Allogeneic bone marrow transplantation for acute lymphoblastic leukaemia: risk factors and clinical outcome.


:We report 12 years' experience with histocompatible, related donor marrow transplantation for 123 patients with acute lymphoblastic leukaemia; 104 > or = second remission. Four regimens were studied: cyclophosphamide (Cy)-+total body irradiation (TBI) (n = 35); Cy+fractionated TBI (n = 45); TBI+high-dose cytarabine (n = 15); and hyperfractionated TBI+Cy (n = 28). 45 patients survive (34 +/- 9%; 95% confidence interval) between 1 and 12.7 years (median 7.8 years) following BMT and 29 +/- 8% survive leukaemia-free. Significantly improved disease-free survival was observed in patients with an initial WBC < 50 x 10(9)/l (P = 0.02). Conditioning regimens tested yielded similar outcomes, though TBI/cytarabine led to greater treatment-associated mortality. Leukaemia relapse was the most frequent cause of failure in 56 +/- 11%; median time of relapse 8 months following BMT, none beyond 2.2 years. Relapse was more frequent with higher WBC, shorter initial remission and previous CNS leukaemia. Acute and/or chronic GVHD was associated with a strong trend (P = 0.06) towards less relapse. Allogeneic BMT may be curative for a substantial fraction of patients with ALL, but additional anti-leukaemic measures beyond these conditioning modifications tested will be required to prevent post-transplant leukaemia recurrence.


Br J Haematol


Weisdorf DJ,Woods WG,Nesbit ME Jr,Uckun F,Dusenbery K,Kim T,Haake R,Thomas W,Kersey JH,Ramsay NK




Has Abstract


1994-01-01 00:00:00












  • The management and outcome of chronic graft-versus-host disease.

    abstract::Chronic graft-versus-host disease (cGVHD) is a common complication following allogeneic haematopoietic cell transplantation (HCT). It is the leading cause of non-relapse mortality in transplant survivors and has a significant impact upon their functional status and quality of life. Despite significant advances being m...

    journal_title:British journal of haematology

    pub_type: 杂志文章,评审


    authors: Fraser CJ,Scott Baker K

    更新日期:2007-07-01 00:00:00

  • Molecular pathology of haemoglobin H disease in Sardinians.

    abstract::We investigated the molecular basis for haemoglobin H disease in 50 Sardinian patients by restriction endonuclease analysis. We found that the majority (78% of the cases) are due to gene deletion (- -/- alpha). Among those with a combination of deletion and nondeletion defects (- -/alpha alpha th), the most prevalent ...

    journal_title:British journal of haematology

    pub_type: 杂志文章


    authors: Paglietti E,Galanello R,Moi P,Pirastu M,Cao A

    更新日期:1986-07-01 00:00:00

  • Identification of a tissue kallikrein in human polymorphonuclear leucocytes.

    abstract::We have identified a tissue kallikrein in polymorphonuclear (PMN) leucocytes of normal human blood and bone marrow by immunocytochemistry, radioimmunoassay and enzymology. Immunoreactive tissue kallikrein was visualized in the mature neutrophil leucocytes and in immature forms such as metamyelocytes and myelocytes. No...

    journal_title:British journal of haematology

    pub_type: 杂志文章


    authors: Figueroa CD,MacIver AG,Bhoola KD

    更新日期:1989-07-01 00:00:00

  • Transient familial haemophagocytic lymphohistiocytosis reactivation post-CD34 haematopoietic stem cell transplantation.

    abstract::Familial haemophagocytic lymphohistiocytosis (FHLH) is a genetic disorder caused by defective lymphocyte cytotoxicity, resulting in impaired lymphocyte homeostasis and macrophage infiltration of solid tissues and bone marrow, with extensive haemophagocytosis. It is invariably fatal unless treated by allogeneic haemato...

    journal_title:British journal of haematology

    pub_type: 杂志文章


    authors: Almousa H,Ouachée-Chardin M,Picard C,Radford-Weiss I,Caillat-Zucman S,Cavazzana-Calvo M,Blanche S,de Saint Basile G,Le Deist F,Fischer A

    更新日期:2005-08-01 00:00:00

  • In non-follicular lymphoproliferative disorders, IGH/BCL2-fusion is not restricted to chronic lymphocytic leukaemia.

