Expression and function of pituitary tumour transforming gene for T-lymphocyte activation.

abstract：:A prospective study of 7065 consecutive new pregnancies identified 230 with a positive screen, of which 27% (62/230) were 'enzyme-only' antibodies. 32 of these (52%) were potentially clinically important and were all of Rh specificity: 22 anti-E, seven anti-Cw, two anti-D and one anti-c. However, only three of these e...

journal_title：British journal of haematology

authors： Clark D,Greiss MA,Urbaniak SJ

更新日期：1999-09-01 00:00:00

abstract：:Total knee replacement (TKR) is a safe treatment for alleviating pain and restoring physical function in end-stage arthropathy of the knee. First reports of TKR in haemophiliacs date back to the mid-1970s, however detailed information on long-term outcome is scarce. This study evaluated factors influencing the outcome...

journal_title：British journal of haematology

authors： Solimeno LP,Mancuso ME,Pasta G,Santagostino E,Perfetto S,Mannucci PM

更新日期：2009-04-01 00:00:00

abstract：:Positron emission tomography using fluorine-18 (FDG-PET) is increasingly used in the staging and follow-up of malignant lymphomas, although its precise role has not yet been determined. This review considers the results reported at the different stages in the disease history and separately considers the major histolog...

journal_title：British journal of haematology

authors： Burton C,Ell P,Linch D

更新日期：2004-09-01 00:00:00

abstract：:We present the results of a novel method developed for evaluation of in situ amplification, a molecular genetic method at the cellular level. Reverse transcription polymerase chain reaction (RT-PCR) was used to study bcr-abl transcript levels in individual cells from patients with chronic myelogenous leukaemia (CML). ...

journal_title：British journal of haematology

authors： Pachmann K,Zhao S,Schenk T,Kantarjian H,El-Naggar AK,Siciliano MJ,Guo JQ,Arlinghaus RB,Andreeff M

更新日期：2001-03-01 00:00:00

abstract：:The inverse of the difference between rates, called the 'number needed to treat' (NNT), was suggested 20 years ago as a good way to present the results of comparisons of success or failure under different therapies. Such comparisons usually arise in randomised controlled trials and meta-analysis. This article reviews ...

journal_title：British journal of haematology

authors： Hutton JL

更新日期：2009-06-01 00:00:00

abstract：:Therapy with imatinib mesylate is limited by cellular resistance in chronic myeloid leukaemia (CML). Further, the limited availability of matching stem cell donors or an unfavourable risk profile for allogeneic stem cell transplantation (SCT) reduces the number of therapeutic options in a number of patients. To assess...

journal_title：British journal of haematology

authors： Kreuzer KA,Klühs C,Baskaynak G,Movassaghi K,Dörken B,le Coutre P

更新日期：2004-01-01 00:00:00

abstract：:A case of immune neutropenia following unrelated stem cell transplantation for chronic myeloid leukaemia is described. The neutropenia developed following herpes zoster viral infection and was associated with antibodies to the human neutrophil antigen (HNA)-2a (formerly known as NB1). The neutropenia was prolonged, pr...

journal_title：British journal of haematology

authors： Pocock CF,Lucas GF,Giles C,Vassiliou G,Cwynarski K,Rezvani K,Apperley JF,Goldman JM

更新日期：2001-05-01 00:00:00

abstract：:We report a patient with congenital homozygous factor V deficiency in whom a large pseudotumour in the right upper leg was successfully surgically excised under continuous substitution with fresh-frozen plasma. ...

journal_title：British journal of haematology

authors： Tanis BC,van der Meer FJ,Bloem RM,Vlasveld LT

更新日期：1998-02-01 00:00:00

abstract：:Employing an immunoblotting procedure, we have identified and characterized an autoantigen carried on glycoprotein (GP) IIb in a patient with chronic idiopathic thrombocytopenic purpura (ITP), and have compared the location of the autoantigen with that of the platelet-specific alloantigen Baka. Immunoblots, using the ...

journal_title：British journal of haematology

authors： Tomiyama Y,Kurata Y,Shibata Y,Honda S,Furubayashi T,Mizutani H,Tsubakio T,Yonezawa T,Tarui S

更新日期：1989-01-01 00:00:00

abstract：:During definitive erythropoiesis, erythroid precursors undergo differentiation through multiple nucleated states to an enucleated reticulocyte, which loses its residual RNA/organelles to become a mature erythrocyte. Over the course of these transformations, continuous changes in membrane proteins occur, including shif...

journal_title：British journal of haematology

authors： Kodippili GC,Spector J,Kang GE,Liu H,Wickrema A,Ritchie K,Low PS

更新日期：2010-09-01 00:00:00

abstract：:In previous trials, the orally active iron chelator deferiprone (L1) has been associated with sporadic agranulocytosis, milder forms of neutropenia and other side-effects. To determine the incidence of these events, we performed a multicentre prospective study of the chelator. Blood counts were performed weekly, and c...

