Parental longevity and survival among patients with multiple myeloma and monoclonal gammopathy of undetermined significance: a population-based study.

abstract：:Antibodies grouped together by the Third Workshop on Leucocyte Differentiation Antigens on the basis of pan-macrophage reactivity on tissue sections were analysed in immunoprecipitation experiments. Antibodies Y2/131, EBM11, Ki-M6 and Ki-M7 all precipitated antigens of Mr 110,000 which were shown to be identical by pr...

journal_title：British journal of haematology

authors： Micklem K,Rigney E,Cordell J,Simmons D,Stross P,Turley H,Seed B,Mason D

更新日期：1989-09-01 00:00:00

abstract：:To examine the role of human DNA topoisomerase IIalpha (topo IIalpha) in drug resistance, we selectively inhibited topo IIalpha gene expression in U937 human monocytic leukaemia cells stably transfected with a plasmid that allowed for Zn-mediated conditional expression of a human alpha-topo IIalpha antisense sequence....

journal_title：British journal of haematology

authors： Towatari M,Adachi K,Marunouchi T,Saito H

更新日期：1998-06-01 00:00:00

abstract：:The platelets of a young man with the grey platelet syndrome were severely depleted of all seven alpha-granule proteins assayed as well as partially deficient in alpha-mannosidase and alpha-fucosidase; four other lysosomal enzymes were present in normal concentrations. Total platelet 5-hydroxytryptamine (5HT) and aden...

journal_title：British journal of haematology

authors： Srivastava PC,Powling MJ,Nokes TJ,Patrick AD,Dawes J,Hardisty RM

更新日期：1987-04-01 00:00:00

abstract：:Patients with idiopathic anaemias associated with abnormal sideroblasts were defined according to morphologic and ferrokinetic criteria and the haematologic and biochemical effects of vitamin B6 therapy were evaluated. While all patients presented similar clinical pictures, peripheral blood changes and bone marrow abn...

journal_title：British journal of haematology

authors： Solomon LR,Hillman RS

更新日期：1979-06-01 00:00:00

abstract：:Splenic lymphoma with villous lymphocytes (SLVL) is a low-grade B-cell lymphoproliferative disorder characterized by splenomegaly and circulating villous lymphocytes. The relationship between SLVL and splenic marginal zone lymphoma (SMZL), a disorder with identical splenic histology to SLVL, is not clear. Previous stu...

journal_title：British journal of haematology

authors： Gruszka-Westwood AM,Matutes E,Coignet LJ,Wotherspoon A,Catovsky D

更新日期：1999-03-01 00:00:00

abstract：:We examined the effect of vitamin D receptor (VDR) polymorphisms at exon 2 (FokI) and intron 8 (BsmI) on the stature and bone mineral density at femoral neck (FBMD) and lumbar spine (LBMD) in 108 prepubertal and pubertal homozygous beta thalassaemic patients, regularly treated. We found significantly shorter stature a...

journal_title：British journal of haematology

authors： Ferrara M,Matarese SM,Francese M,Borrelli B,Coppola A,Coppola L,Esposito L

更新日期：2002-05-01 00:00:00

abstract：:Immune-mediated pathways have been recognized to be of importance in the pathogenesis of chronic lymphocytic leukaemia (CLL). We assessed a broad variety of immune-related and inflammatory conditions and subsequent CLL development among 4 million adult male veterans admitted to VA hospitals. We identified 3,680 CLL ca...

journal_title：British journal of haematology

authors： Landgren O,Gridley G,Check D,Caporaso NE,Morris Brown L

更新日期：2007-12-01 00:00:00

abstract：:Transient myeloproliferative disorder accompanied by Down's syndrome has been characterized as exhibiting self-limiting haematological abnormalities. We studied six patients suffering from this disorder in order to clarify the biological nature of their blast cells. Metaphases of leucocytes stimulated with phytohaemag...

journal_title：British journal of haematology

authors： Suda J,Eguchi M,Ozawa T,Furukawa T,Hayashi Y,Kojima S,Maeda H,Tadokoro K,Sato Y,Miura Y

更新日期：1988-02-01 00:00:00

abstract：:Lysosomal enzyme activities and isoenzyme profiles were measured in lymphoid and non-lymphoid leukaemic cells from childhood patients. High activities, especially of beta-hexosaminidase and alpha-mannosidase, were associated with leukaemic cells of myeloid or monocytic origin. Leukaemic cells from two children with ac...

journal_title：British journal of haematology

authors： Eden OB,Darbyshire P,Simpson RM,Besley GT,Moss S,Gentle T

更新日期：1985-01-01 00:00:00

abstract：:A multicentre modified World Health Organization (WHO)-type international sensitivity index (ISI) calibration has been performed at 10 European Concerted Action on Anticoagulation (ECAA) national laboratories using non-citrated whole-blood on two point-of-care test (POCT) prothrombin time (PT) monitor systems, CoaguCh...

journal_title：British journal of haematology

authors： Poller L,Keown M,Chauhan N,van Den Besselaar AM,Tripodi A,Jespersen J,Shiach C,Horellou MH,Dias D,Egberg N,Iriarte JA,Kontopoulou-Griva I,Otridge B

