A case of peroxidase-positive acute leukaemia expressing only T lineage lymphoid markers.


:We report the clinical presentation and the morphological, immunophenotypic, cytogenetic and molecular genetic characteristics of a 14 1/2-year-old boy who had French-American-British (FAB) type M1 acute non-lymphocytic (ANLL) leukaemia with a common T-ALL immunological phenotype, with no myeloid associated antigen, either on the membrane or in the cytoplasm. ALL-directed induction therapy induced complete remission.


Br J Haematol


Lelong F,Chretien P,Jouault H,Bayani N,Bernaudin F,Lemerle S




Has Abstract


1994-01-01 00:00:00












  • Stage I/II follicular lymphoma: spread of bcl-2/IgH+ cells in blood and bone marrow from primary site of disease and possibility of clearance after involved field radiotherapy.

    abstract::Stage I/IIA follicular lymphoma (FL) is considered a localised disease that can be adequately treated with radiotherapy alone. Bone marrow (BM) and peripheral blood (PB) involvement in FL was investigated by polymerase chain reaction (PCR) in a series of 24 consecutive patients with histologically revised diagnosis an...

    journal_title:British journal of haematology

    pub_type: 杂志文章


    authors: Pulsoni A,Starza ID,Frattarelli N,Ghia E,Carlotti E,Cavalieri E,Matturro A,Tempera S,Rambaldi A,Foà R

    更新日期:2007-05-01 00:00:00

  • Filgrastim-induced stem cell mobilization in chronic myeloid leukaemia patients during imatinib therapy: safety, feasibility and evidence for an efficient in vivo purging.

    abstract::Therapy with imatinib mesylate is limited by cellular resistance in chronic myeloid leukaemia (CML). Further, the limited availability of matching stem cell donors or an unfavourable risk profile for allogeneic stem cell transplantation (SCT) reduces the number of therapeutic options in a number of patients. To assess...

    journal_title:British journal of haematology

    pub_type: 临床试验,杂志文章


    authors: Kreuzer KA,Klühs C,Baskaynak G,Movassaghi K,Dörken B,le Coutre P

    更新日期:2004-01-01 00:00:00

  • Allogeneic bone marrow transplantation for acute lymphoblastic leukaemia: risk factors and clinical outcome.

    abstract::We report 12 years' experience with histocompatible, related donor marrow transplantation for 123 patients with acute lymphoblastic leukaemia; 104 > or = second remission. Four regimens were studied: cyclophosphamide (Cy)-+total body irradiation (TBI) (n = 35); Cy+fractionated TBI (n = 45); TBI+high-dose cytarabine (n...

    journal_title:British journal of haematology

    pub_type: 杂志文章


    authors: Weisdorf DJ,Woods WG,Nesbit ME Jr,Uckun F,Dusenbery K,Kim T,Haake R,Thomas W,Kersey JH,Ramsay NK

    更新日期:1994-01-01 00:00:00

  • Multiple clonal MLL fusions in a patient receiving CHOP-based chemotherapy.

    abstract::MLL rearrangements were analysed in the blood of a patient receiving chemotherapy for diffuse large B-cell lymphoma using inverse polymerase chain reaction targeting exon 12, parallel sequencing and a custom algorithm design. Of thirteen MLL rearrangements detected, five were capable of generating MLL fusion genes, in...

    journal_title:British journal of haematology

    pub_type: 杂志文章


    authors: Shih SJ,Fass J,Buffalo V,Lin D,Singh SP,Diaz MO,Vaughan AT

    更新日期:2012-10-01 00:00:00

  • Circulating immune complexes involving the ABO system after platelet transfusion.

    abstract::It has been proposed that when ABO unmatched platelets are transfused circulating immune complexes (CIC) may be formed between the patient's soluble ABH antigens and the transfused antibodies. Platelets might then be destroyed by bystander mechanisms or by the binding of CIC to the Fc receptor or to C3 binding membran...