    abstract::The translocation t(14;18) and its t(2;18) and t(18,22) variants, which involve the BCL2 genetic hallmark for follicular lymphoma (FL), have been reported in several cases of chronic B-cell lymphoproliferative disease (CLPD) and frequently in chronic lymphocytic leukaemia (CLL). We describe here the clinical, morpholo...

    journal_title:British journal of haematology

    pub_type: 杂志文章


    authors: Baseggio L,Geay MO,Gazzo S,Berger F,Traverse-Glehen A,Ffrench M,Hayette S,Callet-Bauchu E,Verney A,Morel D,Jallades L,Magaud JP,Salles G,Felman P

    更新日期:2012-08-01 00:00:00

  • Patient self-testing is a reliable and acceptable alternative to laboratory INR monitoring.

    abstract::SAn ageing population and the continuing expansion of clinical indications for coumadin therapy have increased pressure on hospital anticoagulant clinics. One solution is patient self-testing (PST) of the international normalized ratio (INR) using capillary blood samples on point-of-care coagulation monitors at home. ...

    journal_title:British journal of haematology

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Gardiner C,Williams K,Mackie IJ,Machin SJ,Cohen H

    更新日期:2005-01-01 00:00:00

  • bcl-2 and immunoglobulin gene rearrangement in patients with hepatitis C virus infection.

    abstract::An association between chronic hepatitis C virus (HCV) infection and clonal proliferation of B cells, including B cell lymphoma, has recently been demonstrated. However, the mechanism of malignant transformation is still unknown. It has been shown that B cells from patients with type II mixed cryoglobulinaemia (MC), s...

    journal_title:British journal of haematology

    pub_type: 杂志文章


    authors: Zuckerman E,Zuckerman T,Sahar D,Streichman S,Attias D,Sabo E,Yeshurun D,Rowe J

    更新日期:2001-02-01 00:00:00

  • Translocation of bcl-2 gene in non-Hodgkin's lymphomas in Hong Kong Chinese.

    abstract::The close association between translocation of the proto-oncogene bcl-2 and follicular lymphomas has been well established in Caucasian patients and the de-regulation of bcl-2 has been implicated in follicular lymphomagenesis. Similar molecular structural alterations have also been detected in diffuse lymphomas with a...

    journal_title:British journal of haematology

    pub_type: 杂志文章


    authors: Loke SL,Pittaluga S,Srivastava G,Raffeld M,Ho FC

    更新日期:1990-09-01 00:00:00

  • Features affecting outcome during remission induction of acute myeloid leukaemia in 619 adult patients.

    abstract::Six hundred and nineteen patients with de novo acute myeloid leukaemia, entered into the Medical Research Council's eighth trial of therapy have been studied. All patients were treated with the same remission induction regimen. Pretreatment variables comprising age, clinical status, haematological status and a detaile...

    journal_title:British journal of haematology

    pub_type: 杂志文章


    authors: Swirsky DM,de Bastos M,Parish SE,Rees JK,Hayhoe FG

    更新日期:1986-11-01 00:00:00

  • Total absence of protein 4.2 and partial deficiency of band 3 in hereditary spherocytosis.

    abstract::Unlike previously reported cases with total protein 4.2 deficiency due to mutations in the EPB42 gene, we describe a total deficiency in protein 4.2 with normal EPB42 alleles. Hereditary spherocytosis (HS) was observed in a Japanese woman (unsplenectomized) and her daughter (splenectomized). The mother showed a partia...

    journal_title:British journal of haematology

    pub_type: 杂志文章


    authors: Kanzaki A,Hayette S,Morlé L,Inoue F,Matsuyama R,Inoue T,Yawata A,Wada H,Vallier A,Alloisio N,Yawata Y,Delaunay J

    更新日期:1997-12-01 00:00:00

  • Congenital dyserythropoiesis with intererythroblastic chromatin bridges and ultrastructurally-normal erythroblast heterochromatin: a new disorder.

    abstract::Two non-anaemic subjects, a father and daughter, with a new form of congenital dyserythropoiesis are reported. The features of their disorder are: (1) an abnormal blood film with basophilic stippling of red cells and oval macrocytes, (2) various dysplastic changes in the erythroblasts, including internuclear chromatin...

