In vitro toxicity of 3'-azido-3'-deoxythymidine, carbovir and 2',3'-didehydro-2',3'-dideoxythymidine to human and murine haematopoietic progenitor cells.

abstract：:Myelodysplastic syndrome (MDS) is a common neoplasm of haematopoietic pluripotent stem cells. Although one third of MDS patients evolve to acute myeloid leukaemia (AML), little is understood about the mechanisms responsible for this progression. We have previously detected the frequent loss of heterozygosity (LOH) on ...

journal_title：British journal of haematology

authors： Mori N,Morosetti R,Mizoguchi H,Koeffler HP

更新日期：2003-07-01 00:00:00

abstract：:Bendamustine + rituximab (BR) is the current first-line standard-of-care for chronic lymphocytic leukaemia (CLL) in fit patients aged 66-70 years, whereas chlorambucil + CD20 antibody is recommended in older patients with co-morbidities. This retrospective real-world study investigated whether risk-adapted BR was safe...

journal_title：British journal of haematology

authors： Mattsson A,Sylvan SE,Asklid A,Wiggh J,Winqvist M,Lundin J,Mansouri L,Rosenquist R,Johansson H,Österborg A,Hansson L

更新日期：2020-11-01 00:00:00

abstract：:This phase 2 study (N = 116) evaluated single-agent vosaroxin, a first-in-class anticancer quinolone derivative, in patients ≥60 years of age with previously untreated unfavourable prognosis acute myeloid leukaemia. Dose regimen optimization was explored in sequential cohorts (A: 72 mg/m(2)  d 1, 8, 15; B: 72 mg/m(2) ...

journal_title：British journal of haematology

authors： Stuart RK,Cripe LD,Maris MB,Cooper MA,Stone RM,Dakhil SR,Turturro F,Stock W,Mason J,Shami PJ,Strickland SA,Costa LJ,Borthakur G,Michelson GC,Fox JA,Leavitt RD,Ravandi F

更新日期：2015-03-01 00:00:00

abstract：:Primary myelofibrosis (PMF) is a myeloproliferative neoplasm characterized by remodelling of the bone marrow, including progressive myelofibrosis and exaggerated angiogenesis. Advanced PMF frequently shows a full-blown fibre meshwork, which avoids aspiration of cells, and the expression profile of genes related to str...

journal_title：British journal of haematology

authors： Bock O,Muth M,Theophile K,Winter M,Hussein K,Büsche G,Kröger N,Kreipe H

更新日期：2009-09-01 00:00:00

abstract：:The sensitivity of populations of human granulocyte precursors to factors with colony stimulating activity (CSA) was assessed in agar culture in vitro. The mean threshold of stimulation was estimated by analysis of dose-response curves of clone growth against concentration of CSA. This method of assessment has the adv...

journal_title：British journal of haematology

authors： Francis GE,Berney JJ,Chipping PM,Hoffbrand AV

更新日期：1979-04-01 00:00:00

abstract：:CD19 and CD21 (CR2) are co-receptors found on B-cells and various B-cell lymphomas, including non-Hodgkin lymphoma. To evaluate their suitability as targets for therapy of such lymphomas using internalization-dependent antibody-drug conjugates [such as antibody-4-(N-maleimidomethyl)cyclohexane-1-carboxylate, (N2'-deac...

journal_title：British journal of haematology

authors： Ingle GS,Chan P,Elliott JM,Chang WS,Koeppen H,Stephan JP,Scales SJ

更新日期：2008-01-01 00:00:00

abstract：:Panobinostat in combination with bortezomib and dexamethasone demonstrated a significant and clinically meaningful progression-free survival benefit compared with placebo, bortezomib and dexamethasone in the phase 3 PANORAMA 1 (Panobinostat Oral in Multiple Myeloma 1) trial. Despite this benefit, patients in the panob...

