Th1 and Th2 cytokines in a patient with Evans' syndrome and profound lymphopenia.

abstract：:MYD88 mutations are present in 95% of Waldenstrom Macroglobulinaemia (WM) patients, and support diagnostic discrimination from other IgM-secreting B-cell malignancies. Diagnostic discrimination can be difficult among suspected wild-type MYD88 (MYD88WT ) WM cases. We systematically reviewed the clinical, pathological a...

journal_title：British journal of haematology

authors： Treon SP,Gustine J,Xu L,Manning RJ,Tsakmaklis N,Demos M,Meid K,Guerrera ML,Munshi M,Chan G,Chen J,Kofides A,Patterson CJ,Yang G,Liu X,Severns P,Dubeau T,Hunter ZR,Castillo JJ

更新日期：2018-02-01 00:00:00

abstract：:Interleukin-6 (IL6) plays a central role in multiple myeloma pathogenesis and confers resistance to corticosteroid-induced apoptosis. We therefore evaluated the efficacy and safety of siltuximab, an anti-IL6 monoclonal antibody, alone and in combination with dexamethasone, for patients with relapsed or refractory mult...

journal_title：British journal of haematology

authors： Voorhees PM,Manges RF,Sonneveld P,Jagannath S,Somlo G,Krishnan A,Lentzsch S,Frank RC,Zweegman S,Wijermans PW,Orlowski RZ,Kranenburg B,Hall B,Casneuf T,Qin X,van de Velde H,Xie H,Thomas SK

更新日期：2013-05-01 00:00:00

abstract：:Acute graft-versus-host disease (GvHD) is an important complication of bone marrow transplantation in humans. Risk factors are imprecisely defined and controversial. We analysed data from 2036 recipients of HLA-identical sibling transplants for leukaemia or aplastic anaemia to identify risk factors for GvHD. Analyses ...

journal_title：British journal of haematology

authors： Gale RP,Bortin MM,van Bekkum DW,Biggs JC,Dicke KA,Gluckman E,Good RA,Hoffmann RG,Kay HE,Kersey JH

更新日期：1987-12-01 00:00:00

abstract：:Persistent lymphocytosis is usually associated with a malignant lymphoproliferative disease (MLPD). We report six female patients presenting a chronic, moderate lymphocytosis of 2-16 years duration with atypical binucleated lymphocytes on peripheral blood smears. Further investigation showed a polyclonal increase in s...

journal_title：British journal of haematology

authors： Troussard X,Valensi F,Debert C,Maynadie M,Schillinger F,Bonnet P,Macintyre EA,Flandrin G

更新日期：1994-10-01 00:00:00

abstract：:Pituitary tumour transforming gene (PTTG) isolated from pituitary tumour cells transforms cells in vitro and causes in vivo tumour formation. PTTG is expressed in several human tumours and cell lines. In normal adult tissues, the testis expresses abundant levels of PTTG mRNA comparable to that found in tumour cells. A...

journal_title：British journal of haematology

authors： Stoika R,Melmed S

更新日期：2002-12-01 00:00:00

abstract：:Routine testing on plasma from a patient due to undergo a coronary artery bypass graft operation revealed a prolonged thrombin clotting time associated with a normal plasma fibrinogen level when this was determined by a method not dependent upon the rate of fibrin formation. Fibrinogen purified from the patient's plas...

journal_title：British journal of haematology

authors： Lane DA,Cuddigan B,VanRoss M,Kakkar VV

更新日期：1980-03-01 00:00:00

abstract：:Since glycoprotein IV (GPIV) has been shown to play an important role in the interaction of platelets with collagen and thrombospondin, the aggregation and secretion of GPIV-deficient platelets were examined. Using a binding assay with monoclonal 125I-OKM5 antibody against CD36 antigen and crossed immunoelectrophoresi...

