Is it possible to cure childhood acute myeloid leukaemia without significant cardiotoxicity?

abstract：:Eltrombopag is a thrombopoietin-receptor agonist that stimulates platelet production and increases platelet counts in patients with chronic immune thrombocytopenia (ITP). This open-label, single-arm study evaluated consistency of response and safety following repeated intermittent dosing of eltrombopag 50 mg daily ove...

journal_title：British journal of haematology

authors： Bussel JB,Saleh MN,Vasey SY,Mayer B,Arning M,Stone NL

更新日期：2013-02-01 00:00:00

abstract：:A prospective study was undertaken to determine the effectiveness of an empirical antibiotic therapy regimen in 34 neutropenic patients undergoing bone marrow transplantation or remission-induction chemotherapy for leukaemia. Throughout the study period a total of 90 pyrexial episodes were monitored in which organisms...

journal_title：British journal of haematology

authors： Barnes RA,Rogers TR

更新日期：1987-05-01 00:00:00

abstract：:Assessment of chronic hepatitis C virus infection requires a liver biopsy in most circumstances. There is a reluctance to perform liver biopsy in haemophiliacs because of a perceived risk of haemorrhage, although with adequate factor concentrate replacement in patients without factor concentrate inhibitors it should b...

journal_title：British journal of haematology

authors： Wong VS,Baglin T,Beacham E,Wight DD,Petrik J,Alexander GJ

更新日期：1997-05-01 00:00:00

abstract：:Peripheral blood globin synthesis studies were done in 11 patients with delta beta-thalassaemia trait, Hb S-delta beta-thalassaemia or delta beta/betao-thalassaemia from two black and two Caucasian families. All patients had elevated Hb F and normal or decreased Hb A2 levels and 10 had family studies confirming the di...

journal_title：British journal of haematology

authors： Kinney TR,Friedman S,Cifuentes E,Kim HC,Schwartz E

更新日期：1978-01-01 00:00:00

abstract：:Ibrutinib is associated with durable responses in patients with Waldenström macroglobulinaemia (WM). We hypothesized that response depth is predictive of progression-free survival (PFS) in WM patients treated with ibrutinib. Using landmark analyses, we evaluated response depth in two cohorts of WM patients treated wit...

journal_title：British journal of haematology

authors： Castillo JJ,Abeykoon JP,Gustine JN,Zanwar S,Mein K,Flynn CA,Demos MG,Guerrera ML,Kofides A,Liu X,Munshi M,Tsakmaklis N,King R,Yang G,Hunter ZR,Advani RH,Palomba ML,Ansell SM,Gertz MA,Kapoor P,Treon SP

更新日期：2020-11-18 00:00:00

abstract：:Three distinct categories of marginal zone lymphomas (MZLs) are currently recognized, principally based on their site of occurrence. They are thought to represent unique entities, but the relationship of one subtype with another is poorly understood. We investigated 17 non-splenic MZLs (seven nodal, 10 extranodal) by ...

journal_title：British journal of haematology

authors： Novak U,Basso K,Pasqualucci L,Dalla-Favera R,Bhagat G

更新日期：2011-11-01 00:00:00

abstract：:Glutathione S-transferases (GSTs) are implicated in cytotoxic drug resistance in leukaemia. In a previous study, expression of mu class GST (GSTM) was associated with poor prognosis in childhood acute lymphoblastic leukaemia (ALL), however, that study did not differentiate between individual GSTM isoforms. This study,...

journal_title：British journal of haematology

authors： Kearns PR,Chrzanowska-Lightowlers ZM,Pieters R,Veerman A,Hall AG

更新日期：2003-01-01 00:00:00

abstract：:We report a patient with hypereosinophilic syndrome (HES), which, 8 years later, transformed into granulocytic sarcoma in the brain and, subsequently, into acute myelocytic leukaemia. Repeated chromosome analyses showed a normal karyotype, until the time of leukaemic transformation when trisomy 8 was confirmed in cell...

journal_title：British journal of haematology

authors： Fujii N,Ikeda K,Takahashi N,Kojima K,Kobayashi Y,Ashiba A,Takenaka K,Fukuda S,Shinagawa K,Ishimaru F,Niiya K,Miura I,Tanimoto M,Harada M

更新日期：2002-12-01 00:00:00

abstract：:The CDKN2 gene, encoding the cyclin-dependent kinase-4 inhibitor p16, is a putative tumour-suppressor gene because it is frequently altered in many malignant tumours. We analysed the CDKN2 gene in 44 cases of adult T-cell leukaemia (ATL) by Southern blot analysis, polymerase chain reaction-mediated single-strand confo...

journal_title：British journal of haematology

authors： Uchida T,Kinoshita T,Watanabe T,Nagai H,Murate T,Saito H,Hotta T

更新日期：1996-09-01 00:00:00

abstract：:We describe a patient with a 9-year history of thrombotic thrombocytopenic purpura (TTP) who exhibited four relapses. Intravenous immunoglobulin (IVIg) was effective for these four episodes. The patient was well and the laboratory findings were within normal ranges between each episode, although unusually large von Wi...

