Single whole-leg compression ultrasound for exclusion of deep vein thrombosis in symptomatic ambulatory patients: a prospective observational cohort study.

abstract：:The use of peripheral blood stem cells instead of bone marrow as the source of haemopoietic cells for allogeneic transplantation is being increasingly explored. We have analysed data from 17 normal donors who underwent stem cell mobilization for allogeneic transplantation with an identical protocol using G-CSF at a do...

journal_title：British journal of haematology

authors： Miflin G,Charley C,Stainer C,Anderson S,Hunter A,Russell N

更新日期：1996-11-01 00:00:00

abstract：:Lenalidomide (LEN) acts directly on multiple myeloma (MM) cells by inducing cereblon-mediated degradation of interferon regulatory factor 4, Ikaros (IKZF)1 and IKZF3, transcription factors that are essential for MM cell survival. The mucin 1 (MUC1) C-terminal transmembrane subunit (MUC1-C) oncoprotein is aberrantly ex...

journal_title：British journal of haematology

authors： Yin L,Tagde A,Gali R,Tai YT,Hideshima T,Anderson K,Avigan D,Kufe D

更新日期：2017-09-01 00:00:00

abstract：:Multiple myeloma (MM) is a plasma cell malignancy that claims thousands of lives each year and has considerable morbidity. The disease remains incurable despite recent advances in the understanding of the disease biology and the introduction of more effective drugs is needed. This study evaluated the anti-MM activity ...

journal_title：British journal of haematology

authors： Kumar S,Raje N,Hideshima T,Ishitsuka K,Podar K,Le Gouille S,Chauhan D,Richardson P,Munshi NC,Anderson K

更新日期：2006-03-01 00:00:00

abstract：:Osteonecrosis is a disabling complication in children and young adults with acute lymphoblastic leukaemia. It can affect any or multiple joints but the hip and knee are most frequently involved and a cause of long-term disability. The problem is almost exclusively that of older children and young adults of whom over 7...

journal_title：British journal of haematology

authors： Vora A

更新日期：2011-12-01 00:00:00

abstract：:In HbSC disease, as in sickle cell anaemia, there is a spectrum of clinical severity. A reduced mean corpuscular volume and haemoglobin concentration, traits typical of thalassaemia, might retard sickling. We therefore ascertained the prevalence of alpha-thalassaemia in 53 adults with HbSC disease and related alpha-gl...

journal_title：British journal of haematology

authors： Steinberg MH,Coleman MB,Adams JG,Platica O,Gillette P,Rieder RF

更新日期：1983-11-01 00:00:00

abstract：:Summary Previous findings of megakaryocytic hypogranulation and dysmegakaryocytopoietic features in acute myeloid leukaemia (AML) strongly indicate defects in platelet production. The bleeding tendency of these patients may result from dysregulated platelet production, resulting in thrombocytopenia as well as qualitat...

journal_title：British journal of haematology

authors： Leinoe EB,Hoffmann MH,Kjaersgaard E,Johnsen HE

更新日期：2004-10-01 00:00:00

abstract：:Persistent lymphocytosis is usually associated with a malignant lymphoproliferative disease (MLPD). We report six female patients presenting a chronic, moderate lymphocytosis of 2-16 years duration with atypical binucleated lymphocytes on peripheral blood smears. Further investigation showed a polyclonal increase in s...

journal_title：British journal of haematology

authors： Troussard X,Valensi F,Debert C,Maynadie M,Schillinger F,Bonnet P,Macintyre EA,Flandrin G

更新日期：1994-10-01 00:00:00

abstract：:The blood-related cancer leukaemias were the first diseases where human cancer stem cells, or leukaemic stem cells (LSC), were isolated. The haematopoietic system is one of the best tissues for investigating cancer stem cells, because the developmental hierarchy of normal blood formation is well defined. Leukaemias ca...

journal_title：British journal of haematology

authors： Bonnet D

更新日期：2005-08-01 00:00:00

abstract：:Forty female patients with either primary anti-phospholipid syndrome (n = 26) or systemic lupus erythematosus (anti-phospholipid syndrome positive) (n = 14) were investigated for levels of factor XII, the presence of lupus anticoagulant and antibodies to cardiolipin, beta 2-glycoprotein I and factor XII. Twenty-one pa...

journal_title：British journal of haematology

authors： Jones DW,MacKie IJ,Gallimore MJ,Winter M

更新日期：2001-05-01 00:00:00

abstract：:Recurrent large-scale somatic copy number alterations (SCNAs), and somatic point mutations can be analysed to stratify patients with chronic lymphocytic leukaemia (CLL) into distinct prognostic groups. To investigate the relationship between SCNAs and somatic mutations, we performed whole-exome sequencing and single n...

journal_title：British journal of haematology

authors： Zhou W,Goldin L,Wang M,McMaster ML,Jones K,Burdett L,Chanock SJ,Yeager M,Dean M,Caporaso NE

更新日期：2018-06-01 00:00:00

abstract：:Serum ferritin level is one of the most commonly requested investigations in both primary and secondary care. Whilst low serum ferritin levels invariably indicate reduced iron stores, raised serum ferritin levels can be due to multiple different aetiologies, including iron overload, inflammation, liver or renal diseas...

journal_title：British journal of haematology

authors： Cullis JO,Fitzsimons EJ,Griffiths WJ,Tsochatzis E,Thomas DW,British Society for Haematology.

