The C677T MTHFR gene mutation is not predictive of risk for recurrent fetal loss.

abstract：:Tumour lysis syndrome (TLS) in plasma cell dyscrasias is extremely rare. TLS has been described in eight cases of multiple myeloma undergoing high-dose therapy with autologous stem cell transplant (ASCT). Recently, clinical trials of intensive chemotherapy followed by autologous or allogeneic stem cell support has bee...

journal_title：British journal of haematology

authors： Akasheh MS,Chang CP,Vesole DH

更新日期：1999-11-01 00:00:00

abstract：:Sickle cell disease (SCD) is increasingly appreciated as an inflammatory condition associated with alterations in immune phenotype and function. In this cross-sectional study we performed a multiparameter analysis of 18 immune markers in 114 paediatric SCD patients divided by treatment group [those receiving hydroxycr...

journal_title：British journal of haematology

authors： Nickel RS,Osunkwo I,Garrett A,Robertson J,Archer DR,Promislow DE,Horan JT,Hendrickson JE,Kean LS

更新日期：2015-05-01 00:00:00

abstract：:Assessment of chronic hepatitis C virus infection requires a liver biopsy in most circumstances. There is a reluctance to perform liver biopsy in haemophiliacs because of a perceived risk of haemorrhage, although with adequate factor concentrate replacement in patients without factor concentrate inhibitors it should b...

journal_title：British journal of haematology

authors： Wong VS,Baglin T,Beacham E,Wight DD,Petrik J,Alexander GJ

更新日期：1997-05-01 00:00:00

abstract：:Stage I/IIA follicular lymphoma (FL) is considered a localised disease that can be adequately treated with radiotherapy alone. Bone marrow (BM) and peripheral blood (PB) involvement in FL was investigated by polymerase chain reaction (PCR) in a series of 24 consecutive patients with histologically revised diagnosis an...

journal_title：British journal of haematology

authors： Pulsoni A,Starza ID,Frattarelli N,Ghia E,Carlotti E,Cavalieri E,Matturro A,Tempera S,Rambaldi A,Foà R

更新日期：2007-05-01 00:00:00

abstract：:Genetic variation in innate immunity may alter host-pathogen defence mechanisms and promote aberrant immune responses and non-Hodgkin lymphoma (NHL). To test this hypothesis, we investigated polymorphisms in innate immune genes in a pooled analysis of two population-based case-control studies of NHL from the San Franc...

journal_title：British journal of haematology

authors： Forrest MS,Skibola CF,Lightfoot TJ,Bracci PM,Willett EV,Smith MT,Holly EA,Roman E

更新日期：2006-07-01 00:00:00

abstract：:The translocation t(1;19)(q23;p13)/der(19)t(1;19) is a risk stratifying aberration in childhood B-cell precursor acute lymphoblastic leukaemia (BCP ALL) in the Nordic countries. We have identified 47 children/adolescents with t(1;19)/der(19)t(1;19)-positive BCP ALL treated on two successive Nordic Society of Paediatri...

journal_title：British journal of haematology

authors： Andersen MK,Autio K,Barbany G,Borgström G,Cavelier L,Golovleva I,Heim S,Heinonen K,Hovland R,Johannsson JH,Johansson B,Kjeldsen E,Nordgren A,Palmqvist L,Forestier E

更新日期：2011-10-01 00:00:00

abstract：:Thirty-six patients with multiple myeloma (23 PR1, nine PR2, four stable disease) were entered into a pilot study evaluating the use of CD34+-selected peripheral blood progenitor cell transplantation (PBPCT) following high-dose melphalan alone or high-dose melphalan and total body irradiation. Peripheral blood progeni...

journal_title：British journal of haematology

authors： Gupta D,Bybee A,Cooke F,Giles C,Davis JG,McDonald C,Armitage SE,McGuigan D,Lyttelton MP,Kanfer EJ,Apperley JF,Samson D