journal_title：British journal of haematology

authors： Cohen AR,Galanello R,Piga A,Dipalma A,Vullo C,Tricta F

更新日期：2000-02-01 00:00:00

abstract：:The 32 kD lipid-raft-associated membrane protein 'stomatin' is deficient from the erythrocyte membrane in the Na+-K+ leaky haemolytic anaemia, overhydrated hereditary stomatocytosis (OHSt). To date, no mutation in the gene coding for this protein has so far been found in OHSt. In this study, we have analysed the distr...

journal_title：British journal of haematology

authors： Fricke B,Parsons SF,Knöpfle G,von Düring M,Stewart GW

更新日期：2005-10-01 00:00:00

abstract：:Platelets from patients with platelet-type von Willebrand disease (vWD) were used as immunogens for the production of murine monoclonal antibodies (MoAbs). One such MoAb, C-34, inhibited ristocetin-induced aggregation of patient or normal platelets, but not aggregation induced by other aggregating agents. As demonstra...

journal_title：British journal of haematology

authors： Miller JL,Hustad KO,Kupinski JM,Lyle VA,Kunicki TJ

更新日期：1990-03-01 00:00:00

abstract：:Paediatric non-Hodgkin lymphomas (pNHL) are a diverse group of malignancies characterised by nodal and/or extranodal involvement. Less common pNHL forms include those derived from mature T- and natural killer (NK) cells. Much of our current understanding of paediatric mature (non-anaplastic) T/NK-cell lymphomas with r...

journal_title：British journal of haematology

authors： Xavier AC,Suzuki R

更新日期：2019-06-01 00:00:00

abstract：:It has been proposed that iron accumulation may contribute to atherogenesis by increasing free radical formation and oxidative stress. Epidemiological studies in which the association of iron status with atherosclerosis was assessed raised conflicting results. To test whether genetic haemochromatosis is associated wit...

journal_title：British journal of haematology

authors： Franco RF,Zago MA,Trip MD,ten Cate H,van den Ende A,Prins MH,Kastelein JJ,Reitsma PH

更新日期：1998-09-01 00:00:00

abstract：:The expression of three onc-genes, c-myc, c-myb and c-fes, has been evaluated at the cellular level in myeloid and erythroid precursors of normal human bone marrow, by "in situ" hybridization with tritium-labelled probes. A relatively large amount of m-RNA from the three onc-genes was detected in myeloblasts and promy...

journal_title：British journal of haematology

authors： Emilia G,Donelli A,Ferrari S,Torelli U,Selleri L,Zucchini P,Moretti L,Venturelli D,Ceccherelli G,Torelli G

更新日期：1986-02-01 00:00:00

abstract：:The outcomes of adult patients transplanted for Fanconi anaemia (FA) have not been well described. We retrospectively analysed 199 adult patients with FA transplanted between 1991 and 2014. Patients were a median of 16 years of age when diagnosed with FA, and underwent transplantation at a median age of 23 years. Time...

journal_title：British journal of haematology

authors： Bierings M,Bonfim C,Peffault De Latour R,Aljurf M,Mehta PA,Knol C,Boulad F,Tbakhi A,Esquirol A,McQuaker G,Sucak GA,Othman TB,Halkes CJM,Carpenter B,Niederwieser D,Zecca M,Kröger N,Michallet M,Risitano AM,Ehninger G

更新日期：2018-01-01 00:00:00

abstract：:Constitutive phosphatidylinositide 3-kinase (PI3K) signalling has been implicated in multiple myeloma (MM) pathophysiology and is regarded as an actionable target for pharmacological intervention. Isoform-specific PI3K inhibition may offer the most focused treatment approach and could result in greater clinical effica...

journal_title：British journal of haematology

authors： Hofmann C,Stühmer T,Schmiedl N,Wetzker R,Mottok A,Rosenwald A,Langer C,Zovko J,Chatterjee M,Einsele H,Bargou RC,Steinbrunn T

更新日期：2014-08-01 00:00:00

abstract：:The alpha+ thalassaemias are the most common single gene disorders of humans, yet little is known about their haematological characteristics in childhood. Blood samples have been collected randomly from more than 2000 individuals in village communities in Vanuatu in the South West Pacific and analysed for alpha thalas...

journal_title：British journal of haematology

authors： Williams TN,Maitland K,Ganczakowski M,Peto TE,Clegg JB,Weatherall DJ,Bowden DK

更新日期：1996-11-01 00:00:00

abstract：:Canine cyclic haematopoiesis (CH) appears to be a multipotential stem cell defect, possibly due to an intrinsic marrow defect. The in vitro adherent marrow cells of the cyclic haematopoietic (CH) dog were cultured as underlayers beneath normal dog nonadherent marrow cells. The marrow granulocyte-committed colony formi...

journal_title：British journal of haematology

authors： Jones JB,Jolly JD

更新日期：1982-04-01 00:00:00

abstract：:Mantle Cell Lymphoma (MCL) is an aggressive lymphoma subtype that accounts for 6-8% of non-Hodgkin lymphomas. The disease is mostly incurable and characterized by a continuous pattern of relapse. Major changes have recently been implemented in the management of MCL, but continuous relapses still mark this disease as a...

