Is the beta thalassaemia trait of clinical importance?

abstract：:Transplantation of T- and B-cell depleted allografts from haploidentical family donors was evaluated within a prospective phase II trial in children with acute lymphoblastic leukaemia, acute myeloid leukaemia and advanced myelodysplastic syndrome (n = 46). 20 patients had active disease; 19 patients received a second ...

journal_title：British journal of haematology

authors： Lang P,Teltschik HM,Feuchtinger T,Müller I,Pfeiffer M,Schumm M,Ebinger M,Schwarze CP,Gruhn B,Schrauder A,Albert MH,Greil J,Urban C,Handgretinger R

更新日期：2014-06-01 00:00:00

abstract：:The prognostic impact of bone marrow biopsy (BMB) histology and CD34 immunoreactivity was compared with that of the more conventional parameters (the FAB diagnosis, peripheral blood values, percentage of BM blasts and some common prognostic scores) in 100 MDS patients. Statistical correlations among the cytological, h...

journal_title：British journal of haematology

authors： Oriani A,Annaloro C,Soligo D,Pozzoli E,Cortelezzi A,Lambertenghi Deliliers G

更新日期：1996-02-01 00:00:00

abstract：:The combination of interleukin (IL)-4 and IL-10 protects against blood-induced cartilage damage in vitro. It has been hypothesized that the combination of these cytokines is effective if applied early in the process of cartilage damage. The present study investigated whether a single intra-articular injection of IL-4 ...

journal_title：British journal of haematology

authors： van Meegeren ME,Roosendaal G,Coeleveld K,Nieuwenhuizen L,Mastbergen SC,Lafeber FP

更新日期：2013-02-01 00:00:00

abstract：:Platelet-derived growth factor (PDGF) is thought to play some role in the genesis of fibrosis associated with myeloproliferative disorders. In addition, transforming growth factor-beta (TGF-beta) has been confirmed to promote fibrotic process. Both PDGF and TGF-beta have been shown to cooperate with epidermal growth f...

journal_title：British journal of haematology

authors： Martyré MC,Magdelenat H,Bryckaert MC,Laine-Bidron C,Calvo F

更新日期：1991-01-01 00:00:00

abstract：:Studies of ethnic disparities in malignancies have revealed variation in clinical outcomes. In multiple myeloma (MM), previous literature has focused only on patients of Caucasian and African-American (AA) descent. We present a Surveillance Epidemiology and End Results (SEER)-based outcome analysis of MM patients from...

journal_title：British journal of haematology

authors： Ailawadhi S,Aldoss IT,Yang D,Razavi P,Cozen W,Sher T,Chanan-Khan A

更新日期：2012-07-01 00:00:00

abstract：:Sickle cell disease (SCD) is increasingly appreciated as an inflammatory condition associated with alterations in immune phenotype and function. In this cross-sectional study we performed a multiparameter analysis of 18 immune markers in 114 paediatric SCD patients divided by treatment group [those receiving hydroxycr...

journal_title：British journal of haematology

authors： Nickel RS,Osunkwo I,Garrett A,Robertson J,Archer DR,Promislow DE,Horan JT,Hendrickson JE,Kean LS

更新日期：2015-05-01 00:00:00

abstract：:Myelodysplastic syndrome (MDS) is a common neoplasm of haematopoietic pluripotent stem cells. Although one third of MDS patients evolve to acute myeloid leukaemia (AML), little is understood about the mechanisms responsible for this progression. We have previously detected the frequent loss of heterozygosity (LOH) on ...

journal_title：British journal of haematology

authors： Mori N,Morosetti R,Mizoguchi H,Koeffler HP

更新日期：2003-07-01 00:00:00

abstract：:We performed a retrospective analysis of outcome in 45 patients with multiple myeloma receiving unrelated donor stem cell transplants (UD-SCT) in the UK between 1993 and 2002; 17 received myeloablative conditioning regimens and 28 received reduced intensity conditioning (RIC) protocols. Forty patients received pretran...

journal_title：British journal of haematology

authors： Shaw BE,Peggs K,Bird JM,Cavenagh J,Hunter A,Alejandro Madrigal J,Russell NH,Sirohi B,Towlson K,Williams CD,Marks DI,Clinical Trials Committee of the British Society of Blood and Marrow Transplantation.

