PI3K-dependent multiple myeloma cell survival is mediated by the PIK3CA isoform.

abstract：:Differentiation therapy using retinoic acids (RAs) or 1alpha25-dihydroxyvitamin D3 (D3) is an attractive alternative to chemotherapy in acute myeloid leukaemia (AML) and myelodysplastic syndromes (MDS). However, with the exception of RA therapy for acute promyelocytic leukaemia (APL), RAs and D3 are not potent enough ...

journal_title：British journal of haematology

authors： Fenton SL,Drayson MT,Hewison M,Vickers E,Brown G,Bunce CM

更新日期：1999-05-01 00:00:00

abstract：:No consensus has been obtained about the question whether autoantibodies, in particular antiphospholipid antibodies (aPL), may cause thrombosis by inhibiting thrombomodulin (TM) mediated protein C activation. In order to clarify the mechanism by which autoantibodies inhibit TM-mediated protein C activation, we have sc...

journal_title：British journal of haematology

authors： Oosting JD,Preissner KT,Derksen RH,de Groot PG

更新日期：1993-12-01 00:00:00

abstract：:We report a case of acquired sideroblastic anaemia precipitated by progesterone. On two separate occasions, over 15 years apart, the patient developed sideroblastic anaemia with iron overload shortly after the administration of progesterone. No other cause for sideroblastic anaemia was found, and treatment with folic ...

journal_title：British journal of haematology

authors： Brodsky RA,Hasegawa S,Fibach E,Dunbar CE,Young NS,Rodgers GP

更新日期：1994-08-01 00:00:00

abstract：:We investigated the complement-susceptibility of paroxysmal nocturnal haemoglobinuria (PNH) lymphocytes in relation to their dysfunction. When assessed by complement-mediated lysis induced by monoclonal antibodies (CD5 or CD20) and rabbit complement, the complement-susceptibility of lymphocytes from patients with PNH,...

journal_title：British journal of haematology

authors： Tomiyama J,Ninomiya H,Abe T

更新日期：1990-12-01 00:00:00

abstract：:Homing of transplanted bone marrow cells (BMC) to the host bone marrow (BM) is the first step of engraftment towards durable multilineage haematopoietic reconstitution. We used an in vivo assay to track PKH-labelled cells in the BM of mice after transplantation, using fluorescence microscopy through an optical window ...

journal_title：British journal of haematology

authors： Askenasy N,Farkas DL

更新日期：2003-02-01 00:00:00

abstract：:Recent studies have suggested the HoxA10, HoxA11 and HoxD11 homeobox genes as candidate loci for the thrombocytopenia with absent radius (TAR) syndrome. For example, targeted disruptions of these Hox genes result in abnormal development of the mouse radius, while overexpression of HoxA10 stimulates mouse megakaryocyte...

journal_title：British journal of haematology

authors： Fleischman RA,Letestu R,Mi X,Stevens D,Winters J,Debili N,Vainchenker W

更新日期：2002-02-01 00:00:00

abstract：:Serum ferritin level is one of the most commonly requested investigations in both primary and secondary care. Whilst low serum ferritin levels invariably indicate reduced iron stores, raised serum ferritin levels can be due to multiple different aetiologies, including iron overload, inflammation, liver or renal diseas...

journal_title：British journal of haematology

authors： Cullis JO,Fitzsimons EJ,Griffiths WJ,Tsochatzis E,Thomas DW,British Society for Haematology.