更新日期：1999-01-01 00:00:00

abstract：:Interleukin-12 (IL-12), a heterodimeric cytokine with potent biological activity, was evaluated for effects on proliferation of human immature progenitor cells in vitro. In vitro proliferation of 5-FU-resistant CD34+ (G0) peripheral blood stem cells (PBSC) in response to sequential cytokine stimulation was examined in...

journal_title：British journal of haematology

authors： Grafte-Faure S,Leveque C,Vasse M,Soria C,Vannier JP

更新日期：1999-04-01 00:00:00

abstract：:A novel colony stimulating factor-1 (CSF-1) binding factor present in the serum from a patient in remission from lymphoma is described. Radioimmunoassay (RIA) repeatedly failed to detect circulating levels of CSF-1 in the peripheral blood system of this patient. Molecular analysis showed a normal CSF-1 gene structure ...

journal_title：British journal of haematology

authors： Baker AH,Cachia PG,Tennant GB,Whittaker JA,White D,Stanley ER,Burnett AK,Padua RA

更新日期：1995-01-01 00:00:00

abstract：:Two patients are described who had evidence of both multiple myeloma and chronic neutrophilic leukaemia at or near the time of presentation. Descriptions of five similar patients were found in the literature supporting an association between the two disorders. This association is further evidence of a link between mye...

journal_title：British journal of haematology

authors： Lewis MJ,Oelbaum MH,Coleman M,Allen S

更新日期：1986-05-01 00:00:00

abstract：:We report 14 normal peripheral blood stem cell (PBSC) donors > or = 60 years of age who had cytokine mobilization followed by PBSC apheresis for allogeneic transplantation. Mobilization was achieved with filgrastim (6 microg/kg twice daily). Their median age was 63.5 years (range 60-77), and 43% had a positive medical...

journal_title：British journal of haematology

authors： Anderlini P,Przepiorka D,Lauppe J,Seong D,Giralt S,Champlin R,Körbling M

更新日期：1997-05-01 00:00:00

abstract：:Fetal haemoglobin levels have been measured prospectively in 135 autopsy cases of sudden, unexpected infant deaths (31 pre-term, 104 full term) using standard laboratory methods. These results have been compared with Hb F values from a normal control group of 570 living infants (145 pre-term, 425 full-term) with a pos...

journal_title：British journal of haematology

authors： Fagan DG,Walker A

更新日期：1992-10-01 00:00:00

abstract：:A DNA-based method was developed to genotype donors for the human platelet antigens HPA-1a and -1b. Sequence-specific primers (SSP) were used in the polymerase chain reaction (PCR) which allowed the HPA-1a/1a, -1b/1b and -1a/1b genotypes to be determined by PCR alone, no second analytical stage was required. 10 donors...

journal_title：British journal of haematology

authors： Metcalfe P,Waters AH

更新日期：1993-09-01 00:00:00

abstract：:Two non-anaemic subjects, a father and daughter, with a new form of congenital dyserythropoiesis are reported. The features of their disorder are: (1) an abnormal blood film with basophilic stippling of red cells and oval macrocytes, (2) various dysplastic changes in the erythroblasts, including internuclear chromatin...

journal_title：British journal of haematology

authors： Wickramasinghe SN,Spearing RL,Hill GR

更新日期：1998-12-01 00:00:00

abstract：:Sickle cell disease (SCD) is complicated by silent cerebral infarcts, visible as white matter hyperintensities (WMHs) on magnetic resonance imaging (MRI). Both local vaso-occlusion, elicited by endothelial dysfunction, and insufficiency of cerebral blood flow (CBF) have been proposed to be involved in the aetiology. W...

journal_title：British journal of haematology

authors： van der Land V,Mutsaerts HJ,Engelen M,Heijboer H,Roest M,Hollestelle MJ,Kuijpers TW,Nederkoorn PJ,Cnossen MH,Majoie CB,Nederveen AJ,Fijnvandraat K