更新日期：2003-12-01 00:00:00

abstract：:A technique for quantitating mononuclear cells expressing E, EA(IgG), EAC receptors, immunoglobulin carrying cells and phagocytic cells in normal human venous blood is described; normal values for each of these classes of mononuclear cell are established. The effects of different methods of cell preparation have been ...

journal_title：British journal of haematology

authors： Habeshaw JA,Young GA

更新日期：1975-01-01 00:00:00

abstract：:Primary infection with Epstein-Barr virus (EBV) in childhood is usually asymptomatic, whereas infection in adolescence may result in infectious mononucleosis (IM) often followed by a fatigue syndrome. EBV latent membrane protein 1 (LMP1) is expressed in latency and in many EBV-associated tumours, including non-Hodgkin...

journal_title：British journal of haematology

authors： Marshall NA,Culligan DJ,Johnston PW,Millar C,Barker RN,Vickers MA

更新日期：2007-10-01 00:00:00

abstract：:We describe eight patients (four children and four adults) with an acute lymphoblastic leukaemia (ALL) with cytoplasmic granules or inclusions. The incidence of this variant of acute leukaemia in our whole series of patients with ALL is 1.8%. The granules or inclusions were usually positive for aspecific esterases (AN...

journal_title：British journal of haematology

authors： Cantù-Rajnoldi A,Invernizzi R,Biondi A,Banfi P,Zoia A,De Fazio P,Polli N

更新日期：1989-11-01 00:00:00

abstract：:A collaborative study on factor VIII related antigen (VIII R:Ag) has been carried out, involving 11 laboratories in the U.K. Samples of two different freeze-dried plasmas were assayed against participants' own local standards by the Laurell electroimmunoassay method. There was reasonably good agreement on the relative...

journal_title：British journal of haematology

authors： Kirkwood TB,Barrowcliffe TW

更新日期：1980-11-01 00:00:00

abstract：:Eighty-two patients with bleeding, disorders registered with our centre were screened for infection with hepatitis G virus (HGV). 80 patients were positive for hepatitis C (HCV) antibodies, 66 of whom (83%) were HCV PCR positive. 11 patients (13%) were HGV RNA-positive, a similar prevalence rate to that of other studi...

journal_title：British journal of haematology

authors： Wilde JT,Ahmed MM,Collingham KE,Skidmore SJ,Pillay D,Mutimer D

更新日期：1997-11-01 00:00:00

abstract：:The number of novel therapies for the treatment of myeloma is rapidly increasing, as are the clinical trials evaluating them in combination with other novel and established therapies. Proteasome inhibitors, immunomodulatory agents and monoclonal antibodies are the most well known and studied classes of novel agents ta...

journal_title：British journal of haematology

authors： Wallington-Beddoe CT,Sobieraj-Teague M,Kuss BJ,Pitson SM

更新日期：2018-07-01 00:00:00

abstract：:Human intravenous immunoglobulin (IVIg) and anti-D immunoglobulin preparations are used in the treatment of immune thrombocytopenic purpura (ITP). One mechanism proposed to explain their therapeutic effects in ITP patients is the induction of expression of anti-inflammatory cytokines, such as interleukin (IL)-10 or IL...

journal_title：British journal of haematology

authors： Aubin E,Lemieux R,Bazin R

更新日期：2007-03-01 00:00:00

abstract：:This study looked for clonal diversity in patients with a myeloproliferative neoplasm associated with more than one acquired genetic lesion. A tyrosine kinase mutation and a cytogenetic lesion were present in the same clone in six of seven patients. By contrast, the genetic lesions were present in separate clones in a...

