In vitro suppression of erythropoiesis by bone marrow adherent cells from some patients with fungal infection.

abstract：:Severe congenital neutropenia (SCN) is an inherited disorder characterized by severe neutropenia and recurrent infections from an early age, with bone marrow showing a maturational arrest of granulopoiesis at the promyelocyte stage. Since the introduction of G-CSF therapy the prognosis for affected children has improv...

journal_title：British journal of haematology

authors： Ryan M,Will AM,Testa N,Hayworth C,Darbyshire PJ

更新日期：1995-09-01 00:00:00

abstract：:Given that donor T cells from a transplant contribute both the desired graft-versus-tumour (GVT) effect and detrimental graft-versus-host disease (GVHD), strategies to separate GVHD and GVT activity are a major clinical goal. We have previously demonstrated that in vivo administration of a recombinant (r)IL-7/HGFβ hyb...

journal_title：British journal of haematology

authors： Hu R,Liu Y,Song Y,Su M,Lu X,Rood D,Lai L

更新日期：2016-11-01 00:00:00

abstract：:Myelofibrosis is an enigmatic myeloproliferative neoplasm, despite noteworthy strides in understanding its genetic underpinnings. Driver mutations involving JAK2, CALR or MPL in 90% of patients mediate constitutive JAK-STAT signaling which, in concert with epigenetic alterations (ASXL1, DNMT3A, SRSF2, EZH2, IDH1/2 mut...

journal_title：British journal of haematology

authors： Gangat N,Tefferi A

更新日期：2020-10-01 00:00:00

abstract：:Microcirculatory disorders are a common finding in sepsis. We have analysed the influence of two factors released in sepsis, endotoxin and tumour necrosis factor (TNF), on rheological properties of blood cells. The deformability of mixed cell suspensions, isolated erythrocytes, mononuclear cells, or polymorphonuclear ...

journal_title：British journal of haematology

authors： Betticher DC,Keller H,Maly FE,Reinhart WH

更新日期：1993-01-01 00:00:00

abstract：:Diamond-Blackfan anaemia (DBA) is an inherited bone marrow failure syndrome (IBMFS) characterized by red cell aplasia. Mutations in ribosomal genes are found in more than 50% of cases. Elevated erythrocyte adenosine deaminase (eADA) was first noted in DBA in 1983. In this study we determined the value of eADA for the ...

journal_title：British journal of haematology

authors： Fargo JH,Kratz CP,Giri N,Savage SA,Wong C,Backer K,Alter BP,Glader B

更新日期：2013-02-01 00:00:00

abstract：:Low concentrations of collagen and anticardiolipin antibodies (ACLA), which were raised in rabbits by immunization with cardiolipin (CL), co-operatively activated human gel-filtrated platelets (GFP). GFP activated by adding ACLA 5 min prior to collagen (ACLA + Col) showed strong responses in cytosolic Ca2+ mobilizatio...

journal_title：British journal of haematology

authors： Wang L,Su CY,Chou KY,Wang CT

更新日期：2002-09-01 00:00:00

abstract：:Patients with idiopathic anaemias associated with abnormal sideroblasts were defined according to morphologic and ferrokinetic criteria and the haematologic and biochemical effects of vitamin B6 therapy were evaluated. While all patients presented similar clinical pictures, peripheral blood changes and bone marrow abn...

journal_title：British journal of haematology

authors： Solomon LR,Hillman RS

更新日期：1979-06-01 00:00:00

abstract：:Lenalidomide (LEN) acts directly on multiple myeloma (MM) cells by inducing cereblon-mediated degradation of interferon regulatory factor 4, Ikaros (IKZF)1 and IKZF3, transcription factors that are essential for MM cell survival. The mucin 1 (MUC1) C-terminal transmembrane subunit (MUC1-C) oncoprotein is aberrantly ex...