    journal_title:British journal of haematology

    pub_type: 杂志文章


    authors: Wickramasinghe SN,Spearing RL,Hill GR

    更新日期:1998-12-01 00:00:00

  • Cytokine activity after human bone marrow transplantation. III. Defect in IL2 production by peripheral blood mononuclear cells is not corrected by stimulation with Ca++ ionophore plus phorbol ester.

    abstract::Previous studies have shown that interleukin 2 (IL2) production by peripheral blood mononuclear cells (PBMC) is severely impaired post allogeneic bone marrow transplantation, whereas production of interferon-gamma (IFN-gamma) is at most marginally depressed. To investigate the mechanisms behind this apparently differe...

    journal_title:British journal of haematology

    pub_type: 杂志文章


    authors: Cooley MA,McLachlan K,Atkinson K

    更新日期:1989-11-01 00:00:00

  • Life expectancy of follicular lymphoma patients in complete response at 30 months is similar to that of the Spanish general population.

    abstract::The use of immunochemotherapy has improved the outcome of follicular lymphoma (FL). Recently, complete response at 30 months (CR30) has been suggested as a surrogate for progression-free survival. This study aimed to analyse the life expectancy of FL patients according to their status at 30 months from the start of tr...

    journal_title:British journal of haematology

    pub_type: 临床试验,杂志文章,多中心研究


    authors: Magnano L,Alonso-Alvarez S,Alcoceba M,Rivas-Delgado A,Muntañola A,Nadeu F,Setoain X,Rodríguez S,Andrade-Campos M,Espinosa-Lara N,Rodríguez G,Sancho JM,Moreno M,Mercadal S,Carro I,Salar A,Garcia-Pallarols F,Arranz R,Ca

    更新日期:2019-05-01 00:00:00

  • Nucleoside incorporation into DNA and RNA in acute leukaemia: differences between the various leukaemia sub-types.

    abstract::The incorporation of the labelled deoxyribonucleosides 3H-deoxythymidine (3H-TdR), H3-deoxycytidine (3H-CdR), 3H-deoxyadenosine (3H-AdR), 3H-deoxyguanosine (3G-GdR), 3H-deoxyuridine (3H-UdR) and of labelled uridine (3H-UR) into DNA and RNA was studied in bone marrow (BM) and peripheral blood (PB) cells from 10 normal ...

    journal_title:British journal of haematology

    pub_type: 杂志文章


    authors: Piga A,Sylwestrowicz T,Ganeshaguru K,Breatnach F,Amos R,Prentice HG,Hoffbrand AV

    更新日期:1982-10-01 00:00:00

  • Quality assessment of immunological marker analysis and the immunological diagnosis in leukaemia and lymphoma: a multi-centre study. Dutch Cooperative Study Group on Immunophenotyping of Leukaemias and Lymphomas (SIHON).

    abstract::In order to standardize and assess the quality of immunophenotyping of leukaemias and lymphomas for diagnostic purposes, a cooperative study group in the Netherlands, SIHON, has formulated guidelines for the composition of antibody panels to be applied and guidelines for the interpretation of the marker analysis. To a...

    journal_title:British journal of haematology

    pub_type: 杂志文章


    authors: van't Veer MB,Kluin-Nelemans JC,van der Schoot CE,van Putten WL,Adriaansen HJ,van Wering ER

    更新日期:1992-04-01 00:00:00

  • Long-term stability of international reference preparations for thromboplastins.

    abstract::Three certified reference materials for thromboplastins are available from the Community Bureau of Reference (BCR) of the European Commission for calibration of commercial thromboplastins used for control of oral anticoagulant therapy. The long-term stability of these reference materials has been monitored by two inde...

    journal_title:British journal of haematology

    pub_type: 杂志文章


    authors: van den Besselaar AM,Hermans J,Beeser H,Loeliger EA

    更新日期:1988-03-01 00:00:00

  • Plasma microparticles and vascular disorders.

    abstract::Microparticles are circulating, phospholipid rich, submicron particles released from the membranes of endothelial cells, platelets, leucocytes and erythrocytes. Investigation into their biological activity has revealed diverse actions in coagulation, cell signalling and cellular interactions. These actions are mediate...