更新日期：2016-01-01 00:00:00

abstract：:Since cardiotoxicity is a life threatening late effect, a reduction of cardiotoxicity in the treatment of acute myeloid leukaemia (AML) is essential. This review is a compilation of the current knowledge about cardiotoxicity after AML treatment and of how future directions in treatment may affect its incidence. A tota...

journal_title：British journal of haematology

authors： Jarfelt M,Andersen NH,Hasle H

更新日期：2016-11-01 00:00:00

abstract：:The transforming growth factor-beta-related factor bone morphogenetic protein 4 (BMP4) is expressed in the human embryonic aorta-gonad-mesonephros (AGM) coincident with the emergence of haematopoietic cells and influences postnatal mammalian haematopoietic stem cells in vitro. To investigate the role of BMP4 in mammal...

journal_title：British journal of haematology

authors： Marshall CJ,Sinclair JC,Thrasher AJ,Kinnon C

更新日期：2007-10-01 00:00:00

abstract：:We investigated the complement-susceptibility of paroxysmal nocturnal haemoglobinuria (PNH) lymphocytes in relation to their dysfunction. When assessed by complement-mediated lysis induced by monoclonal antibodies (CD5 or CD20) and rabbit complement, the complement-susceptibility of lymphocytes from patients with PNH,...

journal_title：British journal of haematology

authors： Tomiyama J,Ninomiya H,Abe T

更新日期：1990-12-01 00:00:00

abstract：:Two single-nucleotide substitutions in PKLR constituted the molecular basis underlying pyruvate kinase (PK) deficiency in a patient with severe haemolytic anaemia. One novel mutation, IVS5+1G>A, abolished the intron 5 donor splice site. The other mutation, c.1436G>A, altered the intron 10 donor splice site consensus s...

journal_title：British journal of haematology

authors： Wijk R,van Wesel AC,Thomas AA,Rijksen G,van Solinge WW

更新日期：2004-04-01 00:00:00

abstract：:Physiological parameters such as pH and oxygen tension probably play significant roles in the regulation of haemopoiesis in the bone marrow microenvironment, but these roles have yet to be characterized in detail. We have found that changes in culture pH (0.2 units) can cause significant changes in the culture composi...

journal_title：British journal of haematology

authors： McAdams TA,Miller WM,Papoutsakis ET

更新日期：1998-11-01 00:00:00

abstract：:Langerhans cell histiocytosis (LCH), the most common histiocytic disorder, is characterized by the accumulation of CD1A(+) /CD207(+) mononuclear phagocytes within granulomatous lesions that can affect nearly all organ systems. Historically, LCH has been presumed to arise from transformed or pathologically activated ep...

journal_title：British journal of haematology

authors： Berres ML,Merad M,Allen CE

更新日期：2015-04-01 00:00:00

abstract：:The thrombopoietin receptor agonists (THPO-RAs), romiplostim and eltrombopag, are effective and safe in immune thrombocytopenia (ITP). However, the value of their sequential use when no response is achieved or when adverse events occur with one THPO-RA has not been clearly established. Here we retrospectively evaluate...

journal_title：British journal of haematology

authors： González-Porras JR,Mingot-Castellano ME,Andrade MM,Alonso R,Caparrós I,Arratibel MC,Fernández-Fuertes F,Cortti MJ,Pascual C,Sánchez-González B,Bernat S,Fuertes-Palacio MA,Vázquez-Paganini JA,Olivera PE,Alvarez-Román MT,Jarq

更新日期：2015-04-01 00:00:00

abstract：:The in vitro effects of a range of concentrations of cyclophosphamide, doxorubicin, actinomycin D, cytarabine and methotrexate on neutrophil phagocytosis of C. albicans was studied. The reduction in phagocytic index (PI) was inversely proportional to the dilution of the drug and there was some inhibition of phagocytos...

journal_title：British journal of haematology

authors： Davies JE,Whittaker JA,Khurshid M

更新日期：1976-01-01 00:00:00

abstract：:A 33-year-old man presented with hepatosplenomegaly and lymphadenopathy. Bone marrow findings were consistent with Philadelphia-positive accelerated-phase chronic granulocytic leukaemia (CGL). Lymph node histology and immunhistochemistry were diagnostic of T lymphoblastic lymphoma. Molecular studies on lymph node DNA ...