    journal_title:British journal of haematology

    pub_type: 杂志文章


    authors: Heal JM,Masel D,Rowe JM,Blumberg N

    更新日期:1993-11-01 00:00:00

  • Spontaneous complete remission and recovery of donor haemopoiesis without GVHD after relapse and apparent marrow graft rejection in poor-prognosis myelodysplastic syndrome.

    abstract::We report a patient with poor-prognosis myelodysplastic syndrome (MDS) after successful treatment of lymphoma, who was given an allogeneic BMT, engrafted and achieved complete remission, but later had a relapse of his MDS with complete disappearance of donor haemopoiesis. After two episodes of CMV pneumonia and contin...

    journal_title:British journal of haematology

    pub_type: 杂志文章


    authors: Beguin Y,Collignon J,Laurent C,Fillet G

    更新日期:1996-09-01 00:00:00

  • High numbers of clonal CD19+ cells in the peripheral blood of a patient with multiple myeloma.

    abstract::Recent studies concerning the numbers of circulating clonal B cells in patients with multiple myeloma (MM) have reported conflicting data regarding the exact levels of clonal B cells and the existence of clonal cells in the CD34 compartment. In this report we show that high numbers of clonal cells with a phenotype of ...

    journal_title:British journal of haematology

    pub_type: 杂志文章


    authors: Rasmussen T,Kastrup J,Knudsen LM,Johnsen HE

    更新日期:1999-04-01 00:00:00

  • Thrombopoietin levels in cord blood plasma and amniotic fluid in fetuses with alloimmune thrombocytopenia and healthy controls.

    abstract::To extend our knowledge of the kinetics of fetal thrombopoietin (TPO), we studied TPO levels in cord blood plasma and amniotic fluid collected from 15 fetuses considered to be at risk of fetomaternal alloimmune thrombocytopenia and also from 10 healthy controls at caesarean delivery. In the plasma of all 25 fetuses an...

    journal_title:British journal of haematology

    pub_type: 杂志文章


    authors: Sainio S,Javela K,Kekomäki R,Teramo K

    更新日期:2000-05-01 00:00:00

  • Ferritin synthesis in inflammation. I. Pathogenesis of impaired iron release.

    abstract::Plasma iron turnover (PIT) and ferritin synthesis in the liver and spleen were studied in rats within the first 24 h of inflammation produced by turpentine injection. Comparison of the sequential changes in PIT and ferritin synthesis showed that alterations in ferritin synthesis preceded the changes in plasma iron exc...

    journal_title:British journal of haematology

    pub_type: 杂志文章


    authors: Konijn AM,Hershko C

    更新日期:1977-09-01 00:00:00

  • High-dose therapy improves the bone remodelling compartment canopy coverage and bone formation in multiple myeloma.

    abstract::Bone loss in multiple myeloma (MM) is caused by an uncoupling of bone formation to resorption trigged by malignant plasma cells. Increasing evidence indicates that the bone remodelling compartment (BRC) canopy, which normally covers the remodelling sites, is important for coupled bone remodelling. Loss of this canopy ...

    journal_title:British journal of haematology

    pub_type: 杂志文章


    authors: Hinge M,Delaisse JM,Plesner T,Clasen-Linde E,Salomo M,Andersen TL

    更新日期:2015-11-01 00:00:00

  • Hypermethylation of the M27beta (DXS255) locus in chronic B-cell leukaemia.

    abstract::We have investigated the methylation status of the M27beta (DXS255) locus in 21 female patients with chronic B-cell leukaemia and in 20 normal controls. DNA was digested with Pst1 and then with the methylation sensitive enzyme HpaII and probed with the M27beta probe. Eight patients (38%) showed hypermethylation of the...

    journal_title:British journal of haematology

    pub_type: 杂志文章


    authors: Crossen PE,Morrison MJ

    更新日期:1998-01-01 00:00:00

  • Reduced intensity allogeneic stem cell transplantation for younger patients with myelofibrosis.

    abstract::Allogeneic stem cell transplantation (alloSCT) is a curative procedure for myelofibrosis. Elderly people are mainly affected, limiting the feasibility of myeloablative regimens. The introduction of reduced-intensity conditioning (RIC) made alloSCT feasible for older patients. Nevertheless, the incidence of myelofibros...