journal_title：British journal of haematology

authors： Yamamoto N,Akamatsu N,Yamazaki H,Tanoue K

更新日期：1992-05-01 00:00:00

abstract：:The Kidd (JK) blood group system is of importance in transfusion medicine. The Jk(null) phenotype is associated with absence of the urea transporter in erythrocytes and moderately reduced ability to concentrate urine. We and others recently reported different molecular alterations in the silenced Jkb-like alleles of P...

journal_title：British journal of haematology

authors： Irshaid NM,Eicher NI,Hustinx H,Poole J,Olsson ML

更新日期：2002-02-01 00:00:00

abstract：:This study was designed to assess the efficacy and safety of substituting cisplatin with oxaliplatin in the DHAP (dexamethasone, cytarabine and cisplatin) regimen for patients with relapsed or refractory non-Hodgkin's lymphoma. Twenty-four evaluable patients with intermediate or high-grade non-Hodgkin's lymphoma were ...

journal_title：British journal of haematology

authors： Chau I,Webb A,Cunningham D,Hill M,Rao S,Ageli S,Norman A,Gill K,Howard A,Catovsky D

更新日期：2001-12-01 00:00:00

abstract：:Globin-gene mapping of DNA from 13 families with normal Hb A2 beta-thalassaemia (both type 1 and type 2) failed to detect any difference from normal in their globin-gene arrangement. We conclude that deletions such as those responsible for gamma beta-thalassaemia or a 'silent' Hb Lepore are not responsible for this ty...

journal_title：British journal of haematology

authors： Kanavakis E,Metaxotou-Mavromati A,Kattamis C,Aksoy M,Weatherall DJ,Wood WG

更新日期：1982-05-01 00:00:00

abstract：:Recent studies have suggested the HoxA10, HoxA11 and HoxD11 homeobox genes as candidate loci for the thrombocytopenia with absent radius (TAR) syndrome. For example, targeted disruptions of these Hox genes result in abnormal development of the mouse radius, while overexpression of HoxA10 stimulates mouse megakaryocyte...

journal_title：British journal of haematology

authors： Fleischman RA,Letestu R,Mi X,Stevens D,Winters J,Debili N,Vainchenker W

更新日期：2002-02-01 00:00:00

abstract：:The in vitro haemostatic functions of fresh whole blood (FWB) are well preserved after cold storage. This study aimed to determine whether platelets derived from FWB and stored whole blood (SWB) contribute to clot formation in tissue injury after transfusion into coagulopathic rats with polytrauma/haemorrhage (T/H). T...

journal_title：British journal of haematology

authors： Wu X,Darlington DN,Montgomery RK,Liu B,Keesee JD,Scherer MR,Benov A,Chen J,Cap AP

更新日期：2017-12-01 00:00:00

abstract：:A novel long-term cultured interleukin (IL)-3-dependent human myelodysplastic cell line, MDS92, was shown to contain several myeloid-lineage cells such as neutrophils, macrophages, eosinophils, and a small number of megakaryocyte-lineage cells. Therefore this cell line possesses at least bipotential characteristics of...

journal_title：British journal of haematology

authors： Tohyama K,Tohyama Y,Nakayama T,Ueda T,Nakamura T,Yoshida Y

更新日期：1995-12-01 00:00:00

abstract：:The bone marrow (BM) microenvironment supports leukaemia cell survival and proliferation. The roles played by adhesive receptor interactions in the survival of T-lineage acute lymphoblastic leukaemia (T-ALL) cells on BM stromal cells are not well understood. Recently, we have developed an assay that partially recapitu...

journal_title：British journal of haematology

authors： Winter SS,Sweatman JJ,Lawrence MB,Rhoades TH,Hart AL,Larson RS

更新日期：2001-12-01 00:00:00

abstract：:We examined the effect of vitamin D receptor (VDR) polymorphisms at exon 2 (FokI) and intron 8 (BsmI) on the stature and bone mineral density at femoral neck (FBMD) and lumbar spine (LBMD) in 108 prepubertal and pubertal homozygous beta thalassaemic patients, regularly treated. We found significantly shorter stature a...