journal_title：British journal of haematology

authors： Beer PA,Jones AV,Bench AJ,Goday-Fernandez A,Boyd EM,Vaghela KJ,Erber WN,Odeh B,Wright C,McMullin MF,Cullis J,Huntly BJ,Harrison CN,Cross NC,Green AR

更新日期：2009-03-01 00:00:00

abstract：:The use of immunochemotherapy has improved the outcome of follicular lymphoma (FL). Recently, complete response at 30 months (CR30) has been suggested as a surrogate for progression-free survival. This study aimed to analyse the life expectancy of FL patients according to their status at 30 months from the start of tr...

journal_title：British journal of haematology

authors： Magnano L,Alonso-Alvarez S,Alcoceba M,Rivas-Delgado A,Muntañola A,Nadeu F,Setoain X,Rodríguez S,Andrade-Campos M,Espinosa-Lara N,Rodríguez G,Sancho JM,Moreno M,Mercadal S,Carro I,Salar A,Garcia-Pallarols F,Arranz R,Ca

更新日期：2019-05-01 00:00:00

abstract：:Tissue specimens from 26 cases of Hodgkin's disease (HD) and six HD-derived cell lines were analysed for tumour necrosis factor (TNF), lymphotoxin (LT), and interleukin (IL)-6 RNA transcripts by in situ hybridization, in some cases subsequent to immunohistology for CD30 antigen. LT and TNF transcripts were found in tu...

journal_title：British journal of haematology

authors： Foss HD,Herbst H,Oelmann E,Samol J,Grebe M,Blankenstein T,Matthes J,Qin ZH,Falini B,Pileri S

更新日期：1993-08-01 00:00:00

abstract：:Clofarabine was the latest new drug to be approved, in 2004, for relapsed or refractory acute lymphoblastic leukaemia (ALL). To investigate its value in the frontline treatment of ALL we applied clofarabine 5 × 40 mg/m(2) in combination with pegylated asparaginase (PEG-ASP) 1 × 2500 iu/m(2) in high risk ALL patients a...

journal_title：British journal of haematology

authors： Escherich G,Zur Stadt U,Zimmermann M,Horstmann MA,CoALL study group.

更新日期：2013-10-01 00:00:00

abstract：:Cold agglutinin syndrome (CAS) is usually associated with IgM cold agglutinins with titres exceeding 1000 at 4 degrees C and a thermal amplitude of 30-32 degrees C. Occasionally patients are encountered who although having clinical and laboratory findings compatible with CAS do not have the characteristic serological ...

journal_title：British journal of haematology

authors： Garratty G,Petz LD,Hoops JK

更新日期：1977-04-01 00:00:00

abstract：:The 1-O-alkyl-2-O-acetyl-sn-glyceryl-3-phosphorylcholine (PAF-acether) aggregates rabbit platelets and desensitizes them to a second challenge with the same agonist but not to arachidonic acid. The desensitizing activities of 14 analogues of PAF-acether were explored with particular attention to the dose-response depe...

journal_title：British journal of haematology

authors： Keraly CL,Coëffier E,Tencé M,Borrel MC,Benveniste J

更新日期：1983-03-01 00:00:00

abstract：:The BRAF V600E mutation has recently been described in all cases of hairy cell leukaemia (HCL). We have developed and validated a rapid and sensitive high-resolution melting analysis (HRMA) assay that detects BRAF exon 15 mutations when hairy cells are as low as 5-10% in a sample. All 48 HCL patients were positive for...

journal_title：British journal of haematology

authors： Boyd EM,Bench AJ,van 't Veer MB,Wright P,Bloxham DM,Follows GA,Scott MA

更新日期：2011-12-01 00:00:00

abstract：:A simple rapid platelet aggregation test was used to evaluate cross-reactivity of four low molecular weight heparins and the heparinoid ORG 10172 in three patients with heparin-induced thrombocytopenia. The low molecular weight heparins cross-reacted in 11 out of 12 tests. The heparinoid ORG 10172 did not cross-react ...