journal_title：British journal of haematology

authors： Jacob A,Rowlands DC,Patton N,Holmes JA

更新日期：1994-10-01 00:00:00

abstract：:Multiple myeloma (MM) is a disease with known immune dysregulation. Natural killer (NK) cells have shown preclinical activity in MM. We conducted a first-in-human study of umbilical cord blood-derived (CB) NK cells for MM patients undergoing high dose chemotherapy and autologous haematopoietic stem cell transplantatio...

journal_title：British journal of haematology

authors： Shah N,Li L,McCarty J,Kaur I,Yvon E,Shaim H,Muftuoglu M,Liu E,Orlowski RZ,Cooper L,Lee D,Parmar S,Cao K,Sobieiski C,Saliba R,Hosing C,Ahmed S,Nieto Y,Bashir Q,Patel K,Bollard C,Qazilbash M,Champlin R,Rezvani

更新日期：2017-05-01 00:00:00

abstract：:The findings of morphologically dysplastic features in haemopoietic cells in de novo acute myeloid leukaemia (AML) has been named AML with trilineage myelodysplasia (AML/TMDS). We analysed the clinical data, karyotypes, and treatment outcomes of 230 de novo AML patients treated with the Japan Adult Leukaemia Study Gro...

journal_title：British journal of haematology

authors： Kuriyama K,Tomonaga M,Matsuo T,Kobayashi T,Miwa H,Shirakawa S,Tanimoto M,Adachi K,Emi N,Hiraoka A

更新日期：1994-04-01 00:00:00

abstract：:This exploratory study assessed apoptosis in peripheral blood leucocytes (PBL) from β-thalassaemia patients receiving chronic transfusions and chelation therapy (deferasirox or deferoxamine) at baseline, 1, 6, and 12 months. At baseline, thalassaemic PBLs presented 50% greater levels of Bax (BAX), 75% higher caspase-3...

journal_title：British journal of haematology

authors： Walter PB,Porter J,Evans P,Kwiatkowski JL,Neufeld EJ,Coates T,Giardina PJ,Grady RW,Vichinsky E,Olivieri N,Trachtenberg F,Alberti D,Fung E,Ames B,Higa A,Harmatz P,Thalassemia Clinical Research Network.

更新日期：2013-02-01 00:00:00

abstract：:Splenic lymphoma with villous lymphocytes (SLVL) is a low-grade B-cell lymphoproliferative disorder characterized by splenomegaly and circulating villous lymphocytes. The relationship between SLVL and splenic marginal zone lymphoma (SMZL), a disorder with identical splenic histology to SLVL, is not clear. Previous stu...

journal_title：British journal of haematology

authors： Gruszka-Westwood AM,Matutes E,Coignet LJ,Wotherspoon A,Catovsky D

更新日期：1999-03-01 00:00:00

abstract：:In a series of 306 cases of myeloproliferative disorders followed over a period of 21 years, 18 cases of well-documented acute leukaemia were encountered. Leukaemias were either acute myeloblastic or myelomonocytic and occurred from 6 months to 20 years after the initial diagnosis. Onset was relatively abrupt and the ...

journal_title：British journal of haematology

authors： Rosenthal DS,Moloney WC

更新日期：1977-07-01 00:00:00

abstract：:Diagnosing central nervous system (CNS) lymphoma remains a challenge. Most patients have to undergo brain biopsy to obtain tissue for diagnosis, with associated risks of serious complications. Diagnostic markers in blood or cerebrospinal fluid (CSF) could facilitate early diagnosis with low complication rates. We perf...

journal_title：British journal of haematology

authors： van Westrhenen A,Smidt LCA,Seute T,Nierkens S,Stork ACJ,Minnema MC,Snijders TJ

更新日期：2018-08-01 00:00:00