更新日期：2002-03-01 00:00:00

abstract：:Gene amplification is defined as a copy number (CN) increase in a restricted region of a chromosome arm, and is a mechanism for acquired drug resistance and oncogene activation. In multiple myeloma (MM), high CNs of genes in a 1q12 approximately 23 amplicon have been associated with disease progression and poor progno...

journal_title：British journal of haematology

authors： Sawyer JR,Tian E,Thomas E,Koller M,Stangeby C,Sammartino G,Goosen L,Swanson C,Binz RL,Barlogie B,Shaughnessy J

更新日期：2009-11-01 00:00:00

abstract：:The efficiency of stored platelet transfusion was evaluated in terms of clinical status in 141 thrombocytopenic patients. In a paired prospective study in which fresh platelets were used as controls, clinical efficiency was assessed on the basis of the ability to increase platelet count (recovery) and the time to the ...

journal_title：British journal of haematology

authors： Norol F,Kuentz M,Cordonnier C,Beaujean F,Haioun C,Vernant JP,Duédari N

更新日期：1994-01-01 00:00:00

abstract：:Raised plasma levels of immunoreactive human calcitonin (i-HCT) have been found in patients with chronic granulocytic leukaemia (CGL) in chronic phase and myeloblastic transformation and in patients with acute myeloid leukaemia at presentation and in relapse. In CGL levels were significantly higher in myeloblastic tra...

journal_title：British journal of haematology

authors： Foa R,Oscier DG,Hillyard CJ,Incarbone E,McIntyre I,Goldman JM

更新日期：1982-02-01 00:00:00

abstract：:Bacteria in platelet components (PC) may result in transfusion-related sepsis (TRS). Pathogen inactivation of PC with amotosalen (A-PC) can abrogate the risk of TRS and hence facilitate storage to 7 d. A randomized, controlled, double-blinded trial to evaluate the efficacy and safety of A-PC stored for 6-7 d was condu...

journal_title：British journal of haematology

authors： Lozano M,Knutson F,Tardivel R,Cid J,Maymó RM,Löf H,Roddie H,Pelly J,Docherty A,Sherman C,Lin L,Propst M,Corash L,Prowse C

更新日期：2011-05-01 00:00:00

abstract：:Using Southern blot, the restriction digests of genomic DNAs in 11 patients with Glanzmann thrombasthenia from 10 unrelated kindreds were probed with a full-length GPIIb cDNA. An additional 2.3 kb Taq I fragment and two 1.65 kb and 0.65 kb fragments with reduced band intensity were found in the genes of two affected s...

journal_title：British journal of haematology

authors： Gu JM,Xu WF,Wang XD,Wu QY,Chi CW,Ruan CG

更新日期：1993-03-01 00:00:00

abstract：:Between 1990 and 1999, 36 children with refractory anaemia with excess blasts (RAEB) and RAEB in transformation (RAEBt), not associated with Down's syndrome, were diagnosed in Britain. A total of 31 children received intensive chemotherapy, six of whom proceeded to a bone marrow allograft in first remission, whereas t...

journal_title：British journal of haematology

authors： Webb DK,Passmore SJ,Hann IM,Harrison G,Wheatley K,Chessells JM

更新日期：2002-04-01 00:00:00

abstract：:Canine cyclic haematopoiesis (CH) appears to be a multipotential stem cell defect, possibly due to an intrinsic marrow defect. The in vitro adherent marrow cells of the cyclic haematopoietic (CH) dog were cultured as underlayers beneath normal dog nonadherent marrow cells. The marrow granulocyte-committed colony formi...

journal_title：British journal of haematology

authors： Jones JB,Jolly JD

更新日期：1982-04-01 00:00:00

abstract：:The use of L-asparaginase (L-ASP) in paediatric patients with acute lymphoblastic leukaemia (ALL) is associated with thrombotic complications. We evaluated the activities of tissue factor (TFa), thrombomodulin (TMa) and procoagulant phospholipids (PPL) in 26 consecutive children with ALL (25 B-ALL and one T-ALL) treat...

journal_title：British journal of haematology

authors： Schneider P,Van Dreden P,Rousseau A,Kassim Y,Legrand E,Vannier JP,Vasse M

更新日期：2010-02-01 00:00:00

abstract：:Myeloma cells thrive in an environment of sustained inflammation, which impacts the development and evolution of the disease, as well as drug resistance. We evaluated the impact of genetic polymorphisms in the Toll-like receptor 4 (TLR4) pathway, which have been implicated in different inflammatory responses in the ou...

journal_title：British journal of haematology

authors： Bagratuni T,Terpos E,Eleutherakis-Papaiakovou E,Kalapanida D,Gavriatopoulou M,Migkou M,Liacos CI,Tasidou A,Matsouka C,Mparmparousi D,Dimopoulos MA,Kastritis E

更新日期：2016-01-01 00:00:00

abstract：:Limited tryptic digestion of native spectrin (Sp) has revealed several variants in hereditary pyropoikilocytosis (HPP) and in a subset of patients with hereditary elliptocytosis (HE). In most cases, tryptic peptide corresponding to the alpha I (N-terminal) 80 kD domain is wholly or partially replaced by smaller fragme...

