Systemic inflammation increases shear stress-induced platelet plug formation measured by the PFA-100.

abstract：:We present the rare occurrence of an inhibitor of factor VIII procoagulant arising in a patient with mild haemophilia A and rheumatoid arthritis. The inhibitor was transient and behaved like a low titre, type II factor VIII procoagulant inhibitor similar to previously reported cases (Biggs et al, 1972b). In vitro stud...

journal_title：British journal of haematology

authors： Bovill EG,Burns SL,Golden EA

更新日期：1985-10-01 00:00:00

abstract：:In two unrelated Spanish males with glucose-6-phosphate dehydrogenase (G6PD) deficiency and haemolytic anaemia, and two different novel point mutations in the G6PD gene, have been identified. A C to T transition at nucleotide 406 resulting in a (136) Arg to Cys substitution and a C to G transition at nucleotide 1155 r...

journal_title：British journal of haematology

authors： Zarza R,Pujades A,Rovira A,Saavedra R,Fernandez J,Aymerich M,Vives Corrons JL

更新日期：1997-09-01 00:00:00

abstract：:The anti-CD30 immunotoxin (IT) Ber-H2/saporin is effective in patients with refractory Hodgkin's disease. However, responses are short and partial, one of the main reasons being the inability to repeat IT doses because of formation of human antibodies against the murine antibody and/or the toxin. To overcome this prob...

journal_title：British journal of haematology

authors： Terenzi A,Bolognesi A,Pasqualucci L,Flenghi L,Pileri S,Stein H,Kadin M,Bigerna B,Polito L,Tazzari PL,Martelli MF,Stirpe F,Falini B

更新日期：1996-03-01 00:00:00

abstract：:Analogous to T cells, Natural Killer (NK) cells may facilitate engraftment, combat infection, and control cancer in bone marrow or haematopoietic stem cell transplantation (HSCT); however, NK cells do not cause graft-versus-host disease. Killer immunoglobulin-like receptors (KIRs) regulate NK cell function, and recent...

journal_title：British journal of haematology

authors： Leung W

更新日期：2011-10-01 00:00:00

abstract：:Previous studies have reported that megakaryocyte progenitors in myeloproliferative disorders (MPD) formed spontaneous megakaryocyte colonies without the addition of megakaryocyte colony-stimulating factor (Meg-CSF). To determine whether this spontaneous colony formation is due to autocrine proliferation of MPD megaka...

journal_title：British journal of haematology

authors： Kobayashi S,Teramura M,Hoshino S,Motoji T,Oshimi K,Mizoguchi H

更新日期：1993-04-01 00:00:00

abstract：:We studied a 2-year-old boy with a phenotype of combined hypo- and dysprothrombinaemia. Sequencing of polymerase-chain-reaction-amplified genomic DNA revealed three different mutations in heterozygosity, a G to A transition at position 7312, resulting in the replacement of arginine 271 by histidine, an A to G transiti...

journal_title：British journal of haematology

authors： Akhavan S,Luciani M,Lavoretano S,Mannucci PM

更新日期：2003-01-01 00:00:00

abstract：:Various techniques have been used to assess the flow properties of blood and blood cells in a range of clinical situations. Filtration through microfilters offers a single technique for measuring the flow properties of all cellular components of blood in one experiment but depends on an assumed ability to recognize ce...

journal_title：British journal of haematology

authors： Jones JG,Adams RA,Cook AM,Evans SA

更新日期：1999-01-01 00:00:00

abstract：:Isolated trisomy 8 (+8) is a frequent cytogenetic abnormality in the myelodysplastic syndromes (MDS), but its characteristics are poorly reported. We performed a retrospective study of 138 MDS patients with isolated +8, classified or reclassified as MDS (excluding MDS/myeloproliferative neoplasm). Myeloproliferative (...

