Most cases of primary salivary mucosa-associated lymphoid tissue lymphoma are associated either with Sjoegren syndrome or hepatitis C virus infection.

abstract：:Immunoglobulin kappa (Igkappa) gene recombinations can be used - similarly to IgH rearrangements - as clonal markers in B-lineage leukaemias. Based on the extensive junctional diversity, these rearrangements represent valuable targets for the analysis of minimal residual disease (MRD). In order to provide a simple met...

journal_title：British journal of haematology

authors： Stolz F,Panzer S,Panzer-Grümayer ER

更新日期：1999-08-01 00:00:00

abstract：:High-dose dexamethasone (HD-Dex) has been reported to benefit AL amyloidosis patients with varying response rates. Our preliminary experience with the usual HD-Dex schedule indicated that the induction phase was rather toxic in AL patients. We therefore adopted a milder schedule consisting of dexamethasone 40 mg on d ...

journal_title：British journal of haematology

authors： Palladini G,Anesi E,Perfetti V,Obici L,Invernizzi R,Balduini C,Ascari E,Merlini G

更新日期：2001-06-01 00:00:00

abstract：:Between 1990 and 1999, 36 children with refractory anaemia with excess blasts (RAEB) and RAEB in transformation (RAEBt), not associated with Down's syndrome, were diagnosed in Britain. A total of 31 children received intensive chemotherapy, six of whom proceeded to a bone marrow allograft in first remission, whereas t...

journal_title：British journal of haematology

authors： Webb DK,Passmore SJ,Hann IM,Harrison G,Wheatley K,Chessells JM

更新日期：2002-04-01 00:00:00

abstract：:18F-fluoro-deoxyglucose (FDG) positron emission tomography (PET) might be a better tool than computerized tomography (CT) in predicting long-term treatment outcome in patients with relapsed chemosensitive lymphoma who are candidates for autologous stem cell transplantation (ASCT). We studied patients with recurrent or...

journal_title：British journal of haematology

authors： Schot B,van Imhoff G,Pruim J,Sluiter W,Vaalburg W,Vellenga E

更新日期：2003-10-01 00:00:00

abstract：:Positron emission tomography using fluorine-18 (FDG-PET) is increasingly used in the staging and follow-up of malignant lymphomas, although its precise role has not yet been determined. This review considers the results reported at the different stages in the disease history and separately considers the major histolog...

journal_title：British journal of haematology

authors： Burton C,Ell P,Linch D

更新日期：2004-09-01 00:00:00

abstract：:While proteasome inhibition is a validated therapeutic approach for multiple myeloma (MM), inhibition of individual constitutive proteasome (c20S) and immunoproteasome (i20S) subunits has not been fully explored owing to a lack of effective tools. We utilized the novel proteasome constitutive/immunoproteasome subunit ...

journal_title：British journal of haematology

authors： Lee SJ,Levitsky K,Parlati F,Bennett MK,Arastu-Kapur S,Kellerman L,Woo TF,Wong AF,Papadopoulos KP,Niesvizky R,Badros AZ,Vij R,Jagannath S,Siegel D,Wang M,Ahmann GJ,Kirk CJ

更新日期：2016-06-01 00:00:00

abstract：:Ibrutinib is associated with durable responses in patients with Waldenström macroglobulinaemia (WM). We hypothesized that response depth is predictive of progression-free survival (PFS) in WM patients treated with ibrutinib. Using landmark analyses, we evaluated response depth in two cohorts of WM patients treated wit...

journal_title：British journal of haematology

authors： Castillo JJ,Abeykoon JP,Gustine JN,Zanwar S,Mein K,Flynn CA,Demos MG,Guerrera ML,Kofides A,Liu X,Munshi M,Tsakmaklis N,King R,Yang G,Hunter ZR,Advani RH,Palomba ML,Ansell SM,Gertz MA,Kapoor P,Treon SP

更新日期：2020-11-18 00:00:00

abstract：:International guidance has recently recommended serial proximal compression ultrasound (CUS) as first line imaging for suspected deep vein thrombosis (DVT). Single whole-leg CUS is a routine alternative diagnostic strategy that can reduce repeated attendances and identify alternative pathology. We conducted a prospect...

journal_title：British journal of haematology

authors： Horner D,Hogg K,Body R,Jones S,Nash MJ,Mackway-Jones K

更新日期：2014-02-01 00:00:00

abstract：:The specific sodium pump antagonist ouabain was used to study the effect of sodium pump inhibition on granulopoietic colony formation by normal human bone marrow cells cultured in soft agar for 7 d. Suppression of colony formation was dose-dependent and occurred at a low and reproducible concentration. The use of an e...

journal_title：British journal of haematology

authors： Steed AJ,Boardman KM,Delamore IW

更新日期：1982-07-01 00:00:00

abstract：:The availability of a preparation of recombinant human erythropoietin (rEp) prompted us to investigate the role of Ep in the regulation of megakaryocytopoiesis in mice, using experimental procedures by which the effects on the mitotic and post-mitotic compartment of megakaryocytes could be evaluated separately. In aga...