journal_title：British journal of haematology

authors： San-Miguel JF,Hungria VTM,Yoon SS,Beksac M,Dimopoulos MA,Elghandour A,Jedrzejczak WW,Guenther A,Na Nakorn T,Siritanaratkul N,Schlossman RL,Hou J,Moreau P,Lonial S,Lee JH,Einsele H,Salwender H,Sopala M,Redhu S,Paul S

更新日期：2017-10-01 00:00:00

abstract：:We report two patients with acute leukaemia who received emetogenic cytotoxic drugs and were on therapeutic doses of sodium valproate for epilepsy. Neither patient reported significant nausea nor vomited at any time during the chemotherapy, at times requiring no anti-emetic treatment whatsoever. We suggest that this a...

journal_title：British journal of haematology

authors： Aiken TC,Collin RC

更新日期：1995-04-01 00:00:00

abstract：:Thrombosis occurs in 37% of children with acute lymphoblastic leukaemia (ALL) and is related to an L-asparaginase-induced acquired antithrombin (AT) deficiency. The incidence dictates the need for anticoagulant prophylaxis. Direct thrombin inhibitors (DTI) are independent of AT for effect and may thus have advantages ...

journal_title：British journal of haematology

authors： Kuhle S,Lau A,Bajzar L,Vegh P,Halton J,Cherrick I,Anderson R,Desai S,McCusker P,Wu J,Abshire T,Mahoney D,Mitchell L

更新日期：2006-09-01 00:00:00

abstract：:Langerhans cell histiocytosis (LCH) is a rare disease, affecting subjects of any age, with extremely variable clinical manifestations. Although most patients with LCH have localized disease, requiring local or even no therapy, those patients with disseminated, 'multi-system' disease require specific therapy because th...

journal_title：British journal of haematology

authors： Aricò M

更新日期：2016-06-01 00:00:00

abstract：:Therapy for a first episode of venous thromboembolism (VTE) typically includes a vitamin K antagonist, such as warfarin, for 3-6 months at an international normalized ratio (INR) of 2-3. After the cessation of warfarin therapy, unprovoked VTE is associated with a recurrence rate of 5-15% per year. Prolonging initial t...

journal_title：British journal of haematology

authors： Bauer KA

更新日期：2004-10-01 00:00:00

abstract：:Pulmonary hypertension (PH) in patients with sickle cell disease (SCD) is linked to intravascular haemolysis, impaired nitric oxide bioavailability, renal dysfunction, and early mortality. Asymmetric dimethylarginine (ADMA), an endogenous inhibitor of nitric oxide synthases (NOS), is associated with vascular disease i...

journal_title：British journal of haematology

authors： Kato GJ,Wang Z,Machado RF,Blackwelder WC,Taylor JG 6th,Hazen SL

更新日期：2009-05-01 00:00:00

abstract：:A simple rapid platelet aggregation test was used to evaluate cross-reactivity of four low molecular weight heparins and the heparinoid ORG 10172 in three patients with heparin-induced thrombocytopenia. The low molecular weight heparins cross-reacted in 11 out of 12 tests. The heparinoid ORG 10172 did not cross-react ...

journal_title：British journal of haematology

authors： Keeling DM,Richards EM,Baglin TP

更新日期：1994-02-01 00:00:00

abstract：:A novel colony stimulating factor-1 (CSF-1) binding factor present in the serum from a patient in remission from lymphoma is described. Radioimmunoassay (RIA) repeatedly failed to detect circulating levels of CSF-1 in the peripheral blood system of this patient. Molecular analysis showed a normal CSF-1 gene structure ...

journal_title：British journal of haematology

authors： Baker AH,Cachia PG,Tennant GB,Whittaker JA,White D,Stanley ER,Burnett AK,Padua RA

更新日期：1995-01-01 00:00:00

abstract：:Detection of a 17p13.1 deletion (loss of TP53) or 11q22.3 deletion (loss of ATM), by fluorescence in situ hybridization (FISH), in chronic lymphocytic leukaemia (CLL) patients is associated with a poorer prognosis. Because TP53 and ATM are integral to the TP53 pathway, we hypothesized that 17p13.1- (17p-) and 11q22.3-...