journal_title：British journal of haematology

authors： Drevon L,Marceau A,Maarek O,Cuccuini W,Clappier E,Eclache V,Cluzeau T,Richez V,Berkaoui I,Dimicoli-Salazar S,Bidet A,Vial JP,Park S,Vieira Dos Santos C,Kaphan E,Berthon C,Stamatoullas A,Delhommeau F,Abermil N,Braun

更新日期：2018-09-01 00:00:00

abstract：:The records of 637 patients with lymphoproliferative disorders and 346 patients with myeloproliferative disorders were retrospectively analysed for the presence of additional autoimmune derangements. The frequency of autoimmune perturbations in lymphoproliferative diseases (51 cases; 8.0%) was significantly higher tha...

journal_title：British journal of haematology

authors： Dührsen U,Augener W,Zwingers T,Brittinger G

更新日期：1987-10-01 00:00:00

abstract：:Systemic inflammation activates the tissue factor/factor VIIa complex (TF/FVIIa), leading to a procoagulant state, which may be enhanced by impairment of physiological anticoagulant pathways, such as the protein C system. Besides impaired protein C activation, resistance to activated protein C (APC) may occur. We stud...

journal_title：British journal of haematology

authors： de Pont AC,Bakhtiari K,Hutten BA,de Jonge E,Vlasuk GP,Rote WE,Levi M,Büller HR,Meijers JC

更新日期：2006-07-01 00:00:00

abstract：:In a retrospective study, we examined the association between cytomegalovirus (CMV) infection and non-neutropenic fever immediately following autologous peripheral blood stem cell transplantation for a variety of haematological malignancies and solid tumours. Sixty non-neutropenic febrile episodes (41 in CMV-seroposit...

journal_title：British journal of haematology

authors： Fassas AB,Bolaños-Meade J,Buddharaju LN,Rapoport A,Cottler-Fox M,Chen T,Lovchik JC,Cross A,Tricot G

更新日期：2001-01-01 00:00:00

abstract：:Twenty-one cases of acute promyelocytic leukaemia (FAB M3) demonstrating t(15,17) chromosomal translocation were studied in detail by immunocytochemical techniques using a panel of monoclonal antibodies. A characteristic myeloid phenotype of the leukaemic cells, co-expression of CD9 and CD68 antigens and absence of HL...

journal_title：British journal of haematology

authors： Erber WN,Asbahr H,Rule SA,Scott CS

更新日期：1994-09-01 00:00:00

abstract：:Platelet activating factor (PAF) derived from antigen-stimulated, IgE-sensitized rabbit basophils acts on platelets to induce aggregation and secretion of their content of granule-bound vasoactive amines. Despite this, PAF did not activate platelet factor 3. In contrast, collagen induced aggregation, secretion and PF3...

journal_title：British journal of haematology

authors： Henson PM,Landes RR

更新日期：1976-10-01 00:00:00

abstract：:Marizomib (MRZ) is an irreversible, pan-subunit proteasome inhibitor (PI) in clinical development for relapsed/refractory multiple myeloma (RRMM) and glioma. This study analysed MRZ, pomalidomide (POM) and low-dose dexamethasone (Lo-DEX) [PMD] in RRMM to evaluate safety and determine the maximum tolerated dose (MTD) a...

journal_title：British journal of haematology

authors： Spencer A,Harrison S,Zonder J,Badros A,Laubach J,Bergin K,Khot A,Zimmerman T,Chauhan D,Levin N,MacLaren A,Reich SD,Trikha M,Richardson P

更新日期：2018-01-01 00:00:00

abstract：:The peripheral blood (PB) mononuclear cells in patients with multiple myeloma (MM) have been reported to include CD34-expressing cells that are clonally related to the myeloma cells. To determine whether there were elevated levels of CD34 mRNA or whether CD34+ cells in the PB include myeloma-related cells, we develope...

