HbF levels ameliorate β-thalassaemia and sickle cell anaemia. Fetal haemoglobin levels are regulated by complex mechanism...

    journal_title：British journal of haematology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2141.2010.08303.x

    authors： Petruzzelli R,Gaudino S,Amendola G,Sessa R,Puzone S,Di Concilio R,d'Urzo G,Amendolara M,Izzo P,Grosso M

    更新日期：2010-09-01 00:00:00

  • Role of prospective screening of blood for invasive aspergillosis by polymerase chain reaction in febrile neutropenic recipients of haematopoietic stem cell transplants and patients with acute leukaemia.

    abstract：:Guidelines for the use of polymerase chain reaction (PCR)-based assays to aid the diagnosis of invasive aspergillosis (IA) in high-risk haematology patients have not been formulated. We prospectively evaluated a nested PCR assay to detect Aspergillus in blood during 95 febrile neutropenic episodes, in patients with ha...

    journal_title：British journal of haematology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2141.2005.05887.x

    authors： Halliday C,Hoile R,Sorrell T,James G,Yadav S,Shaw P,Bleakley M,Bradstock K,Chen S

    更新日期：2006-02-01 00:00:00

  • Variations in globin synthesis in delta-beta-thalassaemia.

    abstract：:Peripheral blood globin synthesis studies were done in 11 patients with delta beta-thalassaemia trait, Hb S-delta beta-thalassaemia or delta beta/betao-thalassaemia from two black and two Caucasian families. All patients had elevated Hb F and normal or decreased Hb A2 levels and 10 had family studies confirming the di...

    journal_title：British journal of haematology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2141.1978.tb07103.x

    authors： Kinney TR,Friedman S,Cifuentes E,Kim HC,Schwartz E

    更新日期：1978-01-01 00:00:00

  • Investigation and management of a raised serum ferritin.

    abstract：:Serum ferritin level is one of the most commonly requested investigations in both primary and secondary care. Whilst low serum ferritin levels invariably indicate reduced iron stores, raised serum ferritin levels can be due to multiple different aetiologies, including iron overload, inflammation, liver or renal diseas...

    journal_title：British journal of haematology

    pub_type： 信件,评审

    doi：10.1111/bjh.15166

    authors： Cullis JO,Fitzsimons EJ,Griffiths WJ,Tsochatzis E,Thomas DW,British Society for Haematology.

    更新日期：2018-05-01 00:00:00

  • Progression of myelodysplastic syndrome: allelic loss on chromosomal arm 1p.

    abstract：:Myelodysplastic syndrome (MDS) is a common neoplasm of haematopoietic pluripotent stem cells. Although one third of MDS patients evolve to acute myeloid leukaemia (AML), little is understood about the mechanisms responsible for this progression. We have previously detected the frequent loss of heterozygosity (LOH) on ...

    journal_title：British journal of haematology

    pub_type： 杂志文章

    doi：10.1046/j.1365-2141.2003.04434.x

    authors： Mori N,Morosetti R,Mizoguchi H,Koeffler HP

    更新日期：2003-07-01 00:00:00

  • Effect of different resuspension media on the post-thaw characteristics of frozen blood.

    abstract：:Red blood cells frozen by the low-glycerol fast-freezing technique were thawed, deglycerolized and resuspended in various media. The use of ACD-saline for resuspension markedly reduced in vitro haemolysis such that the red cells could be transfused up to 5 d after thawing. At this time the cells contained satisfactory...

    journal_title：British journal of haematology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2141.1980.tb08718.x

    authors： Amer KA,Pepper DS,Prowse CV

    更新日期：1980-04-01 00:00:00

  • A point mutation (Arg271-->Cys) of a homozygote for dysfunctional prothrombin, prothrombin Obihiro, which has a region of high sequence variability.

    abstract：:The molecular defect of a congenitally dysfunctional form of prothrombin, prothrombin Obihiro, was identified in a patient with a severe bleeding tendency. He showed reduced fibrinogen clotting activity, despite a normal prothrombin antigen level. Nucleotide sequencing of amplified DNA revealed a C-->T change at nucle...

    journal_title：British journal of haematology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2141.1995.tb05601.x

    authors： Miyata T,Zheng YZ,Kato A,Kato H

    更新日期：1995-07-01 00:00:00

  • Interaction of thrombin with human platelets.

    abstract：:The first step in thrombin-induced aggregation of blood platelets is binding of thrombin to specific receptors on the platelet membrane. Elucidation of the nature of this receptor in human platelets was attempted using radioactively labelled thrombin. In disc gel electrophoresis an extract of thrombin-treated platelet...

    journal_title：British journal of haematology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2141.1975.tb02748.x

    authors： Ganguly P

    更新日期：1975-04-01 00:00:00

  • Moderate endurance exercise in patients with sickle cell anaemia: effects on oxidative stress and endothelial activation.

    abstract：:Very few studies have investigated the effects of exercise on the biological parameters involved in vaso-occlusive events in sickle cell anaemia (SCA). The aim of this study was to test how a mild-moderate endurance exercise modulates oxidative stress, nitric oxide bioavailability and endothelial activation in SCA pat...

    journal_title：British journal of haematology

    pub_type： 杂志文章

    doi：10.1111/bjh.12594

    authors： Faes C,Balayssac-Siransy E,Connes P,Hivert L,Danho C,Bogui P,Martin C,Pialoux V

    更新日期：2014-01-01 00:00:00