journal_title：British journal of haematology

authors： Greipp PT,Smoley SA,Viswanatha DS,Frederick LS,Rabe KG,Sharma RG,Slager SL,Van Dyke DL,Shanafelt TD,Tschumper RC,Zent CS

更新日期：2013-11-01 00:00:00

abstract：:In recent years there has been a paradigm shift in our understanding of the epidemiology and clinical features of hepatitis E virus (HEV) infection. Once classically described as an acute hepatitis associated with waterborne outbreaks in areas of poor sanitation, HEV is now recognised to be endemic in Europe and is pr...

journal_title：British journal of haematology

authors： O'Gorman J,Burke Á,O'Flaherty N

更新日期：2018-06-01 00:00:00

abstract：:137 patients with severe aplastic anaemia (SAA) were treated in Basel from 1976 to 1986. 34 underwent bone marrow transplantation (BMT) and 103 received antilymphocyte globulin (ALG) therapy. We have analysed the incidence of late haematological complications in both groups of patients. 20 patients treated with ALG de...

journal_title：British journal of haematology

authors： Tichelli A,Gratwohl A,Würsch A,Nissen C,Speck B

更新日期：1988-07-01 00:00:00

abstract：:Hepatitis B virus (HBV) reactivation of various degrees of severity, including fulminant hepatitis, may develop in 20-50% of hepatitis B virus surface antigen (HbsAg)-positive patients undergoing immunosuppressive or cytostatic treatment. Lamivudine is a nucleoside analogue that can directly suppress HBV replication. ...

journal_title：British journal of haematology

authors： Rossi G,Pelizzari A,Motta M,Puoti M

更新日期：2001-10-01 00:00:00

abstract：:Over the last few years there has been rapid and radical change in the way clinical research in the UK is funded and supported within the NHS. This has resulted from restructuring and major new investment in research infrastructure, co-ordinated through Clinical Local Research Networks (CLRNs) and equivalent organisat...

journal_title：British journal of haematology

authors： Collins PW,Baglin TP,Dang R,Evans G,Greaves M,Laffan M,Pasi KJ,Rose P,Stanworth S,Toh CH

更新日期：2010-09-01 00:00:00

abstract：:A single immunoglobulin light chain lambda was identified in the blast cells of two out of 12 patients with common acute lymphoblastic leukaemia (C-ALL) using the alkaline phosphatase/anti-alkaline phosphatase (APAAP) technique. Inhibition at the cell surface proved that the reaction was a genuine anti-lambda reaction...

journal_title：British journal of haematology

authors： Markey GM,Alexander HD,Nolan RL,Morris TC,Robertson JH

更新日期：1989-01-01 00:00:00

abstract：:This exploratory study assessed apoptosis in peripheral blood leucocytes (PBL) from β-thalassaemia patients receiving chronic transfusions and chelation therapy (deferasirox or deferoxamine) at baseline, 1, 6, and 12 months. At baseline, thalassaemic PBLs presented 50% greater levels of Bax (BAX), 75% higher caspase-3...

journal_title：British journal of haematology

authors： Walter PB,Porter J,Evans P,Kwiatkowski JL,Neufeld EJ,Coates T,Giardina PJ,Grady RW,Vichinsky E,Olivieri N,Trachtenberg F,Alberti D,Fung E,Ames B,Higa A,Harmatz P,Thalassemia Clinical Research Network.