journal_title：British journal of haematology

authors： Rasmussen T,Jensen L,Honoré L,Andersen H,Johnsen HE

更新日期：1999-12-01 00:00:00

abstract：:Detection of a 17p13.1 deletion (loss of TP53) or 11q22.3 deletion (loss of ATM), by fluorescence in situ hybridization (FISH), in chronic lymphocytic leukaemia (CLL) patients is associated with a poorer prognosis. Because TP53 and ATM are integral to the TP53 pathway, we hypothesized that 17p13.1- (17p-) and 11q22.3-...

journal_title：British journal of haematology

authors： Greipp PT,Smoley SA,Viswanatha DS,Frederick LS,Rabe KG,Sharma RG,Slager SL,Van Dyke DL,Shanafelt TD,Tschumper RC,Zent CS

更新日期：2013-11-01 00:00:00

abstract：:To determine the long-term efficacy of FLT3 inhibitors (FLT3i) in the salvage setting for relapsed and refractory (rel/ref) acute myeloid leukemia (AML) with FLT3 internal tandem duplication (AML FLT3-ITD), we conducted a retrospective study of 120 patients with rel/ref AML FLT3-ITD who received salvage therapy with e...

journal_title：British journal of haematology

authors： Takahashi K,Kantarjian H,Pemmaraju N,Andreeff M,Borthakur G,Faderl S,Garcia-Manero G,Pierce S,Luthra R,Cardenas-Turanzas M,Estrov Z,Ravandi F,Cortes J

更新日期：2013-06-01 00:00:00

abstract：:Peripheral T-cell lymphomas (PTCL) have suboptimal outcomes using conventional CHOP (cyclophosphamide, doxorubicin, vincristine, prednisone) chemotherapy. The anti-folate pralatrexate, the first drug approved for patients with relapsed/refractory PTCL, provided a rationale to incorporate it into the front-line setting...

journal_title：British journal of haematology

authors： Advani RH,Ansell SM,Lechowicz MJ,Beaven AW,Loberiza F,Carson KR,Evens AM,Foss F,Horwitz S,Pro B,Pinter-Brown LC,Smith SM,Shustov AR,Savage KJ,Vose JM

更新日期：2016-02-01 00:00:00

abstract：:Kinetic analysis of a single intravenous injection of 100 mg iron(III) hydroxide-sucrose complex (Venofer) mixed with 52Fe(III) hydroxide-sucrose as a tracer was followed for 3-6 h in four generally anaesthetized, artificially ventilated minipigs using positron emission tomography (PET). The amount of injected radioac...

journal_title：British journal of haematology

authors： Beshara S,Lundqvist H,Sundin J,Lubberink M,Tolmachev V,Valind S,Antoni G,Långström B,Danielson BG

更新日期：1999-02-01 00:00:00

abstract：:Post-transfusion graft-versus-host disease (PTGVHD) is one of the most severe side-effects of blood transfusion. To characterize the effector cells causing this disease, we cloned lymphocytes from a PTGVHD patient's peripheral blood. T-cell and B-cell clones were established, the origins of which were proven to be tra...

journal_title：British journal of haematology

authors： Nishimura M,Uchida S,Mitsunaga S,Tokunaga K,Tadokoro K,Juji T

更新日期：1996-03-01 00:00:00

abstract：:Mutations of the p53 tumour suppressor gene occur in 20% of chronic myeloid leukaemia (CML) patients in blastic crisis, but it is still uncertain whether this inactivation plays a role in the pathogenesis of blastic transformation or in maintaining the leukaemic proliferation in CML, as it does in several solid tumour...

journal_title：British journal of haematology

authors： Lanza F,Bi S,Moretti S,Castoldi G,Goldman JM

更新日期：1995-05-01 00:00:00

abstract：:The objective of the present study was to further disclose the autoantigenic repertoire carried by the platelet glycoprotein (GP) IIb/IIIa complex. IgG-F(ab')2 fragments were prepared from two prototype ITP patients, and their ability to block the binding of GPIIb/IIIa reactive antibodies derived from other patients w...

