Current understanding of allergic transfusion reactions: incidence, pathogenesis, laboratory tests, prevention and treatment.

abstract：:Peripheral blood and bone marrow mononuclear cells from 10 patients with newly diagnosed Waldenström's macroglobulinaemia were analysed for the presence of leucocyte differentiation antigens using flow cytometry. Most patients had circulating intracytoplasmic-mu cells that were positive for the B-cell specific antigen...

journal_title：British journal of haematology

authors： Kucharska-Pulczynska M,Ellegaard J,Hokland P

更新日期：1987-04-01 00:00:00

abstract：:2-3-Dihydroxybenzoic acid was evaluated as a potentially useful, orally effective iron-chelating drug by performing iron balance studies in patients with beta-thalassaemia major. The administration of this substance at 25 mg/kg/d to five patients for 8 d caused an average increase in iron excretion of 4.5 mg/d. When t...

journal_title：British journal of haematology

authors： Peterson CM,Graziano JH,Grady RW,Jones RL,Vlassara HV,Canale VC,Miller DR,Cerami A

更新日期：1976-08-01 00:00:00

abstract：:The significance of serum lactate dehydrogenase (LDH) in light chain (AL) amyloidosis has not been previously explored. We studied 1019 newly diagnosed patients and correlated the elevation of LDH above the upper limit of normal (ULN) with disease characteristics and outcome. Four hundred and nine patients had an LDH ...

journal_title：British journal of haematology

authors： Muchtar E,Dispenzieri A,Lacy MQ,Buadi FK,Kapoor P,Hayman SR,Gonsalves W,Warsame R,Kourelis TV,Chakraborty R,Russell S,Lust JA,Lin Y,Go RS,Zeldenrust S,Dingli D,Leung N,Rajkumar SV,Kyle RA,Kumar SK,Gertz MA

更新日期：2017-09-01 00:00:00

abstract：:Hereditary angioedema (HAE) is a rare autosomal dominant genetic disorder clinically characterized by recurrent attacks of subcutaneous and mucosal swelling that can result in significant morbidity and even mortality. Several novel therapies introduced since 2008 have dramatically transformed the approach to managemen...

journal_title：British journal of haematology

authors： Zuraw BL,Christiansen SC

更新日期：2016-06-01 00:00:00

abstract：:We describe five adult patients with sickle cell anaemia (SS) who developed clinical, radiological and histological evidence of splenic regrowth while receiving regular blood transfusions. Five patients, all homozygous SS, range 23-34 years, were commenced on hypertransfusion therapy. Three patients were transfused be...

journal_title：British journal of haematology

authors： Campbell PJ,Olatunji PO,Ryan KE,Davies SC

更新日期：1997-01-01 00:00:00

abstract：:Relapse remains the leading cause of treatment failure in children with acute lymphoblastic leukaemia (ALL) undergoing allogeneic haematopoietic stem cell transplantation (HSCT). We retrospectively investigated the prognostic role of minimal residual disease (MRD) before and after HSCT in 119 children transplanted in ...

journal_title：British journal of haematology

authors： Lovisa F,Zecca M,Rossi B,Campeggio M,Magrin E,Giarin E,Buldini B,Songia S,Cazzaniga G,Mina T,Acquafredda G,Quarello P,Locatelli F,Fagioli F,Basso G

更新日期：2018-03-01 00:00:00

abstract：:UK National External Quality Assessment Service surveys indicate continuing problems in malaria diagnosis: inaccurate calculation of parasitaemia or failure to estimate it altogether, difficulty distinguishing Plasmodium vivax from P. ovale, reporting malaria parasites when none were present and misidentification of P...

journal_title：British journal of haematology

authors： Bailey JW,Williams J,Bain BJ,Parker-Williams J,Chiodini PL,General Haematology Task Force of the British Committee for Standards in Haematology.

更新日期：2013-12-01 00:00:00

abstract：:Idiopathic thrombotic thrombocytopenic purpura (TTP) is characterized by frequent recurrences. Effective screening for relapses will enable intervention prior to overt episodes of TTP. The present study used a modified assay to detect ADAMTS13 (a disintegrin and metalloprotease with thrombospondin type 1 motif, 13) ac...

journal_title：British journal of haematology

authors： Jin M,Casper TC,Cataland SR,Kennedy MS,Lin S,Li YJ,Wu HM

更新日期：2008-05-01 00:00:00

abstract：:A 2-year-old girl is described with severe haemophilia A (factor VIII: C < 0.01 units/ml). Both of her parents were phenotypically normal. Cytogenetic analysis on the proband demonstrated an interstitial X chromosome deletion encompassing Xq26-q28. Molecular studies with several polymorphic markers close to and within...

journal_title：British journal of haematology

authors： Windsor S,Lyng A,Taylor SA,Ewenstein BM,Neufeld EJ,Lillicrap D

更新日期：1995-08-01 00:00:00

abstract：:We report 12 years' experience with histocompatible, related donor marrow transplantation for 123 patients with acute lymphoblastic leukaemia; 104 > or = second remission. Four regimens were studied: cyclophosphamide (Cy)-+total body irradiation (TBI) (n = 35); Cy+fractionated TBI (n = 45); TBI+high-dose cytarabine (n...

