Prognostic implications of the microenvironment for follicular lymphoma under immunomodulation therapy.

Abstract:

:Follicular lymphoma (FL) constitutes a significant proportion of lymphomas and shows frequent relapses. Beyond conventional chemotherapy, new therapeutic approaches have emerged, focussing on the interplay between lymphoma cells and the microenvironment. Here we report the immunophenotypic investigation of the microenvironment of a clinically well-characterized prospective cohort (study SAKK35/10, NCT01307605) of 154 treatment-naïve FL patients in need of therapy, who have been treated with rituximab only or a combination of rituximab and the immunomodulatory drug lenalidomide/Revlimid® A high ratio of CD4- to CD8-positive T cells (P = 0·009) and increased amounts of PD1+ tumour-infiltrating T cells (P = 0·007) were associated with inferior progression-free survival in the whole cohort. Interestingly, the prognostic impact of PD1+ T cells and the CD4/CD8 ratio lost its significance in the subgroup treated with R2 . In the latter group, high amounts of GATA3+ T helper (Th2) equivalents were associated with better progression-free survival (P < 0·001). We identified tumour microenvironmental features that allow prognostic stratification with respect to immuno- and combined immuno- and immunomodulatory therapy. Our analysis indicates that lenalidomide may compensate the adverse prognostic implication of higher amounts of CD4+ and, particularly, PD1+ T cells and that it has favourable effects mainly in cases with higher amounts of Th2 equivalents. [Correction added on 11 February 2020, after online publication: The NCT-trial number was previously incorrect and has been updated in this version].

journal_name

Br J Haematol

authors

Menter T,Tzankov A,Zucca E,Kimby E,Hultdin M,Sundström C,Beiske K,Cogliatti S,Banz Y,Cathomas G,Karjalainen-Lindsberg ML,Grobholz R,Mazzucchelli L,Sander B,Hawle H,Hayoz S,Dirnhofer S

doi

10.1111/bjh.16414

subject

Has Abstract

pub_date

2020-05-01 00:00:00

pages

707-717

issue

4

eissn

0007-1048

issn

1365-2141

journal_volume

189

pub_type

杂志文章
  • Mucormycosis in patients with haematological malignancies: a retrospective clinical study of 37 cases. GIMEMA Infection Program (Gruppo Italiano Malattie Ematologiche Maligne dell'Adulto).

    abstract::A retrospective study of 37 patients with haematological malignancy (21 acute myeloid leukaemia, 11 acute lymphoid leukaemia, two lymphoma, two hairy cell leukaemia, one Hodgkin's disease) and histologically documented mucormycosis was conducted to evaluate the clinical characteristics and ascertain the factors which ...

    journal_title:British journal of haematology

    pub_type: 杂志文章,多中心研究

    doi:10.1046/j.1365-2141.1997.3983214.x

    authors: Pagano L,Ricci P,Tonso A,Nosari A,Cudillo L,Montillo M,Cenacchi A,Pacilli L,Fabbiano F,Del Favero A

    更新日期:1997-11-01 00:00:00

  • Polycythaemia-inducing mutations in the erythropoietin receptor (EPOR): mechanism and function as elucidated by epidermal growth factor receptor-EPOR chimeras.

    abstract::Primary familial and congenital polycythaemia (PFCP) is a disease characterized by increased red blood cell mass, and can be associated with mutations in the intracellular region of the erythropoietin (EPO) receptor (EPOR). Here we explore the mechanisms by which EPOR mutations induce PFCP, using an experimental syste...

    journal_title:British journal of haematology

    pub_type: 杂志文章

    doi:10.1111/bjh.12782

    authors: Gross M,Ben-Califa N,McMullin MF,Percy MJ,Bento C,Cario H,Minkov M,Neumann D

    更新日期:2014-05-01 00:00:00

  • Plasminogen activator inhibitor-1 is an independent diagnostic marker as well as severity predictor of hepatic veno-occlusive disease after allogeneic bone marrow transplantation in adults conditioned with busulphan and cyclophosphamide.

    abstract::We attempted to identify the diagnostic markers and severity predictors of hepatic veno-occlusive disease (VOD) in 115 adult patients who were uniformly conditioned with busulphan and cyclophosphamide and who underwent allogeneic bone marrow transplantation (BMT). A diagnosis of VOD was made according to clinical crit...

    journal_title:British journal of haematology

    pub_type: 杂志文章

    doi:10.1046/j.1365-2141.2002.03748.x

    authors: Lee JH,Lee KH,Lee JH,Kim S,Seol M,Park CJ,Chi HS,Kang W,Kim ST,Kim WK,Lee JS

