A possible anti-emetic role for sodium valproate in cytotoxic chemotherapy.

abstract：:A patient with Jo-1 antibody-associated polymyositis (Jo-1 PM) had a Karnofsky score of 40% and severe muscle, liver and lung damage that was refractory to standard therapy. The female patient received an autologous T-cell-depleted haematopoietic stem cell transplant (HSCT) after myeloablative conditioning. The transp...

journal_title：British journal of haematology

authors： Baron F,Ribbens C,Kaye O,Fillet G,Malaise M,Beguin Y

更新日期：2000-08-01 00:00:00

abstract：:Because the phagocytic function of non-stimulated human polymorphonuclear granulocytes (PMN) is impaired after incubation with either polynuclear Fe(III) or Fe(II), we decided to study lipid peroxidation of PMN and monocytes by these iron complexes. Lipid peroxidation was assessed by measuring thiobarbituric acid reac...

journal_title：British journal of haematology

authors： Hoepelman IM,Bezemer WA,van Doornmalen E,Verhoef J,Marx JJ

更新日期：1989-08-01 00:00:00

abstract：:Distinguishing Burkitt lymphoma (BL) from B cell lymphoma, unclassifiable with features intermediate between diffuse large B-cell lymphoma (DLBCL) and BL (DLBCL/BL), and DLBCL is challenging. We propose an immunohistochemistry and fluorescent in situ hybridization (FISH) based scoring system that is employed in three ...

journal_title：British journal of haematology

authors： Naresh KN,Ibrahim HA,Lazzi S,Rince P,Onorati M,Ambrosio MR,Bilhou-Nabera C,Amen F,Reid A,Mawanda M,Calbi V,Ogwang M,Rogena E,Byakika B,Sayed S,Moshi E,Mwakigonja A,Raphael M,Magrath I,Leoncini L

更新日期：2011-09-01 00:00:00

abstract：:Impaired switching from fetal haemoglobin (HbF) to adult globin gene expression leads to hereditary persistence of fetal haemoglobin (HPFH) in adult life. This is of prime interest because elevated HbF levels ameliorate β-thalassaemia and sickle cell anaemia. Fetal haemoglobin levels are regulated by complex mechanism...

journal_title：British journal of haematology

authors： Petruzzelli R,Gaudino S,Amendola G,Sessa R,Puzone S,Di Concilio R,d'Urzo G,Amendolara M,Izzo P,Grosso M

更新日期：2010-09-01 00:00:00

abstract：:Thrombocytopenia and neutropenia are common among neonates in intensive care units. Bone marrow aspirations are sometimes performed as part of their evaluation. However, marrow biopsies have not been reported from living neonates. Since architecture and cellularity cannot generally be accurately assessed from marrow a...

journal_title：British journal of haematology

authors： Sola MC,Rimsza LM,Christensen RD

更新日期：1999-11-01 00:00:00

abstract：:The in vitro haemostatic functions of fresh whole blood (FWB) are well preserved after cold storage. This study aimed to determine whether platelets derived from FWB and stored whole blood (SWB) contribute to clot formation in tissue injury after transfusion into coagulopathic rats with polytrauma/haemorrhage (T/H). T...

journal_title：British journal of haematology

authors： Wu X,Darlington DN,Montgomery RK,Liu B,Keesee JD,Scherer MR,Benov A,Chen J,Cap AP

更新日期：2017-12-01 00:00:00

abstract：:Persistent lymphocytosis is usually associated with a malignant lymphoproliferative disease (MLPD). We report six female patients presenting a chronic, moderate lymphocytosis of 2-16 years duration with atypical binucleated lymphocytes on peripheral blood smears. Further investigation showed a polyclonal increase in s...

journal_title：British journal of haematology

authors： Troussard X,Valensi F,Debert C,Maynadie M,Schillinger F,Bonnet P,Macintyre EA,Flandrin G

更新日期：1994-10-01 00:00:00

abstract：:The threat of infection by conventional transfusion-transmitted agents has been essentially eliminated from the blood supply in developed countries, thus focusing attention on the potential risk from emerging infections. Over recent years, actions have been taken to manage a number of such risks to blood safety. These...

journal_title：British journal of haematology

authors： Dodd RY

更新日期：2012-10-01 00:00:00

abstract：:Management of the acute painful crisis (APC) of sickle cell disease (SCD) remains unsatisfactory despite advances in the understanding and management of acute pain in other clinical settings. One reason for this is an unsophisticated approach to the use of opioid analgesics for pain management. This applies to haemato...

journal_title：British journal of haematology

authors： Telfer P,Bahal N,Lo A,Challands J

更新日期：2014-07-01 00:00:00

abstract：:In a patient with immune thrombocytopenic purpura (ITP), we found a novel platelet-activating IgG (act-IgG) and an inhibitory IgG (inhi-IgG) that prevented activation induced by both CD9 monoclonal antibody (mAb) and the act-IgG. Purified IgG from the patient plasma caused a rise in [Ca2+]i and the aggregation of norm...