journal_title：British journal of haematology

authors： Grossi A,Vannucchi AM,Rafanelli D,Rossi Ferrini P

更新日期：1989-04-01 00:00:00

abstract：:The expression of the VAV proto-oncogene in 57 patients with chronic myeloproliferative disease (CMD), B-cell acute lymphoblastic leukaemia (B-ALL) and B-cell non-Hodgkin Lymphoma (B-NHL), and 61 with B-cell chronic lymphocytic leukaemia (B-CLL) was analysed. VAV overexpression was observed in 19.5% of cases and 81% o...

journal_title：British journal of haematology

authors： Prieto-Sánchez RM,Hernández JA,García JL,Gutiérrez NC,San Miguel J,Bustelo XR,Hernández JM

更新日期：2006-06-01 00:00:00

abstract：:The CDKN2 gene, encoding the cyclin-dependent kinase-4 inhibitor p16, is a putative tumour-suppressor gene because it is frequently altered in many malignant tumours. We analysed the CDKN2 gene in 44 cases of adult T-cell leukaemia (ATL) by Southern blot analysis, polymerase chain reaction-mediated single-strand confo...

journal_title：British journal of haematology

authors： Uchida T,Kinoshita T,Watanabe T,Nagai H,Murate T,Saito H,Hotta T

更新日期：1996-09-01 00:00:00

abstract：:Over 1000 monoclonal antibodies (MAB), previously characterized in terms of reactivity with various haemopoietic cells and including representatives from each of the currently known Clusters of Differentiation (CD), have now been evaluated by us for reactivity against human endothelial cells. In the current study, scr...

journal_title：British journal of haematology

authors： Favaloro EJ,Moraitis N,Bradstock K,Koutts J

更新日期：1990-04-01 00:00:00

abstract：:In a series of 306 cases of myeloproliferative disorders followed over a period of 21 years, 18 cases of well-documented acute leukaemia were encountered. Leukaemias were either acute myeloblastic or myelomonocytic and occurred from 6 months to 20 years after the initial diagnosis. Onset was relatively abrupt and the ...

journal_title：British journal of haematology

authors： Rosenthal DS,Moloney WC

更新日期：1977-07-01 00:00:00

abstract：:The levels of platelet-associated Igs (PAIgs) and plasma circulating antiplatelet antibodies were evaluated by a flow cytometric immunofluorescence assay (FCIFA), an enzyme-linked immunoassay (ELISA), and a platelet radioactive antiglobulin test (PRAT), in a group of 45 human immunodeficiency virus (HIV)-infected intr...

journal_title：British journal of haematology

authors： Gonzalez-Conejero R,Rivera J,Rosillo MC,Cano A,Rodriguez T,Vicente V

更新日期：1996-05-01 00:00:00

abstract：:Sideroblastic anaemia includes a heterogeneous group of rare conditions, characterized by decreased haem synthesis and mitochondrial iron overload, which are diagnosed by the presence of ringed sideroblasts in the bone marrow aspirate. The most frequent form is X-linked sideroblastic anaemia, caused by mutations of de...

journal_title：British journal of haematology

authors： Camaschella C

更新日期：2008-10-01 00:00:00

abstract：:In order to evaluate the feasibility of first trimester prenatal diagnosis of beta-thalassaemia by restriction fragment length polymorphism (RFLP) in Campania, one of the most affected regions in Southern Italy, DNA polymorphism analysis was performed on 40 unrelated patients, affected with homozygous beta-thalassaemi...

journal_title：British journal of haematology

authors： Carestia C,Pagano L,Fioretti G,Mastrobuoni A

更新日期：1987-10-01 00:00:00

abstract：:Plasma cells isolated from bone marrow (BM) aspirates of 15 patients with active multiple myeloma (MM) were cultured and analysed for in vitro proliferative response and Ig-synthesis upon stimulation with interleukin-3 (IL-3), interleukin-4 (IL-4) and interleukin-6 (IL-6). The proliferative response, determined as Ki-...

journal_title：British journal of haematology

authors： Sonneveld P,Schoester M,de Leeuw K

更新日期：1991-12-01 00:00:00

abstract：:The proteasome inhibitor, bortezomib, potentially increases cell sensitivity to chemotherapy. This study was performed to determine the overall response rate (ORR), overall survival (OS), progression-free survival (PFS) and toxicity of CHOP (cyclophosphamide, doxorubicin, vincristine and prednisolone) compared to CHOP...

journal_title：British journal of haematology

authors： Furtado M,Johnson R,Kruger A,Turner D,Rule S

更新日期：2015-01-01 00:00:00

abstract：:The combination of interleukin (IL)-4 and IL-10 protects against blood-induced cartilage damage in vitro. It has been hypothesized that the combination of these cytokines is effective if applied early in the process of cartilage damage. The present study investigated whether a single intra-articular injection of IL-4 ...

journal_title：British journal of haematology

authors： van Meegeren ME,Roosendaal G,Coeleveld K,Nieuwenhuizen L,Mastbergen SC,Lafeber FP