    更新日期:2002-09-01 00:00:00

  • A modified high-dose dexamethasone regimen for primary systemic (AL) amyloidosis.

    abstract::High-dose dexamethasone (HD-Dex) has been reported to benefit AL amyloidosis patients with varying response rates. Our preliminary experience with the usual HD-Dex schedule indicated that the induction phase was rather toxic in AL patients. We therefore adopted a milder schedule consisting of dexamethasone 40 mg on d ...

    journal_title:British journal of haematology

    pub_type: 杂志文章

    doi:10.1046/j.1365-2141.2001.02859.x

    authors: Palladini G,Anesi E,Perfetti V,Obici L,Invernizzi R,Balduini C,Ascari E,Merlini G

    更新日期:2001-06-01 00:00:00

  • Serial studies of methylation of CDKN2B and CDKN2A in relapsed acute promyelocytic leukaemia treated with arsenic trioxide.

    abstract::Ninety consecutive patients with acute promyelocytic leukaemia were investigated for promoter methylation of CDKN2B (alias p15) and CDKN2A (alias p16) in disease relapse and progression. CDKN2B methylation was significantly more frequent at first relapse (30/36, 83%) than at presentation (48/77, 62%) (P=0.025), while ...

    journal_title:British journal of haematology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2141.2005.05818.x

    authors: Au WY,Fung AT,Ma ES,Chan CH,Wong KF,Chim CS,Liang RH,Kwong YL

    更新日期:2005-12-01 00:00:00

  • Cytokines and fungal infections.

    abstract::The very poor outcome of invasive fungal infections (IFI) in patients with haematological malignancies or recipients of haematopoietic stem cell transplantation is largely attributed to their compromised host defence mechanisms. The restoration or augmentation of immune responses in these patients is now considered as...

    journal_title:British journal of haematology

    pub_type: 杂志文章,评审

    doi:10.1111/j.1365-2141.2005.05498.x

    authors: Antachopoulos C,Roilides E

    更新日期:2005-06-01 00:00:00

  • 125I fibrinogen turnover in polycythaemia: the effect of phlebotomy.

    abstract::Patients with polycythaemia vera and secondary polycythaemia studied with 125I-labelled fibrinogen, had a significantly increased plasma fibrinogen turnover. The abnormalities were greater in polycythaemia vera and correlated with platelet count but not with packed cell volume. In six patients with polycythaemia vera,...

    journal_title:British journal of haematology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2141.1983.tb01990.x

    authors: Boughton BJ,Dallinger KJ

    更新日期:1983-01-01 00:00:00

  • Malignant histiocytosis-like B-cell lymphoma, a distinct pathologic variant of intravascular lymphomatosis: a report of five cases and review of the literature.

    abstract::Malignant histiocytosis (MH)-like B-cell lymphoma (BCL) is a neoplastic proliferation of large B cells clinically characterized by fever, hepatosplenomegaly, haemophagocytosis and abnormal laboratory data, without lymphadenopathy or skin lesions. Interestingly, most cases have been reported in Asian patients, and it i...

    journal_title:British journal of haematology

    pub_type: 杂志文章,评审

    doi:10.1046/j.1365-2141.1997.4623265.x

    authors: Murase T,Nakamura S,Tashiro K,Suchi T,Hiraga J,Hayasaki N,Kimura M,Murakami M,Mizoguchi Y,Suzuki T,Saito H

    更新日期:1997-12-01 00:00:00

  • Donor lymphocyte infusion for childhood acute lymphoblastic leukaemia relapsing after bone marrow transplantation.

    abstract::Four children with acute lymphoblastic leukaemia (ALL) who relapsed after allogeneic bone marrow transplantation (BMT) were treated with donor lymphocyte infusion (DLI) without prior conditioning. Three patients had previously received a non-T-cell-depleted matched sibling BMT and the fourth had a T-cell-depleted matc...

    journal_title:British journal of haematology

    pub_type: 杂志文章

    doi:10.1046/j.1365-2141.1997.62650.x

    authors: Atra A,Millar B,Shepherd V,Shankar A,Wilson K,Treleaven J,Pritchard-Jones K,Meller ST,Pinkerton CR

    更新日期:1997-04-01 00:00:00

  • Progress in understanding the pathogenesis of Langerhans cell histiocytosis: back to Histiocytosis X?

    abstract::Langerhans cell histiocytosis (LCH), the most common histiocytic disorder, is characterized by the accumulation of CD1A(+) /CD207(+) mononuclear phagocytes within granulomatous lesions that can affect nearly all organ systems. Historically, LCH has been presumed to arise from transformed or pathologically activated ep...