journal_title：British journal of haematology

authors： Yanabu M,Nomura S,Fukuroi T,Suzuki M,Kawakatsu T,Kido H,Yamaguchi K,Kokawa T,Yasunaga K

更新日期：1993-08-01 00:00:00

abstract：:Between 1990 and 1999, 36 children with refractory anaemia with excess blasts (RAEB) and RAEB in transformation (RAEBt), not associated with Down's syndrome, were diagnosed in Britain. A total of 31 children received intensive chemotherapy, six of whom proceeded to a bone marrow allograft in first remission, whereas t...

journal_title：British journal of haematology

authors： Webb DK,Passmore SJ,Hann IM,Harrison G,Wheatley K,Chessells JM

更新日期：2002-04-01 00:00:00

abstract：:To investigate the relationship between normal B-cells, B-cell chronic lymphocytic leukaemia (B-CLL) cells and hairy cell leukaemia (HCL) cells the three cell types were incubated with phorbol myristic acetate (PMA). The parameters studied were morphology, immunophenotype and tartrate resistant acid phosphatase (TRAP)...

journal_title：British journal of haematology

authors： Visser L,Poppema S

更新日期：1990-07-01 00:00:00

abstract：:Both atypical haemolytic uraemic syndrome (aHUS) and the HELLP syndrome (haemolytic anaemia, elevated liver enzymes, and low platelets) are thrombotic microangiopathies characterized by microvascular endothelial activation, cell injury and thrombosis. aHUS is a disease of complement dysregulation, specifically a gain ...

journal_title：British journal of haematology

authors： Fang CJ,Richards A,Liszewski MK,Kavanagh D,Atkinson JP

更新日期：2008-11-01 00:00:00

abstract：:Thrombopoietin (TPO) is the primary regulator of platelet production and acts through binding its receptor, c-mpl, found on megakaryocyte progenitor cells, megakaryocytes and platelets. Circulating levels of TPO are regulated primarily by the clearance of TPO after it binds to c-mpl receptors on circulating platelets....

journal_title：British journal of haematology

authors： Li J,Xia Y,Kuter DJ

更新日期：1999-08-01 00:00:00

abstract：:The primary pathophysiological event in sickling is the intracellular polymerization of deoxygenated haemoglobin S. Tucaresol (589C80;4[2-formyl-3-hydroxyphenoxymethyl] benzoic acid), a substituted benzaldehyde, was designed to interact with haemoglobin to increase oxygen affinity and has been shown to inhibit sicklin...

journal_title：British journal of haematology

authors： Arya R,Rolan PE,Wootton R,Posner J,Bellingham AJ

更新日期：1996-06-01 00:00:00

abstract：:Three novel point mutations were detected in the glucocerebrosidase gene of three unrelated Gaucher's disease patients by direct sequencing of PCR products. The first is a C to G change at position 4263 in the genomic sequence (exon 7) which results in a proline to arginine change at position 266 in the mature enzyme ...

journal_title：British journal of haematology

authors： Walley AJ,Ellis I,Harris A

更新日期：1995-10-01 00:00:00

abstract：:This study was designed to assess the efficacy and safety of substituting cisplatin with oxaliplatin in the DHAP (dexamethasone, cytarabine and cisplatin) regimen for patients with relapsed or refractory non-Hodgkin's lymphoma. Twenty-four evaluable patients with intermediate or high-grade non-Hodgkin's lymphoma were ...

journal_title：British journal of haematology

authors： Chau I,Webb A,Cunningham D,Hill M,Rao S,Ageli S,Norman A,Gill K,Howard A,Catovsky D

更新日期：2001-12-01 00:00:00

abstract：:The changes in bone marrow (BM) stem cell reserve and function and stromal cell function in patients with active systemic lupus erythematosus (SLE) were investigated. The study was carried out on seven SLE patients and 28 healthy controls using flow cytometry and in vitro cell culture assays. We found that patients ha...

journal_title：British journal of haematology

authors： Papadaki HA,Boumpas DT,Gibson FM,Jayne DR,Axford JS,Gordon-Smith EC,Marsh JC,Eliopoulos GD

更新日期：2001-10-01 00:00:00

abstract：:This study systematically reviewed and meta-analysed the prognostic value of complete remission status at end-of-treatment (18) F-fluoro-2-deoxy-d-glucose positron emission tomography (FDG-PET) in diffuse large B-cell lymphoma (DLBCL) patients treated with rituximab, cyclophosphamide, doxorubicin, vincristine and pred...

journal_title：British journal of haematology

authors： Adams HJ,Nievelstein RA,Kwee TC

更新日期：2015-07-01 00:00:00

abstract：:Tumour necrosis factor-α (TNF) is an inflammatory cytokine that is elevated in a number of autoimmune diseases including immune thrombocytopenia (ITP), a bleeding disorder characterized by low platelet counts. In vitro TNF blockade increases expansion of the regulatory T cell (Treg) IKZF2 (also termed Helios) subset i...

