Abstract:
:Marizomib, a natural marine product, is an irreversible proteasome inhibitor currently under investigation in relapsed-refractory multiple myeloma (RRMM) and malignant glioma. Central nervous system-multiple myeloma (CNS-MM) is a rare manifestation of extra-medullary disease with few therapeutic options, highlighting the unmet clinical need in these patients. Marizomib demonstrated encouraging activity in RRMM and has emerging clinical activity in glioma, making it a potential CNS-MM therapeutic intervention. Herein, we present two patients with RRMM and CNS involvement who benefited from marizomib-based therapy. These cases provide the first proof of principle for further exploring marizomib in CNS-MM patients.
journal_name
Br J Haematoljournal_title
British journal of haematologyauthors
Badros A,Singh Z,Dhakal B,Kwok Y,MacLaren A,Richardson P,Trikha M,Hari Pdoi
10.1111/bjh.14498subject
Has Abstractpub_date
2017-04-01 00:00:00pages
221-225issue
2eissn
0007-1048issn
1365-2141journal_volume
177pub_type
杂志文章abstract::Human blood platelets were stored in autologous plasma at 4 degrees C or 22 degrees C and their surface changes were probed with three lectins--wheat germ agglutinin, lentil lectin and concanavalin A. Platelets stored at either temperature for different times showed increased sensitivity to lectins. Lectins which were...
journal_title:British journal of haematology
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journal_title:British journal of haematology
pub_type: 杂志文章
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journal_title:British journal of haematology
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abstract::We evaluated the feasibility of collecting peripheral blood progenitor cells (PBPC) in patients with acute myeloid leukaemia (AML) following two cycles of induction chemotherapy with idarubicin, cytarabine and etoposide (ICE), and one cycle of consolidation therapy with high-dose cytarabine and mitoxantrone (HAM). Thi...
journal_title:British journal of haematology
pub_type: 杂志文章
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journal_title:British journal of haematology
pub_type: 杂志文章,评审
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abstract::Peripheral T-cell lymphomas (PTCL) have suboptimal outcomes using conventional CHOP (cyclophosphamide, doxorubicin, vincristine, prednisone) chemotherapy. The anti-folate pralatrexate, the first drug approved for patients with relapsed/refractory PTCL, provided a rationale to incorporate it into the front-line setting...
journal_title:British journal of haematology
pub_type: 杂志文章,多中心研究
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pub_type: 杂志文章
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pub_type: 杂志文章
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journal_title:British journal of haematology
pub_type: 杂志文章
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更新日期:2007-07-01 00:00:00
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journal_title:British journal of haematology
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doi:10.1111/j.1365-2141.1994.tb03253.x
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pub_type: 杂志文章
doi:10.1111/j.1365-2141.2009.07869.x
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journal_title:British journal of haematology
pub_type: 杂志文章
doi:
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journal_title:British journal of haematology
pub_type: 杂志文章
doi:10.1046/j.1365-2141.1998.00924.x
更新日期:1998-10-01 00:00:00
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journal_title:British journal of haematology
pub_type: 杂志文章
doi:10.1046/j.1365-2141.1997.d01-2032.x
更新日期:1997-02-01 00:00:00
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journal_title:British journal of haematology
pub_type: 杂志文章
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pub_type: 杂志文章
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journal_title:British journal of haematology
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pub_type: 杂志文章,多中心研究
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journal_title:British journal of haematology
pub_type: 杂志文章
doi:10.1046/j.1365-2141.1997.1262940.x
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pub_type: 杂志文章,评审
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journal_title:British journal of haematology
pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:2004-01-01 00:00:00
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journal_title:British journal of haematology
pub_type: 杂志文章
doi:10.1111/j.1365-2141.1989.tb07733.x
更新日期:1989-07-01 00:00:00
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journal_title:British journal of haematology
pub_type: 临床试验,杂志文章
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更新日期:1995-01-01 00:00:00
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journal_title:British journal of haematology
pub_type: 信件,评审
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更新日期:2018-05-01 00:00:00
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journal_title:British journal of haematology
pub_type: 杂志文章
doi:10.1111/j.1365-2141.1985.tb07451.x
更新日期:1985-07-01 00:00:00