    journal_title:British journal of haematology

    pub_type: 杂志文章


    authors: Mannina D,Zabelina T,Wolschke C,Heinzelmann M,Triviai I,Christopeit M,Badbaran A,Bonmann S,von Pein UM,Janson D,Ayuk F,Kröger N

    更新日期:2019-08-01 00:00:00

  • A dose of 75 microg/kg/d of i.v. anti-D increases the platelet count more rapidly and for a longer period of time than 50 microg/kg/d in adults with immune thrombocytopenic purpura.

    abstract::Treatment with 75 microg/kg/d intravenous (i.v.) anti-D was compared with 50 microg/kg/d in a prospective randomized study of 27 RhD-positive, human immunodeficiency virus-negative, adult, acute, non-splenectomized patients with immune thrombocytopenic purpura (ITP) and platelet counts < or = 30 x 109/l. The higher do...

    journal_title:British journal of haematology

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Newman GC,Novoa MV,Fodero EM,Lesser ML,Woloski BM,Bussel JB

    更新日期:2001-03-01 00:00:00

  • The use of real-time quantitative polymerase chain reaction and comparative genomic hybridization to identify amplification of the REL gene in follicular lymphoma.

    abstract::Using comparative genomic hybridization (CGH), aberrations in DNA copy number were studied before and after transformation of follicular lymphoma to diffuse large B-cell lymphoma in six patients (15 lymph node biopsies in total). The most common and also the most discrete and intense amplification occurring in four ou...

    journal_title:British journal of haematology

    pub_type: 杂志文章


    authors: Goff LK,Neat MJ,Crawley CR,Jones L,Jones E,Lister TA,Gupta RK

    更新日期:2000-11-01 00:00:00

  • Measurement of platelet life-span in normal subjects and patients with myeloproliferative disease with indium oxine labelled platelets.

    abstract::The use of 111Indium oxine as a platelet label for the performance of platelet life-span studies has been examined. Platelet life-span in normal subjects varied between 8 X 10 and 10 X 36 d. Patients with primary thrombocythaemia had clearly reduced platelet life-span whether or not they presented with vascular occlus...

    journal_title:British journal of haematology

    pub_type: 杂志文章


    authors: Bautista AP,Buckler PW,Towler HM,Dawson AA,Bennett B

    更新日期:1984-12-01 00:00:00

  • Interleukin 2 enhances cytotoxic cell function in vitro after T-cell depleted marrow transplantation.

    abstract::After T-cell depleted marrow transplantation, there is a rapid recovery of cytotoxic effector cells, with activity against targets not susceptible to killing by 'resting' natural killer cells. These targets include Epstein-Barr virus transformed B cells and leukaemic cell lines. Activated killer cell function declines...

    journal_title:British journal of haematology

    pub_type: 杂志文章


    authors: Leger O,Drexler HG,Reittie JE,Secker-Walker L,Prentice HG,Brenner MK

    更新日期:1987-11-01 00:00:00

  • Platelets derived from fresh and cold-stored whole blood participate in clot formation in rats with acute traumatic coagulopathy.

    abstract::The in vitro haemostatic functions of fresh whole blood (FWB) are well preserved after cold storage. This study aimed to determine whether platelets derived from FWB and stored whole blood (SWB) contribute to clot formation in tissue injury after transfusion into coagulopathic rats with polytrauma/haemorrhage (T/H). T...

    journal_title:British journal of haematology

    pub_type: 杂志文章


    authors: Wu X,Darlington DN,Montgomery RK,Liu B,Keesee JD,Scherer MR,Benov A,Chen J,Cap AP

    更新日期:2017-12-01 00:00:00

  • Rapid and specific detection of clinically significant haemoglobinopathies using electrospray mass spectrometry-mass spectrometry.

    abstract::Increasing demand for population screening for the haemoglobinopathies gives rise to a requirement for high throughput systems, which allow for cost effective, rapid, sensitive and specific screening of clinically significant haemoglobins. We have developed a practical and efficient approach using tryptic digestion an...

