Prognostic factors and outcome for children after second central nervous system relapse of acute lymphoblastic leukaemia.

abstract：:Iron uptake and storage in peripheral blood leucocytes has been studies to test the hypothesis that the basic lesion in idiopathic haemochromatosis resides in a failure of mononuclear phagocytic cells to store iron. In seven fully treated cases of this disease there was no evidence of any abnormality in iron uptake, s...

journal_title：British journal of haematology

authors： Jacobs A,Summers MR

更新日期：1981-12-01 00:00:00

abstract：:This study analysed the outcome of 267 patients with relapse/refractory acute myeloid leukaemia (AML) who received sequential chemotherapy including fludarabine, cytarabine and amsacrine followed by reduced-intensity conditioning (RIC) and allogeneic haematopoietic stem cell transplantation (HSCT). The transplants in ...

journal_title：British journal of haematology

authors： Ringdén O,Labopin M,Schmid C,Sadeghi B,Polge E,Tischer J,Ganser A,Michallet M,Kanz L,Schwerdtfeger R,Nagler A,Mohty M,Acute Leukaemia Working Party of the EBMT.

更新日期：2017-02-01 00:00:00

abstract：:Congenital thrombotic thrombocytopenic purpura (cTTP) is a rare, recessively inherited genetic disorder with varying clinical presentation that is caused by ADAMTS13 mutations. Several studies have found limited associations between ADAMTS13 mutations and cTTP phenotype. The use of in silico tools that examine multipl...

journal_title：British journal of haematology

authors： Hing ZA,Schiller T,Wu A,Hamasaki-Katagiri N,Struble EB,Russek-Cohen E,Kimchi-Sarfaty C

更新日期：2013-03-01 00:00:00

abstract：:Selinexor, an oral Selective Inhibitor of Nuclear Export, targets Exportin 1 (XPO1, also termed CRM1). Non-clinical studies support combining selinexor with proteasome inhibitors (PIs) and corticosteroids to overcome resistance in relapsed/refractory multiple myeloma (RRMM). We conducted a phase I dose-escalation tria...

journal_title：British journal of haematology

authors： Jakubowiak AJ,Jasielec JK,Rosenbaum CA,Cole CE,Chari A,Mikhael J,Nam J,McIver A,Severson E,Stephens LA,Tinari K,Rosebeck S,Zimmerman TM,Hycner T,Turowski A,Karrison T,Zonder JA

更新日期：2019-08-01 00:00:00

abstract：:B cell receptor (BCR) signalling is an important pathway in diffuse large B cell lymphoma (DLBCL). In response to BCR triggering, normal and malignant B cells secrete the chemokines CCL3 and CCL4 to attract accessory cells to the tissue microenvironment. We measured CCL3 and CCL4 serum concentrations in 102 patients w...

journal_title：British journal of haematology

authors： Takahashi K,Sivina M,Hoellenriegel J,Oki Y,Hagemeister FB,Fayad L,Romaguera JE,Fowler N,Fanale MA,Kwak LW,Samaniego F,Neelapu S,Xiao L,Huang X,Kantarjian H,Keating MJ,Wierda W,Fu K,Chan WC,Vose JM,O'Brien S,Davi

更新日期：2015-12-01 00:00:00

abstract：:Recently, leukaemia-associated antigens (LAA) recognized by T lymphocytes, such as Wilm's tumour-1 (WT-1) or pathogenesis-related protein-1 (PR-1), have been identified. For immunotherapies that employ antigen peptides, either alone or pulsed on dendritic cells (DC), the expression of human leucocyte antigen (HLA) mol...

journal_title：British journal of haematology

authors： Vollmer M,Li L,Schmitt A,Greiner J,Reinhardt P,Ringhoffer M,Wiesneth M,Döhner H,Schmitt M

更新日期：2003-03-01 00:00:00

abstract：:Pralatrexate inhibits folic acid metabolism, and preclinical studies have shown that it is cytotoxic to multiple myeloma cells. This phase 1 study investigated the safety and efficacy of pralatrexate in combination with bortezomib in adults with relapsed or refractory multiple myeloma. A standard 3 + 3 design was used...

