Significant amount of hepatocyte growth factor detected in blood and bone marrow plasma of leukaemia patients.


:Hepatocyte growth factor (HGF) has been known as a versatile functional molecule, and as being involved in the colony formation of haemopoietic progenitor cells. Clinically, an elevated HGF level in the blood has been associated with liver diseases such as fulminant hepatic failure and acute hepatitis. We have found a high level of HGF in blood and bone marrow plasma from patients with various types of leukaemia and lymphoma. In particular, 21/31 acute myeloblastic leukaemia (AML) patients showed a significant level of HGF (> 0.40 ng/ml) in their blood or bone marrow plasma. The mean value of HGF in the plasma of AML patients was 2.03 ng/ml, which was higher than that in the serum of patients with acute hepatitis. This demonstrates, for the first time, evidence of frequent association of increased levels of HGF in non-lymphocytic leukaemias, though its significance in the disease remains unknown.


Br J Haematol


Nakamura S,Gohda E,Matsuo Y,Yamamoto I,Minowada J




Has Abstract


1994-07-01 00:00:00












  • H2-mismatched transplantation with repetitive cell infusions and CD40 ligand antibody infusions without myeloablation.

    abstract::Graft rejection and graft-versus-host disease are major problems in mismatched marrow transplants along with toxicity from standard myeloablative host treatments. We have established a tolerization model, using 1 Gy irradiation, which reduces stem cell capacity to < 10% of control while causing minimal myelosuppressio...

    journal_title:British journal of haematology

    pub_type: 杂志文章


    authors: Lambert JF,Colvin GA,Zhong S,Wang H,D'Hondt L,Abedi M,Frimberger AE,Stewart FM,Quesenberry PJ

    更新日期:2002-10-01 00:00:00

  • Minimal residual disease directed therapy for childhood acute myeloid leukaemia: the time is now.

    abstract::The continued improvement in the prognosis of childhood acute myeloid leukaemia (AML) has been paralleled by the use of increasingly intensive therapy. This has led to attempts to develop risk-directed strategies in which the most intensive treatment is reserved for those at highest risk of relapse. Unfortunately, cur...

    journal_title:British journal of haematology

    pub_type: 杂志文章


    authors: Goulden N,Virgo P,Grimwade D

    更新日期:2006-08-01 00:00:00

  • A recurrent frameshift mutation of the ankyrin gene associated with severe hereditary spherocytosis.

    abstract::During a survey of typical, dominant hereditary spherocytosis (HS) patients, we identified a frameshift mutation of the ankyrin gene in three unrelated probands. All three probands, who were from different ethnic backgrounds, suffered from severe HS requiring splenectomy. Analysis of both intragenic and flanking polym...

    journal_title:British journal of haematology

    pub_type: 杂志文章


    authors: Gallagher PG,Ferreira JD,Costa FF,Saad ST,Forget BG

    更新日期:2000-12-01 00:00:00

  • A novel simultaneous clot-fibrinolysis waveform analysis for assessing fibrin formation and clot lysis in haemorrhagic disorders.

    abstract::Simultaneous evaluation of coagulation and fibrinolysis facilitates an overall understanding of normal and pathological haemostasis. We established an assay for assessing clot formation and fibrinolysis simultaneously using clot waveform analysis by the trigger of a mixture of activated partial thromboplastin time rea...

    journal_title:British journal of haematology

    pub_type: 杂志文章


    authors: Nogami K,Matsumoto T,Sasai K,Ogiwara K,Arai N,Shima M

    更新日期:2019-11-01 00:00:00

  • Marizomib for central nervous system-multiple myeloma.

    abstract::Marizomib, a natural marine product, is an irreversible proteasome inhibitor currently under investigation in relapsed-refractory multiple myeloma (RRMM) and malignant glioma. Central nervous system-multiple myeloma (CNS-MM) is a rare manifestation of extra-medullary disease with few therapeutic options, highlighting ...

    journal_title:British journal of haematology

    pub_type: 杂志文章


    authors: Badros A,Singh Z,Dhakal B,Kwok Y,MacLaren A,Richardson P,Trikha M,Hari P

    更新日期:2017-04-01 00:00:00

  • The C677T MTHFR gene mutation is not predictive of risk for recurrent fetal loss.