    journal_title:British journal of haematology

    pub_type: 杂志文章


    authors: Daniel YA,Turner C,Haynes RM,Hunt BJ,Dalton RN

    更新日期:2005-08-01 00:00:00

  • Haemoglobin F levels in sudden infant deaths.

    abstract::Fetal haemoglobin levels have been measured prospectively in 135 autopsy cases of sudden, unexpected infant deaths (31 pre-term, 104 full term) using standard laboratory methods. These results have been compared with Hb F values from a normal control group of 570 living infants (145 pre-term, 425 full-term) with a pos...

    journal_title:British journal of haematology

    pub_type: 杂志文章


    authors: Fagan DG,Walker A

    更新日期:1992-10-01 00:00:00

  • The 12.6 kilobase DNA deletion in Dutch beta zero-thalassaemia.

    abstract::The Dutch beta zero-thalassaemia has few clinical symptoms in homozygotes, elevated fetal haemoglobin (4-11%) in heterozygotes, and has a DNA deletion previously estimated as 10 kb which removes the beta-globin gene (Gilman et al, 1984). A DNA fragment containing the breakpoints of the Dutch beta zero-thalassaemia del...

    journal_title:British journal of haematology

    pub_type: 杂志文章


    authors: Gilman JG

    更新日期:1987-11-01 00:00:00

  • Quantitation of subclasses of mononuclear cells in normal human blood by membrane receptor studies.

    abstract::A technique for quantitating mononuclear cells expressing E, EA(IgG), EAC receptors, immunoglobulin carrying cells and phagocytic cells in normal human venous blood is described; normal values for each of these classes of mononuclear cell are established. The effects of different methods of cell preparation have been ...

    journal_title:British journal of haematology

    pub_type: 杂志文章


    authors: Habeshaw JA,Young GA

    更新日期:1975-01-01 00:00:00

  • The TEL-AML1 real-time quantitative polymerase chain reaction (PCR) might replace the antigen receptor-based genomic PCR in clinical minimal residual disease studies in children with acute lymphoblastic leukaemia.

    abstract::Prospective studies in children with B-precursor acute lymphoblastic leukaemia (ALL) have shown that polymerase chain reaction (PCR)-based detection of minimal residual disease (MRD) using immunoglobin (Ig) and T-cell receptor (TCR) gene rearrangements as targets can be used to identify patients with a high relapse ri...

    journal_title:British journal of haematology

    pub_type: 杂志文章


    authors: de Haas V,Breunis WB,Dee R,Verhagen OJ,Kroes W,van Wering ER,van Dongen JJ,van den Berg H,van der Schoot CE

    更新日期:2002-01-01 00:00:00

  • Investigation and management of a raised serum ferritin.

    abstract::Serum ferritin level is one of the most commonly requested investigations in both primary and secondary care. Whilst low serum ferritin levels invariably indicate reduced iron stores, raised serum ferritin levels can be due to multiple different aetiologies, including iron overload, inflammation, liver or renal diseas...

    journal_title:British journal of haematology

    pub_type: 信件,评审


    authors: Cullis JO,Fitzsimons EJ,Griffiths WJ,Tsochatzis E,Thomas DW,British Society for Haematology.

    更新日期:2018-05-01 00:00:00

  • Hb Arta [beta 45 (CD4) Phe-->Cys]: a new unstable haemoglobin with reduced oxygen affinity in trans with beta-thalassaemia.

    abstract::The interaction of rare Hb variants with beta(0)-thalassaemia results in a quasihomozygous state where the erythrocytes contain the variant as the only major adult Hb component. Such a situation is a unique model that enables functional studies even in the case of a neutral variant that could not be isolated from Hb A...

    journal_title:British journal of haematology

    pub_type: 杂志文章


    authors: Vassilopoulos G,Papassotiriou I,Voskaridou E,Stamoulakatou A,Premetis E,Kister J,Marden M,Griffon N,Poyart C,Wajcman H

    更新日期:1995-11-01 00:00:00

  • Cardiac morbidity in advanced chronic myelogenous leukaemia patients treated by successive allogeneic stem cell transplantation with busulphan/cyclophosphamide conditioning after imatinib mesylate administration.