    journal_title:British journal of haematology

    pub_type: 杂志文章,评审

    doi:10.1111/bjh.13247

    authors: Berres ML,Merad M,Allen CE

    更新日期:2015-04-01 00:00:00

  • Cytogenetic and molecular study of 32 Down syndrome families: potential leukaemia predisposing role of the most proximal segment of chromosome 21q.

    abstract::Down syndrome (DS) children have a 10-20-fold increased risk of developing ALL or AML compared to non-DS children. An increased disomic homozygosity of the polymorphic DNA markers in the pericentromeric region of chromosome 21q (21q11) has repeatedly been found in DS patients with ANLL-M7 and DS-specific transient abn...

    journal_title:British journal of haematology

    pub_type: 杂志文章

    doi:10.1046/j.1365-2141.1998.00924.x

    authors: Cavani S,Perfumo C,Argusti A,Pierluigi M,Perroni L,Schmiegelow K,Petersen MB,Cotter FE,Strigini P,Dagna-Bricarelli F,Nizetić D

    更新日期:1998-10-01 00:00:00

  • CD99 expression is strongly associated with clinical outcome in children with B-cell precursor acute lymphoblastic leukaemia.

    abstract::Our study aimed to determine the expression pattern and clinical relevance of CD99 in paediatric B-cell precursor acute lymphoblastic leukaemia (BCP-ALL). Our findings demonstrate that high expression levels of CD99 are mainly found in high-risk BCP-ALL, e.g. BCR-ABL1 and CRLF2Re/Hi, and that high CD99 mRNA levels are...

    journal_title:British journal of haematology

    pub_type: 杂志文章

    doi:10.1111/bjh.15683

    authors: Chen D,Camponeschi A,Wu Q,Gerasimcik N,Li H,Shen X,Tan Y,Sjögren H,Nordlund J,Lönnerholm G,Abrahamsson J,Fogelstrand L,Mårtensson IL

    更新日期:2019-02-01 00:00:00

  • Bone involvement in sickle cell disease.

    abstract::Bone involvement is the commonest clinical manifestation of sickle cell disease both in the acute setting such as painful vaso-occlusive crises, and as a source of chronic, progressive disability such as avascular necrosis. Management of these problems is often difficult because of the diagnostic imprecision of most l...

    journal_title:British journal of haematology

    pub_type: 杂志文章,评审

    doi:10.1111/j.1365-2141.2005.05476.x

    authors: Almeida A,Roberts I

    更新日期:2005-05-01 00:00:00

  • Novel alleles at the JK blood group locus explain the absence of the erythrocyte urea transporter in European families.

    abstract::The Kidd (JK) blood group system is of importance in transfusion medicine. The Jk(null) phenotype is associated with absence of the urea transporter in erythrocytes and moderately reduced ability to concentrate urine. We and others recently reported different molecular alterations in the silenced Jkb-like alleles of P...

    journal_title:British journal of haematology

    pub_type: 杂志文章

    doi:10.1046/j.1365-2141.2002.03238.x

    authors: Irshaid NM,Eicher NI,Hustinx H,Poole J,Olsson ML

    更新日期:2002-02-01 00:00:00

  • Detection of clonal T-cell populations in gastrointestinal lymphomas by analysis of cRNA conformational polymorphisms of rearranged T-cell-receptor-gamma genes.

    abstract::Analysis of complementary RNA molecules of junctional regions of rearranged T-cell-receptor-gamma genes show a pattern of conformational polymorphisms which is specific for an individual lymphocytic clone. In a blinded study we analysed formalin-fixed, paraffin-embedded histological specimens from gastrointestinal lym...

    journal_title:British journal of haematology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2141.1994.tb04732.x

    authors: Koch OM,Probst M,Tiemann M,Jakob I,Volkenandt M,Wienecke R,Buer J,Atzpodien J,Lenz HJ,Danenberg PV

    更新日期:1994-02-01 00:00:00

  • P-glycoprotein expression on acute myeloid leukaemia blast cells at diagnosis predicts response to chemotherapy and survival.

    abstract::P-glycoprotein (Pgp) expression, which is associated with the multi-drug resistance (MDR) phenotype, has been reported to be a useful predictor of treatment outcome in acute leukaemia. We have examined the expression of Pgp on acute myeloid leukaemia (AML) cells in 54 newly diagnosed patients, using a novel streptavid...

    journal_title:British journal of haematology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2141.1994.tb08305.x

    authors: Wood P,Burgess R,MacGregor A,Yin JA

    更新日期:1994-07-01 00:00:00

  • Advances in understanding the pulmonary infiltration in acute promyelocytic leukaemia.

