No evidence for a major role of heterozygous deletion 657del5 within the NBS1 gene in the pathogenesis of non-Hodgkin's lymphoma of childhood and adolescence.

abstract：:Granulocyte-macrophage colony-stimulating factor (GM-CSF) is a multifunctional haematopoietin which can promote production of several blood cell lineages, though the predominant target cells are neutrophils, monocytes, and their precursors. Occasional undesirable clinical effects include eosinophilia, an increase in b...

journal_title：British journal of haematology

authors： Kurzrock R,Talpaz M,Gomez JA,Estey EH,O'Brien S,Hirsch-Ginsberg C,Koller C,Freireich EJ,Gutterman JU

更新日期：1991-07-01 00:00:00

abstract：:Sphingosine-1-phosphate (S1P) is a potent lipid mediator that is produced during the metabolism of sphingolipid by sphingosine kinase. S1P has been implicated in the migration and trafficking of lymphocytes and several lymphoid malignancies through S1P receptors. Moreover, the overexpression of sphingosine-1-phosphate...

journal_title：British journal of haematology

authors： Koresawa R,Yamazaki K,Oka D,Fujiwara H,Nishimura H,Akiyama T,Hamasaki S,Wada H,Sugihara T,Sadahira Y

更新日期：2016-07-01 00:00:00

abstract：:Between 1984 and 1992, 21 patients with chronic myeloid leukaemia (CML) in chronic phase (CP) were treated with high-dose chemotherapy (or chemoradiotherapy) followed by autografting with unmanipulated peripheral blood stem cells (PBSC). 12 of these patients survive at a median of 82 months from the time of autografti...

journal_title：British journal of haematology

authors： Hoyle C,Gray R,Goldman J

更新日期：1994-01-01 00:00:00

abstract：:Forty female patients with either primary anti-phospholipid syndrome (n = 26) or systemic lupus erythematosus (anti-phospholipid syndrome positive) (n = 14) were investigated for levels of factor XII, the presence of lupus anticoagulant and antibodies to cardiolipin, beta 2-glycoprotein I and factor XII. Twenty-one pa...

journal_title：British journal of haematology

authors： Jones DW,MacKie IJ,Gallimore MJ,Winter M

更新日期：2001-05-01 00:00:00

abstract：:While imatinib and other tyrosine kinase inhibitors (TKIs) are highly efficacious in the treatment of chronic myeloid leukaemia (CML), some patients become refractory to these therapies. After confirming that interleukin-3 receptor (IL3R, CD123) is highly expressed on CD34(+) /CD38(-) BCR-ABL1(+) CML stem cells, we in...

journal_title：British journal of haematology

authors： Frolova O,Benito J,Brooks C,Wang RY,Korchin B,Rowinsky EK,Cortes J,Kantarjian H,Andreeff M,Frankel AE,Konopleva M

更新日期：2014-09-01 00:00:00

abstract：:It is widely recognized that thrombosis is the major event in the evolution of stable vascular disease to unstable ischaemic syndromes including myocardial infarction and stroke. The purpose of this case-control study was to establish clinical and laboratory data on the possible relationship between specific component...

journal_title：British journal of haematology

authors： Freeburn JC,Wallace JM,Strain JJ,Sinnamon DG,Craig BM,Johnson D,Gilmore WS

更新日期：1998-07-01 00:00:00

abstract：:Primary non-engraftment or early rejection after transplantation of haematopoietic stem cells represent life-threatening complications of allogeneic stem cell transplantation. Management of early graft failure has been problematic, as the risk of fatal infectious complications increases with the time of pancytopenia a...

journal_title：British journal of haematology

authors： Schlegel PG,Eyrich M,Bader P,Handgretinger R,Lang P,Niethammer D,Klingebiel T