journal_title：British journal of haematology

authors： Weisdorf DJ,Woods WG,Nesbit ME Jr,Uckun F,Dusenbery K,Kim T,Haake R,Thomas W,Kersey JH,Ramsay NK

更新日期：1994-01-01 00:00:00

abstract：:This study was designed to investigate the ability of long-term primary cultures of adult human hepatocytes to secrete the main haemostasis proteins. Factors II, V, VII, VIII, PIVKA-II (protein induced by vitamin K 1 absence or antagonist II), fibrinogen and antithrombin were quantified in culture medium by immunologi...

journal_title：British journal of haematology

authors： Biron-Andréani C,Bezat-Bouchahda C,Raulet E,Pichard-Garcia L,Fabre JM,Saric J,Baulieux J,Schved JF,Maurel P

更新日期：2004-06-01 00:00:00

abstract：:Patients with idiopathic anaemias associated with abnormal sideroblasts were defined according to morphologic and ferrokinetic criteria and the haematologic and biochemical effects of vitamin B6 therapy were evaluated. While all patients presented similar clinical pictures, peripheral blood changes and bone marrow abn...

journal_title：British journal of haematology

authors： Solomon LR,Hillman RS

更新日期：1979-06-01 00:00:00

abstract：:A new method of in vivo bioassay for erythropoietin (EPO) is described. This method is based on the measurement of immature reticulocytes in EPO-treated mice using an automatic microcell counter, and is simpler and more precise than the existing methods of polycythaemic mouse assay and starved rat assay. Normal mice w...

journal_title：British journal of haematology

authors： Kawamura A,Imai N,Kawaguchi T,Hayakawa T

更新日期：1991-03-01 00:00:00

abstract：:Plasma iron turnover (PIT) and ferritin synthesis in the liver and spleen were studied in rats within the first 24 h of inflammation produced by turpentine injection. Comparison of the sequential changes in PIT and ferritin synthesis showed that alterations in ferritin synthesis preceded the changes in plasma iron exc...

journal_title：British journal of haematology

authors： Konijn AM,Hershko C

更新日期：1977-09-01 00:00:00

abstract：:The myelotoxicities of three antiretroviral agents, 3'-azido-3'-deoxythymidine (AZT), carbovir (CBV) and 2',3'-didehydro-2',3'-dideoxythymidine (d4T), were evaluated in vitro with normal human and murine haematopoietic progenitor cells. These studies demonstrated that continuous AZT exposure was more inhibitory to hum...

journal_title：British journal of haematology

authors： Du DL,Volpe DA,Grieshaber CK,Murphy MJ Jr

更新日期：1992-04-01 00:00:00

abstract：:Chronic lymphocytic leukaemia/small lymphocytic lymphoma (CLL) is one of the more common forms of B cell malignancy. Although the condition has a variable clinical course, the trend is towards eventual relapse and the disease is considered incurable. Whilst the majority of the circulating CD5-positive neoplastic B cel...

journal_title：British journal of haematology

authors： Ramsay AD,Rodriguez-Justo M

更新日期：2013-07-01 00:00:00

abstract：:The primary immune response to a viral antigen (tick-borne encephalitis, TBE) has been determined in haemophiliacs. Twelve HIV-negative and four clinically asymptomatic, HIV-positive haemophiliacs as well as 16 age-matched healthy controls were included in the study. Antibody responses after TBE vaccination were compa...

journal_title：British journal of haematology

authors： Wolf HM,Pum M,Jáger R,István L,Mannhalter JW,Eibl MM

更新日期：1992-10-01 00:00:00

abstract：:Neurological emergencies are frequently catastrophic events in the course of haematological malignancies (HM) that, if not promptly recognized and treated, may lead to lethal outcomes or chronic sequelae. They may occur at any time during the disease course, but are more frequently observed following relapse. Practice...

journal_title：British journal of haematology

authors： de la Fuente MI,Alderuccio JP,Lossos IS

更新日期：2020-06-01 00:00:00

abstract：:Interferon(rIFN)-alpha, a successful therapeutic agent in the control of thrombocytosis, has been shown to suppress human megakaryopoiesis. We investigated bone marrow biopsies from 12 patients with thrombocytosis due to chronic myeloproliferative disorders. Prior to treatment as well as during rIFN-alpha-2c therapy, ...

journal_title：British journal of haematology

authors： Chott A,Gisslinger H,Thiele J,Fritz E,Linkesch W,Radaszkiewicz T,Ludwig H

更新日期：1990-01-01 00:00:00

abstract：:Culture medium was harvested after co-incubation of mononuclear cells collected and pooled from the peripheral blood of two different normal donors and was tested for colony-stimulating activity (CSA) in agar culture. With bone marrow from normal donors or peripheral blood from patients with chronic granulocytic leuka...

journal_title：British journal of haematology

authors： Hellmann A,Th'ng KH,Goldman JM

更新日期：1980-06-01 00:00:00

abstract：:The peripheral T-cell neoplasms are a biologically and clinically heterogeneous group of rare disorders that result from clonal proliferation of mature post-thymic lymphocytes. Natural killer (NK) cell neoplasms are included in this group. The World Health Organization classification of haemopoietic malignancies has d...

journal_title：British journal of haematology

authors： Dearden CE,Johnson R,Pettengell R,Devereux S,Cwynarski K,Whittaker S,McMillan A,British Committee for Standards in Haematology.