journal_title：British journal of haematology

authors： Ferrara M,Matarese SM,Francese M,Borrelli B,Coppola A,Coppola L,Esposito L

更新日期：2002-05-01 00:00:00

abstract：:Prospective studies in children with B-precursor acute lymphoblastic leukaemia (ALL) have shown that polymerase chain reaction (PCR)-based detection of minimal residual disease (MRD) using immunoglobin (Ig) and T-cell receptor (TCR) gene rearrangements as targets can be used to identify patients with a high relapse ri...

journal_title：British journal of haematology

authors： de Haas V,Breunis WB,Dee R,Verhagen OJ,Kroes W,van Wering ER,van Dongen JJ,van den Berg H,van der Schoot CE

更新日期：2002-01-01 00:00:00

abstract：:A total of 229 patients with chronic myeloid leukaemia (CML) in chronic phase were randomized between 1986 and 1990 to receive or not receive additional splenic irradiation as part of their conditioning prior to bone marrow transplantation (BMT). Both groups, 115 patients with and 114 patients without splenic irradiat...

journal_title：British journal of haematology

authors： Gratwohl A,Hermans J,van Biezen A,Arcese W,Debusscher L,Ernst P,Ferrant A,Frassoni F,Gahrton G,Iriondo A,Kolb HJ,Link H,Niederwieser D,Ruutu T,Siegert W,Zwaan FE

更新日期：1996-12-01 00:00:00

abstract：:Treatment response assessment in multiple myeloma (MM) relies on the detection of paraprotein in serum and/or urine, bone marrow morphology and immunohistochemistry. With remarkable advances in therapy, particularly in the newly diagnosed setting, achievement of complete remission became frequent, creating the need to...

journal_title：British journal of haematology

authors： Bal S,Weaver A,Cornell RF,Costa LJ

更新日期：2019-09-01 00:00:00

abstract：:We report two cases of acute myeloid leukaemia FAB classification M4Eo with high white cell counts at presentation, who developed acute respiratory failure with pulmonary infiltrates on chest radiograph soon after commencing conventional cytotoxic chemotherapy plus all-trans retinoic acid (ATRA). We suggest that in pa...

journal_title：British journal of haematology

authors： Lester WA,Hull DR,Fegan CD,Morris TC

更新日期：2000-06-01 00:00:00

abstract：:Human monocytes contain a series of alpha-naphthyl acetate (alpha NA) esterases which are not present in other blood cells and which can be specifically inhibited by bis(4-nitrophenyl)-phosphate (BNPP). This inhibitor is non-toxic at the concentration used and thus enabled studies on the possible significance of this ...

journal_title：British journal of haematology

authors： Oertel J,Hagner G,Kastner M,Huhn D

更新日期：1985-12-01 00:00:00

abstract：:The proviral copy (PVC) number in peripheral blood mononuclear cells (PBMCs) of human immunodeficiency virus (HIV)-infected individuals was measured by a quantitative polymerase chain reaction (PCR) assay to determine over time the relation between the viral load and the evolution towards the disease in HIV-infected p...

journal_title：British journal of haematology

authors： Lefrère JJ,Mariotti M,Wattel E,Lefrère F,Inchauspe G,Costagliola D,Prince A

更新日期：1992-10-01 00:00:00

abstract：:Although individuals with sickle cell anaemia (SCA) have elevated baseline inflammation and endothelial activation, the acute phase response to maximal exercise has not been evaluated among children with SCA. We measured the acute phase response to maximal exercise testing for soluble vascular cell adhesion molecule (...

journal_title：British journal of haematology

authors： Liem RI,Onyejekwe K,Olszewski M,Nchekwube C,Zaldivar FP,Radom-Aizik S,Rodeghier MJ,Thompson AA