更新日期：2000-11-01 00:00:00

abstract：:We studied erythrocyte calcium levels and uptake in a group of patients with sickle haemoglobinopathies of different clinical severity in an attempt to relate these measurements to the production of irreversibly sickled cells and disease severity. Erythrocyte calcium levels were measured by atomic absorption spectrosc...

journal_title：British journal of haematology

authors： Steinberg MH,Eaton JW,Berger E,Coleman MB,Oelshlegel FJ

更新日期：1978-12-01 00:00:00

abstract：:The myelodysplastic syndromes (MDS) display both haematological and biological heterogeneity with variable leukaemia potential. MicroRNAs play an important role in tumour suppression and the regulation of self-renewal and differentiation of haematopoietic progenitors. Using a microarray platform, we evaluated microRNA...

journal_title：British journal of haematology

authors： Sokol L,Caceres G,Volinia S,Alder H,Nuovo GJ,Liu CG,McGraw K,Clark JA,Sigua CA,Chen DT,Moscinski L,Croce CM,List AF

更新日期：2011-04-01 00:00:00

abstract：:A reduction of donor effects during centrifugal plateletpheresis with the Haemonetics Blood Processor was achieved by reducing the concentration of the citrate anticoagulant. Serum citrate and ionized calcium levels, immediately and 1 h post-pheresis, were affected to a lesser extent by using 5.0 g total ionized citra...

journal_title：British journal of haematology

authors： Mishler JM,Janes AW,Lowes B,Farfan C,Emerson PM

更新日期：1976-11-01 00:00:00

abstract：:We have characterized the molecular defect in two families with severe factor VII (FVII) deficiency. In family I, the proband was found to be homozygous for a novel 18 bp deletion in exon 8 (g.10896-10913del) resulting in the in-frame deletion of six amino acids in the serine protease domain. Molecular modelling sugge...

journal_title：British journal of haematology

authors： Gomez K,Laffan MA,Kemball-Cook G,Pasi J,Layton M,Singer JD,Tuddenham EG,McVey JH

更新日期：2004-07-01 00:00:00

abstract：:Nasal T/natural killer (NK) cell lymphoma is a distinct clinicopathologic entity which is more prevalent in Asia than in America and Europe. The clonal nature of the infiltrating lymphoid cells is difficult to demonstrate because of the lack of immunologic markers for clonality and the absence of clonal T-cell recepto...

journal_title：British journal of haematology

authors： Tien HF,Su IJ,Tang JL,Liu MC,Lee FY,Chen YC,Chuang SM

更新日期：1997-06-01 00:00:00

abstract：:We assessed the clinical utility of next-generation sequencing (NGS)-based monitoring of minimal residual disease (MRD) in a uniformly treated cohort of 79 patients with paediatric B-cell acute lymphoblastic leukaemia. Bone marrow samples were collected at the time of diagnosis, days 33 and 80, pre- (4-5 months) and p...

journal_title：British journal of haematology

authors： Sekiya Y,Xu Y,Muramatsu H,Okuno Y,Narita A,Suzuki K,Wang X,Kawashima N,Sakaguchi H,Yoshida N,Hama A,Takahashi Y,Kato K,Kojima S

更新日期：2017-01-01 00:00:00

abstract：:We studied the lysis in vitro of group A red cells by IgG anti-A. IgG anti-A, which strongly lysed A red cells from adults, did not lyse A red cells from cord blood, if fresh cord serum from a child with blood group AB was used as a source of complement. In cases of haemolytic disease of the newborn due to A-O or B-O ...

journal_title：British journal of haematology

authors： Brouwers HA,Overbeeke MA,Huiskes E,Bos MJ,Ouwehand WH,Engelfriet CP

更新日期：1988-03-01 00:00:00

abstract：:Acute promyelocytic leukaemia (APL) is a rare subtype of acute myeloid leukaemia. The outcome of paediatric APL has improved substantially over the past 20 years; cure rates above 80% are expected when all-trans retinoic acid (ATRA) is given with anthracycline-based regimens. The presenting features of paediatric APL ...