journal_title：British journal of haematology

authors： Dunn TJ,Dinner S,Price E,Coutré SE,Gotlib J,Hao Y,Berube C,Medeiros BC,Liedtke M

更新日期：2016-04-01 00:00:00

abstract：:Dickkopf-1 (DKK1), expressed by myeloma cells, suppresses osteoblast function and plays a key role in bone disease in multiple myeloma. BHQ880, a human neutralizing IgG1 anti-DKK1 monoclonal antibody, is being investigated for its impact on multiple myeloma-related bone disease and as an agent with potential anti-myel...

journal_title：British journal of haematology

authors： Iyer SP,Beck JT,Stewart AK,Shah J,Kelly KR,Isaacs R,Bilic S,Sen S,Munshi NC

更新日期：2014-11-01 00:00:00

abstract：:To explore the potential efficacy of l-asparaginase treatment in acute myeloid leukaemia (AML) patients, we studied the in vitro resistance of French-American-British (FAB) subtypes of childhood AML to l-asparaginase using a methyl-thiazol-tetrazolium assay. We tested leukaemic cells obtained from 177 common acute lym...

journal_title：British journal of haematology

authors： Okada S,Hongo T,Yamada S,Watanabe C,Fujii Y,Ohzeki T,Horikoshi Y,Ito T,Yazaki M,Komada Y,Tawa A

更新日期：2003-12-01 00:00:00

abstract：:The combination of bortezomib and rituximab was evaluated in patients with mantle cell lymphoma (MCL), follicular lymphoma (FL) and Waldenström macroglobulinaemia (WM), in a Phase I and later, a randomized Phase II study. In the randomized study, 42 patients with recurrent/refractory disease received either: bortezomi...

journal_title：British journal of haematology

authors： Agathocleous A,Rohatiner A,Rule S,Hunter H,Kerr JP,Neeson SM,Matthews J,Strauss S,Montoto S,Johnson P,Radford J,Lister A

更新日期：2010-11-01 00:00:00

abstract：:Myeloid-derived suppressor cells (MDSCs) are a heterogeneous population of immature myeloid cells at different stages of maturation that play a role in cancer tolerance and function as an immune-suppressive cell subpopulation. They utilize different mechanisms to block both innate and adaptive arms of anti-tumour immu...

journal_title：British journal of haematology

authors： Tadmor T,Attias D,Polliack A

更新日期：2011-06-01 00:00:00

abstract：:Metabolic tumour volume (MTV) and total lesion glycolysis (TLG) are positron-emission tomography/computed tomography (PET/CT) variables for predicting multiple myeloma's (MM) outcome. We retrospectively investigated and compared the predictive value of MTV, TLG and high-risk PET/CT variables in clinical practice in 18...

journal_title：British journal of haematology

authors： Terao T,Machida Y,Tsushima T,Miura D,Narita K,Kitadate A,Takeuchi M,Matsue K

更新日期：2020-10-01 00:00:00

abstract：:Growing evidence supports the efficacy of cord blood transplantation (CBT) to treat patients with haematological malignancies, and the number of CBTs is rapidly increasing. Herein, we review considerations regarding conditioning regimens for CBT, the impact of double unit transplantation on CBT outcomes, and data rega...

journal_title：British journal of haematology

authors： Delaney C,Gutman JA,Appelbaum FR

更新日期：2009-10-01 00:00:00

abstract：:T-cell large granular lymphocyte leukaemia (T-LGL) is a clonal disorder of T cells associated with neutropenia and anaemia. The clinical consequences are recurrent infections and transfusion dependence. The optimum treatment for severely affected patients remains to be defined. Current therapies require long-term admi...

journal_title：British journal of haematology

authors： Sternberg A,Eagleton H,Pillai N,Leyden K,Turner S,Pearson D,Littlewood T,Hatton C

更新日期：2003-02-01 00:00:00

abstract：:Pituitary tumour transforming gene (PTTG) isolated from pituitary tumour cells transforms cells in vitro and causes in vivo tumour formation. PTTG is expressed in several human tumours and cell lines. In normal adult tissues, the testis expresses abundant levels of PTTG mRNA comparable to that found in tumour cells. A...