journal_title：British journal of haematology

authors： Yin L,Tagde A,Gali R,Tai YT,Hideshima T,Anderson K,Avigan D,Kufe D

更新日期：2017-09-01 00:00:00

abstract：:The reasons why some patients with multiple myeloma (MM) do not develop severe bone loss, or even develop sclerotic bone lesions, remain unclear. In order to answer this question at the cellular and tissue level, we evaluated the histological bone condition of 10 patients with MM who never developed lytic bone lesions...

journal_title：British journal of haematology

authors： Bataille R,Chappard D,Marcelli C,Rossi JF,Dessauw P,Baldet P,Sany J,Alexandre C

更新日期：1990-12-01 00:00:00

abstract：:Nine patients with Fanconi anaemia (FA) were conditioned for HLA-identical sibling bone marrow transplant (BMT) with reduced dose of cyclophosphamide (Cy) without radiation or antithymocyte globulin (ATG). The total dose of Cy was 140 mg/kg (n = 2) or 120 mg/kg (n = 7). The median patient age was 8 years (range 4-19)....

journal_title：British journal of haematology

authors： Flowers ME,Zanis J,Pasquini R,Deeg HJ,Ribeiro R,Longton G,Medeiros CR,Doney K,Sanders J,Bryant J

更新日期：1996-03-01 00:00:00

abstract：:The addition of radioimmunotherapy to conventional and reduced-intensity conditioning has been shown to be feasible and effective. Within an ongoing prospective phase II trial, 22 patients with advanced myeloid malignancies and a median age of 65 years (range 54-76) received anti-CD66 Rhenium radioimmunotherapy follow...

journal_title：British journal of haematology

authors： Lauter A,Strumpf A,Platzbecker U,Schetelig J,Wermke M,Radke J,Kiani A,Wunderlich G,Thiede C,Ehninger G,Kotzerke J,Bornhäuser M

更新日期：2010-03-01 00:00:00

abstract：:The arrangement of the T-cell receptor and immunoglobulin genes has been analysed in five cases of Lennert's lymphoma. All cases showed rearrangement of the gene coding for the beta chain of the T-cell receptor and a germline configuration of the immunoglobulin genes. This provides strong evidence that Lennert's lymph...

journal_title：British journal of haematology

authors： O'Connor NT,Feller AC,Wainscoat JS,Gatter KC,Pallesen G,Stein H,Lennert K,Mason DY

更新日期：1986-11-01 00:00:00

abstract：:The routine methods for estimating erythrocyte size (volume and surface area) are not generally unbiased. Using geometric models introduces a bias determined by the ways in which real red blood corpuscles depart in size and shape from the simplistic ideal. Employing haematocrit and red corpuscle count to estimate mean...

journal_title：British journal of haematology

authors： Mayhew TM,Mwamengele GL,Self TJ,Travers JP

更新日期：1994-02-01 00:00:00

abstract：:Minimal residual disease (MRD) assessments were performed retrospectively after allogeneic stem cell transplantation (SCT) in 32 patients (23 children and nine adults) with acute lymphoblastic leukaemia (ALL). Using immunoglobulin and T-cell receptor rearrangements as clonal markers, MRD was detected after SCT in nine...

journal_title：British journal of haematology

authors： Uzunel M,Jaksch M,Mattsson J,Ringdén O

更新日期：2003-09-01 00:00:00

abstract：:Recently, leukaemia-associated antigens (LAA) recognized by T lymphocytes, such as Wilm's tumour-1 (WT-1) or pathogenesis-related protein-1 (PR-1), have been identified. For immunotherapies that employ antigen peptides, either alone or pulsed on dendritic cells (DC), the expression of human leucocyte antigen (HLA) mol...

journal_title：British journal of haematology

authors： Vollmer M,Li L,Schmitt A,Greiner J,Reinhardt P,Ringhoffer M,Wiesneth M,Döhner H,Schmitt M