    journal_title:British journal of haematology

    pub_type: 杂志文章,评审


    authors: Lynch SF,Ludlam CA

    更新日期:2007-04-01 00:00:00

  • Role of the cold shock domain protein A in the transcriptional regulation of HBG expression.

    abstract::Impaired switching from fetal haemoglobin (HbF) to adult globin gene expression leads to hereditary persistence of fetal haemoglobin (HPFH) in adult life. This is of prime interest because elevated HbF levels ameliorate β-thalassaemia and sickle cell anaemia. Fetal haemoglobin levels are regulated by complex mechanism...

    journal_title:British journal of haematology

    pub_type: 杂志文章


    authors: Petruzzelli R,Gaudino S,Amendola G,Sessa R,Puzone S,Di Concilio R,d'Urzo G,Amendolara M,Izzo P,Grosso M

    更新日期:2010-09-01 00:00:00

  • Studies on the subcellular organelles of neutrophils in chronic granulocytic leukaemia with special reference to alkaline phosphatase.

    abstract::The organelle pathology of neutrophils in chronic granulocytic leukaemia (CGL) was investigated by analytical subcellular fractionation. There were minor reductions in activity of some granule enzymes with an abnormal distribution in sucrose density gradients of the specific granules. There was a marked reduction of 5...

    journal_title:British journal of haematology

    pub_type: 杂志文章


    authors: Rustin GJ,Peters TJ

    更新日期:1979-04-01 00:00:00

  • Acute leukaemia immunophenotyping in bone-marrow routine sections.

    abstract::Immunohistochemistry of acute leukaemias in bone-marrow paraffin sections is commonly thought to be useless because of the poor preservation of many lineage-related markers. The recent development of antibodies against fixative-resistant epitopes and of new antigen retrieval techniques, however, has expanded the possi...

    journal_title:British journal of haematology

    pub_type: 杂志文章


    authors: Pileri SA,Ascani S,Milani M,Visani G,Piccioli M,Orcioni GF,Poggi S,Sabattini E,Santini D,Falini B

    更新日期:1999-05-01 00:00:00

  • Interferon production in leukaemia.

    abstract::Leucocyte interferon production in vitro and circulating interferon levels were studied in healthy subjects and in 80 patients with acute or chronic leukaemia. Circulating interferon was not found in either group. Interferon synthesis in response to a virus was normal in patients with acute leukaemia and appeared to b...

    journal_title:British journal of haematology

    pub_type: 杂志文章


    authors: Chisholm M,Cartwright T

    更新日期:1978-09-01 00:00:00

  • Virus inactivation and prevalence of GBV-C in haemophiliacs.

    abstract::A new putative hepatitis virus has recently been discovered and termed GB virus C (GBV-C). We investigated the prevalence of this virus among 50 haemophiliacs treated with non-virus-inactivated clotting factor concentrates prior to 1985 and 21 haemophiliacs treated exclusively with virus-inactivated clotting factor co...

    journal_title:British journal of haematology

    pub_type: 杂志文章


    authors: Uhle C,Zimmermann R,Goeser T,Seelig R

    更新日期:1997-12-01 00:00:00

  • Allele and haplotype frequency at human leucocyte antigen class I/II and immunomodulatory cytokine loci in patients with myelodysplasia and acute myeloid leukaemia: in search of an autoimmune aetiology.

    abstract::An autoimmune mechanism in the pathogenesis of myelodysplastic syndrome (MDS) is suggested by response to immunosuppression, with CD8+ T-lymphocytes implicated in the haematopoietic suppression. We therefore sought evidence for human leucocyte antigen (HLA) restriction and variant frequency differences in selected pol...

    journal_title:British journal of haematology

    pub_type: 杂志文章


    authors: Gowans D,O'Sullivan A,Rollinson S,Roddam P,Groves M,Fegan C,Morgan G,Bowen D

    更新日期:2002-06-01 00:00:00

  • The incidence of dysfunctional antithrombin variants: four cases in 210 patients with thromboembolic disease.

    abstract::210 patients, with a history of venous thrombosis, have undergone prothrombotic investigations. In nine cases a consistent deficiency of antithrombin was identified. In five there was a reduction in the plasma antigenic concentration of antithrombin and in a further four cases deficiency was due to the presence of a d...