journal_title：British journal of haematology

authors： Obrador-Hevia A,Serra-Sitjar M,Rodríguez J,Belayachi L,Bento L,García-Recio M,Sánchez JM,Villalonga P,Gutiérrez A,Fernández de Mattos S

更新日期：2016-09-01 00:00:00

abstract：:A patient with apparent anaemia and thrombocytopenia caused by a monoclonal paraprotein is described. The patient's serum contained a monoclonal IgM kappa, a cryoglobulin and a cold agglutinin. The cryoglobulin, similar to the serum paraprotein, was a monoclonal IgM kappa. Serum was studied to determine the relationsh...

journal_title：British journal of haematology

authors： Pujol M,Ribera JM,Jimenez C,Ribera A,Abad E,Feliu E

更新日期：1998-03-01 00:00:00

abstract：:The presence of autoimmune diseases, including Systemic Sclerosis (SSc), suggest failure of the normal immune regulatory processes leading to activation and expansion of autoreactive effector immune cells. Recently, stem cell transplantation emerged as a novel rescue therapy for a variety of refractory autoimmune dise...

journal_title：British journal of haematology

authors： Cipriani P,Ruscitti P,Giacomelli R

更新日期：2015-02-01 00:00:00

abstract：:The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-associated coronavirus disease 2019 (COVID-19) is primarily manifested as a respiratory tract infection, but may affect and cause complications in multiple organ systems (cardiovascular, gastrointestinal, kidneys, haematopoietic and immune systems), whil...

journal_title：British journal of haematology

authors： Kastritis E,Wechalekar A,Schönland S,Sanchorawala V,Merlini G,Palladini G,Minnema M,Roussel M,Jaccard A,Hegenbart U,Kumar S,Cibeira MT,Blade J,Dimopoulos MA

更新日期：2020-08-01 00:00:00

abstract：:Graft-versus-host disease (GVHD) is a major cause of transplant-related mortality (TRM) after allogeneic haematopoietic stem cell transplantation (HSCT) and presents a challenge in haploidentical HSCT. GVHD may be prevented by ex vivo graft T-cell depletion or in vivo depletion of proliferating lymphocytes. However, b...

journal_title：British journal of haematology

authors： Roy DC,Lachance S,Cohen S,Delisle JS,Kiss T,Sauvageau G,Busque L,Ahmad I,Bernard L,Bambace N,Boumédine RS,Guertin MC,Rezvani K,Mielke S,Perreault C,Roy J

更新日期：2019-09-01 00:00:00

abstract：:Marizomib, a natural marine product, is an irreversible proteasome inhibitor currently under investigation in relapsed-refractory multiple myeloma (RRMM) and malignant glioma. Central nervous system-multiple myeloma (CNS-MM) is a rare manifestation of extra-medullary disease with few therapeutic options, highlighting ...

journal_title：British journal of haematology

authors： Badros A,Singh Z,Dhakal B,Kwok Y,MacLaren A,Richardson P,Trikha M,Hari P

更新日期：2017-04-01 00:00:00

abstract：:There is evidence for increased factor VII turnover and the associated increased thrombin generation and fibrinolytic activities in sickle cell disease (SCD) that may affect in vivo platelet and endothelial cell reactivity. We studied the release of specific eicosanoids that are indicative of in vivo platelet activati...

journal_title：British journal of haematology

authors： Kurantsin-Mills J,Ibe BO,Natta CL,Raj JU,Siegel RS,Lessin LS

更新日期：1994-07-01 00:00:00

abstract：:We have investigated the molecular basis of alpha thalassaemia in the so-called 'Cape Coloured' population of Cape Town. DNA from 17 cases was analysed by Southern blotting and hybridization with an alpha globin complementary DNA probe. Three types of alpha thalassaemia genetic determinants were detected: the 3.5 kb d...

journal_title：British journal of haematology

authors： Mathew CG,Rousseau J,Rees JS,Harley EH

更新日期：1983-09-01 00:00:00

abstract：:B cell receptor (BCR) signalling is an important pathway in diffuse large B cell lymphoma (DLBCL). In response to BCR triggering, normal and malignant B cells secrete the chemokines CCL3 and CCL4 to attract accessory cells to the tissue microenvironment. We measured CCL3 and CCL4 serum concentrations in 102 patients w...

journal_title：British journal of haematology

authors： Takahashi K,Sivina M,Hoellenriegel J,Oki Y,Hagemeister FB,Fayad L,Romaguera JE,Fowler N,Fanale MA,Kwak LW,Samaniego F,Neelapu S,Xiao L,Huang X,Kantarjian H,Keating MJ,Wierda W,Fu K,Chan WC,Vose JM,O'Brien S,Davi

更新日期：2015-12-01 00:00:00

abstract：:The object of this study was to determine whether there were any differences between the 'typical' child with fever and neutropenia and their adult counterpart with regard to infection type and outcome, by analysis of 3080 patients, including 759 children < 18 years of age and 2321 adults. These represented patients r...

journal_title：British journal of haematology

authors： Hann I,Viscoli C,Paesmans M,Gaya H,Glauser M

更新日期：1997-12-01 00:00:00