更新日期：2018-05-01 00:00:00

abstract：:T- and B-cell function after autologous bone marrow transplantation (ABMT) was assessed and compared with that found after allogeneic BMT and after chemotherapy only. In all 16 patients with acute leukaemia in remission treated with high-dose chemotherapy and single or double ABMT, T-helper numbers and function in an ...

journal_title：British journal of haematology

authors： Armitage RJ,Goldstone AH,Richards JD,Cawley JC

更新日期：1986-08-01 00:00:00

abstract：:This study describes the effect of ferritin on lymphocyte function in vitro. Peripheral blood lymphocytes isolated from normal donors were incubated with purified human splenic ferritin, and the mitogenic effect of phytohaemagglutinin (PHA), concanavalin A (Con A), pokeweed mitogen (PWM) and mixed lymphocyte reaction ...

journal_title：British journal of haematology

authors： Matzner Y,Hershko C,Polliack A,Konijn AM,Izak G

更新日期：1979-07-01 00:00:00

abstract：:Aspergillus fumigatus is an opportunistic filamentous fungus that is currently the most frequent cause of invasive fungal disease in immunosuppressed individuals. Recent advances in our understanding of the pathogenesis of invasive aspergillosis have highlighted the multifactorial nature of A. fumigatus virulence and ...

journal_title：British journal of haematology

authors： Ben-Ami R,Lewis RE,Kontoyiannis DP

更新日期：2010-08-01 00:00:00

abstract：:Liposomes prepared from rabbit brain extracts (RBE) and individual pure lipids (high phosphatidyl serine content, HIPS) were compared with frozen-thawed platelets (PLTS) in the dilute Russell Viper venom time (dRVVt). While all three preparations demonstrated sensitivity to lupus anticoagulant (LA) the highest detecti...

journal_title：British journal of haematology

authors： Stevenson KJ,Seddon JM

更新日期：1994-03-01 00:00:00

abstract：:This study compared how Enoxaparin and unfractionated (UF) heparin influenced in vivo coagulation in patients randomized to receive, by twice daily subcutaneous injections, either 30 mg of Enoxaparin or 7500 I.U. of UF heparin after elective hip surgery. These two regimens were equally effective in reducing the incide...

journal_title：British journal of haematology

authors： Ofosu FA,Levine M,Craven S,Dewar L,Shafai S,Blajchman MA

更新日期：1992-10-01 00:00:00

abstract：:Experiments were performed to investigate the relative role of phospholipase A2 (PLA2) in the activation and cytokine-mediated priming of neutrophil superoxide production. PLA2 activity was measured with a radiometric assay which discriminates between PLA2 and the downstream enzyme, 5-lipoxygenase. In cells that had n...

journal_title：British journal of haematology

authors： Roberts PJ,Williams SL,Linch DC

更新日期：1996-03-01 00:00:00

abstract：:A prospective study was undertaken to determine the effectiveness of an empirical antibiotic therapy regimen in 34 neutropenic patients undergoing bone marrow transplantation or remission-induction chemotherapy for leukaemia. Throughout the study period a total of 90 pyrexial episodes were monitored in which organisms...

journal_title：British journal of haematology

authors： Barnes RA,Rogers TR

更新日期：1987-05-01 00:00:00

abstract：:Accumulating evidence indicates that a graft-vs.-myeloma effect (GVM) and its associated clinical remission of the disease can be induced by donor lymphocyte infusion in myeloma patients who have relapsed after allogeneic bone marrow transplantation. Although it is believed that GVM is induced by allospecific T cells,...

journal_title：British journal of haematology

authors： Chiriva-Internati M,Du J,Cannon M,Barlogie B,Yi Q

更新日期：2001-02-01 00:00:00

abstract：:The changes in bone marrow (BM) stem cell reserve and function and stromal cell function in patients with active systemic lupus erythematosus (SLE) were investigated. The study was carried out on seven SLE patients and 28 healthy controls using flow cytometry and in vitro cell culture assays. We found that patients ha...

journal_title：British journal of haematology

authors： Papadaki HA,Boumpas DT,Gibson FM,Jayne DR,Axford JS,Gordon-Smith EC,Marsh JC,Eliopoulos GD