journal_title：British journal of haematology

authors： Stoika R,Melmed S

更新日期：2002-12-01 00:00:00

abstract：:This article reviews the use of aberrant antigen expression detected by flow cytometry in the diagnosis and clinical handling of acute myeloid leukaemia (AML) and the myelodysplastic syndromes (MDS). Such aberrancies offer a valuable tool for the proper classification of these myeloid malignancies according the World ...

journal_title：British journal of haematology

authors： Ossenkoppele GJ,van de Loosdrecht AA,Schuurhuis GJ

更新日期：2011-05-01 00:00:00

abstract：:Genetic risk factors play an important role in the aetiology of vascular diseases. The insertion/deletion polymorphism (4G/5G) in the promotor region of the plasminogen activator inhibitor 1 (PAI-1) gene has been associated with an increased risk of myocardial infarction. We investigated 136 patients with minor stroke...

journal_title：British journal of haematology

authors： Endler G,Lalouschek W,Exner M,Mitterbauer G,Häring D,Mannhalter C

更新日期：2000-08-01 00:00:00

abstract：:In a 2.5-month-old infant with beta-thalassaemia major, DNA analysis of the gamma-beta region revealed homozygosity for two large deletions removing the entire psi beta and beta regions including their 5' promoter regions but leaving the delta gene intact. The downstream deletion was predicted to be 7.6 kb in length e...

journal_title：British journal of haematology

authors： Oner C,Oner R,Gürgey A,Altay C

更新日期：1995-02-01 00:00:00

abstract：:Since grey zone lymphoma (GZL) was originally included in the 2008 World Health Organization classification as a B-cell lymphoma unclassifiable with features intermediate between diffuse large B-cell lymphoma (DLBCL) and classical Hodgkin lymphoma (cHL), new biological and clinical knowledge have been learned. It is i...

journal_title：British journal of haematology

authors： Kritharis A,Pilichowska M,Evens AM

更新日期：2016-08-01 00:00:00

abstract：:Splenic lymphoma with villous lymphocytes (SLVL) is a low-grade B-cell lymphoproliferative disorder characterized by splenomegaly and circulating villous lymphocytes. The relationship between SLVL and splenic marginal zone lymphoma (SMZL), a disorder with identical splenic histology to SLVL, is not clear. Previous stu...

journal_title：British journal of haematology

authors： Gruszka-Westwood AM,Matutes E,Coignet LJ,Wotherspoon A,Catovsky D

更新日期：1999-03-01 00:00:00

abstract：:Follow-up studies of natural killer (NK) cells, NK activity and antibody dependent cellular cytotoxicity (ADCC) in the course of hairy cell leukaemia (HCL) were carried out in a series of patients affected by the disease. NK activity against K562 targets was found to be high in all the patients with non-symptomatic st...

journal_title：British journal of haematology

authors： Demeter J,Pálóczi K,Lehoczky D,Benczúr M

更新日期：1989-02-01 00:00:00

abstract：:Aspergillus fumigatus is an opportunistic filamentous fungus that is currently the most frequent cause of invasive fungal disease in immunosuppressed individuals. Recent advances in our understanding of the pathogenesis of invasive aspergillosis have highlighted the multifactorial nature of A. fumigatus virulence and ...

journal_title：British journal of haematology

authors： Ben-Ami R,Lewis RE,Kontoyiannis DP

更新日期：2010-08-01 00:00:00

abstract：:A murine monoclonal IgM erythrocyte antibody appeared to have anti-P (anti-globoside) specificity. The antibody was a relatively weak cold agglutinin, but a strong haemolysin and its reactivity with red cells was markedly enhanced by enzyme treatment. This antibody was used to study the cell and tissue distribution of...

journal_title：British journal of haematology

authors： von dem Borne AE,Bos MJ,Joustra-Maas N,Tromp JF,van't Veer MB,van Wijngaarden-du Bois R,Tetteroo PA

更新日期：1986-05-01 00:00:00

abstract：:In the present study, we aimed to identify distinct structural and numerical chromosomal aberrations in peripheral blood B cells of patients with myeloma and monoclonal gammopathy of undetermined significance (MGUS), which reflect changes thought to occur at different stages of the disease process. Peripheral blood fr...

