Acute leukaemia immunophenotyping in bone-marrow routine sections.

abstract：:Akt mediates growth and drug resistance in multiple myeloma (MM) cells in the bone marrow (BM) microenvironment. We have shown that a novel Akt inhibitor Perifosine induces significant cytotoxicity in MM cells in the BM milieu. This study further delineated molecular mechanisms whereby Perifosine triggered cytotoxicit...

journal_title：British journal of haematology

authors： Hideshima T,Catley L,Raje N,Chauhan D,Podar K,Mitsiades C,Tai YT,Vallet S,Kiziltepe T,Ocio E,Ikeda H,Okawa Y,Hideshima H,Munshi NC,Yasui H,Richardson PG,Anderson KC

更新日期：2007-09-01 00:00:00

abstract：:Glanzmann thrombasthenia (GT) is a rare autosomal recessive bleeding disorder, caused by a quantitative or qualitative defect of the GPIIb-IIIa integrin (alpha IIb beta 3), which functions as the platelet fibrinogen receptor. We report a case of type I GT due to a homozygous mutation resulting in Ser 870 to stop codon...

journal_title：British journal of haematology

authors： Vinciguerra C,Khelif A,Alemany M,Morle F,Grenier C,Uzan G,Gulino D,Dechavanne M,Negrier C

更新日期：1996-11-01 00:00:00

abstract：:Between January 1987 and January 1997, 69 eligible patients with acute myeloid leukaemia (AML) in either second (CR2) or third (CR3) complete remission (CR2 = 60, CR3 = 9) underwent 4-hydroperoxycyclophosphamide-purged autologous bone marrow transplantation (BMT) at the Johns Hopkins Oncology Center. The patients' med...

journal_title：British journal of haematology

authors： Smith BD,Jones RJ,Lee SM,Piantadosi S,Vala MS,Fuller D,Gore SD,Noga SJ,O'Donnell PV,Braine H,Vogelsang GB,Fuchs EJ,Flinn IW,Brodsky RA,Ambinder RF,Miller CB

更新日期：2002-06-01 00:00:00

abstract：:To explore the possible role of a residual or variant alphaIIbbeta3 integrin (alphaIIbbeta3) in thrombogenesis, we used a new ex vivo perfusion chamber model to examine blood from patients with different subtypes of Glanzmann's thrombasthenia (GT). Non-anticoagulated blood was perfused through capillaries coated with ...

journal_title：British journal of haematology

authors： Hainaud P,Brouland JP,André P,Simoneau G,Bal Dit Sollier C,Drouet L,Caen J,Bellucci S

更新日期：2002-12-01 00:00:00

abstract：:The granulocytes of 23 patients with chronic granulocytic leukaemia were examined in the indirect immunofluorescence test and some also in the microleucoagglutination test, with specific alloantisera against the NA1, NA2, NB1 and ND1 antigens and a specific granulocyte xenoantiserum. In 10 cases a complete loss of all...

journal_title：British journal of haematology

authors： Reijden JH,von dem Borne AE,Verheugt FW,Floor-van Gent AB,Melief CJ,Engelfriet CP

更新日期：1979-12-01 00:00:00

abstract：:Pituitary tumour transforming gene (PTTG) isolated from pituitary tumour cells transforms cells in vitro and causes in vivo tumour formation. PTTG is expressed in several human tumours and cell lines. In normal adult tissues, the testis expresses abundant levels of PTTG mRNA comparable to that found in tumour cells. A...

journal_title：British journal of haematology

authors： Stoika R,Melmed S

更新日期：2002-12-01 00:00:00

abstract：:In a 2.5-month-old infant with beta-thalassaemia major, DNA analysis of the gamma-beta region revealed homozygosity for two large deletions removing the entire psi beta and beta regions including their 5' promoter regions but leaving the delta gene intact. The downstream deletion was predicted to be 7.6 kb in length e...