更新日期：2013-02-01 00:00:00

abstract：:Liposome-entrapped desferrioxamine was administered to iron-over-loaded 59Fe lavelled mice. When given orally or intraperitoneally entrapment did not enhance the effect of the chelator, but given intravenously liposomal desferrioxamine doubled the 59Fe excretion for a given dose of the drug, and excretion after a sing...

journal_title：British journal of haematology

authors： Young SP,Baker E,Huehns ER

更新日期：1979-03-01 00:00:00

abstract：:Dehydrated hereditary stomatocytosis (DHSt) is an inherited haemolytic anaemia associated with increased red cell membrane permeability to Na(+) and K(+). It is increasingly recognized that a syndrome of self-limiting perinatal ascites can accompany the haemolysis. The cause of the perinatal ascites is unknown, and it...

journal_title：British journal of haematology

authors： Rees DC,Portmann B,Ball C,Mieli-Vergani G,Nicolaou A,Chetty MC,Stewart GW

更新日期：2004-07-01 00:00:00

abstract：:Granulocyte colony-stimulating factor (G-CSF)-induced alteration of phosphoprotein during differentiation of HL-60 cells was studied. From the two-dimensional gel electrophoresis analysis of phosphoproteins, a 45 kD phosphoprotein in the cytosolic fraction of DMSO-pretreated HL-60 cells was rapidly dephosphorylated by...

journal_title：British journal of haematology

authors： Yamaguchi T,Oshizawa T,Yamaguchi T,Suzuki K,Yamamoto Y,Hayakawa T

更新日期：1998-08-01 00:00:00

abstract：:We report a case of indolent B-chronic lymphocytic leukaemia (B-CLL) in a stage A patient, treated for 10 years only by theophylline for bronchial asthma. As suggested by the spontaneous apoptosis in the patient's blood (10%), theophylline at 50 micrograms/ml increased spontaneous apoptosis after 72 h in culture by a ...

journal_title：British journal of haematology

authors： Mentz F,Merle-Beral H,Ouaaz F,Binet JL

更新日期：1995-08-01 00:00:00

abstract：:We recently identified a human minor histocompatibility (H) antigen, encoded by UDP glycosyltransferase 2 family, polypeptide B17 (UGT2B17), whose immunogenicity results from differential expression in donor and recipient cells as a consequence of a homozygous deletion of the UGT2B17 gene. UGT2B17 is highly expressed ...

journal_title：British journal of haematology

authors： Terakura S,Murata M,Nishida T,Emi N,Akatsuka Y,Riddell SR,Morishima Y,Kodera Y,Naoe T

更新日期：2005-04-01 00:00:00

abstract：:Thirty-four patients with refractory multiple myeloma were treated with 4-d continuous infusions of vincristine and adriamycin in combination with 4-d pulsed high-dose dexamethasone (VAD). Of 31 evaluable patients, 16 entered a complete remission (50%) and three a partial remission (10%). No difference in response rat...

journal_title：British journal of haematology

authors： Lokhorst HM,Meuwissen OJ,Bast EJ,Dekker AW

更新日期：1989-01-01 00:00:00

abstract：:The platelets of a young man with the grey platelet syndrome were severely depleted of all seven alpha-granule proteins assayed as well as partially deficient in alpha-mannosidase and alpha-fucosidase; four other lysosomal enzymes were present in normal concentrations. Total platelet 5-hydroxytryptamine (5HT) and aden...

journal_title：British journal of haematology

authors： Srivastava PC,Powling MJ,Nokes TJ,Patrick AD,Dawes J,Hardisty RM

更新日期：1987-04-01 00:00:00

abstract：:Severe congenital neutropenia (SCN) is an inherited disorder characterized by severe neutropenia and recurrent infections from an early age, with bone marrow showing a maturational arrest of granulopoiesis at the promyelocyte stage. Since the introduction of G-CSF therapy the prognosis for affected children has improv...

journal_title：British journal of haematology

authors： Ryan M,Will AM,Testa N,Hayworth C,Darbyshire PJ

更新日期：1995-09-01 00:00:00

abstract：:In order to clarify the mechanism of the effect of erythropoietin (Epo) on the fetal haemoglobin (HbF) phenotype of peripheral erythrocytes, we studied the dose-response effect of Epo on HbF production by erythroid precursors derived from the peripheral blood of normal adult individuals and grown in a two-phase liquid...

journal_title：British journal of haematology

authors： Fibach E,Schechter AN,Noguchi CT,Rodgers GP

更新日期：1994-09-01 00:00:00