Central nervous system emergencies in haematological malignancies.

Abstract:

:Neurological emergencies are frequently catastrophic events in the course of haematological malignancies (HM) that, if not promptly recognized and treated, may lead to lethal outcomes or chronic sequelae. They may occur at any time during the disease course, but are more frequently observed following relapse. Practice guidelines are lacking in the management of most central nervous system (CNS) complications in HM. Herein we review the pathophysiology, presentation and treatment of elevated intracranial pressure, spinal cord compression, status epilepticus, neurovascular complications, CNS infection, leucostasis and hyperviscosity. Further, we discuss the expanding spectrum of neurological complications of old and novel treatments in HM.

journal_name

Br J Haematol

authors

de la Fuente MI,Alderuccio JP,Lossos IS

doi

10.1111/bjh.16184

subject

Has Abstract

pub_date

2020-06-01 00:00:00

pages

1028-1037

issue

6

eissn

0007-1048

issn

1365-2141

journal_volume

189

pub_type

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