journal_title：British journal of haematology

authors： Oner C,Oner R,Gürgey A,Altay C

更新日期：1995-02-01 00:00:00

abstract：:Erythropoietin (EPO) and stem cell factor (SCF) are two important factors in human erythropoiesis. We have recently demonstrated that SCF and EPO synergistically activate mitogen-activated protein (MAP) kinase, thereby promoting growth of human erythroid colony-forming cells (ECFCs). In the present study, we have exam...

journal_title：British journal of haematology

authors： Sui X,Krantz SB,Zhao ZJ

更新日期：2000-07-01 00:00:00

abstract：:Blood from five donors, previously shown to be positive for cytomegalovirus (CMV) DNA following polymerase chain reaction (PCR) amplification, was filtered through commercially available leucocyte filters. Analysis of pre- and post-filtration samples by PCR with ethidium bromide staining has shown that filtration was ...

journal_title：British journal of haematology

authors： Smith KL,Cobain T,Dunstan RA

更新日期：1993-04-01 00:00:00

abstract：:Translocations involving the MLL gene on the chromosome 11 (11q23) are frequently observed in acute leukaemia. The detection of this genetic change has a unique significance as a result of its implication of poor prognosis. To reveal the utility of fluorescence in situ hybridization (FISH) in detecting the MLL translo...

journal_title：British journal of haematology

authors： Kim HJ,Cho HI,Kim EC,Ko EK,See CJ,Park SY,Lee DS

更新日期：2002-12-01 00:00:00

abstract：:We present the rare occurrence of an inhibitor of factor VIII procoagulant arising in a patient with mild haemophilia A and rheumatoid arthritis. The inhibitor was transient and behaved like a low titre, type II factor VIII procoagulant inhibitor similar to previously reported cases (Biggs et al, 1972b). In vitro stud...

journal_title：British journal of haematology

authors： Bovill EG,Burns SL,Golden EA

更新日期：1985-10-01 00:00:00

abstract：:The development of neutralising antibodies to factor VIII (FVIII) is a major complication of haemophilia A (HA) therapy. We aimed to construct an individual risk profile for the development of inhibitors in HA and started by screening for the causative mutation in our HA patient population. A total of 109 patients and...

journal_title：British journal of haematology

authors： Boekhorst J,Verbruggen B,Lavergne JM,Costa JM,Schoormans SC,Brons PP,van Kraaij MG,Nováková IR,van Heerde WL

更新日期：2005-10-01 00:00:00

abstract：:The highly conserved 350-bp major regulatory element HS-40 (or alphaMRE) upstream of the human alpha-globin gene cluster is involved in the regulation of alpha-globin gene expression. The study of alphaMRE differences between human populations and the evolution of alphaMRE sequences in mammals may lead to a better und...

journal_title：British journal of haematology

authors： Harteveld CL,Muglia M,Passarino G,Kielman MF,Bernini LF

更新日期：2002-12-01 00:00:00

abstract：:While imatinib and other tyrosine kinase inhibitors (TKIs) are highly efficacious in the treatment of chronic myeloid leukaemia (CML), some patients become refractory to these therapies. After confirming that interleukin-3 receptor (IL3R, CD123) is highly expressed on CD34(+) /CD38(-) BCR-ABL1(+) CML stem cells, we in...

journal_title：British journal of haematology

authors： Frolova O,Benito J,Brooks C,Wang RY,Korchin B,Rowinsky EK,Cortes J,Kantarjian H,Andreeff M,Frankel AE,Konopleva M

更新日期：2014-09-01 00:00:00

abstract：:Clinical management of chronic lymphocytic leukaemia (CLL) in patients aged ≥80 years is based on limited evidence due to the lack of published information. Therefore, we analysed CLL patients aged ≥80 years using data from seven phase III clinical trials of the German CLL Study Group. Among 3552 participants, 152 wer...