    abstract::We have investigated the potency of the C677T mutation in the methylene tetrahydrofolate reductase (MTHFR) gene as a genetic risk factor in women with a history of early (12 weeks gestation) recurrent miscarriage (three or more consecutive pregnancy losses). Fifty-seven of the tota...

    journal_title:British journal of haematology

    pub_type: 杂志文章


    authors: Holmes ZR,Regan L,Chilcott I,Cohen H

    更新日期:1999-04-01 00:00:00

  • Genetic susceptibility, smoking, obesity and risk of venous thromboembolism.

    abstract::The F5 G1691A (Factor V Leiden) and F2 G20210A (prothrombin) mutations are linked to an increase in the incidence rate of venous thromboembolism (VTE), but their effects are highly variable. We investigated whether the effects of smoking and obesity might explain this variability. In a case-cohort study including the ...

    journal_title:British journal of haematology

    pub_type: 杂志文章


    authors: Severinsen MT,Overvad K,Johnsen SP,Dethlefsen C,Madsen PH,Tjønneland A,Kristensen SR

    更新日期:2010-04-01 00:00:00

  • Generation of a conditionally immortalized myeloid progenitor cell line requiring the presence of both interleukin-3 and stem cell factor to survive and proliferate.

    abstract::The H-2Kappab temperature-sensitive (ts) A58 transgenic (Immorto) mouse has been used previously to generate conditionally immortalized cells from a number of tissues. The present study aimed to investigate characteristics of primitive myeloid precursor cells derived from H-2Kappab-tsA58 bone marrow. Cell populations ...

    journal_title:British journal of haematology

    pub_type: 杂志文章


    authors: Lee C,Evans CA,Spooncer E,Pierce A,Mottram R,Whetton AD

    更新日期:2003-09-01 00:00:00

  • Auto-anti-Jka in Evans' syndrome with negative direct antiglobulin test.

    abstract::A patient presented with haemolytic anaemia and a negative direct antiglobulin test (DAT), and was found to have an IgG antibody with anti-Jka specificity in his serum. His red cells were typed as Jk(a-b+). Later he developed idiopathic thrombocytopenic purpura (ITP), and had a positive DAT due to anti-Jka bound to hi...

    journal_title:British journal of haematology

    pub_type: 杂志文章


    authors: Ganly PS,Laffan MA,Owen I,Hows JM

    更新日期:1988-08-01 00:00:00

  • Simultaneous SIL-TAL1 RT-PCR detection of all tal(d) deletions and identification of novel tal(d) variants.

    abstract::Site-specific deletions of the 5' part of the TAL1 gene (tal(d)) are among the most frequent non-random genetic abnormalities in T-cell acute lymphoblastic leukaemia (T-ALL). They are usually detected by PCR from DNA with several primer pairs or by Southern blot analysis. Since tal(d) lead to expression of a SIL-TAL1 ...

    journal_title:British journal of haematology

    pub_type: 杂志文章


    authors: Delabesse E,Bernard M,Landman-Parker J,Davi F,Leboeuf D,Varet B,Valensi F,Macintyre EA

    更新日期:1997-12-01 00:00:00

  • Immunodeficiency and IL-6 production by peripheral blood monocytes in multicentric Castleman's disease.

    abstract::To study the pathogenesis of multicentric Castleman's disease (MCD), IL-6 producing cells and immune function were investigated in four MCD patients. The expression of IL-6 mRNA in one MCD lymph node was analysed by in situ hybridization. IL-6 mRNA expressing cells were scattered in the interfollicular areas and did n...

    journal_title:British journal of haematology

    pub_type: 杂志文章


    authors: Ishiyama T,Nakamura S,Akimoto Y,Koike M,Tomoyasu S,Tsuruoka N,Murata Y,Sato T,Wakabayashi Y,Chiba S

    更新日期:1994-03-01 00:00:00

  • Expression and function of pituitary tumour transforming gene for T-lymphocyte activation.

    abstract::Pituitary tumour transforming gene (PTTG) isolated from pituitary tumour cells transforms cells in vitro and causes in vivo tumour formation. PTTG is expressed in several human tumours and cell lines. In normal adult tissues, the testis expresses abundant levels of PTTG mRNA comparable to that found in tumour cells. A...