更新日期：2003-03-01 00:00:00

abstract：:Infections continue to be a serious problem for severely neutropenic oncology and haematopoietic progenitor cell (HPC) transplant patients. Although it is now possible to collect much larger numbers of neutrophils (PMNs) from donors stimulated with granulocyte colony-stimulating factor + corticosteroids, the efficacy ...

journal_title：British journal of haematology

authors： Strauss RG

更新日期：2012-08-01 00:00:00

abstract：:Accurate clinical staging is crucial for adequate risk-adapted treatment in Hodgkin lymphoma (HL) to prevent patients from under- or over-treatment. Within the latest German Hodgkin Study Group trial generation, diagnostic findings such as histopathology, computerized tomography imaging and clinical risk factors were ...

journal_title：British journal of haematology

authors： Bröckelmann PJ,Goergen H,Fuchs M,Kriz J,Semrau R,Baues C,Kobe C,Behringer K,Eichenauer DA,von Tresckow B,Klimm B,Halbsguth T,Wongso D,Plütschow A,Haverkamp H,Dietlein M,Eich HT,Stein H,Diehl V,Borchmann P,Engert A

更新日期：2015-11-01 00:00:00

abstract：:Flow cytometry represents an alternative method to agglutination assays for the accurate quantification of mixed field populations of erythrocytes observed after bone marrow transplantation. Murine monoclonal antibodies directed against the blood group ABH antigens were selected and processed in order to prepare ready...

journal_title：British journal of haematology

authors： Blanchard D,Bruneau V,Bernard D,Germond-Arnoult F,Gourbil A,David B,Muller JY

更新日期：1995-04-01 00:00:00

abstract：:Physiological parameters such as pH and oxygen tension probably play significant roles in the regulation of haemopoiesis in the bone marrow microenvironment, but these roles have yet to be characterized in detail. We have found that changes in culture pH (0.2 units) can cause significant changes in the culture composi...

journal_title：British journal of haematology

authors： McAdams TA,Miller WM,Papoutsakis ET

更新日期：1998-11-01 00:00:00

abstract：:Gaucher disease (GD) is an autosomal recessive inherited defect of the lysosomal enzyme glucocerebrosidase (GluCerase) that leads to glucosylceramide (GluCer) accumulation. We previously demonstrated the existence of imbalances in certain lymphocyte populations in GD patients. We now show that GluCerase-deficient mono...

journal_title：British journal of haematology

authors： Balreira A,Lacerda L,Miranda CS,Arosa FA

更新日期：2005-06-01 00:00:00

abstract：:Diagnosing central nervous system (CNS) lymphoma remains a challenge. Most patients have to undergo brain biopsy to obtain tissue for diagnosis, with associated risks of serious complications. Diagnostic markers in blood or cerebrospinal fluid (CSF) could facilitate early diagnosis with low complication rates. We perf...

journal_title：British journal of haematology

authors： van Westrhenen A,Smidt LCA,Seute T,Nierkens S,Stork ACJ,Minnema MC,Snijders TJ

更新日期：2018-08-01 00:00:00

abstract：:A mutation in factor XIII (Val34Leu) was reported to protect against venous thromboembolism. We evaluated the effect of Val34Leu on thrombotic risk in 352 factor V Leiden carriers who were first-degree relatives of 132 thrombotic propositi carrying factor V Leiden. The total observation period was 2,594 years in 92 Va...

journal_title：British journal of haematology

authors： Franco RF,Middeldorp S,Meinardi JR,van Pampus EC,Reitsma PH

更新日期：2000-10-01 00:00:00

abstract：:A 43-year-old man with chronic myeloid leukaemia underwent a second transplant with CD34+ bone marrow cells selected from his two-loci HLA-mismatched sibling after rejection of the first graft from an HLA-matched unrelated donor. By immunomagnetic positive selection, CD34+ marrow cells at 0.95 x 10(6)/kg with 97% puri...

journal_title：British journal of haematology

authors： Fujimori Y,Kanamaru A,Hashimoto N,Okamoto T,Okada M,Kawaguchi K,Mori A,Saheki K,Takatsuka H,Wada H,Takemoto Y,Kohsaki M,Imai N,Kakishita E,Nagai K