更新日期：2018-05-01 00:00:00

abstract：:Graft failure is a life-threatening complication after allogeneic haematopoietic stem cell transplantation (HSCT). We report a cohort of 19 consecutive patients (median age: 8·5 years) with acute leukaemias (n = 14) and non-malignant diseases (n = 5) who experienced graft failure after previous HSCT from matched (n = ...

journal_title：British journal of haematology

authors： Teltschik HM,Heinzelmann F,Gruhn B,Feuchtinger T,Schlegel P,Schumm M,Kremens B,Müller I,Ebinger M,Schwarze CP,Ottinger H,Zips D,Handgretinger R,Lang P

更新日期：2016-10-01 00:00:00

abstract：:Death during the induction phase of chemotherapy remains a common event in patients with aggressive non-Hodgkin's lymphoma (NHL). In a series of patients with aggressive NHL homogeneously treated with intensive induction chemotherapy [ACVB (doxorubicin, cyclophosphamide, vindesine, bleomycin, prednisone) regimen], we ...

journal_title：British journal of haematology

authors： Dumontet C,Mounier N,Munck JN,Bosly A,Morschauser F,Simon D,Marit G,Casasnovas O,Reman O,Molina T,Reyes F,Coiffier B

更新日期：2002-07-01 00:00:00

abstract：:This study was undertaken to evaluate the toxicity and pharmacokinetics of a dimethyl sulphoxide (DMSO)-based intravenous formulation of busulphan in the conditioning of 45 patients undergoing allogeneic or autologous stem cell transplantation (SCT). Busulphan was given as a single daily dose. In 15 patients a single ...

journal_title：British journal of haematology

authors： Schuler US,Renner UD,Kroschinsky F,Johne C,Jenke A,Naumann R,Bornhäuser M,Deeg HJ,Ehninger G

更新日期：2001-09-01 00:00:00

abstract：:Overt ischaemic stroke is one of the most devastating complications in children with sickle cell disease (SCD). The compensatory response to anaemia in SCD includes an increase in cerebral blood flow (CBF) by accessing cerebrovascular dilatory reserve. Exhaustion of dilatory reserve secondary to anaemic stress may lea...

journal_title：British journal of haematology

authors： Kosinski PD,Croal PL,Leung J,Williams S,Odame I,Hare GM,Shroff M,Kassner A

更新日期：2017-01-01 00:00:00

abstract：:Children with Down syndrome have a 20- to 50-fold increased risk of acute lymphocytic or myeloid leukaemia. Whole or partial gains of chromosome 21 have been described in multiple childhood leukaemias, and have recently been reported as a likely primary event in B-precursor-acute lymphoblastic leukaemia. It is unclear...

journal_title：British journal of haematology

authors： Canzonetta C,Hoischen A,Giarin E,Basso G,Veltman JA,Nacheva E,Nizetic D,Groet J

更新日期：2012-04-01 00:00:00

abstract：:Given that donor T cells from a transplant contribute both the desired graft-versus-tumour (GVT) effect and detrimental graft-versus-host disease (GVHD), strategies to separate GVHD and GVT activity are a major clinical goal. We have previously demonstrated that in vivo administration of a recombinant (r)IL-7/HGFβ hyb...

journal_title：British journal of haematology

authors： Hu R,Liu Y,Song Y,Su M,Lu X,Rood D,Lai L

更新日期：2016-11-01 00:00:00

abstract：:Mantle cell lymphoma is a distinct clinicopathological entity associated with t(11;14) and cyclin D1 overexpression. The majority of cases show uniform morphological and phenotypic features characterized by a monotonous proliferation of small-to-medium-sized irregular B cells that express CD5 and bright surface immuno...

journal_title：British journal of haematology

authors： Pittaluga S,Tierens A,Pinyol M,Campo E,Delabie J,De Wolf-Peeters C

更新日期：1998-09-01 00:00:00

abstract：:Monoclonal B-cell populations have been detected in the peripheral blood of apparently healthy individuals by flow cytometry. In 2005, the term monoclonal B-cell lymphocytosis (MBL) was proposed to describe these findings. MBL may be immunophenotypically similar to chronic lymphocytic leukaemia (CLL) and, like CLL, th...

