Abstract:
:In the last few years, mutations that cause disease through increased efficiency of mRNA translation have been discovered. Hereditary hyperferritinaemia-cataract syndrome (HHCS) arises from various point mutations or deletions within the iron-responsive element (IRE) in the 5'-UTR of the L-ferritin mRNA. Each unique mutation confers a characteristic degree of hyperferritinaemia and severity of cataract in affected individuals. We report a novel six-nucleotide deletion identified in an Italian family presenting with elevated serum ferritin and early onset bilateral cataract. This deletion involves a sequence with a TCT repetition and may have occurred through a mechanism of slippage mispairing. Because of the above repetition, the observed mutation can be interpreted as deletion 22-27, 23-28, 24-29 or 25-30. Structural modelling predicted an IRE stem modification that is expected to markedly reduce the binding to iron-regulatory proteins. A double-gradient denaturing gradient gel electrophoresis (DG-DGGE) method easily detected the above deletion.
journal_name
Br J Haematoljournal_title
British journal of haematologyauthors
Cazzola M,Foglieni B,Bergamaschi G,Levi S,Lazzarino M,Arosio Pdoi
10.1046/j.0007-1048.2001.03310.xsubject
Has Abstractpub_date
2002-03-01 00:00:00pages
667-70issue
3eissn
0007-1048issn
1365-2141pii
3310journal_volume
116pub_type
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