    journal_title:British journal of haematology

    pub_type: 杂志文章


    authors: Stoika R,Melmed S

    更新日期:2002-12-01 00:00:00

  • High serum levels of M-CSF and G-CSF in Kawasaki disease.

    abstract::To examine any role of macrophage colony-stimulating factor (M-CSF), in the immune responses in Kawasaki disease (KD), we serially assayed M-CSF and several related cytokines using ELISA. In 10 paediatric patients with KD the level of M-CSF was significantly higher in the acute phase than in the convalescent phase (14...

    journal_title:British journal of haematology

    pub_type: 杂志文章


    authors: Igarashi H,Hatake K,Tomizuka H,Yamada M,Gunji Y,Momoi MY

    更新日期:1999-06-01 00:00:00

  • Histopathology, cell proliferation indices and clinical outcome in 304 patients with mantle cell lymphoma (MCL): a clinicopathological study from the European MCL Network.

    abstract::Mantle cell lymphoma (MCL) is a distinct lymphoma subtype with a particularly poor clinical outcome. The clinical relevance of the morphological characteristics of these tumours remains uncertain. The European MCL Network reviewed 304 cases of MCL to determine the prognostic significance of histopathological character...

    journal_title:British journal of haematology

    pub_type: 杂志文章,多中心研究


    authors: Tiemann M,Schrader C,Klapper W,Dreyling MH,Campo E,Norton A,Berger F,Kluin P,Ott G,Pileri S,Pedrinis E,Feller AC,Merz H,Janssen D,Hansmann ML,Krieken H,Möller P,Stein H,Unterhalt M,Hiddemann W,Parwaresch R,Europ

    更新日期:2005-10-01 00:00:00

  • Short Report: Engraftment of T-cell-depleted allogeneic haematopoietic stem cells using a reduced intensity conditioning regimen.

    abstract::Graft-versus-host disease (GVHD) remains a significant complication in patients undergoing allogeneic stem cell transplantation (SCT) using a reduced intensity conditioning regimen. Although T-cell depletion (TCD) reduces the risk of GVHD after a myeloablative conditioning regimen, it is associated with an increased r...

    journal_title:British journal of haematology

    pub_type: 杂志文章


    authors: Craddock C,Bardy P,Kreiter S,Johnston R,Apperley J,Marks D,Huber C,Kolbe K,Goulding R,Lawler M,Goldman J,Hughes T,Derigs G

    更新日期:2000-12-01 00:00:00

  • CD34+ cell immunoselection from G-CSF-alone-primed peripheral blood in children with low body mass.

    abstract::We report the data of CD34+ cell immunoselection from peripheral blood after G-CSF-alone mobilization (10 micrograms/kg/d s.c.) in nine children with neuroblastoma (median age 4-5 years (2-8), median body weight 16 kg (10-20). Leukaphereses were carried out on a Cobe Spectra separator and two consecutive harvests (4 b...

    journal_title:British journal of haematology

    pub_type: 杂志文章


    authors: Kanold J,Berger M,Rapatel C,de Lumley L,Lutz P,Plantaz D,Vannier JP,Bergeron C,Mechinaud F,Favrot M

    更新日期:1995-10-01 00:00:00

  • European Concerted Action on Anticoagulation (ECAA): multicentre international sensitivity index calibration of two types of point-of-care prothrombin time monitor systems.

    abstract::A multicentre modified World Health Organization (WHO)-type international sensitivity index (ISI) calibration has been performed at 10 European Concerted Action on Anticoagulation (ECAA) national laboratories using non-citrated whole-blood on two point-of-care test (POCT) prothrombin time (PT) monitor systems, CoaguCh...

    journal_title:British journal of haematology

    pub_type: 杂志文章,多中心研究


    authors: Poller L,Keown M,Chauhan N,van Den Besselaar AM,Tripodi A,Jespersen J,Shiach C,Horellou MH,Dias D,Egberg N,Iriarte JA,Kontopoulou-Griva I,Otridge B

    更新日期:2002-03-01 00:00:00

  • Comparison of five biochemical markers of bone resorption in multiple myeloma: elevated pre-treatment levels of S-ICTP and U-Ntx are predictive for early progression of the bone disease during standard chemotherapy.