journal_title：British journal of haematology

authors： Hou M,Stockelberg D,Kutti J,Wadenvik H

更新日期：1995-12-01 00:00:00

abstract：:The interaction of rare Hb variants with beta(0)-thalassaemia results in a quasihomozygous state where the erythrocytes contain the variant as the only major adult Hb component. Such a situation is a unique model that enables functional studies even in the case of a neutral variant that could not be isolated from Hb A...

journal_title：British journal of haematology

authors： Vassilopoulos G,Papassotiriou I,Voskaridou E,Stamoulakatou A,Premetis E,Kister J,Marden M,Griffon N,Poyart C,Wajcman H

更新日期：1995-11-01 00:00:00

abstract：:Calcium uptake into isolated membrane vesicles from two patients with a grey platelet syndrome has been investigated. An increase in calcium transport appears in both patients when compared to controls. Determination of the kinetic parameters of the calcium transport system gave similar apparent affinity for calcium a...

journal_title：British journal of haematology

authors： Enouf J,Lebret M,Bredoux R,Levy-Toledano S,Caen JP

更新日期：1987-04-01 00:00:00

abstract：:Amiodarone has been implicated as a cause of thrombocytopenia but the responsible mechanism is unknown. We performed studies in three patients to characterize the pathogenesis of this complication. No amiodarone-dependent, platelet-reactive antibodies were identified using conventional serological techniques. However,...

journal_title：British journal of haematology

authors： Sahud MA,Caulfield M,Clarke N,Koch R,Bougie D,Aster R

更新日期：2013-10-01 00:00:00

abstract：:18F-fluoro-deoxyglucose (FDG) positron emission tomography (PET) might be a better tool than computerized tomography (CT) in predicting long-term treatment outcome in patients with relapsed chemosensitive lymphoma who are candidates for autologous stem cell transplantation (ASCT). We studied patients with recurrent or...

journal_title：British journal of haematology

authors： Schot B,van Imhoff G,Pruim J,Sluiter W,Vaalburg W,Vellenga E

更新日期：2003-10-01 00:00:00

abstract：:Bruton's tyrosine kinase (BTK) was previously demonstrated to be a mediator of oxidative stress-induced apoptosis in irradiated neoplastic B-cells and B-cell precursors. Defective BTK expression in leukaemic B-cell precursors from infants with t(4;11) acute lymphoblastic leukaemia has been associated with radiation re...

journal_title：British journal of haematology

authors： Uckun F,Ozer Z,Vassilev A

更新日期：2007-02-01 00:00:00

abstract：:The myelodysplastic syndromes (MDS) have a significant frequency of evolution into acute myeloid leukaemia (AML). Approximately 30% of MDS patients show activating mutations of the N-RAS proto-oncogene, and these patients are at increased risk of leukaemic evolution. Long-term survivors of aplastic anaemia (AA) and pa...

journal_title：British journal of haematology

authors： White JR,Josten KM,Chopra R,Tooze J,Saso R,Gordon-Smith EC,Rutherford TR

更新日期：1995-12-01 00:00:00

abstract：:A DNA-based method was developed to genotype donors for the human platelet antigens HPA-1a and -1b. Sequence-specific primers (SSP) were used in the polymerase chain reaction (PCR) which allowed the HPA-1a/1a, -1b/1b and -1a/1b genotypes to be determined by PCR alone, no second analytical stage was required. 10 donors...

journal_title：British journal of haematology

authors： Metcalfe P,Waters AH

更新日期：1993-09-01 00:00:00

abstract：:The humanized CD52 monoclonal antibody Campath-1H was used as first-line therapy in nine patients with progressive chronic lymphocytic leukaemia (CLL). Intravenous (n = 5) or subcutaneous (n = 4) injections (up to 30 mg/inj.) were given three times a week for a maximum of 18 weeks. Three patients achieved a complete r...

journal_title：British journal of haematology

authors： Osterborg A,Fassas AS,Anagnostopoulos A,Dyer MJ,Catovsky D,Mellstedt H

更新日期：1996-04-01 00:00:00