Congenital dyserythropoiesis with intererythroblastic chromatin bridges and ultrastructurally-normal erythroblast heterochromatin: a new disorder.

Abstract:

:Two non-anaemic subjects, a father and daughter, with a new form of congenital dyserythropoiesis are reported. The features of their disorder are: (1) an abnormal blood film with basophilic stippling of red cells and oval macrocytes, (2) various dysplastic changes in the erythroblasts, including internuclear chromatin bridges, (3) ultrastructurally-normal erythroblast heterochromatin, (4) normal serum thymidine kinase activity, and (5) a probable autosomal dominant inheritance. The last three features distinguish this disorder from CDA type I.

journal_name

Br J Haematol

authors

Wickramasinghe SN,Spearing RL,Hill GR

doi

10.1046/j.1365-2141.1998.01058.x

subject

Has Abstract

pub_date

1998-12-01 00:00:00

pages

831-4

issue

3

eissn

0007-1048

issn

1365-2141

journal_volume

103

pub_type

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