Abstract:
:The use of L-asparaginase (L-ASP) in paediatric patients with acute lymphoblastic leukaemia (ALL) is associated with thrombotic complications. We evaluated the activities of tissue factor (TFa), thrombomodulin (TMa) and procoagulant phospholipids (PPL) in 26 consecutive children with ALL (25 B-ALL and one T-ALL) treated by the French Acute Lymphoblastic Leukemia group (FRALLE)-2000 protocol. Samples were obtained at diagnosis, after glucocorticoid (GC) therapy, during the induction phase with L-ASP, vincristine (VCR) and adriamycin (ADR), during the re-induction and within the week after treatment. Plasma levels of TFa, TMa and PPL increased gradually and significantly during the different phases of the treatment, with higher levels observed during the induction period, and decreased after treatment discontinuation. In vitro studies showed that the different drugs used for ALL treatment could induce a weak expression of TF and procoagulant activity (PCA) on normal and leukaemia blood cells, while a marked effect was observed on endothelial cells. In conclusion, these data indicate that, in addition to the well-identified increased in coagulation factors and inhibitor deficiencies, the injury of the endothelium could lead to the release of TF and PPL and could contribute to the hypercoagulability of children treated for ALL.
journal_name
Br J Haematoljournal_title
British journal of haematologyauthors
Schneider P,Van Dreden P,Rousseau A,Kassim Y,Legrand E,Vannier JP,Vasse Mdoi
10.1111/j.1365-2141.2009.07958.xsubject
Has Abstractpub_date
2010-02-01 00:00:00pages
582-92issue
4eissn
0007-1048issn
1365-2141pii
BJH7958journal_volume
148pub_type
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journal_title:British journal of haematology
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journal_title:British journal of haematology
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