    abstract::Increased osteoclastic bone resorption is the major causal factor of bone disease in multiple myeloma. Recently, non-invasive methods have been developed for the estimation of bone resorptive activity. To evaluate the biological sensitivity and clinical usefulness of five biochemical assays for measuring the C-termina...

    journal_title:British journal of haematology

    pub_type: 杂志文章


    authors: Abildgaard N,Brixen K,Kristensen JE,Eriksen EF,Nielsen JL,Heickendorff L

    更新日期:2003-01-01 00:00:00

  • Mutation at position -12 of intron 45 (c-->t) plays a prevalent role in the partial skipping of exon 46 from the transcript of allele alphaLELY in erythroid cells.

    abstract::Allele alphaLELY is a common low-expression allele of the erythroid spectrin SPTA1 gene. It results in the aggravated expression of hereditary elliptocytosis due to SPTA1 gene mutations occurring in trans. Allele alphaLELY contains, in particular, mutations in introns 45 and 46, both in polypyrimidine tracts, and caus...

    journal_title:British journal of haematology

    pub_type: 杂志文章


    authors: Wilmotte R,Marechal J,Delaunay J

    更新日期:1999-03-01 00:00:00

  • Suppressive effect of ferritin on in vitro lymphocyte function.

    abstract::This study describes the effect of ferritin on lymphocyte function in vitro. Peripheral blood lymphocytes isolated from normal donors were incubated with purified human splenic ferritin, and the mitogenic effect of phytohaemagglutinin (PHA), concanavalin A (Con A), pokeweed mitogen (PWM) and mixed lymphocyte reaction ...

    journal_title:British journal of haematology

    pub_type: 杂志文章


    authors: Matzner Y,Hershko C,Polliack A,Konijn AM,Izak G

    更新日期:1979-07-01 00:00:00

  • Lenalidomide oral monotherapy produces a high response rate in patients with relapsed or refractory mantle cell lymphoma.

    abstract::Mantle cell lymphoma (MCL) is an aggressive non-Hodgkin lymphoma with a poor prognosis following first relapse. We present a subgroup analysis of an open-label phase II trial investigating the efficacy and safety of lenalidomide in patients with relapsed or refractory MCL. Oral lenalidomide 25 mg was self-administered...

    journal_title:British journal of haematology

    pub_type: 杂志文章,多中心研究


    authors: Habermann TM,Lossos IS,Justice G,Vose JM,Wiernik PH,McBride K,Wride K,Ervin-Haynes A,Takeshita K,Pietronigro D,Zeldis JB,Tuscano JM

    更新日期:2009-05-01 00:00:00

  • Targeted mutation screening of 292 candidate genes in 38 children with inborn haematological cytopenias efficiently identifies novel disease-causing mutations.

    abstract::Establishing a precise diagnosis is essential in inborn haematological cytopenias to enable appropriate treatment decisions and avoid secondary organ damage. However, both diversity and phenotypic overlap of distinct disease entities may make the identification of underlying genetic aetiologies by classical Sanger seq...

    journal_title:British journal of haematology

    pub_type: 杂志文章


    authors: Kager L,Jimenez Heredia R,Hirschmugl T,Dmytrus J,Krolo A,Müller H,Bock C,Zeitlhofer P,Dworzak M,Mann G,Holter W,Haas O,Boztug K

    更新日期:2018-07-01 00:00:00

  • Prediction of the haemostatic effects of bypassing therapy using comprehensive coagulation assays in emicizumab prophylaxis-treated haemophilia A patients with inhibitors.

    abstract::In emicizumab prophylaxis, the concomitant therapy using bypassing agents (BPAs) is required for breakthrough bleeding and invasive procedures with attention to thrombotic complications. To predict coagulant effects of BPAs in emicizumab-treated patients with haemophilia A (PwHA) with inhibitor (PwHAwI), blood samples...

    journal_title:British journal of haematology

    pub_type: 杂志文章


    authors: Furukawa S,Nogami K,Shimonishi N,Nakajima Y,Matsumoto T,Shima M

    更新日期:2020-09-01 00:00:00

  • The Bcl-2 family member Bfl-1/A1 is strongly repressed in normal and malignant plasma cells but is a potent anti-apoptotic factor for myeloma cells.