    abstract::In acute promyelocytic leukaemia (APL), differentiation therapy can be complicated by the development of a differentiation syndrome (DS). Pulmonary infiltration of differentiating leukaemic cells is a key event in the development of DS. Several mediators have been identified that may promote migration and extravasatio...

    journal_title:British journal of haematology

    pub_type: 杂志文章,评审

    doi:10.1111/j.1365-2141.2010.08325.x

    authors: Luesink M,Jansen JH

    更新日期:2010-11-01 00:00:00

  • Red blood cell aggregation and sedimentation: the role of the cell shape.

    abstract::The influence of erythrocyte shape changes on the sedimentation rate was studied in vitro and in vivo. In vitro the highest sedimentation rate was observed with a slight degree of stomatocytosis (morphological index-0.3; i.e. one red cell out of three being a stomatocyte I). With increasing degrees of stomatocytosis t...

    journal_title:British journal of haematology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2141.1989.tb00296.x

    authors: Reinhart WH,Singh A,Straub PW

    更新日期:1989-12-01 00:00:00

  • The safety and effectiveness of deferiprone in a large-scale, 3-year study in Italian patients.

    abstract::In 1997, the Italian Ministry of Health created a special programme for the controlled distribution of deferiprone to collect data and to evaluate its safety and effectiveness in long-term use. Five hundred and thirty-two thalassaemia patients from 86 treatment centres were enrolled in this programme. One hundred and ...

    journal_title:British journal of haematology

    pub_type: 临床试验,杂志文章,多中心研究

    doi:10.1046/j.1365-2141.2002.03554.x

    authors: Ceci A,Baiardi P,Felisi M,Cappellini MD,Carnelli V,De Sanctis V,Galanello R,Maggio A,Masera G,Piga A,Schettini F,Stefàno I,Tricta F

    更新日期:2002-07-01 00:00:00

  • Haemolytic anaemia due to glucose-6-phosphate dehydrogenase (G6PD) deficiency: demonstration of two new biochemical variants, G6PD Hamm and G6PD Tarsus.

    abstract::Two new variants of erythrocytic glucose-6-phosphate dehydrogenase have been found in one German patient and in another patient of Turkish origin. The enzymes were partially purified 165-fold and 111-fold respectively. Both revealed reduced activity, increased thermolability and a pH-optimum in the alkaline region (8....

    journal_title:British journal of haematology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2141.1976.tb03552.x

    authors: Gahr M,Bornhalm D,Schröter W

    更新日期:1976-07-01 00:00:00

  • Avascular necrosis of bone after allogeneic bone marrow transplantation: analysis of risk factors for 4388 patients by the Société Française de Greffe de Moëlle (SFGM).

    abstract::Increasing numbers of patients are surviving after allogeneic bone marrow transplantation and are therefore at risk for developing late complications. Among these complications, avascular necrosis of bone has been reported, but only two single-centre studies included sufficient patients to enable analysis of the risk ...

    journal_title:British journal of haematology

    pub_type: 杂志文章

    doi:10.1046/j.1365-2141.1997.1262940.x

    authors: Socié G,Cahn JY,Carmelo J,Vernant JP,Jouet JP,Ifrah N,Milpied N,Michallet M,Lioure B,Pico JL,Witz F,Molina L,Fischer A,Bardou VJ,Gluckman E,Reiffers J

    更新日期:1997-06-01 00:00:00

  • A novel cell line derived from de novo acute myeloblastic leukaemia with trilineage myelodysplasia which proliferates in response to a Notch ligand, Delta-1 protein.

    abstract::A novel human leukaemia cell line, designated TMD7, was established from blast cells of a patient with de novo acute myeloblastic leukaemia with trilineage myelodysplasia (AML/TLD). As seen in the original blast cells, TMD7 cells expressed CD7, CD13, CD33 and CD34 and showed an abnormal karyotype containing -5, -7, -8...

    journal_title:British journal of haematology

    pub_type: 杂志文章

    doi:10.1046/j.1365-2141.2002.03446.x

    authors: Tohda S,Sakano S,Ohsawa M,Murakami N,Nara N

    更新日期:2002-05-01 00:00:00

  • Flow cytometry analysis of dual red blood cell populations after bone marrow transplantation.

    abstract::Flow cytometry represents an alternative method to agglutination assays for the accurate quantification of mixed field populations of erythrocytes observed after bone marrow transplantation. Murine monoclonal antibodies directed against the blood group ABH antigens were selected and processed in order to prepare ready...

    journal_title:British journal of haematology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2141.1995.tb08410.x

    authors: Blanchard D,Bruneau V,Bernard D,Germond-Arnoult F,Gourbil A,David B,Muller JY

