Abstract:
:In this study we have carried out haplotype analysis at the beta-globin gene cluster and defined the beta-thalassaemia mutations in a large Sardinian family, ascertained through a proband with thalassaemia major, in which several members were carriers of a beta-thalassaemia allele characterized by microcytosis, hypochromia and normal Hb A2 levels (type 2 normal Hb A2 heterozygous beta-thalassemia). The proband was a compound heterozygote for the beta zero 39 and the beta + IVS-2, nt 745 mutations and all the beta-thalassaemia heterozygotes with normal Hb A2 showed the beta + IVS-2, nt 745 mutation, always associated with haplotype VII. Because of the consistent association of a specific beta-thalassaemia mutation and normal Hb A2 levels, we postulate that this beta-thalassaemia chromosome carries a delta gene (delta-thalassaemia) which is unable to increase the delta-globin output in response to beta-thalassaemia.
journal_name
Br J Haematoljournal_title
British journal of haematologyauthors
Oggiano L,Pirastu M,Moi P,Longinotti M,Perseu L,Cao Adoi
10.1111/j.1365-2141.1987.tb02331.xsubject
Has Abstractpub_date
1987-10-01 00:00:00pages
225-9issue
2eissn
0007-1048issn
1365-2141journal_volume
67pub_type
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journal_title:British journal of haematology
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