更新日期：2013-02-01 00:00:00

abstract：:This study assessed the relevance of 2013 European LeukaemiaNet (ELN) response categories on patients treated with common frontline tyrosine kinase inhibitors (TKI) in chronic myeloid leukaemia in chronic phase (CML-CP). Four hundred and eighty-seven patients treated with imatinib (400 mg; IM 400, n = 70; 800 mg; IM80...

journal_title：British journal of haematology

authors： Jain P,Kantarjian H,Sasaki K,Jabbour E,Dasarathula J,Nogueras Gonzalez G,Verstovsek S,Borthakur G,Wierda W,Kadia T,Dellasala S,Pierce S,Ravandi F,O'Brien S,Cortes J

更新日期：2016-04-01 00:00:00

abstract：:Membrane protein synthesis in human immature erythroid cells was studied by incubating the cells with 35S-methionine in vitro. The radioactive precursor amino acid was incorporated into membrane protein in a linear fashion for approximately 60 min, after which there was only a slight increase in incorporation. Intrace...

journal_title：British journal of haematology

authors： Krasnow SH,Pielichowski HJ,Caro J,Burka ER,Ballas SK

更新日期：1981-02-01 00:00:00

abstract：:We evaluated the performance of eight d-assays for the exclusion of deep vein thrombosis (DVT); Biopool AutoDimer, Biopool MiniQuant, bioMèrieux MDA D-Dimer, VIDAS, Dade Behring D-Dimer Plus, Trinity Biotech AMAX, NycoCard D-dimer and IL Test D-Dimer. The assays were evaluated both as stand-alone tests, and in combina...

journal_title：British journal of haematology

authors： Gardiner C,Pennaneac'h C,Walford C,Machin SJ,Mackie IJ

更新日期：2005-03-01 00:00:00

abstract：:Parameters of host defence were investigated in 30 patients with sickle cell disease (SCD). A newly devised perfusion system was used to study the kinetics in whole blood of leucocyte adherence, phagocytosis, killing and solubilization of a mixture of Staph. aureus and Str. pneumoniae, and secretion of lactoferrin. A ...

journal_title：British journal of haematology

authors： Boghossian SH,Wright G,Webster AD,Segal AW

更新日期：1985-03-01 00:00:00

abstract：:Terminal B-cell differentiation is a multi-step process, from short-lived plasmablasts to mature long-lived plasma cells (PC). The anti-apoptotic Bcl-2 family member Bfl-1/A1 plays a critical role in the survival of mature B cells. However, its potential involvement at the later stages of B-cell development remains hi...

journal_title：British journal of haematology

authors： Tarte K,Jourdan M,Veyrune JL,Berberich I,Fiol G,Redal N,Shaughnessy J Jr,Klein B

更新日期：2004-05-01 00:00:00

abstract：:The replicative potential of human CD56(+) CD3(-) natural killer (NK) cells is unknown. We found that by exposing NK cells to the leukaemic cell line K562 genetically modified to express 4-1BB ligand and interleukin 15 (K562-mb15-41BBL), they expanded for up to 30 population doublings, achieving numbers that ranged fr...

journal_title：British journal of haematology

authors： Fujisaki H,Kakuda H,Imai C,Mullighan CG,Campana D

更新日期：2009-06-01 00:00:00

abstract：:The mechanisms involved in regulating von Willebrand factor (VWF) clearance remain poorly understood. However recent studies have shown that macrophages play a critical role in regulating the half-life of VWF, and have identified specific lectin (including asialoglycoprotein, macrophage galactose-type lectin, Sigec-5 ...

journal_title：British journal of haematology

authors： O'Sullivan JM,Ward S,Lavin M,O'Donnell JS

更新日期：2018-10-01 00:00:00

abstract：:Duffy blood group negative erythrocytes from blacks are refractory to invasion by Plasmodium knowlesi merozoites in vitro, and blacks with this genotype are resistant to infection by P. vivax in vivo. In order to evaluate in a direct manner the role of Duffy blood group determinants in invasion by P. knowlesi merozoit...

journal_title：British journal of haematology

authors： Mason SJ,Miller LH,Shiroishi T,Dvorak JA,McGinniss MH

更新日期：1977-07-01 00:00:00

abstract：:To explore the potential efficacy of l-asparaginase treatment in acute myeloid leukaemia (AML) patients, we studied the in vitro resistance of French-American-British (FAB) subtypes of childhood AML to l-asparaginase using a methyl-thiazol-tetrazolium assay. We tested leukaemic cells obtained from 177 common acute lym...

journal_title：British journal of haematology

authors： Okada S,Hongo T,Yamada S,Watanabe C,Fujii Y,Ohzeki T,Horikoshi Y,Ito T,Yazaki M,Komada Y,Tawa A

更新日期：2003-12-01 00:00:00

abstract：:Significant increases in prolyl hydroxylase activity, a key enzyme in the collagen biosynthetic pathway, were noted in the hepatic homogenates of iron-loaded animals as compared to controls. The increase in prolyl hydroxylase activity was seen without any light microscopic histologic evidence of cell necrosis or accum...

journal_title：British journal of haematology

authors： Weintraub LR,Goral A,Grasso J,Franzblau C,Sullivan A,Sullivan S

更新日期：1985-02-01 00:00:00