journal_title：British journal of haematology

authors： Al-Sawaf O,Bahlo J,Robrecht S,Fischer K,Herling CD,Hoechstetter M,Fink AM,von Tresckow J,Langerbeins P,Cramer P,Stilgenbauer S,Wendtner CM,Eichhorst B,Hallek M,Goede V

更新日期：2018-12-01 00:00:00

abstract：:Knowledge of the absolute and relative risk of venous thromboembolism (VTE) in and around pregnancy would be crucial in identifying when to commence and cease thromboprophylaxis in women who would benefit from such intervention. We addressed this hypothesis using a large prospective primary care database from the Unit...

journal_title：British journal of haematology

authors： Sultan AA,West J,Tata LJ,Fleming KM,Nelson-Piercy C,Grainge MJ

更新日期：2012-02-01 00:00:00

abstract：:Hepatocyte growth factor (HGF) has been known as a versatile functional molecule, and as being involved in the colony formation of haemopoietic progenitor cells. Clinically, an elevated HGF level in the blood has been associated with liver diseases such as fulminant hepatic failure and acute hepatitis. We have found a...

journal_title：British journal of haematology

authors： Nakamura S,Gohda E,Matsuo Y,Yamamoto I,Minowada J

更新日期：1994-07-01 00:00:00

abstract：:To assess sources of variability in platelet function tests in normal subjects, 64 healthy young adults were tested on 2-6 occasions at 2 week intervals using four methods: platelet aggregation (AGG) in platelet-rich plasma (PRP) in the Bio/Data PAP-4 Aggregometer (BD) and Chrono-Log Lumi-Aggregometer (CL); and AGG in...

journal_title：British journal of haematology

authors： Miller CH,Rice AS,Garrett K,Stein SF

更新日期：2014-06-01 00:00:00

abstract：:Endogenous production of carbon monoxide (VCO), red cell survival and iron kinetics were studied in 15 subjects with Hodgkin's disease. The subjects were divided into two groups, namely: eight patients with anaemia (group A, haemoglobin (Hb) concentration less than 11.5 g/dl) and seven patients without anaemia (group ...

journal_title：British journal of haematology

authors： Cavallin-Ståhl E,Mercke C,Lundh B

更新日期：1976-02-01 00:00:00

abstract：:Previous studies report conflicting results concerning the potential significance of thrombophilic genotypes in postarthroplasty venous thromboembolism (VTE). This study assessed thrombophilic genotypes, haemostatic and clinical variables as independent risk factors for VTE postarthroplasty. A total number of 569 pati...

journal_title：British journal of haematology

authors： Joseph JE,Low J,Courtenay B,Neil MJ,McGrath M,Ma D

更新日期：2005-04-01 00:00:00

abstract：:T(3;14)(q27;q32) is frequently detected in B-cell non-Hodgkin's lymphomas, especially the diffuse large cell type and the follicular type. The BCL6 gene encoding a putative transcriptional factor which resides on 3q27 rearranges to the immunoglobulin heavy chain (IgH) gene on 14q32 in this chromosomal translocation. T...

journal_title：British journal of haematology

authors： Kawamata N,Nakamura Y,Miki T,Sato E,Isobe Y,Furusawa S,Hirosawa S,Oshimi K

更新日期：1998-03-01 00:00:00

abstract：:beta2-glycoprotein I (beta2GPI) bears the epitope(s) for autoimmune anticardiolipin antibodies (aCL) frequently present in patients with antiphospholipid syndrome (APS). beta2GPI is involved in coagulation and fibrinolytic systems, including inhibition of contact activation. Coagulation factor XII is an initiator of i...

journal_title：British journal of haematology

authors： Takeuchi R,Atsumi T,Ieko M,Amasaki Y,Ichikawa K,Koike T

更新日期：2002-12-01 00:00:00

abstract：:Parameters of host defence were investigated in 30 patients with sickle cell disease (SCD). A newly devised perfusion system was used to study the kinetics in whole blood of leucocyte adherence, phagocytosis, killing and solubilization of a mixture of Staph. aureus and Str. pneumoniae, and secretion of lactoferrin. A ...

