Abstract:
:A 70-year-old man from an endemic area of human T-cell lymphotropic virus type I (HTLV-I) developed rapid generalized lymphadenopathy and abdominal tumours. The white blood cell count was 198.3 x 10(9)/l with 93% lymphocytes, 66.3% of which expressed large granular lymphocytes (LGLs). Bone marrow and lymph nodes were also infiltrated by LGLs. Surface markers were positive for CD4, CD25 and HLA-DR, and negative for CD3, CD8, CD16, CD56 and CD57. A monoclonal integration of HTLV-I proviral DNA was demonstrated on these LGLs by Southern blot hybridization analysis. This fact indicates that some adult T-cell leukaemia/lymphoma may morphologically present LGL leukaemia.
journal_name
Br J Haematoljournal_title
British journal of haematologyauthors
Sakamoto Y,Kawachi Y,Uchida T,Abe T,Mori M,Setsu K,Indo Ndoi
10.1111/j.1365-2141.1994.tb04745.xsubject
Has Abstractpub_date
1994-02-01 00:00:00pages
383-5issue
2eissn
0007-1048issn
1365-2141journal_volume
86pub_type
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