journal_title：British journal of haematology

authors： Abla O,Ribeiro RC

更新日期：2014-01-01 00:00:00

abstract：:In order to clarify the mechanism of the effect of erythropoietin (Epo) on the fetal haemoglobin (HbF) phenotype of peripheral erythrocytes, we studied the dose-response effect of Epo on HbF production by erythroid precursors derived from the peripheral blood of normal adult individuals and grown in a two-phase liquid...

journal_title：British journal of haematology

authors： Fibach E,Schechter AN,Noguchi CT,Rodgers GP

更新日期：1994-09-01 00:00:00

abstract：:Adult T-cell leukaemia lymphoma (ATLL) is an aggressive disease caused by the human T-lymphotropic virus 1 (HTLV-I) with a short survival. Responses to interferon alpha (IFN-alpha) and zidovudine (AZT) have been documented but not with long-term follow-up. We treated 15 ATLL patients with IFN and AZT. Eleven patients ...

journal_title：British journal of haematology

authors： Matutes E,Taylor GP,Cavenagh J,Pagliuca A,Bareford D,Domingo A,Hamblin M,Kelsey S,Mir N,Reilly JT

更新日期：2001-06-01 00:00:00

abstract：:Therapeutic options for treatment of recurrence of leukaemia after allogeneic bone marrow transplantation (BMT) are limited. A beneficial effect of donor lymphocyte infusions (DLI) has not previously been described in acute myeloid leukaemia (AML) relapse. We report a case of AML with t(8;21), relapsing 3 months after...

journal_title：British journal of haematology

authors： Buzyn-Veil A,Belanger C,Audat F,Hermine O,Bodemer C,Ribrag V,Radford I,Poirel H,Chane C,Valensi F,Macintyre E,Varet B

更新日期：1996-02-01 00:00:00

abstract：:Heparin-induced thrombocytopenia (HIT) is mediated by a heparin-dependent antibody/platelet factor 4/heparin complex binding to platelets via the Fc gamma receptor (type IIA). A single base polymorphism at position 131 of Fc gamma RIIA changes the native arginine to histidine. In the presence of murine monoclonal IgG1...

journal_title：British journal of haematology

authors： Burgess JK,Lindeman R,Chesterman CN,Chong BH

更新日期：1995-11-01 00:00:00

abstract：:A serial study of coagulation activation and whole-blood viscosity was performed on 37 patients with local or systemic bacterial infection, malaria, or a viral infection. Thrombocytopenia, without consumption of coagulation factors, was the main feature of benign tertian malaria and viral infection, whereas in septica...

journal_title：British journal of haematology

authors： Richardson SG,Matthews KB,Cruickshank JK,Geddes AM,Stuart J

更新日期：1979-07-01 00:00:00

abstract：:Association between HLA haplotypes and long survival was investigated in 116 children with acute lymphoblastic leukaemia. It was found that patients with A2 B12 and/or A2 B40 haplotypes survived longer than patients wtihout these two haplotypes. Since all children were treated with transfer factor obtained from their ...

journal_title：British journal of haematology

authors： De Bruyère M,Cornu G,Heremans-Bracke T,Malchaire J,Sokal G

更新日期：1980-02-01 00:00:00

abstract：:The in vitro haemostatic functions of fresh whole blood (FWB) are well preserved after cold storage. This study aimed to determine whether platelets derived from FWB and stored whole blood (SWB) contribute to clot formation in tissue injury after transfusion into coagulopathic rats with polytrauma/haemorrhage (T/H). T...

journal_title：British journal of haematology

authors： Wu X,Darlington DN,Montgomery RK,Liu B,Keesee JD,Scherer MR,Benov A,Chen J,Cap AP