    abstract::Terminal B-cell differentiation is a multi-step process, from short-lived plasmablasts to mature long-lived plasma cells (PC). The anti-apoptotic Bcl-2 family member Bfl-1/A1 plays a critical role in the survival of mature B cells. However, its potential involvement at the later stages of B-cell development remains hi...

    journal_title:British journal of haematology

    pub_type: 杂志文章


    authors: Tarte K,Jourdan M,Veyrune JL,Berberich I,Fiol G,Redal N,Shaughnessy J Jr,Klein B

    更新日期:2004-05-01 00:00:00

  • Adjusted dose continuous infusion of factor VIII in patients with haemophilia A.

    abstract::Surgical interventions in patients suffering from haemophilia A require infusions of large doses of factor VIII (F VIII) concentrates. These are expensive and may pose a burden on the immune system, which is already compromised in many haemophiliacs. F VIII is usually given as bolus injections, although there are repo...

    journal_title:British journal of haematology

    pub_type: 杂志文章


    authors: Martinowitz U,Schulman S,Gitel S,Horozowski H,Heim M,Varon D

    更新日期:1992-12-01 00:00:00

  • Inhibition by interleukin-1 of the action of erythropoietin on erythroid precursors and its possible role in the pathogenesis of hypoplastic anaemias.

    abstract::Highly purified and cloned preparations of interleukin-1 (IL-1) were found to antagonize the capacity of erythropoietin (Epo) to stimulate the proliferation of mouse spleen and bone marrow erythroid precursor cells (EPC) in culture. Cloned murine IL-1 and purified and cloned human IL-1 alpha and IL-1 beta were approxi...

    journal_title:British journal of haematology

    pub_type: 杂志文章


    authors: Schooley JC,Kullgren B,Allison AC

    更新日期:1987-09-01 00:00:00

  • Ocular presentation of primary central nervous system lymphoma: diagnosis and treatment.

    abstract::Primary ocular lymphoma (POL), a lymphoma of the globe, is a restricted form of primary central nervous system lymphoma (PCNSL) that often progresses to the brain and meninges; frequently it is misdiagnosed until central nervous system (CNS) lymphoma develops. The optimal treatment has not yet been identified. We retr...

    journal_title:British journal of haematology

    pub_type: 杂志文章


    authors: Hormigo A,Abrey L,Heinemann MH,DeAngelis LM

    更新日期:2004-07-01 00:00:00

  • Where are we at with point-of-care testing in haematology?

    abstract::Point-of-care testing (POCT) in haematology has continued to grow in popularity and uptake throughout the world. The increasing demand to reduce the turnaround time of test results, coupled with rapid improvements in technology, have led to the development of several devices that are designed for use in different clin...

    journal_title:British journal of haematology

    pub_type: 杂志文章,评审


    authors: Briggs C,Kimber S,Green L

    更新日期:2012-09-01 00:00:00

  • The mean fluorescence intensities of anti-HLA antibodies detected using micro-bead flow cytometry predict the risk of platelet transfusion refractoriness.

    abstract::There are no accepted methods to predict the development of platelet transfusion refractoriness (PTR) due to human leucocyte antigen (HLA)-alloimmunization. Hence, matched platelets are usually given only to patients demonstrating PTR, necessarily resulting in some ineffective random donor platelets (RDPLT) transfusio...

    journal_title:British journal of haematology

    pub_type: 杂志文章


    authors: Beligaswatte A,Tsiopelas E,Humphreys I,Bennett G,Robinson K,Davis K,Bardy P

    更新日期:2013-08-01 00:00:00

  • Vaccination of patients with haematological malignancies with one or two doses of influenza vaccine: a randomised study.

    abstract::An open, randomised study was performed to determine whether two doses of influenza vaccine were more effective than one to elicit an immune response in 70 patients with haematological malignancies. The responses were not improved by two doses compared with one (influenza A virus serotypes H1/N1 18% vs. 22% and H3/N2 ...

    journal_title:British journal of haematology

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Ljungman P,Nahi H,Linde A

    更新日期:2005-07-01 00:00:00