Platelets release novel thiol isomerase enzymes which are recruited to the cell surface following activation.

abstract：:We report a patient with uterine myoma (leiomyoma) and erythrocytosis in whom erythropoietin (Epo) production in the leiomyoma tissue was identified by reverse transcription polymerase chain reaction (RT-PCR) and enzyme-linked immunosorbent assay (ELISA). A 48-year-old Japanese woman with uterine myoma showed marked e...

journal_title：British journal of haematology

authors： Suzuki M,Takamizawa S,Nomaguchi K,Suzu S,Yamada M,Igarashi T,Sato I

更新日期：2001-04-01 00:00:00

abstract：:Myeloablative conditioning prior to allogeneic stem cell transplantation causes a rapid increase in transferrin saturation and potentially toxic non-transferrin-bound iron (NTBI) in plasma. We have studied the ability of repeatedly administered apotransferrin to maintain this iron in a transferrin-bound form. Twenty a...

journal_title：British journal of haematology

authors： Parkkinen J,Sahlstedt L,von Bonsdorff L,Salo H,Ebeling F,Ruutu T

更新日期：2006-10-01 00:00:00

abstract：:Highly efficient systems remove toxic and pro-inflammatory haemoglobin (Hb) from the circulation and local sites of tissue damage. Macrophages are major Hb-clearing cells; CD163 was recently recognized as the specific haemoglobin-haptoglobin scavenger receptor (HSR). We show that dexamethasone strongly induced the spe...

journal_title：British journal of haematology

authors： Schaer DJ,Boretti FS,Schoedon G,Schaffner A

更新日期：2002-10-01 00:00:00

abstract：:Reducing infectious morbidity is an important goal to improve childhood acute lymphoblastic leukaemia (ALL) survival. To explore the impact of chemotherapy reduction on infectious morbidity, we compared outpatient and inpatient infectious morbidity of reduced versus intensive (conventional) chemotherapy. One hundred a...

journal_title：British journal of haematology

authors： van Tilburg CM,Sanders EA,Nibbelke EE,Pieters R,Revesz T,Westers P,Wolfs TF,Bierings MB

更新日期：2011-02-01 00:00:00

abstract：:We recently identified a human minor histocompatibility (H) antigen, encoded by UDP glycosyltransferase 2 family, polypeptide B17 (UGT2B17), whose immunogenicity results from differential expression in donor and recipient cells as a consequence of a homozygous deletion of the UGT2B17 gene. UGT2B17 is highly expressed ...

journal_title：British journal of haematology

authors： Terakura S,Murata M,Nishida T,Emi N,Akatsuka Y,Riddell SR,Morishima Y,Kodera Y,Naoe T

更新日期：2005-04-01 00:00:00

abstract：:Whole exome sequencing and copy number aberration (CNA) analysis were performed on cells taken from peripheral blood (PB) and lymph nodes (LN) of patients with chronic lymphocytic leukaemia (CLL). Of 64 non-silent somatic mutations, 54 (84·4%) were clonal in both compartments, 3 (4·7%) were PB-specific and 7 (10·9%) w...

journal_title：British journal of haematology

authors： Del Giudice I,Marinelli M,Wang J,Bonina S,Messina M,Chiaretti S,Ilari C,Cafforio L,Raponi S,Mauro FR,Di Maio V,De Propris MS,Nanni M,Ciardullo C,Rossi D,Gaidano G,Guarini A,Rabadan R,Foà R

更新日期：2016-02-01 00:00:00

abstract：:In four unrelated patients with chronic haemolysis and markedly reduced red blood cell (RBC) glutathione (49.5%, 12.6%, 11.5% and 15% of the normal concentration respectively), a severe glutathione synthetase (GSH-S, EC 6.3.2.3) deficiency was found. One case exhibited a neonatal haemolytic anaemia associated with oxo...

journal_title：British journal of haematology

authors： Corrons JL,Alvarez R,Pujades A,Zarza R,Oliva E,Lasheras G,Callis M,Ribes A,Gelbart T,Beutler E

更新日期：2001-02-01 00:00:00

abstract：:T-cells from patients with B-cell chronic lymphocytic leukaemia (B-CLL) have abnormal T4/T8 ratios and functions. Previously, we demonstrated that peripheral blood (PB) mononuclear cells from B-CLL patients secrete significant amounts of interleukin 2 (IL2) with an apparent dysregulation of accessory cells controlling...

journal_title：British journal of haematology

authors： Rossi JF,Klein B,Commes T,Jourdan M,Janbon C

更新日期：1988-02-01 00:00:00

abstract：:Membrane protein synthesis in human immature erythroid cells was studied by incubating the cells with 35S-methionine in vitro. The radioactive precursor amino acid was incorporated into membrane protein in a linear fashion for approximately 60 min, after which there was only a slight increase in incorporation. Intrace...