更新日期：2015-12-01 00:00:00

abstract：:The number of granulocyte-macrophage clones formed in agar culture of bone marrow is dependent on levels of colony stimulating activity (CSA) a proposed in vivo haemopoietic regulator. A dose-response relationship for stimulation of human haemopoietic cells by CSA is demonstrated, which could be explained by threshold...

journal_title：British journal of haematology

authors： Francis GE,Berney JJ,Hoffebrand AV

更新日期：1977-04-01 00:00:00

abstract：:The prognostic relevance of karyotype has been established in adult acute lymphoblastic leukaemia (ALL) patients treated with chemotherapy but not definitively evaluated in an allogeneic bone marrow transplantation (BMT) setting. To determine the factors affecting the outcome of allogeneic BMT for adults with precurso...

journal_title：British journal of haematology

authors： Lee S,Kim DW,Kim YJ,Park YH,Min CK,Lee JW,Min WS,Kim CC

更新日期：2002-04-01 00:00:00

abstract：:The changes in bone marrow (BM) stem cell reserve and function and stromal cell function in patients with active systemic lupus erythematosus (SLE) were investigated. The study was carried out on seven SLE patients and 28 healthy controls using flow cytometry and in vitro cell culture assays. We found that patients ha...

journal_title：British journal of haematology

authors： Papadaki HA,Boumpas DT,Gibson FM,Jayne DR,Axford JS,Gordon-Smith EC,Marsh JC,Eliopoulos GD

更新日期：2001-10-01 00:00:00

abstract：:Givinostat, a histone-deacetylase inhibitor (HDACi), inhibits proliferation of cells bearing the JAK2 V617F mutation and has shown significant activity with good tolerability in patients with chronic myeloproliferative neoplasms (MPN). In this multicentre, open-label, phase II study, 44 patients with polycythaemia ver...

journal_title：British journal of haematology

authors： Finazzi G,Vannucchi AM,Martinelli V,Ruggeri M,Nobile F,Specchia G,Pogliani EM,Olimpieri OM,Fioritoni G,Musolino C,Cilloni D,Sivera P,Barosi G,Finazzi MC,Di Tollo S,Demuth T,Barbui T,Rambaldi A

更新日期：2013-06-01 00:00:00

abstract：:This study was performed to assess the methods which gave maximal recovery of purified CD34/45+ cells from a cord blood specimen and optimal growth of progenitors cultured from the purified cells. Cord blood samples were separated using Percoll gradients (either one (1.080) or two successive (1.080 and 1.068) gradient...

journal_title：British journal of haematology

authors： Charbord P,Newton I,Voillat L,Schaal JP,Herve P

更新日期：1996-09-01 00:00:00

abstract：:Anti-thymocyte globulins (ATG) are currently used to prevent graft-versus-host disease in haematopoietic stem cell transplants from alternative donors and to treat and prevent acute organ rejection after transplantation. Many recent studies have demonstrated that ATG can also be beneficial in patients with myeloma, ly...

journal_title：British journal of haematology

authors： Polito L,Bortolotti M,Farini V,Pedrazzi M,Tazzari PL,Bolognesi A

更新日期：2009-12-01 00:00:00

abstract：:In advanced chronic myeloid leukaemia patients, STI-571 produces complete haematological response in most cases and cytogenetic response in up to 50%. However, these patients often suffer periods of pancytopenia, which can lead to life-threatening complications, and is probably due to the small number of residual norm...

journal_title：British journal of haematology

authors： Lewalle P,Meuleman N,Verhest A,Bron D,Martiat P

更新日期：2002-07-01 00:00:00

abstract：:The platelets of a young man with the grey platelet syndrome were severely depleted of all seven alpha-granule proteins assayed as well as partially deficient in alpha-mannosidase and alpha-fucosidase; four other lysosomal enzymes were present in normal concentrations. Total platelet 5-hydroxytryptamine (5HT) and aden...

journal_title：British journal of haematology

authors： Srivastava PC,Powling MJ,Nokes TJ,Patrick AD,Dawes J,Hardisty RM

更新日期：1987-04-01 00:00:00