Erythrocyte calcium abnormalities and the clinical severity of sickling disorders.

abstract：:Minimal residual disease (MRD) assessments were performed retrospectively after allogeneic stem cell transplantation (SCT) in 32 patients (23 children and nine adults) with acute lymphoblastic leukaemia (ALL). Using immunoglobulin and T-cell receptor rearrangements as clonal markers, MRD was detected after SCT in nine...

journal_title：British journal of haematology

authors： Uzunel M,Jaksch M,Mattsson J,Ringdén O

更新日期：2003-09-01 00:00:00

abstract：:Tissue specimens from 26 cases of Hodgkin's disease (HD) and six HD-derived cell lines were analysed for tumour necrosis factor (TNF), lymphotoxin (LT), and interleukin (IL)-6 RNA transcripts by in situ hybridization, in some cases subsequent to immunohistology for CD30 antigen. LT and TNF transcripts were found in tu...

journal_title：British journal of haematology

authors： Foss HD,Herbst H,Oelmann E,Samol J,Grebe M,Blankenstein T,Matthes J,Qin ZH,Falini B,Pileri S

更新日期：1993-08-01 00:00:00

abstract：:Anti-thymocyte globulins (ATG) are currently used to prevent graft-versus-host disease in haematopoietic stem cell transplants from alternative donors and to treat and prevent acute organ rejection after transplantation. Many recent studies have demonstrated that ATG can also be beneficial in patients with myeloma, ly...

journal_title：British journal of haematology

authors： Polito L,Bortolotti M,Farini V,Pedrazzi M,Tazzari PL,Bolognesi A

更新日期：2009-12-01 00:00:00

abstract：:Primary long-term bone marrow cultures grown in 40 mM HEPES-buffered McCoy's 5A medium produced granulocyte-macrophage colony-forming units (CFU-GM) for a median of 9 weeks compared with 7 weeks with CO2/bicarbonate-buffered cultures. Reducing the medium glucose concentration (from 12.5 to 2.75 mM) extended the cultur...

journal_title：British journal of haematology

authors： Tennant GB,Truran LN,Bailey-Wood R,Burnett AK

更新日期：2000-06-01 00:00:00

abstract：:In a 2.5-month-old infant with beta-thalassaemia major, DNA analysis of the gamma-beta region revealed homozygosity for two large deletions removing the entire psi beta and beta regions including their 5' promoter regions but leaving the delta gene intact. The downstream deletion was predicted to be 7.6 kb in length e...

journal_title：British journal of haematology

authors： Oner C,Oner R,Gürgey A,Altay C

更新日期：1995-02-01 00:00:00

abstract：:The major pathways of glucose metabolism in the malaria parasite, Plasmodium falciparum, have now been elucidated, and the structures and properties of parasite-specific enzymes are presently being investigated. Little is known, however, about the enzymes catalysing monosaccharide interconversions in the parasite. In ...

journal_title：British journal of haematology

authors： Weidanz JA,Campbell P,Moore D,DeLucas LJ,Rodén L,Thompson JN,Vezza AC

更新日期：1996-12-01 00:00:00

abstract：:The level of venous thrombosis risk in women who experience spontaneous or induced pregnancy loss has previously been uncertain. However, recent data indicate that the risk of venous thrombosis in women undergoing pregnancy termination in the first trimester is increased two-fold compared to non-pregnant women but red...

journal_title：British journal of haematology

authors： Bagot CN,Pavord S,Hunt BJ,British Society of Haematology Obstetric Haematology Special Interest Group.

更新日期：2020-07-01 00:00:00

abstract：:A phase II A study was conducted to evaluate the safety and efficacy of Givinostat, a novel Histone-Deacetylases inhibitor, in patients with Polycythaemia Vera (PV, n = 12), Essential Thrombocythaemia (ET, n = 1) and Myelofibrosis (n = 16), bearing the JAK2V617F mutation. The study was approved by the local ethics com...

journal_title：British journal of haematology

authors： Rambaldi A,Dellacasa CM,Finazzi G,Carobbio A,Ferrari ML,Guglielmelli P,Gattoni E,Salmoiraghi S,Finazzi MC,Di Tollo S,D'Urzo C,Vannucchi AM,Barosi G,Barbui T

更新日期：2010-08-01 00:00:00

abstract：:Hereditary angioedema (HAE) is a rare autosomal dominant genetic disorder clinically characterized by recurrent attacks of subcutaneous and mucosal swelling that can result in significant morbidity and even mortality. Several novel therapies introduced since 2008 have dramatically transformed the approach to managemen...

journal_title：British journal of haematology

authors： Zuraw BL,Christiansen SC

更新日期：2016-06-01 00:00:00

abstract：:This study investigated the response of acute lymphoblastic leukaemia (ALL) cells to Wnt proteins. Accumulation of beta-catenin was measured by Western blotting and immunofluorescence microscopy. Reverse transcription polymerase chain reaction (RT-PCR) analysis of B-cell progenitor acute lymphoblastic leukaemia (ALL) ...