更新日期：2017-12-01 00:00:00

abstract：:Comparative data on immunochemotherapy regimens for Waldenström macroglobulinaemia/lymphoplasmacytic lymphoma (WM/LPL) are lacking. We analysed overall survival (OS), risk of hospitalizations, transfusions and plasmapheresis in a population-based cohort of patients ≥65 years old initiating WM/LPL therapy in 1999-2013....

journal_title：British journal of haematology

authors： Olszewski AJ,Chen C,Gutman R,Treon SP,Castillo JJ

更新日期：2017-10-01 00:00:00

abstract：:In acute promyelocytic leukaemia (APL), differentiation therapy can be complicated by the development of a differentiation syndrome (DS). Pulmonary infiltration of differentiating leukaemic cells is a key event in the development of DS. Several mediators have been identified that may promote migration and extravasatio...

journal_title：British journal of haematology

authors： Luesink M,Jansen JH

更新日期：2010-11-01 00:00:00

abstract：:Drug-related neutropenia is a common observation in AIDS patients. Haematological growth factors are therefore increasingly used in combination with myelotoxic agents to reduce the risk of infection and to improve the haematological tolerance of these regimens. We report a case of an AIDS patient with Kaposi's sarcoma...

journal_title：British journal of haematology

authors： Hermans P,Gori A,Lemone M,Franchioly P,Clumeck N

更新日期：1994-06-01 00:00:00

abstract：UNLABELLED:Transplant-related mortality (TRM) remains a major problem in older patients undergoing allogeneic haemopoietic stem cell transplants (HSCTs). We have therefore explored a less intensive conditioning in 33 patients with a median age of 52 years (range 43-60) transplanted from human leucocyte antigen (HLA)-id...

journal_title：British journal of haematology

authors： Raiola AM,Van Lint MT,Lamparelli T,Gualandi F,Mordini N,Berisso G,Bregante S,Frassoni F,Sessarego M,Fugazza G,Di Stefano F,Pitto A,Bacigalupo A

更新日期：2000-06-01 00:00:00

abstract：:The existence of two genetic variants (allotypes) of normal human factor IX is used for carrier detection in three families with severe and one with mild haemophilia B. By analysis of IX:Ag with two different monoclonal antibodies in 93 members of the families, allelic assignment is shown to be a complement in carrier...

journal_title：British journal of haematology

authors： Wallmark A,Ljung R,Nilsson IM

更新日期：1987-12-01 00:00:00

abstract：:Increasing demand for population screening for the haemoglobinopathies gives rise to a requirement for high throughput systems, which allow for cost effective, rapid, sensitive and specific screening of clinically significant haemoglobins. We have developed a practical and efficient approach using tryptic digestion an...

journal_title：British journal of haematology

authors： Daniel YA,Turner C,Haynes RM,Hunt BJ,Dalton RN

更新日期：2005-08-01 00:00:00

abstract：:The Complement 1 trial investigated the efficacy and safety of ofatumumab + chlorambucil with chlorambucil monotherapy in patients with previously untreated chronic lymphocytic leukaemia (CLL). On long-term follow-up in the chemoimmunotherapy arm vs. the chemotherapy arm there was an estimated 12% (not significant) an...

journal_title：British journal of haematology

authors： Offner F,Robak T,Janssens A,Govind Babu K,Kloczko J,Grosicki S,Mayer J,Panagiotidis P,Schuh A,Pettitt A,Montillo M,Werner O,Vincent G,Khanna S,Hillmen P

更新日期：2020-09-01 00:00:00

abstract：:We have previously shown that polymorphonuclear leucocytes (PMN) harvested from children with cancer and exposed to chemotherapy exhibit defective bactericidal activities against both Gram-positive and Gram-negative microorganisms as well as accelerated apoptosis. In this study, PMN from children with cancer were eval...

journal_title：British journal of haematology

authors： Lejeune M,Cantinieaux B,Harag S,Ferster A,Devalck C,Sariban E

更新日期：1999-09-01 00:00:00