journal_title：British journal of haematology

authors： Rachel JM,Zucker ML,Fox CM,Plapp FV,Menitove JE,Abbasi F,Marti GE

更新日期：2007-12-01 00:00:00

abstract：:Graft rejection and graft-versus-host disease are major problems in mismatched marrow transplants along with toxicity from standard myeloablative host treatments. We have established a tolerization model, using 1 Gy irradiation, which reduces stem cell capacity to < 10% of control while causing minimal myelosuppressio...

journal_title：British journal of haematology

authors： Lambert JF,Colvin GA,Zhong S,Wang H,D'Hondt L,Abedi M,Frimberger AE,Stewart FM,Quesenberry PJ

更新日期：2002-10-01 00:00:00

abstract：:The 3q21q26 syndrome leukaemias are characterised by dystrophic megakaryocytes, elevated platelet counts, ectopic EVI1 protein production and poor prognosis. To investigate the molecular basis of this disease, we developed a model system to examine the biological activity of EVI1 in a megakaryocyte progenitor cell lin...

journal_title：British journal of haematology

authors： Kilbey A,Alzuherri H,McColl J,Calés C,Frampton J,Bartholomew C

更新日期：2005-09-01 00:00:00

abstract：:Activities of the red cell enzymes hexokinase, glucose 6-phosphate dehydrogenase, 6-phosphogluconate dehydrogenase, lactic dehydrogenase and aspartate aminotransferase were measured in 17 chronic haemodialysis patients receiving androgen therapy, 15 untreated chronic haemodialysis patients and 15 normal subjects. Comp...

journal_title：British journal of haematology

authors： Solomon LR,Hendler ED

更新日期：1987-02-01 00:00:00

abstract：:We examined major histocompatibility complex (MHC) class II expression in B cells, peripheral blood monocytes, activated T cells, epidermal Langerhans cells, monocyte-derived dendritic cells, dermal microvascular endothelial cells (DMEC) and fibroblasts of twin brothers with MHC class II deficiency. Although residual ...

journal_title：British journal of haematology

authors： Wolf HM,Thon V,Gulle H,Lechleitner S,Eibl MM,Petzelbauer P

更新日期：2001-11-01 00:00:00

abstract：:Hereditary hyperferritinaemia cataract syndrome is an autosomal dominant disorder caused by heterogeneous mutations of the iron regulatory element (IRE) in the ferritin l-chain mRNA. The mutations are rare and fast DNA scanning would facilitate diagnosis. The aim of the study was to compare the analytical performances...

journal_title：British journal of haematology

authors： Cremonesi L,Paroni R,Foglieni B,Galbiati S,Fermo I,Soriani N,Belloli S,Ruggeri G,Biasiotto G,Cazzola M,Ferrari F,Ferrari M,Arosio P

更新日期：2003-04-01 00:00:00

abstract：:We describe genetic, haematological and biochemical properties of a new mouse pigment mutant, cocoa (coa). Cocoa is a recessive mutation located on the centromeric end of chromosome 3 near the Car-2 locus. The mutation causes increased bleeding time accompanied by symptoms of platelet storage pool deficiency (SPD), in...

journal_title：British journal of haematology

authors： Novak EK,Sweet HO,Prochazka M,Parentis M,Soble R,Reddington M,Cairo A,Swank RT

更新日期：1988-07-01 00:00:00

abstract：:This study investigates the value of performing a staging bone marrow in patients with diffuse large B-cell lymphoma (DLBCL), follicular lymphoma (FL) and classical hodgkin lymphoma (CHL). The results of 3112 staging bone marrow examinations were assessed for impact on prognostic assessment and critical treatment deci...

journal_title：British journal of haematology

authors： Painter D,Smith A,de Tute R,Crouch S,Roman E,Jack A

更新日期：2015-07-01 00:00:00

abstract：:Using a reverse transcription-polymerase chain reaction (RT-PCR), we identified a patient with typical clinical features of chronic myelogenous leukaemia (CML) in the chronic phase who showed no amplification of the CML-type BCR/ABL transcript. RT-PCR with primers detecting the acute lymphoid leukaemia (ALL)-type tran...