journal_title：British journal of haematology

authors： Khan NI,Bradstock KF,Bendall LJ

更新日期：2007-08-01 00:00:00

abstract：:Down syndrome (DS) children have a 10-20-fold increased risk of developing ALL or AML compared to non-DS children. An increased disomic homozygosity of the polymorphic DNA markers in the pericentromeric region of chromosome 21q (21q11) has repeatedly been found in DS patients with ANLL-M7 and DS-specific transient abn...

journal_title：British journal of haematology

authors： Cavani S,Perfumo C,Argusti A,Pierluigi M,Perroni L,Schmiegelow K,Petersen MB,Cotter FE,Strigini P,Dagna-Bricarelli F,Nizetić D

更新日期：1998-10-01 00:00:00

abstract：:Bone marrow fibrosis is known in myelomatosis and depends on the extent of plasma cell infiltration. The serum concentration of the aminoterminal propeptide of type III procollagen (PIIINP) has previously been reported to reflect fibrogenesis in the marrow in myelofibrosis. Here we followed 15 consecutive patients wit...

journal_title：British journal of haematology

authors： Taube T,Franssila K,Risteli L,Risteli J,Elomaa I

更新日期：1992-09-01 00:00:00

abstract：:Platelet and cell stimulation lead to plasma membrane remodelling, resulting in phosphatidylserine (PS) externalisation in the outer leaflet of the membrane, associated with the shedding of PS-rich microparticles (MPs), and contributes to thrombin generation by promoting the assembly of coagulation enzyme complexes. A...

journal_title：British journal of haematology

authors： Proulle V,Hugel B,Guillet B,Grunebaum L,Lambert T,Freyssinet JM,Dreyfus M

更新日期：2005-11-01 00:00:00

abstract：:We evaluated the level of MCL1 gene expression using quantitative reverse transcription polymerase chain reaction in lymph nodes of patients with non-Hodgkin lymphoma (NHL). MCL1 expression in patients in complete remission (CR) was significantly lower than in patients with progressive disease (PD, P = 0.0043). The di...

journal_title：British journal of haematology

authors： Kuramoto K,Sakai A,Shigemasa K,Takimoto Y,Asaoku H,Tsujimoto T,Oda K,Kimura A,Uesaka T,Watanabe H,Katoh O

更新日期：2002-01-01 00:00:00

abstract：:The importance of the subclassification of nodular sclerosing Hodgkin's disease (NSHD) according to the British National Lymphoma Investigation Group (BNLI) criteria, which had an independent prognostic value for 90 unselected patients diagnosed in our region in the period 1972-83, is still equivocal. Because survival...

journal_title：British journal of haematology

authors： van Spronsen DJ,Vrints LW,Hofstra G,Crommelin MA,Coebergh JW,Breed WP

更新日期：1997-02-01 00:00:00

abstract：:We report stability of a clonal immunoglobulin heavy chain (IgH) gene rearrangement in a case of childhood acute lymphoblastic leukaemia (ALL) relapsing 17 years after completion of first-line therapy. Clonal stability was shown by polymerase chain reaction amplification of the hypervariable CDRIII region of IgH gene....

journal_title：British journal of haematology

authors： Frost L,Goodeve A,Wilson G,Peake I,Barker H,Vora A

更新日期：1997-09-01 00:00:00

abstract：:Post-transfusion graft-versus-host disease (PTGVHD) is one of the most severe side-effects of blood transfusion. To characterize the effector cells causing this disease, we cloned lymphocytes from a PTGVHD patient's peripheral blood. T-cell and B-cell clones were established, the origins of which were proven to be tra...

journal_title：British journal of haematology

authors： Nishimura M,Uchida S,Mitsunaga S,Tokunaga K,Tadokoro K,Juji T

更新日期：1996-03-01 00:00:00

abstract：:The incidence, characteristics and risk factors for the development of osteonecrosis of the jaw (ONJ) were evaluated among 303 myeloma patients. Only patients who received bisphosphonates developed ONJ (28/254; 11%). Zoledronic acid produced 9.5-fold greater risk for developing ONJ than pamidronate alone (P = 0.042) a...

journal_title：British journal of haematology

authors： Zervas K,Verrou E,Teleioudis Z,Vahtsevanos K,Banti A,Mihou D,Krikelis D,Terpos E

更新日期：2006-09-01 00:00:00

abstract：:There is limited information concerning the impact of physical activity and obesity on non-Hodgkin lymphoma (NHL) prognosis. We examined the associations between pre-diagnosis physical activity and body mass index (BMI) with survival in 238 diffuse large B-cell (DLBCL) and 175 follicular lymphoma cases, with follow-up...

journal_title：British journal of haematology

authors： Boyle T,Connors JM,Gascoyne RD,Berry BR,Sehn LH,Bashash M,Spinelli JJ

更新日期：2017-08-01 00:00:00

abstract：:Measurements were made of levels of D-dimer in plasma and serum, thrombin-antithrombin complex (TAT) in plasma and fibrinogen/fibrin fragment E antigen (FgE) in serum in a normal healthy control group and in patients with a range of disorders associated with hypercoagulability. Levels were determined in 31 normal heal...