journal_title：British journal of haematology

authors： Keeling DM,Richards EM,Baglin TP

更新日期：1994-02-01 00:00:00

abstract：:Marizomib, a natural marine product, is an irreversible proteasome inhibitor currently under investigation in relapsed-refractory multiple myeloma (RRMM) and malignant glioma. Central nervous system-multiple myeloma (CNS-MM) is a rare manifestation of extra-medullary disease with few therapeutic options, highlighting ...

journal_title：British journal of haematology

authors： Badros A,Singh Z,Dhakal B,Kwok Y,MacLaren A,Richardson P,Trikha M,Hari P

更新日期：2017-04-01 00:00:00

abstract：:About 30% of patients with severe aplastic anaemia (SAA) unresponsive to one course of immunosuppressive (IS) therapy with antithymocyte or antilymphocyte globulin can achieve complete or partial remission after a second IS treatment. Among various second-line treatments, rabbit ATG (r-ATG) could represent a safe and ...

journal_title：British journal of haematology

authors： Di Bona E,Rodeghiero F,Bruno B,Gabbas A,Foa P,Locasciulli A,Rosanelli C,Camba L,Saracco P,Lippi A,Iori AP,Porta F,De Rossi G,Comotti B,Iacopino P,Dufour C,Bacigalupo A

更新日期：1999-11-01 00:00:00

abstract：:Isoelectric focusing (IEF) in the pH range 2.5-5.0 has been used to compare the immunoreactive (ir) erythropoietin (Epo) in paired samples of serum and urine from three patients, two with idiopathic aplastic anaemia and one with paroxysmal nocturnal haemoglobinuria and also from three anaemic rats. Serum samples only ...

journal_title：British journal of haematology

authors： Tam RC,Coleman SL,Tiplady RJ,Storring PL,Cotes PM

更新日期：1991-11-01 00:00:00

abstract：:We developed a novel method for the chemical modification of cytokines with synthetic polymers to increase the therapeutic efficacy of the former in vivo. A pH-reversible amino-protective reagent, dimethylmaleic anhydride (DMMAn), was used for modification of interleukin-6 (IL-6) with polyethylene glycol (PEG). The no...

journal_title：British journal of haematology

authors： Tsunoda S,Ishikawa T,Watanabe M,Kamada H,Yamamoto Y,Tsutsumi Y,Hirano T,Mayumi T

更新日期：2001-01-01 00:00:00

abstract：:Platelet activating factor (PAF) derived from antigen-stimulated, IgE-sensitized rabbit basophils acts on platelets to induce aggregation and secretion of their content of granule-bound vasoactive amines. Despite this, PAF did not activate platelet factor 3. In contrast, collagen induced aggregation, secretion and PF3...

journal_title：British journal of haematology

authors： Henson PM,Landes RR

更新日期：1976-10-01 00:00:00

abstract：:Relapse of childhood acute lymphoblastic leukaemia (ALL) involving the eye is a rare but challenging problem. Twenty cases occurred in patients treated on the Medical Research Council United Kingdom Acute Lymphoblastic Leukaemia XI and ALL97 trials between 1991 and 2001, representing 2.2% of ALL relapses. Seventeen oc...

journal_title：British journal of haematology

authors： Somervaille TC,Hann IM,Harrison G,Eden TO,Gibson BE,Hill FG,Mitchell C,Kinsey SE,Vora AJ,Lilleyman JS,MRC Childhood Leukaemia Working Party.

更新日期：2003-04-01 00:00:00

abstract：:The odds ratio of homozygosity or heterozygosity for the TNF2 polymorphism in 575 patients with venous thromboembolism compared to controls was found to be 1.0 (95% CI 0.4-2.1) and 1.1 (95% CI 0.8-1.4) respectively. Comparing subgroups of patients and controls with the factor V Leiden mutation the odds ratio for the T...

journal_title：British journal of haematology

authors： Brown K,Luddington R,Baglin T

更新日期：1998-06-01 00:00:00