journal_title：British journal of haematology

authors： Lecomte MC,Gautero H,Garbarz M,Boivin P,Dhermy D

更新日期：1990-11-01 00:00:00

abstract：:Genetic risk factors play an important role in the aetiology of vascular diseases. The insertion/deletion polymorphism (4G/5G) in the promotor region of the plasminogen activator inhibitor 1 (PAI-1) gene has been associated with an increased risk of myocardial infarction. We investigated 136 patients with minor stroke...

journal_title：British journal of haematology

authors： Endler G,Lalouschek W,Exner M,Mitterbauer G,Häring D,Mannhalter C

更新日期：2000-08-01 00:00:00

abstract：:Simultaneous evaluation of coagulation and fibrinolysis facilitates an overall understanding of normal and pathological haemostasis. We established an assay for assessing clot formation and fibrinolysis simultaneously using clot waveform analysis by the trigger of a mixture of activated partial thromboplastin time rea...

journal_title：British journal of haematology

authors： Nogami K,Matsumoto T,Sasai K,Ogiwara K,Arai N,Shima M

更新日期：2019-11-01 00:00:00

abstract：:Autologous transplantation has an established role in the treatment of lymphoproliferative disorders, but allogeneic transplantation remains controversial. In an attempt to reduce the high procedure-related mortality reported with allografting in lymphoma, we have used BEAM (BCNU, etoposide, cytarabine and melphalan),...

journal_title：British journal of haematology

authors： Cull GM,Haynes AP,Byrne JL,Carter GI,Miflin G,Rebello P,Hale G,Waldmann H,Russell NH

更新日期：2000-03-01 00:00:00

abstract：:During the past years, several authors have used labelled leucocytes to detect inflammatory foci. However, before routine use in man. It is necessary to control the viability of labelled cells. Five leucocyte labelling techniques (111In-oxine, 111In-oxine without extraction, 99mTc oxine, pyrophosphate 99mTc, 51Cr) wer...

journal_title：British journal of haematology

authors： Colas-Linhart N,Barbu M,Gougerot MA,Bok B

更新日期：1983-01-01 00:00:00

abstract：:The putative natural killer (NK) cell lymphomas/leukaemias are a group of recently characterized haematolymphoid malignancies sharing an immunophenotype of CD3/Leu4- CD3epsilon+ CD56+, and a genotype of germline T-cell receptor genes. They frequently present in extranodal sites and exhibit a highly aggressive clinical...

journal_title：British journal of haematology

authors： Wong KF,Chan JK,Kwong YL

更新日期：1997-09-01 00:00:00

abstract：:The mechanisms involved in regulating von Willebrand factor (VWF) clearance remain poorly understood. However recent studies have shown that macrophages play a critical role in regulating the half-life of VWF, and have identified specific lectin (including asialoglycoprotein, macrophage galactose-type lectin, Sigec-5 ...

journal_title：British journal of haematology

authors： O'Sullivan JM,Ward S,Lavin M,O'Donnell JS

更新日期：2018-10-01 00:00:00

abstract：:The use of microfabrication technology in the study of biological systems continues to grow rapidly in both prevalence and ascendancy. Customised microdevices that provide superior results than traditional macroscopic methods can be designed in order to investigate specific cell types and cellular processes. This stud...

journal_title：British journal of haematology

authors： Gifford SC,Derganc J,Shevkoplyas SS,Yoshida T,Bitensky MW

更新日期：2006-11-01 00:00:00

abstract：:A serial study of coagulation activation and whole-blood viscosity was performed on 37 patients with local or systemic bacterial infection, malaria, or a viral infection. Thrombocytopenia, without consumption of coagulation factors, was the main feature of benign tertian malaria and viral infection, whereas in septica...

journal_title：British journal of haematology

authors： Richardson SG,Matthews KB,Cruickshank JK,Geddes AM,Stuart J

更新日期：1979-07-01 00:00:00

abstract：:We have investigated the kinetics of colony formation by progenitor cells in chronic myeloid leukaemia (CML) using erythroid burst-forming units (BFU-E) as a model system. For this, we scored the numbers of subcolonies produced by individual BFU-E in cultures of normal marrow and blood cells and in cultures of CML blo...

journal_title：British journal of haematology

authors： Marley SB,Lewis JL,Goldman JM,Gordon MY

更新日期：1996-06-01 00:00:00

abstract：:This study looked for clonal diversity in patients with a myeloproliferative neoplasm associated with more than one acquired genetic lesion. A tyrosine kinase mutation and a cytogenetic lesion were present in the same clone in six of seven patients. By contrast, the genetic lesions were present in separate clones in a...

journal_title：British journal of haematology

authors： Beer PA,Jones AV,Bench AJ,Goday-Fernandez A,Boyd EM,Vaghela KJ,Erber WN,Odeh B,Wright C,McMullin MF,Cullis J,Huntly BJ,Harrison CN,Cross NC,Green AR

更新日期：2009-03-01 00:00:00