    abstract::Imatinib mesylate is useful for facilitating allogeneic stem cell transplantation (allo-SCT) in advanced-phase chronic myelogenous leukaemia (AP-CML) patients. However, although the side-effects of imatinib are usually minor, cardiac morbidity can develop as a latent adverse effect post SCT when a myeloablative SCT is...

    journal_title:British journal of haematology

    pub_type: 杂志文章


    authors: Sohn SK,Kim JG,Kim DH,Lee KB

    更新日期:2003-05-01 00:00:00

  • Outcome disparities in multiple myeloma: a SEER-based comparative analysis of ethnic subgroups.

    abstract::Studies of ethnic disparities in malignancies have revealed variation in clinical outcomes. In multiple myeloma (MM), previous literature has focused only on patients of Caucasian and African-American (AA) descent. We present a Surveillance Epidemiology and End Results (SEER)-based outcome analysis of MM patients from...

    journal_title:British journal of haematology

    pub_type: 杂志文章


    authors: Ailawadhi S,Aldoss IT,Yang D,Razavi P,Cozen W,Sher T,Chanan-Khan A

    更新日期:2012-07-01 00:00:00

  • Phase II study of bendamustine, bortezomib and dexamethasone (BBD) in the first-line treatment of patients with multiple myeloma who are not candidates for high dose chemotherapy.

    abstract::The combination of bendamustine, bortezomib and dexamethasone (BBD) was evaluated as a first-line therapy for multiple myeloma. The original treatment regimen of bendamustine 80 mg/m2 , days 1, 4; bortezomib 1·3 mg/m2 , days 1, 4, 8, 11; dexamethasone 40 mg, days 1, 2, 3, 4 on a 28-day cycle (up to 8 cycles) was effic...

    journal_title:British journal of haematology

    pub_type: 杂志文章,多中心研究


    authors: Berdeja JG,Bauer T,Arrowsmith E,Essell J,Murphy P,Reeves JA Jr,Boccia RV,Donnellan W,Flinn I

    更新日期:2017-04-01 00:00:00

  • Resistance to proteasome inhibitors and other targeted therapies in myeloma.

    abstract::The number of novel therapies for the treatment of myeloma is rapidly increasing, as are the clinical trials evaluating them in combination with other novel and established therapies. Proteasome inhibitors, immunomodulatory agents and monoclonal antibodies are the most well known and studied classes of novel agents ta...

    journal_title:British journal of haematology

    pub_type: 杂志文章,评审


    authors: Wallington-Beddoe CT,Sobieraj-Teague M,Kuss BJ,Pitson SM

    更新日期:2018-07-01 00:00:00

  • The use of IgH fingerprinting and ASO-dependent PCR for the investigation of residual disease (MRD) in ALL.

    abstract::In acute lymphoblastic leukaemia (ALL), investigation of minimal residual disease by conventional morphology and immunology fails to detect levels of residual disease of < 1 leukaemic in 10-100 normal cells. The use of polymerase chain reaction (PCR) to exploit the diversity of the complementarity determining region (...

    journal_title:British journal of haematology

    pub_type: 临床试验,杂志文章


    authors: Chim JC,Coyle LA,Yaxley JC,Cole-Sinclair MF,Cannell PK,Hoffbrand VA,Foroni L

    更新日期:1996-01-01 00:00:00

  • Thirteen novel mutations in the factor VIII gene in the Nijmegen haemophilia A patient population.

    abstract::The development of neutralising antibodies to factor VIII (FVIII) is a major complication of haemophilia A (HA) therapy. We aimed to construct an individual risk profile for the development of inhibitors in HA and started by screening for the causative mutation in our HA patient population. A total of 109 patients and...

    journal_title:British journal of haematology

    pub_type: 杂志文章


    authors: Boekhorst J,Verbruggen B,Lavergne JM,Costa JM,Schoormans SC,Brons PP,van Kraaij MG,Nováková IR,van Heerde WL

    更新日期:2005-10-01 00:00:00