    更新日期:1995-04-01 00:00:00

  • Continuous complete remission in adult patients with acute lymphocytic leukaemia at a median observation of 12 years after autologous bone marrow transplantation.

    abstract::We report our long-term experience with autologous bone marrow transplantation (ABMT) for 32 adult patients with acute lymphocytic leukaemia (ALL) in second or later remission (CR), or in first CR but with high-risk. Bone marrow was purged with mafosfamide (n = 25) or with immunomagnetic beads and monoclonal antibodie...

    journal_title:British journal of haematology

    pub_type: 杂志文章

    doi:10.1046/j.1365-2141.2001.02634.x

    authors: Abdallah A,Egerer G,Goldschmidt H,Wannenmacher M,Körbling M,Ho AD

    更新日期:2001-03-01 00:00:00

  • A good prognosis group in childhood acute lymphoblastic leukaemia.

    abstract::The records of 121 children presenting with acute lymphoblastic leukaemia between 1969 and 1982 were reviewed. The overall relapse free survival rate was 50%. However, girls presenting with a total white blood cell count of 20 X 10(9)/l or less (35% of all patients) had a particularly favourable prognosis with an 80% ...

    journal_title:British journal of haematology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2141.1983.tb01246.x

    authors: Stockley RJ,Ahlquist PY,Mott MG

    更新日期:1983-10-01 00:00:00

  • X-chromosome inactivation analysis of isolated Reed-Sternberg cells in nodular sclerosing Hodgkin's disease.

    abstract::In spite of several studies of immunoglobulin (Ig) gene rearrangements in whole Hodgkin's disease (HD) tissues and in isolated single Reed-Sternberg (RS) cells, the issue of clonality of the RS cell in HD remains incompletely resolved. Analysis of X-chromosome inactivation patterns (XCIPs) can be used to determine whe...

    journal_title:British journal of haematology

    pub_type: 杂志文章

    doi:10.1046/j.1365-2141.1999.01727.x

    authors: Chang HW,Chong SM,Peh SC,Lee SH

    更新日期:1999-12-01 00:00:00

  • von Willebrand factor clearance - biological mechanisms and clinical significance.

    abstract::The mechanisms involved in regulating von Willebrand factor (VWF) clearance remain poorly understood. However recent studies have shown that macrophages play a critical role in regulating the half-life of VWF, and have identified specific lectin (including asialoglycoprotein, macrophage galactose-type lectin, Sigec-5 ...

    journal_title:British journal of haematology

    pub_type: 杂志文章,评审

    doi:10.1111/bjh.15565

    authors: O'Sullivan JM,Ward S,Lavin M,O'Donnell JS

    更新日期:2018-10-01 00:00:00

  • Successful treatment of a non-haemophilic patient with inhibitor to factor VIII by double-filtration plasmapheresis.

    abstract::Factor VIII (FVIII) inhibitors appear in 3-20% of haemophilia A patients after injection of FVIII concentrates. However, autoantibodies to FVIII are also reported in non-haemophiliacs. In these patients FVIII inhibitor disappears spontaneously or diminishes in response to immunosuppressive therapy. However, a few pati...

    journal_title:British journal of haematology

    pub_type: 杂志文章

    doi:10.1046/j.1365-2141.1999.01220.x

    authors: Sunagawa T,Uezu Y,Kadena K,Tokuyama K,Kinjo F,Saito A

    更新日期:1999-03-01 00:00:00

  • LISA: a web-based decision-support system for trial management of childhood acute lymphoblastic leukaemia.

    abstract::Continuation chemotherapy is a key component of the treatment of childhood acute lymphoblastic leukaemia. During this treatment phase, weekly dose adjustments are carried out based on current and historical full blood counts (FBCs). The dose decision pathway is complex and suboptimal therapy may result if information ...

    journal_title:British journal of haematology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2141.2005.05541.x

    authors: Bury J,Hurt C,Roy A,Cheesman L,Bradburn M,Cross S,Fox J,Saha V

    更新日期:2005-06-01 00:00:00

  • Hairy cell leukaemia: a heterogeneous disease?

    abstract::The US National Cancer Institute's Surveillance, Epidemiology and End Results program was used to develop aetiological clues for hairy cell leukaemia (HCL). Descriptive techniques (age-adjusted incidence trends, age-specific incidence rates (IR), and age distributions-at-diagnosis) were supplemented with mathematical ...

    journal_title:British journal of haematology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2141.2008.07156.x

    authors: Dores GM,Matsuno RK,Weisenburger DD,Rosenberg PS,Anderson WF

    更新日期:2008-07-01 00:00:00