Abstract:
:The incidence of alpha-thalassaemia in an Italian population has been determined by a survey of random cord bloods for the presence of Hb Bart's. 144 out of 4730 (3%) had detectable amounts of Hb Bart's. Furthermore, alpha-globin gene analysis of 100 random cord bloods showed that five out of 100 had the common type of alpha-thalassaemia caused by a single alpha-globin gene deletion (-alpha). The molecular basis of alpha-thalassaemia was also determined in a selected group of 34 newborns with detectable levels of Hb Bart's. 25 of these cases had the -alpha 3.7 deletion type of alpha-thalassaemia and nine had nondeletion types of alpha-thalassaemia in four of which the molecular defect was detectable directly by restriction enzyme analysis.
journal_name
Br J Haematoljournal_title
British journal of haematologyauthors
Velati C,Sampietro M,Biassoni M,Cappellini MD,Wainscoat JS,Higgs DR,Fiorelli Gdoi
10.1111/j.1365-2141.1986.tb07526.xsubject
Has Abstractpub_date
1986-07-01 00:00:00pages
497-501issue
3eissn
0007-1048issn
1365-2141journal_volume
63pub_type
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