journal_title：British journal of haematology

authors： Zhong H,Bussel J,Yazdanbakhsh K

更新日期：2015-01-01 00:00:00

abstract：:Post-transplantation lymphoproliferative disorders (PTLDs) are a well-recognized and potentially life-threatening complication of solid organ transplantation. While the vast majority of PTLDs are B-cell lymphoproliferations, T-cell PTLDs are rarely seen. Among 898 patients receiving cardiac transplants between 1990 an...

journal_title：British journal of haematology

authors： Draoua HY,Tsao L,Mancini DM,Addonizio LJ,Bhagat G,Alobeid B

更新日期：2004-11-01 00:00:00

abstract：:Sources for allogeneic stem cells for patients with haematological disorders lacking a histocompatible sibling donor include matched unrelated donor (MUD) and umbilical cord blood (UCB). A total of 51 patients with haematological disorders, treated with myeloablation and transplantation with either unrelated human leu...

journal_title：British journal of haematology

authors： Hamza NS,Lisgaris M,Yadavalli G,Nadeau L,Fox R,Fu P,Lazarus HM,Koc ON,Salata RA,Laughlin MJ

更新日期：2004-02-01 00:00:00

abstract：:A collaborative study on factor VIII related antigen (VIII R:Ag) has been carried out, involving 11 laboratories in the U.K. Samples of two different freeze-dried plasmas were assayed against participants' own local standards by the Laurell electroimmunoassay method. There was reasonably good agreement on the relative...

journal_title：British journal of haematology

authors： Kirkwood TB,Barrowcliffe TW

更新日期：1980-11-01 00:00:00

abstract：:Patients with solid tumours undergoing high-dose chemotherapy with autologous bone marrow transplantation use an average of 10 units of packed red blood cells (PRBC) while awaiting haemopoietic reconstitution. They are also known to have inappropriately low endogenous erythropoietin levels for their degree of anaemia....

journal_title：British journal of haematology

authors： Ayash LJ,Elias A,Hunt M,Demetri G,Wheeler C,Tepler I,Schwartz G,Mazanet R,Reich E,McCauley M

更新日期：1994-05-01 00:00:00

abstract：:We have previously shown that allogeneic bone marrow transplantation (BMT) with cryopreserved donor marrow cells can be used without prolonging the engraftment time or interfering with the reconstitution of haemopoiesis. In this report we extend our initial observations of the first 40 patients who underwent allogenei...

journal_title：British journal of haematology

authors： Stockschläder M,Hassan HT,Krog C,Krüger W,Löliger C,Horstman M,Altnöder M,Clausen J,Grimm J,Kabisch H,Zander A

更新日期：1997-02-01 00:00:00

abstract：:Early detection of platelet activation is important for the diagnosis and follow-up of several pathological conditions that primarily or secondarily involve platelets in their pathogenesis. The golden standard assay to detect thrombocyte activation is represented by the release of serotonin, classically performed by d...

journal_title：British journal of haematology

authors： Gobbi G,Mirandola P,Tazzari PL,Ricci F,Caimi L,Cacchioli A,Papa S,Conte R,Vitale M

更新日期：2003-06-01 00:00:00

abstract：:The induction of anaemia and reticulocytosis by arylhydrazines was influenced by substituents on the benzene ring of phenylhydrazine. Arylhydrazines with ortho substituents, which would hinder the binding by haemoglobin of a ligand derived from the arylhydrazine, resulted in the least anaemia and reticulocytosis. Thes...

journal_title：British journal of haematology

authors： Itano HA,Hosokawa K,Hirota K

更新日期：1976-01-01 00:00:00

abstract：:We report our long-term experience with autologous bone marrow transplantation (ABMT) for 32 adult patients with acute lymphocytic leukaemia (ALL) in second or later remission (CR), or in first CR but with high-risk. Bone marrow was purged with mafosfamide (n = 25) or with immunomagnetic beads and monoclonal antibodie...

journal_title：British journal of haematology

authors： Abdallah A,Egerer G,Goldschmidt H,Wannenmacher M,Körbling M,Ho AD

更新日期：2001-03-01 00:00:00

abstract：:We describe two British families with similar, dominantly-inherited, temperature-related variants of hereditary stomatocytosis, consistent with the original description of 'cryohydrocytosis'. The cells show a 5-6-fold increase in passive permeability at 37 degrees C with abnormal intracellular Na and K levels at 15-20...

journal_title：British journal of haematology

authors： Coles SE,Chetty MC,Ho MM,Nicolaou A,Kearney JW,Wright SD,Stewart GW

更新日期：1999-06-01 00:00:00

abstract：:The combined incidence of classical Philadelphia-negative myeloproliferative neoplasm (MPN) is 6-9/100 000 with a peak frequency between 50 and 70 years. MPN is less frequent in women of reproductive age. However, for essential thrombocythaemia (ET) in particular there is a second peak in women of reproductive age and...

journal_title：British journal of haematology

authors： Robinson SE,Harrison CN

更新日期：2020-05-01 00:00:00