journal_title：British journal of haematology

authors： Krasnow SH,Pielichowski HJ,Caro J,Burka ER,Ballas SK

更新日期：1981-02-01 00:00:00

abstract：:Sixty patients with von Willebrand's disease belonging to 34 unrelated families were classified into the various types of the disease by analysis of the multimer patterns of von Willebrand factor. Type I disease was observed in 62% of the families, a finding similar to the recently published British and Swedish series...

journal_title：British journal of haematology

authors： Berliner SA,Seligsohn U,Zivelin A,Zwang E,Sofferman G

更新日期：1986-03-01 00:00:00

abstract：:A multiparameter flow-cytometrical method for the quantitation of CD34(+)-cells present in adult human peripheral blood cells (PBMC) has been developed. PBMC from 13 healthy adult subjects were analysed for CD34(+)-cells by flow-cytometry, with only the lymphoid population of cells negative for anti-CD3-moAb included ...

journal_title：British journal of haematology

authors： Serke S,Säuberlich S,Huhn D

更新日期：1991-04-01 00:00:00

abstract：:Highly purified and cloned preparations of interleukin-1 (IL-1) were found to antagonize the capacity of erythropoietin (Epo) to stimulate the proliferation of mouse spleen and bone marrow erythroid precursor cells (EPC) in culture. Cloned murine IL-1 and purified and cloned human IL-1 alpha and IL-1 beta were approxi...

journal_title：British journal of haematology

authors： Schooley JC,Kullgren B,Allison AC

更新日期：1987-09-01 00:00:00

abstract：:Alpha haemoglobin stabilising protein (AHSP) binds free alpha-globin chains and plays an important role in the protection of red cells, particularly during beta-thalassaemia. Murine ASHP was discovered as a GATA-1 target gene and human AHSP is directly regulated by GATA-1. More recently, AHSP was rediscovered as a hig...

journal_title：British journal of haematology

authors： Keys JR,Tallack MR,Hodge DJ,Cridland SO,David R,Perkins AC

更新日期：2007-01-01 00:00:00

abstract：:Over the past four decades, remarkable progress has been made in the treatment and prognosis of multiple myeloma (MM), although it remains an incurable disease. Chemotherapy resistance is a major hurdle for treatment efficacy. Drug resistance can be innate and so driven by genes involved in the drug metabolism pathway...

journal_title：British journal of haematology

authors： Macauda A,Castelli E,Buda G,Pelosini M,Butrym A,Watek M,Kruszewski M,Vangsted AJ,Rymko M,Jamroziak K,Abildgaard N,Haastrup EK,Mazur G,Ríos R,Jurczyszyn A,Zawirska D,Dudziński M,Raźny M,Dutka M,Tomczak W,Suska A,

更新日期：2018-11-01 00:00:00

abstract：:Umbilical cord blood is an alternative stem cell source for patients without matched family donors. In this study, we examined several parameters that have not been studied in detail -- radiation dose, cell dose, age of mice, and maternal and neonatal characteristics of the cord blood donor -- that affect engraftment ...

journal_title：British journal of haematology

authors： Ballen KK,Valinski H,Greiner D,Shultz LD,Becker PS,Hsieh CC,Stewart FM,Quesenberry PJ

更新日期：2001-07-01 00:00:00

abstract：:Lysosomal enzyme activities and isoenzyme profiles were measured in lymphoid and non-lymphoid leukaemic cells from childhood patients. High activities, especially of beta-hexosaminidase and alpha-mannosidase, were associated with leukaemic cells of myeloid or monocytic origin. Leukaemic cells from two children with ac...

journal_title：British journal of haematology

authors： Eden OB,Darbyshire P,Simpson RM,Besley GT,Moss S,Gentle T

更新日期：1985-01-01 00:00:00

abstract：:A patient presented with haemolytic anaemia and a negative direct antiglobulin test (DAT), and was found to have an IgG antibody with anti-Jka specificity in his serum. His red cells were typed as Jk(a-b+). Later he developed idiopathic thrombocytopenic purpura (ITP), and had a positive DAT due to anti-Jka bound to hi...

journal_title：British journal of haematology

authors： Ganly PS,Laffan MA,Owen I,Hows JM

更新日期：1988-08-01 00:00:00

abstract：:Physiological parameters such as pH and oxygen tension probably play significant roles in the regulation of haemopoiesis in the bone marrow microenvironment, but these roles have yet to be characterized in detail. We have found that changes in culture pH (0.2 units) can cause significant changes in the culture composi...

journal_title：British journal of haematology

authors： McAdams TA,Miller WM,Papoutsakis ET

更新日期：1998-11-01 00:00:00

abstract：:In order to clarify the mechanism of the effect of erythropoietin (Epo) on the fetal haemoglobin (HbF) phenotype of peripheral erythrocytes, we studied the dose-response effect of Epo on HbF production by erythroid precursors derived from the peripheral blood of normal adult individuals and grown in a two-phase liquid...

journal_title：British journal of haematology

authors： Fibach E,Schechter AN,Noguchi CT,Rodgers GP

更新日期：1994-09-01 00:00:00

abstract：:In the last few years, mutations that cause disease through increased efficiency of mRNA translation have been discovered. Hereditary hyperferritinaemia-cataract syndrome (HHCS) arises from various point mutations or deletions within the iron-responsive element (IRE) in the 5'-UTR of the L-ferritin mRNA. Each unique m...