journal_title：British journal of haematology

authors： Kondo H,Imamura T

更新日期：2000-03-01 00:00:00

abstract：:A new glucose-6-phosphate dehydrogenase variant detected in an Italian man from the Po delta is described and designated as G6PD Modena. Biochemical characterization of the variant enzyme revealed an activity 21% of normal, a slow electrophoretic mobility, increased Km value for NADP, decreased Km value for G6P and a ...

journal_title：British journal of haematology

authors： Cappellini MD,Sampietro M,Toniolo D,Carandina G,Pittalis S,Martinez di Montemuros F,Tavazzi D,Fiorelli G

更新日期：1994-05-01 00:00:00

abstract：:Adhesive interactions between haemopoietic progenitor cells and bone marrow sinusoidal endothelium are potentially important in the homing of these cells back to the extravascular compartment of the marrow to re-establish haemopoiesis following stem cell transplantation. A simple method for the isolation and culture o...

journal_title：British journal of haematology

authors： Masek LC,Sweetenham JW

更新日期：1994-12-01 00:00:00

abstract：:Cytogenetic deletions of the short arm of chromosome 12 are common recurring alterations found in a wide range of haematological neoplasias, including childhood acute lymphoblastic leukaemia (ALL), the most frequent paediatric malignancy. Such a loss of genetic material suggests the presence of a tumour suppressor gen...

journal_title：British journal of haematology

authors： Baccichet A,Sinnett D

更新日期：1997-10-01 00:00:00

abstract：:This study investigated the relationship between duodenal mucosal mRNA levels of the transcription factor, NF-E2, H-ferritin (a putative NF-E2 regulated gene) and iron absorption in mice. CD1-strain mice with normal and altered iron metabolism (hypoxic, iron-deficient, iron-loaded) and animals with genetic defects of ...

journal_title：British journal of haematology

authors： Raja KB,Gerard B,McKie AT,Simpson RJ,Peters TJ,Grandchamp B,Beaumont C

更新日期：1995-10-01 00:00:00

abstract：:This trial explored the efficacy of re-induction chemotherapy including bortezomib in paediatric relapsed/refractory acute lymphoblastic leukaemia. Patients were randomized 1:1 to bortezomib (1.3 mg/m2 /dose) administered early or late to a dexamethasone and vincristine backbone. Both groups did not differ regarding p...

journal_title：British journal of haematology

authors： Kaspers GJL,Niewerth D,Wilhelm BAJ,Scholte-van Houtem P,Lopez-Yurda M,Berkhof J,Cloos J,de Haas V,Mathôt RA,Attarbaschi A,Baruchel A,de Bont ES,Fagioli F,Rössig C,Klingebiel T,De Moerloose B,Nelken B,Palumbo G,Reinhar

更新日期：2018-05-01 00:00:00

abstract：:The role of factor XI (FXI) in blood coagulation has been clarified in recent years by descriptions of FXI-deficient patients who are prone to excessive bleeding after haemostatic challenge. We have studied a large kindred of an Italian FXI-deficient patient with a previously undescribed mutation. The propositus, a 68...

journal_title：British journal of haematology

authors： Alhaq A,Mitchell M,Sethi M,Rahman S,Flynn G,Boulton P,Caeno G,Smith M,Savidge G

更新日期：1999-01-01 00:00:00

abstract：:The use of 111Indium oxine as a platelet label for the performance of platelet life-span studies has been examined. Platelet life-span in normal subjects varied between 8 X 10 and 10 X 36 d. Patients with primary thrombocythaemia had clearly reduced platelet life-span whether or not they presented with vascular occlus...

journal_title：British journal of haematology

authors： Bautista AP,Buckler PW,Towler HM,Dawson AA,Bennett B

更新日期：1984-12-01 00:00:00

abstract：:We have identified a tissue kallikrein in polymorphonuclear (PMN) leucocytes of normal human blood and bone marrow by immunocytochemistry, radioimmunoassay and enzymology. Immunoreactive tissue kallikrein was visualized in the mature neutrophil leucocytes and in immature forms such as metamyelocytes and myelocytes. No...

journal_title：British journal of haematology

authors： Figueroa CD,MacIver AG,Bhoola KD

更新日期：1989-07-01 00:00:00

abstract：:In countries with a good standard of health care, intracranial haemorrhage (ICH) during the neonatal period affects 3.5-4.0% of all haemophilia boys, which is considerably (40-80 times) higher than expected in the normal population. ICHs are also frequent after the neonatal period, affecting 3-10% of the haemophilia p...

journal_title：British journal of haematology

authors： Ljung RC

更新日期：2008-02-01 00:00:00

abstract：:Studies of ethnic disparities in malignancies have revealed variation in clinical outcomes. In multiple myeloma (MM), previous literature has focused only on patients of Caucasian and African-American (AA) descent. We present a Surveillance Epidemiology and End Results (SEER)-based outcome analysis of MM patients from...