journal_title：British journal of haematology

authors： Okamoto K,Karasawa M,Sakai H,Ogura H,Morita K,Naruse T

更新日期：1997-03-01 00:00:00

abstract：:The outcome of children with acute lymphoblastic leukaemia (ALL) and early relapse remains unsatisfactory. In January 1995, the AIEOP (Associazione Italiana di Oncologia ed Ematologia Pediatrica) group opened a trial for children with ALL in first isolated or combined bone marrow relapse defined at high risk according...

journal_title：British journal of haematology

authors： Testi AM,Del Giudice I,Arcese W,Moleti ML,Giona F,Basso G,Biondi A,Conter V,Messina C,Rondelli R,Micozzi A,Micalizzi C,Barisone E,Locatelli F,Dini G,Aricò M,Casale F,Comis M,Ladogana S,Lippi A,Mura R,Pinta MF,

更新日期：2002-09-01 00:00:00

abstract：:Restriction fragment length polymorphisms (RFLP) of the X-chromosome genes phosphoglycerate kinase (PGK) and hypoxanthine phorphoribosyltransferase (HPRT) were used to determine the clonal nature of myelodysplastic syndromes (MDS) in 22 patients. These included eight with refractory anaemia (RA), four with RA with rin...

journal_title：British journal of haematology

authors： Tsukamoto N,Morita K,Maehara T,Okamoto K,Karasawa M,Omine M,Naruse T

更新日期：1993-04-01 00:00:00

abstract：:Reported here is the first example of a partial D antigen stimulating the production of anti-D: stimulation was of fetal origin. During her second pregnancy, anti-D developed in the serum of a D-negative mother who had received Rh immunoglobulin after the birth of her first D-positive child. Her second baby had modera...

journal_title：British journal of haematology

authors： Mayne K,Bowell P,Woodward T,Sibley C,Lomas C,Tippett P

更新日期：1990-12-01 00:00:00

abstract：:Marginal zone lymphoma represents about 10% of all non-Hodgkin lymphomas (NHLs). 33% of patients with acquired angioedema (AAE) due to acquired C1-inhibitor (C1-INH) deficiency (C1-INH-AAE) have or will develop NHLs. C1-INH-AAE is a rare condition. We report the follow-up of 72 C1-INH-AAE patients, followed for a medi...

journal_title：British journal of haematology

authors： Castelli R,Wu MA,Arquati M,Zanichelli A,Suffritti C,Rossi D,Cicardi M

更新日期：2016-03-01 00:00:00

abstract：:The dependence of survival time on a set of prognostic factors was explored by means of Cox's regression model in 137 cases of myelofibrosis with myeloid metaplasia (MMM). The following parameters recorded at diagnosis proved to be important independent indicators of a poor prognosis: a higher value for age, a lower v...

journal_title：British journal of haematology

authors： Barosi G,Berzuini C,Liberato LN,Costa A,Polino G,Ascari E

更新日期：1988-12-01 00:00:00

abstract：:Monocytes, lymphocytes and polymorphs were separated from the peripheral blood of normal human subjects. Ferritin concentrations were determined with antibodies to both human spleen and heart ferritins. The heart type ferritin concentration in monocytes was 38.4 +/- 21.6 fg/cell (mean +/- SD), in lymphocytes 8.6 +/- 6...

journal_title：British journal of haematology

authors： Jones BM,Worwood M,Jacobs A

更新日期：1983-09-01 00:00:00

abstract：:We describe five adult patients with sickle cell anaemia (SS) who developed clinical, radiological and histological evidence of splenic regrowth while receiving regular blood transfusions. Five patients, all homozygous SS, range 23-34 years, were commenced on hypertransfusion therapy. Three patients were transfused be...

journal_title：British journal of haematology

authors： Campbell PJ,Olatunji PO,Ryan KE,Davies SC

更新日期：1997-01-01 00:00:00