journal_title：British journal of haematology

authors： Zojer N,Schuster-Kolbe J,Assmann I,Ackermann J,Strasser K,Hübl W,Drach J,Ludwig H

更新日期：2002-06-01 00:00:00

abstract：:To identify and treat patients at high risk of cytomegalovirus (CMV) pneumonia after bone marrow transplantation (BMT), we tested for CMV viraemia weekly, and performed broncho-alveolar lavage (BAL) on day 35 post-transplant in 63 recipients. 36 allogeneic BMT recipients were at a high risk of CMV pneumonia (25 CMV-se...

journal_title：British journal of haematology

authors： Ibrahim A,Gautier E,Roittmann S,Bourhis JH,Fajac A,Charnoz I,Terrier P,Salord JM,Tancrède C,Hayat M,Bernaudin JF,Pico JL

更新日期：1997-07-01 00:00:00

abstract：:Leukaemic stem cells (LSC) have been experimentally defined as the leukaemia-propagating population and are thought to be the cellular reservoir of relapse in acute myeloid leukaemia (AML). Therefore, LSC measurements are warranted to facilitate accurate risk stratification. Previously, we published the composition of...

journal_title：British journal of haematology

authors： Hanekamp D,Snel AN,Kelder A,Scholten WJ,Khan N,Metzner M,Irno-Consalvo M,Sugita M,de Jong A,Oude Alink S,Eidhof H,Wilhelm M,Feuring-Buske M,Slomp J,van der Velden VHJ,Sonneveld E,Guzman M,Roboz GJ,Buccisano F,Vyas P

更新日期：2020-09-01 00:00:00

abstract：:Thirty-six patients with multiple myeloma (23 PR1, nine PR2, four stable disease) were entered into a pilot study evaluating the use of CD34+-selected peripheral blood progenitor cell transplantation (PBPCT) following high-dose melphalan alone or high-dose melphalan and total body irradiation. Peripheral blood progeni...

journal_title：British journal of haematology

authors： Gupta D,Bybee A,Cooke F,Giles C,Davis JG,McDonald C,Armitage SE,McGuigan D,Lyttelton MP,Kanfer EJ,Apperley JF,Samson D

更新日期：1999-01-01 00:00:00

abstract：:Employing an immunoblotting procedure, we have identified and characterized an autoantigen carried on glycoprotein (GP) IIb in a patient with chronic idiopathic thrombocytopenic purpura (ITP), and have compared the location of the autoantigen with that of the platelet-specific alloantigen Baka. Immunoblots, using the ...

journal_title：British journal of haematology

authors： Tomiyama Y,Kurata Y,Shibata Y,Honda S,Furubayashi T,Mizutani H,Tsubakio T,Yonezawa T,Tarui S

更新日期：1989-01-01 00:00:00

abstract：:Eradication of Helicobacter pylori infection has been associated with the correction of thrombocytopenia in patients with idiopathic thrombocytopenic purpura (ITP). We have analysed the response to eradication of H. pylori in a series of 56 adult patients with chronic ITP. Forty patients had H. pylori infection (71%) ...

journal_title：British journal of haematology

authors： Jarque I,Andreu R,Llopis I,De la Rubia J,Gomis F,Senent L,Jiménez C,Martín G,Martínez JA,Sanz GF,Ponce J,Sanz MA

更新日期：2001-12-01 00:00:00

abstract：:Clonal heterogeneity in multisited or recurrent lymphoid neoplasms is a phenomenon that has been increasingly studied in recent years. However, in mucosa-associated lymphoid tissue (MALT) lymphomas it remains largely unexplored. Patients diagnosed at our institution with multisited MALT lymphoma, from January 2009 to ...

journal_title：British journal of haematology

authors： Condom M,Climent F,Fernández D,Colomer D,Lopez-Guerra M,Varela M,Carro I,Maluquer C,Mercadal S,Oliveira AC,Pané M,Matias-Guiu X,González-Barca E,Sureda A,Domingo-Domenech E

更新日期：2020-05-23 00:00:00