journal_title：British journal of haematology

authors： Boghossian SH,Wright G,Webster AD,Segal AW

更新日期：1985-03-01 00:00:00

abstract：:We used a murine model to determine the impact of donor lymphocyte subsets on the incidence of primary marrow graft failure after transplantation of lymphocyte-depleted bone marrow. After lethal irradiation with 7.5 Gy, Balb/c mice received 1 x 10(5) to 4 x 10(7) GvH-nonreactive (C57 x Balb)F1 or GvH-reactive C57Bl/6 ...

journal_title：British journal of haematology

authors： Uharek L,Glass B,Gaska T,Gassmann W,Loeffler H,Mueller-Ruchholtz W

更新日期：1994-09-01 00:00:00

abstract：:The expression and prognostic significance of hepatocyte growth factor (HGF) and its receptor c-MET (MET proto-oncogene) was analysed in 96 cases of diffuse large B-cell lymphoma (DLBCL). Tissue sections were immunohistochemically stained for HGF and c-Met. The prognosis of HGF-positive and c-Met-positive cases was si...

journal_title：British journal of haematology

authors： Kawano R,Ohshima K,Karube K,Yamaguchi T,Kohno S,Suzumiya J,Kikuchi M,Tamura K

更新日期：2004-11-01 00:00:00

abstract：:A comparison has been made between the prothrombin time test using British Comparative Thromboplastin (BCT) and a chromogenic substrate assay for factor VII in the assessment of laboratory control of oral anticoagulants in short-term and long-term patients. Opportunity was also taken to compare the findings with paral...

journal_title：British journal of haematology

authors： Poller L,Thomson JM,Bodzenta A,Easton AC,Latallo ZS,Chmielewska J

更新日期：1981-09-01 00:00:00

abstract：:Patients with aplastic anaemia (AA) frequently develop paroxysmal nocturnal haemoglobinuria (PNH) as a late complication. We investigated the frequency of the development of PNH features including a glycosyl phosphatidylinositol (GPI) anchoring defect in 73 Japanese patients with AA. A deficient expression of CD59 was...

journal_title：British journal of haematology

authors： Azenishi Y,Ueda E,Machii T,Nishimura J,Hirota T,Shibano M,Nakao S,Kinoshita T,Mizoguchi H,Kitani T

更新日期：1999-03-01 00:00:00

abstract：:The CS1 antigen provides a unique target for the development of an immunotherapeutic strategy to treat patients with multiple myeloma (MM). This study aimed to identify HLA-A2(+) immunogenic peptides from the CS1 antigen, which induce peptide-specific cytotoxic T lymphocytes (CTL) against HLA-A2(+) MM cells. We iden...

journal_title：British journal of haematology

authors： Bae J,Song W,Smith R,Daley J,Tai YT,Anderson KC,Munshi NC

更新日期：2012-06-01 00:00:00

abstract：:Deregulated Hedgehog (Hh) signalling activity may be associated with a broad range of cancer types and hence has become an attractive target for therapeutic intervention. Although initial haematological interest focused on the therapeutic targeting of this pathway in chronic myeloid leukaemia), small molecule inhibito...

journal_title：British journal of haematology

authors： Khan AA,Harrison CN,McLornan DP

更新日期：2015-08-01 00:00:00

abstract：:We report a patient with hypereosinophilic syndrome (HES), which, 8 years later, transformed into granulocytic sarcoma in the brain and, subsequently, into acute myelocytic leukaemia. Repeated chromosome analyses showed a normal karyotype, until the time of leukaemic transformation when trisomy 8 was confirmed in cell...

journal_title：British journal of haematology

authors： Fujii N,Ikeda K,Takahashi N,Kojima K,Kobayashi Y,Ashiba A,Takenaka K,Fukuda S,Shinagawa K,Ishimaru F,Niiya K,Miura I,Tanimoto M,Harada M

更新日期：2002-12-01 00:00:00