更新日期：2011-05-01 00:00:00

abstract：:A patient with apparent anaemia and thrombocytopenia caused by a monoclonal paraprotein is described. The patient's serum contained a monoclonal IgM kappa, a cryoglobulin and a cold agglutinin. The cryoglobulin, similar to the serum paraprotein, was a monoclonal IgM kappa. Serum was studied to determine the relationsh...

journal_title：British journal of haematology

authors： Pujol M,Ribera JM,Jimenez C,Ribera A,Abad E,Feliu E

更新日期：1998-03-01 00:00:00

abstract：:The spleen acts as a blood filter and lymphopoietic organ. Asplenic and hyposplenic individuals are more susceptible to serious infections caused by encapsulated bacteria but they can be protected by antibiotic prophylaxis and immunizations. Recent progress in vaccinology means prophylaxis is now successful in the vas...

journal_title：British journal of haematology

authors： Kuchar E,Miśkiewicz K,Karlikowska M

更新日期：2015-12-01 00:00:00

abstract：:We tested four negative and two positive selection methods for separation of CD34+ cells from mobilized blood cells, and analysed fold-enrichment, purity and recovery of CD34+ cells after selection procedures. The elimination of mature CD34- cells was achieved by adhesion to nylon-wool fibre (5.9 +/- 1.0 mean fold-enr...

journal_title：British journal of haematology

authors： Di Nicola M,Bregni M,Siena S,Ruffini PA,Milanesi M,Ravagnani F,Gianni AM

更新日期：1996-09-01 00:00:00

abstract：:Monoclonal antibody (mAb) drugs are desirable for the improvement of multiple myeloma (MM) treatment. In this study, we found for the first time that CD48 was highly expressed on MM plasma cells. In 22 out of 24 MM patients, CD48 was expressed on more than 90% of MM plasma cells at significantly higher levels than it ...

journal_title：British journal of haematology

authors： Hosen N,Ichihara H,Mugitani A,Aoyama Y,Fukuda Y,Kishida S,Matsuoka Y,Nakajima H,Kawakami M,Yamagami T,Fuji S,Tamaki H,Nakao T,Nishida S,Tsuboi A,Iida S,Hino M,Oka Y,Oji Y,Sugiyama H

更新日期：2012-01-01 00:00:00

abstract：:Paediatric non-Hodgkin lymphomas (pNHL) are a diverse group of malignancies characterised by nodal and/or extranodal involvement. Less common pNHL forms include those derived from mature T- and natural killer (NK) cells. Much of our current understanding of paediatric mature (non-anaplastic) T/NK-cell lymphomas with r...

journal_title：British journal of haematology

authors： Xavier AC,Suzuki R

更新日期：2019-06-01 00:00:00

abstract：:The hepatitis C virus-positive (HCV+) mixed cryoglobulinaemia (MC) is associated with haematological alterations such as monoclonal B-cell lymphocytosis or non-Hodgkin lymphomas (NHLs). Antiviral therapy for MC, based on interferon and ribavirin, has been shown to be able to eliminate the viral replication as well as ...

journal_title：British journal of haematology

authors： Pozzato G,Mazzaro C,Artemova M,Abdurakhmanov D,Grassi G,Crosato I,Mauro E,Ghersetti M,Zorat F,Bomben R,Bulian P,Gattei V

更新日期：2020-08-13 00:00:00

abstract：:We studied erythrocyte calcium levels and uptake in a group of patients with sickle haemoglobinopathies of different clinical severity in an attempt to relate these measurements to the production of irreversibly sickled cells and disease severity. Erythrocyte calcium levels were measured by atomic absorption spectrosc...

journal_title：British journal of haematology

authors： Steinberg MH,Eaton JW,Berger E,Coleman MB,Oelshlegel FJ

更新日期：1978-12-01 00:00:00

abstract：:There are considerable differences in haemopoietic activity between young children and adults on the one hand, and between adults and the elderly on the other. A fundamental unanswered question is whether these differences relate to discrete stages or are part of a continuous process. We have sought to define aspects ...

journal_title：British journal of haematology

authors： Marley SB,Lewis JL,Davidson RJ,Roberts IA,Dokal I,Goldman JM,Gordon MY

更新日期：1999-07-01 00:00:00

abstract：:New diagnostic criteria for the diagnosis of the various myelodysplastic syndromes (MDS) are proposed, and a detailed description is given of the features that may help define MDS. Five MDS are described: (1) refractory anaemia (RA), (2) RA with ring sideroblasts, (3) RA with excess of blasts (RAEB), (4) chronic myelo...

journal_title：British journal of haematology

authors： Bennett JM,Catovsky D,Daniel MT,Flandrin G,Galton DA,Gralnick HR,Sultan C

更新日期：1982-06-01 00:00:00