Significant amount of hepatocyte growth factor detected in blood and bone marrow plasma of leukaemia patients.

Abstract:

:Hepatocyte growth factor (HGF) has been known as a versatile functional molecule, and as being involved in the colony formation of haemopoietic progenitor cells. Clinically, an elevated HGF level in the blood has been associated with liver diseases such as fulminant hepatic failure and acute hepatitis. We have found a high level of HGF in blood and bone marrow plasma from patients with various types of leukaemia and lymphoma. In particular, 21/31 acute myeloblastic leukaemia (AML) patients showed a significant level of HGF (> 0.40 ng/ml) in their blood or bone marrow plasma. The mean value of HGF in the plasma of AML patients was 2.03 ng/ml, which was higher than that in the serum of patients with acute hepatitis. This demonstrates, for the first time, evidence of frequent association of increased levels of HGF in non-lymphocytic leukaemias, though its significance in the disease remains unknown.

journal_name

Br J Haematol

authors

Nakamura S,Gohda E,Matsuo Y,Yamamoto I,Minowada J

doi

10.1111/j.1365-2141.1994.tb08330.x

subject

Has Abstract

pub_date

1994-07-01 00:00:00

pages

640-2

issue

3

eissn

0007-1048

issn

1365-2141

journal_volume

87

pub_type

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