更新日期：2001-10-01 00:00:00

abstract：:The number of novel therapies for the treatment of myeloma is rapidly increasing, as are the clinical trials evaluating them in combination with other novel and established therapies. Proteasome inhibitors, immunomodulatory agents and monoclonal antibodies are the most well known and studied classes of novel agents ta...

journal_title：British journal of haematology

authors： Wallington-Beddoe CT,Sobieraj-Teague M,Kuss BJ,Pitson SM

更新日期：2018-07-01 00:00:00

abstract：:Duffy blood group antigens are carried on a glycoprotein that is predicted to pass through the erythrocyte membrane seven times and is a promiscuous chemokine receptor. The Fy(a- b-) phenotype is present in two-thirds of African-American Blacks but is rare in Caucasians. In Blacks, the phenotype is due to a non-functi...

journal_title：British journal of haematology

authors： Rios M,Chaudhuri A,Mallinson G,Sausais L,Gomensoro-Garcia AE,Hannon J,Rosenberger S,Poole J,Burgess G,Pogo O,Reid M

更新日期：2000-02-01 00:00:00

abstract：:The humanized CD52 monoclonal antibody Campath-1H was used as first-line therapy in nine patients with progressive chronic lymphocytic leukaemia (CLL). Intravenous (n = 5) or subcutaneous (n = 4) injections (up to 30 mg/inj.) were given three times a week for a maximum of 18 weeks. Three patients achieved a complete r...

journal_title：British journal of haematology

authors： Osterborg A,Fassas AS,Anagnostopoulos A,Dyer MJ,Catovsky D,Mellstedt H

更新日期：1996-04-01 00:00:00

abstract：:A mutation in factor XIII (Val34Leu) was reported to protect against venous thromboembolism. We evaluated the effect of Val34Leu on thrombotic risk in 352 factor V Leiden carriers who were first-degree relatives of 132 thrombotic propositi carrying factor V Leiden. The total observation period was 2,594 years in 92 Va...

journal_title：British journal of haematology

authors： Franco RF,Middeldorp S,Meinardi JR,van Pampus EC,Reitsma PH

更新日期：2000-10-01 00:00:00

abstract：:Infections continue to be a serious problem for severely neutropenic oncology and haematopoietic progenitor cell (HPC) transplant patients. Although it is now possible to collect much larger numbers of neutrophils (PMNs) from donors stimulated with granulocyte colony-stimulating factor + corticosteroids, the efficacy ...

journal_title：British journal of haematology

authors： Strauss RG

更新日期：2012-08-01 00:00:00

abstract：:The success of genetically engineered T cells that express chimeric antigen receptors (CARTs) has been a momentous step forward in harnessing the potent cancer fighting abilities of the immune system. The efficacy seen in relapsed/refractory (r/r) acute lymphoblastic leukaemia (ALL), not only by inducing remission, bu...

journal_title：British journal of haematology

authors： Orlowski RJ,Porter DL,Frey NV

更新日期：2017-04-01 00:00:00

abstract：:The US National Cancer Institute's Surveillance, Epidemiology and End Results program was used to develop aetiological clues for hairy cell leukaemia (HCL). Descriptive techniques (age-adjusted incidence trends, age-specific incidence rates (IR), and age distributions-at-diagnosis) were supplemented with mathematical ...

journal_title：British journal of haematology

authors： Dores GM,Matsuno RK,Weisenburger DD,Rosenberg PS,Anderson WF

更新日期：2008-07-01 00:00:00

abstract：:We report a 22-year-old woman with acute, plasma refractory thrombotic thrombocytopenic purpura (TTP) in whom splenectomy led to consistent stabilization of platelet counts, but who showed complete inhibition of vonWillebrand factor-cleaving protease (VWF-cp) after 6 months of follow up. Persistent protease deficiency...

journal_title：British journal of haematology

authors： Langer F,Bergmann F,Budde U,Hegewisch-Becker S,Hossfeld DK

更新日期：2002-07-01 00:00:00

abstract：:Canine cyclic haematopoiesis (CH) appears to be a multipotential stem cell defect, possibly due to an intrinsic marrow defect. The in vitro adherent marrow cells of the cyclic haematopoietic (CH) dog were cultured as underlayers beneath normal dog nonadherent marrow cells. The marrow granulocyte-committed colony formi...

journal_title：British journal of haematology

authors： Jones JB,Jolly JD

更新日期：1982-04-01 00:00:00

abstract：:An anomalous organization of the cytoskeleton has been described in lymphocytes from chronic lymphatic leukaemia and in only few cell lines. We have now studied normal and neoplastic lymphocytes and lymphoid cell lines of both T and B lineage in order to detect morphological differences in the expression of microfilam...

journal_title：British journal of haematology

authors： Zauli D,Gobbi M,Crespi C,Tazzari PL,Miserocchi F,Tassinari A

更新日期：1988-04-01 00:00:00