journal_title：British journal of haematology

authors： Boisclair MD,Lane DA,Wilde JT,Ireland H,Preston FE,Ofosu FA

更新日期：1990-04-01 00:00:00

abstract：:Chronic lymphocytic leukaemia/small lymphocytic lymphoma (CLL) is one of the more common forms of B cell malignancy. Although the condition has a variable clinical course, the trend is towards eventual relapse and the disease is considered incurable. Whilst the majority of the circulating CD5-positive neoplastic B cel...

journal_title：British journal of haematology

authors： Ramsay AD,Rodriguez-Justo M

更新日期：2013-07-01 00:00:00

abstract：:Using artificial receptors, it is possible to redirect the specificity of immune cells to tumour-associated antigens, which is expected to provide a useful strategy for cancer immunotherapy. Given that B-cell non-Hodgkin lymphoma (B-NHL) cells invariably express CD19 and CD38, these antigens may be suitable molecular ...

journal_title：British journal of haematology

authors： Mihara K,Yanagihara K,Takigahira M,Kitanaka A,Imai C,Bhattacharyya J,Kubo T,Takei Y,Yasunaga S,Takihara Y,Kimura A

更新日期：2010-10-01 00:00:00

abstract：:2-3-Dihydroxybenzoic acid was evaluated as a potentially useful, orally effective iron-chelating drug by performing iron balance studies in patients with beta-thalassaemia major. The administration of this substance at 25 mg/kg/d to five patients for 8 d caused an average increase in iron excretion of 4.5 mg/d. When t...

journal_title：British journal of haematology

authors： Peterson CM,Graziano JH,Grady RW,Jones RL,Vlassara HV,Canale VC,Miller DR,Cerami A

更新日期：1976-08-01 00:00:00

abstract：:Therapy with imatinib mesylate is limited by cellular resistance in chronic myeloid leukaemia (CML). Further, the limited availability of matching stem cell donors or an unfavourable risk profile for allogeneic stem cell transplantation (SCT) reduces the number of therapeutic options in a number of patients. To assess...

journal_title：British journal of haematology

authors： Kreuzer KA,Klühs C,Baskaynak G,Movassaghi K,Dörken B,le Coutre P

更新日期：2004-01-01 00:00:00

abstract：:In a 61-year-old man with glucose-6-phosphate dehydrogenase (G6PD) deficiency and poorly controlled non-insulin-dependent diabetes mellitus, an episode of acute haemolysis occurred after the administration of glyburide (glibenclamide). Erythrocyte fragmentation, with haemoglobin condensation zones next to clear zones,...

journal_title：British journal of haematology

authors： Meloni G,Meloni T

更新日期：1996-01-01 00:00:00

abstract：:The 'high and low responder phenomenon' of monocyte tissue factor (MTF) activity has been attributed to effects on monocytes by granulocytes, platelets and lipopolysaccharide (LPS). To study the possible contribution of plasma to the high and low responder phenomenon, we measured the MTF activity in isolated cryoprese...

journal_title：British journal of haematology

authors： Nijziel M,van Oerle R,van 't Veer C,van Pampus E,Lindhout T,Hamulyák K

更新日期：2001-01-01 00:00:00

abstract：:Most haemolytic disease is mediated by immunoglobulin G (IgG) antibodies and leads to red blood cell destruction outside of the circulatory system. However, rare syndromes, such as paroxysmal cold haemoglobinuria, show IgG antibodies causing intravascular destruction. Haemolysis may also occur because of immunoglobuli...

journal_title：British journal of haematology

authors： Gertz MA

更新日期：2007-08-01 00:00:00

abstract：:Chronic myeloid leukaemia invariably progresses from a drug-sensitive to a drug-resistant, aggressive acute leukaemia. The mechanisms responsible for this are unknown, although loss of p53 has been reported in approximately 25% of cases. Elevated expression of Bcr-Abl is also associated with disease progression. We ha...

journal_title：British journal of haematology

authors： Keeshan K,Cotter TG,McKenna SL

更新日期：2003-10-01 00:00:00

abstract：:We have previously shown that allogeneic bone marrow transplantation (BMT) with cryopreserved donor marrow cells can be used without prolonging the engraftment time or interfering with the reconstitution of haemopoiesis. In this report we extend our initial observations of the first 40 patients who underwent allogenei...

journal_title：British journal of haematology

authors： Stockschläder M,Hassan HT,Krog C,Krüger W,Löliger C,Horstman M,Altnöder M,Clausen J,Grimm J,Kabisch H,Zander A

更新日期：1997-02-01 00:00:00

abstract：:We conducted a study to demonstrate vincristine-induced apoptosis in vivo in peripheral blood mononuclear cells of children with newly diagnosed acute lymphoblastic leukaemia (ALL). In five children, apoptosis was detected by terminal deoxynucleotide transferase-mediated dUTP-digoxigenin nick-end labelling (TUNEL) ass...

journal_title：British journal of haematology

authors： Groninger E,de Graaf SS,Meeuwsen-de Boer GJ,Sluiter WJ,Poppema S

更新日期：2000-12-01 00:00:00