journal_title：British journal of haematology

authors： Cazzola M,Foglieni B,Bergamaschi G,Levi S,Lazzarino M,Arosio P

更新日期：2002-03-01 00:00:00

abstract：:Four children with acute lymphoblastic leukaemia (ALL) who relapsed after allogeneic bone marrow transplantation (BMT) were treated with donor lymphocyte infusion (DLI) without prior conditioning. Three patients had previously received a non-T-cell-depleted matched sibling BMT and the fourth had a T-cell-depleted matc...

journal_title：British journal of haematology

authors： Atra A,Millar B,Shepherd V,Shankar A,Wilson K,Treleaven J,Pritchard-Jones K,Meller ST,Pinkerton CR

更新日期：1997-04-01 00:00:00

abstract：:Protein S is expressed in a number of tissue types, one of the most physiologically relevant being the liver. However, transcriptional control of protein S gene expression is poorly understood. We have characterised a 638 bp area in the 5' flanking region of the human protein S gene, spanning all 10 previously reporte...

journal_title：British journal of haematology

authors： Hall AJ,Peake IR,Winship PR

更新日期：2006-11-01 00:00:00

abstract：:Previously thought to be best described as a plasma cell disorder, Waldenström macroglobulinaemia (WM) is now understood to be a distinct clinicobiological entity. WM shares B-cell origin and certain other features with both chronic lymphocytic leukaemia (CLL) and multiple myeloma (MM). WM and CLL arise from B-cells a...

journal_title：British journal of haematology

authors： McMaster ML,Caporaso N

更新日期：2007-12-01 00:00:00

abstract：:The regulation of granulocyte-colony stimulating factor (G-CSF) and interleukin-6 (IL-6) mRNA was studied in human adherent monocytes in response to the protein kinase C activator, oleolyl-acetylglycerol (OAG), the calcium-ionophore A23187 and the cyclic AMP elevating agents, dibutyryl c-AMP (DBcAMP), cholera toxin an...

journal_title：British journal of haematology

authors： Vellenga E,van der Vinne B,De Wolf JT,Halie MR

更新日期：1991-05-01 00:00:00

abstract：:Recombinant factor VIII variants with overlapping deletions spanning the region Lys713-Ile1668 have been expressed in mammalian cells, and analysed for biological activity both in vitro and in vivo. Two distinct assay systems were used to measure the activity in vitro. The one-stage coagulation assay served to assess ...

journal_title：British journal of haematology

authors： Mertens K,Donath MJ,van Leen RW,de Keyzer-Nellen MJ,Verbeet MP,Klaasse Bos JM,Leyte A,van Mourik JA

更新日期：1993-09-01 00:00:00

abstract：:Six hundred and nineteen patients with de novo acute myeloid leukaemia, entered into the Medical Research Council's eighth trial of therapy have been studied. All patients were treated with the same remission induction regimen. Pretreatment variables comprising age, clinical status, haematological status and a detaile...

journal_title：British journal of haematology

authors： Swirsky DM,de Bastos M,Parish SE,Rees JK,Hayhoe FG

更新日期：1986-11-01 00:00:00

abstract：:The bleeding time in healthy volunteers was determined according to both the Ivy and the Simplate II techniques. A significantly longer bleeding time in people with blood group O than in people with non-O blood groups was demonstrated with both techniques. This difference could not be attributed to a difference in sex...

journal_title：British journal of haematology

authors： Caekebeke-Peerlinck KM,Koster T,Briët E

更新日期：1989-10-01 00:00:00

abstract：:We investigated the molecular basis of factor VII deficiency in a Japanese patient and identified a novel missense mutation in the signal sequence of the gene. Factor VII activity and antigen level measured in the patient were 10.7% and 11% of normal, respectively. All exons except 1B and the 5'-flanking region contai...

journal_title：British journal of haematology

authors： Ozawa T,Takikawa Y,Niiya K,Ejiri N,Suzuki K,Sato S,Sakuragawa N

更新日期：1998-04-01 00:00:00

abstract：:We describe three patients with chronic granulocytic leukaemia who developed impaired visual acuity in association with high leucocyte counts. Two of the patients were in the chronic phase of their disease and the third developed visual symptoms at the time of blastic transformation. Fundoscopy showed retinal haemorrh...

journal_title：British journal of haematology

authors： Mehta AB,Goldman JM,Kohner E

更新日期：1984-04-01 00:00:00

abstract：:Culture medium was harvested after co-incubation of mononuclear cells collected and pooled from the peripheral blood of two different normal donors and was tested for colony-stimulating activity (CSA) in agar culture. With bone marrow from normal donors or peripheral blood from patients with chronic granulocytic leuka...

journal_title：British journal of haematology

authors： Hellmann A,Th'ng KH,Goldman JM

更新日期：1980-06-01 00:00:00