    journal_title:British journal of haematology

    pub_type: 杂志文章


    authors: Harper PL,Luddington RJ,Daly M,Bruce D,Williamson D,Edgar PF,Perry DJ,Carrell RW

    更新日期:1991-03-01 00:00:00

  • ASXL1 mutations, previous vascular complications and age at diagnosis predict survival in 85 WHO-defined polycythaemia vera patients.

    abstract::Polycythaemia vera (PV) patients have an overall comparatively favourable prognosis, but disease progression is very heterogeneous and life-threatening thrombosis and bleedings are frequent complications in untreated disease. Moreover, transformation to more severe secondary myelofibrosis and acute myeloid leukaemia c...

    journal_title:British journal of haematology

    pub_type: 杂志文章


    authors: Andréasson B,Pettersson H,Wasslavik C,Johansson P,Palmqvist L,Asp J

    更新日期:2020-06-01 00:00:00

  • High frequencies of chromosomal aberrations in multiple myeloma and monoclonal gammopathy of undetermined significance in direct chromosome preparation.

    abstract::Although many cases of multiple myeloma (MM) and monoclonal gammopathy of undetermined significance (MGUS) are cytogenetically normal, interphase fluorescence in situ hybridization (FISH) analyses reveal aberrations in the majority of the cases. Most likely, non-neoplastic cells are more prone to divide in culture tha...

    journal_title:British journal of haematology

    pub_type: 杂志文章


    authors: Nilsson T,Lenhoff S,Rylander L,Höglund M,Turesson I,Mitelman F,Westin J,Johansson B

    更新日期:2004-08-01 00:00:00

  • Circulating clonal cells in multiple myeloma do not express CD34 mRNA, as measured by single-cell and real-time RT-PCR assays.

    abstract::The peripheral blood (PB) mononuclear cells in patients with multiple myeloma (MM) have been reported to include CD34-expressing cells that are clonally related to the myeloma cells. To determine whether there were elevated levels of CD34 mRNA or whether CD34+ cells in the PB include myeloma-related cells, we develope...

    journal_title:British journal of haematology

    pub_type: 杂志文章


    authors: Rasmussen T,Jensen L,Honoré L,Andersen H,Johnsen HE

    更新日期:1999-12-01 00:00:00

  • Generation of a conditionally immortalized myeloid progenitor cell line requiring the presence of both interleukin-3 and stem cell factor to survive and proliferate.

    abstract::The H-2Kappab temperature-sensitive (ts) A58 transgenic (Immorto) mouse has been used previously to generate conditionally immortalized cells from a number of tissues. The present study aimed to investigate characteristics of primitive myeloid precursor cells derived from H-2Kappab-tsA58 bone marrow. Cell populations ...

    journal_title:British journal of haematology

    pub_type: 杂志文章


    authors: Lee C,Evans CA,Spooncer E,Pierce A,Mottram R,Whetton AD

    更新日期:2003-09-01 00:00:00

  • Induction of Fc gamma R-III (CD16) expression on neutrophils affected by paroxysmal nocturnal haemoglobinuria by administration of granulocyte colony-stimulating factor.

    abstract::The inducibility of glycosyl-phosphatidylinositol (GPI)-anchored proteins on affected paroxysmal nocturnal haemoglobinuria (PNH) neutrophils (PMN) after both in vitro and in vivo stimulation was investigated. Fc gamma R-III (CD16), decay-accelerating factor (DAF/CD55) and 20 kD homologous restriction factor (HRF20/CD5...

    journal_title:British journal of haematology

    pub_type: 杂志文章


    authors: Ninomiya H,Muraki Y,Shibuya K,Nagasawa T,Abe T

    更新日期:1993-07-01 00:00:00

  • Impact of age, sex, ethnicity, socio-economic deprivation and novel pharmaceuticals on the overall survival of patients with multiple myeloma in New Zealand.

    abstract::The impact of age, ethnicity and socio-economic deprivation in the era of novel anti-myeloma agents is unclear. Using linked national data from New Zealand, we evaluated the incidence, prevalence and overall survival (OS) of individuals who were diagnosed with myeloma between 2004 and 2016. The crude incidence rate in...

    journal_title:British journal of haematology

    pub_type: 杂志文章


    authors: Chan HSH,Milne RJ

    更新日期:2020-03-01 00:00:00