更新日期：1996-07-01 00:00:00

abstract：:Salivary gland mucosa-associated lymphoid tissue (MALT) lymphomas (SGML) are rare, as are data concerning their behaviour. We analysed clinical features at presentation, particularly the association with Sjoegren syndrome (SS) and hepatitis C virus (HCV) infection, and outcome in 33 cases of SGML diagnosed between Mar...

journal_title：British journal of haematology

authors： Ambrosetti A,Zanotti R,Pattaro C,Lenzi L,Chilosi M,Caramaschi P,Arcaini L,Pasini F,Biasi D,Orlandi E,D'Adda M,Lucioni M,Pizzolo G

更新日期：2004-07-01 00:00:00

abstract：:Very few studies have investigated the effects of exercise on the biological parameters involved in vaso-occlusive events in sickle cell anaemia (SCA). The aim of this study was to test how a mild-moderate endurance exercise modulates oxidative stress, nitric oxide bioavailability and endothelial activation in SCA pat...

journal_title：British journal of haematology

authors： Faes C,Balayssac-Siransy E,Connes P,Hivert L,Danho C,Bogui P,Martin C,Pialoux V

更新日期：2014-01-01 00:00:00

abstract：:Deregulated Hedgehog (Hh) signalling activity may be associated with a broad range of cancer types and hence has become an attractive target for therapeutic intervention. Although initial haematological interest focused on the therapeutic targeting of this pathway in chronic myeloid leukaemia), small molecule inhibito...

journal_title：British journal of haematology

authors： Khan AA,Harrison CN,McLornan DP

更新日期：2015-08-01 00:00:00

abstract：:Twelve consecutive adults with severe acute aplastic anaemia, not having a bone marrow transplantation option, were prospectively randomized to receive either cyclosporin A alone or an equivalent amount of this immunosuppressive agent in combination with antilymphocyte serum. The minimum follow-up is 36 months, with h...

journal_title：British journal of haematology

authors： Jacobs P,Wood L,Martell RW

更新日期：1985-10-01 00:00:00

abstract：:Fanconi anaemia (FA) is an autosomal recessive disease strongly predisposing to bone marrow failure and acute myeloid leukaemia (AML). Four FA genes, corresponding to complementation groups A, C, F and G, have been cloned, but the molecular functions of the corresponding proteins are unknown. The high risk of AML in F...

journal_title：British journal of haematology

authors： Xie Y,de Winter JP,Waisfisz Q,Nieuwint AW,Scheper RJ,Arwert F,Hoatlin ME,Ossenkoppele GJ,Schuurhuis GJ,Joenje H

更新日期：2000-12-01 00:00:00

abstract：:We investigated the use of a new conditioning regimen followed by allogeneic bone marrow transplantation (BMT) for treating children with acute lymphoblastic leukaemia (ALL) after relapse within 6 months of the completion of therapy. One hundred and sixteen children with acute lymphoblastic leukaemia in second or subs...

journal_title：British journal of haematology

authors： Bordigoni P,Esperou H,Souillet G,Pico J,Michel G,Lacour B,Reiffers J,Sadoun A,Rohrlich P,Jouet JP,Milpied N,Lutz P,Plouvier E,Cornu G,Vannier JP,Gandemer V,Rubie H,Gratecos N,Leverger G,Stephan JL,Boutard P,Vern

更新日期：1998-08-01 00:00:00

abstract：:Drug-related neutropenia is a common observation in AIDS patients. Haematological growth factors are therefore increasingly used in combination with myelotoxic agents to reduce the risk of infection and to improve the haematological tolerance of these regimens. We report a case of an AIDS patient with Kaposi's sarcoma...

journal_title：British journal of haematology

authors： Hermans P,Gori A,Lemone M,Franchioly P,Clumeck N

更新日期：1994-06-01 00:00:00