journal_title：British journal of haematology

authors： Ailawadhi S,Aldoss IT,Yang D,Razavi P,Cozen W,Sher T,Chanan-Khan A

更新日期：2012-07-01 00:00:00

abstract：:Myeloablative conditioning prior to allogeneic stem cell transplantation causes a rapid increase in transferrin saturation and potentially toxic non-transferrin-bound iron (NTBI) in plasma. We have studied the ability of repeatedly administered apotransferrin to maintain this iron in a transferrin-bound form. Twenty a...

journal_title：British journal of haematology

authors： Parkkinen J,Sahlstedt L,von Bonsdorff L,Salo H,Ebeling F,Ruutu T

更新日期：2006-10-01 00:00:00

abstract：:Oxygen dissociation studies were carried out on red cells and lysates from a patient heterozygous for Hb Hammersmith. The oxygen affinity of the cells at pH 7.1 was decreased, partly by an increased cellular concentration of 2,3-DPG and more importantly by an intrinsic low affinity of Hb Hammersmity. Haem-haem interac...

journal_title：British journal of haematology

authors： May A,Huehns ER

更新日期：1975-06-01 00:00:00

abstract：:The expression and prognostic significance of hepatocyte growth factor (HGF) and its receptor c-MET (MET proto-oncogene) was analysed in 96 cases of diffuse large B-cell lymphoma (DLBCL). Tissue sections were immunohistochemically stained for HGF and c-Met. The prognosis of HGF-positive and c-Met-positive cases was si...

journal_title：British journal of haematology

authors： Kawano R,Ohshima K,Karube K,Yamaguchi T,Kohno S,Suzumiya J,Kikuchi M,Tamura K

更新日期：2004-11-01 00:00:00

abstract：:Sézary syndrome and Mycosis fungoides are the most common forms of cutaneous T-cell lymphomas. To assess the response to different therapies especially in Sézary syndrome, it is helpful to monitor the percentage of circulating tumour cells in the blood. The use of T-cell receptor (TCR)-Vbeta specific monoclonal antibo...

journal_title：British journal of haematology

authors： Schwab C,Willers J,Niederer E,Ludwig E,Kündig T,Grob P,Burg G,Dummer R

更新日期：2002-09-01 00:00:00

abstract：:Plasma iron turnover (PIT) and ferritin synthesis in the liver and spleen were studied in rats within the first 24 h of inflammation produced by turpentine injection. Comparison of the sequential changes in PIT and ferritin synthesis showed that alterations in ferritin synthesis preceded the changes in plasma iron exc...

journal_title：British journal of haematology

authors： Konijn AM,Hershko C

更新日期：1977-09-01 00:00:00

abstract：:In recent years there has been a paradigm shift in our understanding of the epidemiology and clinical features of hepatitis E virus (HEV) infection. Once classically described as an acute hepatitis associated with waterborne outbreaks in areas of poor sanitation, HEV is now recognised to be endemic in Europe and is pr...

journal_title：British journal of haematology

authors： O'Gorman J,Burke Á,O'Flaherty N

更新日期：2018-06-01 00:00:00

abstract：:Besides circulating in normal plasma, von Willebrand factor (VWF) is also stored at relatively high concentration within the alpha-granules of platelets. This pool of platelet VWF exists distinct from plasma VWF, and is enriched in haemostatically-active high molecular weight multimers. Interestingly, the glycosylatio...

journal_title：British journal of haematology

authors： McGrath RT,McRae E,Smith OP,O'Donnell JS

更新日期：2010-03-01 00:00:00

abstract：:The presence of oestrogen receptors (ER) and type II oestrogen binding sites (type II EBS) have been investigated by a whole cell assay in seven cases of acute lymphoid leukaemia (ALL) and 16 cases of acute myeloid leukaemia (AML). ER were detected in 6/7 ALL patients with values ranging between 133 and 2268 sites/cel...

journal_title：British journal of haematology

authors： Larocca LM,Piantelli M,Leone G,Sica S,Teofili L,Panici PB,Scambia G,Mancuso S,Capelli A,Ranelletti FO

更新日期：1990-08-01 00:00:00

abstract：:To create immortal mesenchymal cell lines, we transduced primary human bone marrow mesenchymal cells with telomerase reverse transcriptase (TERT). TERT+ mesenchymal cells continued to grow for > 2 years; parallel TERT- cultures underwent senescence after 15 weeks. TERT+ mesenchymal cells did not form foci in soft agar...

journal_title：British journal of haematology

authors： Mihara K,Imai C,Coustan-Smith E,Dome JS,Dominici M,Vanin E,Campana D

更新日期：2003-03-01 00:00:00

abstract：:The transforming growth factor-beta-related factor bone morphogenetic protein 4 (BMP4) is expressed in the human embryonic aorta-gonad-mesonephros (AGM) coincident with the emergence of haematopoietic cells and influences postnatal mammalian haematopoietic stem cells in vitro. To investigate the role of BMP4 in mammal...

journal_title：British journal of haematology

authors： Marshall CJ,Sinclair JC,Thrasher AJ,Kinnon C

更新日期：2007-10-01 00:00:00