Comparative outcomes of immunochemotherapy regimens in Waldenström macroglobulinaemia.

abstract：:Beta2-glycoprotein I (beta2GPI) is an important target antigen for antiphospholipid antibodies (aPL) and thus beta2GPI polymorphisms may influence aPL production and the development of antiphospholipid syndrome. We have studied the relationship between the Val247Leu and Trp316Ser beta2GPI polymorphisms and the aPL sta...

journal_title：British journal of haematology

authors： Camilleri RS,Mackie IJ,Humphries SE,Machin SJ,Cohen H

更新日期：2003-03-01 00:00:00

abstract：:Serum antiplatelet IgG and platelet-associated IgG (PAIgG) were studied in 68 AIDS-free human immunodeficiency virus (HIV)-infected patients with severe immunologic thrombocytopenic purpura (ITP), for the presence of platelet autoantibodies. Serum IgG with antiplatelet activity was found in 72% of the sera. However, t...

journal_title：British journal of haematology

authors： Bettaieb A,Oksenhendler E,Fromont P,Duedari N,Bierling P

更新日期：1989-10-01 00:00:00

abstract：:An indirect immunofluorescence technique with single and double labelling has been used to examine cultured human megakaryocytes for ABH antigens. This technique demonstrated the presence of these antigens on megakaryocytes and a population of small mononuclear cells that probably represent the differentiated precurso...

journal_title：British journal of haematology

authors： Dunstan RA

更新日期：1986-03-01 00:00:00

abstract：:Unfractionated heparin (UFH) and low-molecular weight heparin (LMWH) are well defined anticoagulant agents. Recent data suggest that both LMWH and UFH may also have potent anti-inflammatory properties; however, their mechanism of action responsible for the anti-inflammatory effect is not yet fully elucidated. This stu...

journal_title：British journal of haematology

authors： Hochart H,Jenkins PV,Smith OP,White B

更新日期：2006-04-01 00:00:00

abstract：:Notwithstanding the improvement in treatment results for paediatric T cell acute lymphoblastic leukaemia (T-ALL) it remains important to understand if genetic aberrations influence therapy response. PTEN tumour suppressor gene inactivation is a frequent event in T-ALL but its effect on patient therapy response is deba...

journal_title：British journal of haematology

authors： Paganin M,Grillo MF,Silvestri D,Scapinello G,Buldini B,Cazzaniga G,Biondi A,Valsecchi MG,Conter V,Te Kronnie G,Basso G

更新日期：2018-09-01 00:00:00

abstract：:The multimeric plasma protein von Willebrand factor (VWF) is regulated in size by its protease, ADAMTS13 (a disintegrin and metalloproteinase with thrombospondin type 1 motif, member 13). Y1605-M1606 cleavage site mutations and single nucleotide polymorphisms (SNPs) in the VWF A1 and A2 domains were examined for alter...

journal_title：British journal of haematology

authors： Pruss CM,Notley CR,Hegadorn CA,O'Brien LA,Lillicrap D

更新日期：2008-11-01 00:00:00

abstract：:Eltrombopag is a thrombopoietin-receptor agonist that stimulates platelet production and increases platelet counts in patients with chronic immune thrombocytopenia (ITP). This open-label, single-arm study evaluated consistency of response and safety following repeated intermittent dosing of eltrombopag 50 mg daily ove...

journal_title：British journal of haematology

authors： Bussel JB,Saleh MN,Vasey SY,Mayer B,Arning M,Stone NL

更新日期：2013-02-01 00:00:00

abstract：:Despite the significance of red blood cell (RBC) alloimmunization, the lack of standardized registries in the US has prevented the completion of large studies. Data from 3·5 years of the Recipient Epidemiology and Donor Evaluation Study-III (REDS-III) recipient database, containing information from 12 hospitals, were ...

journal_title：British journal of haematology

authors： Karafin MS,Westlake M,Hauser RG,Tormey CA,Norris PJ,Roubinian NH,Wu Y,Triulzi DJ,Kleinman S,Hendrickson JE,NHLBI Recipient Epidemiology and Donor Evaluation Study-III (REDS-III).

更新日期：2018-06-01 00:00:00

abstract：:Primary non-engraftment or early rejection after transplantation of haematopoietic stem cells represent life-threatening complications of allogeneic stem cell transplantation. Management of early graft failure has been problematic, as the risk of fatal infectious complications increases with the time of pancytopenia a...

journal_title：British journal of haematology

authors： Schlegel PG,Eyrich M,Bader P,Handgretinger R,Lang P,Niethammer D,Klingebiel T

更新日期：2000-11-01 00:00:00

abstract：:Heterozygosity for a C8524T transition in the protein C gene converting Ser270(TCG) to Leu(TTG) in the protease domain was identified in a family with venous thrombosis. The mutation was associated with parallel reduction in plasma levels of protein C anticoagulant activity and protein C antigen, which is consistent w...

journal_title：British journal of haematology

authors： Lind B,Koefoed P,Thorsen S

更新日期：2001-06-01 00:00:00

abstract：:We describe a familial study of AT III, a type III antithrombin III variant which was identified in the propositus by gene analysis as Pro 41 Leu heterozygous mutation. None of the four members of the family who presented with defective heparin cofactor (hep-cofactor) activity, and therefore probably carried the mutat...

journal_title：British journal of haematology

authors： de Roux N,Chadeuf G,Molho-Sabatier P,Plouin PF,Aiach M

更新日期：1990-06-01 00:00:00

abstract：:A human plasma cell leukaemia cell line (HSM-2) and a subclone (HSM-2.3) have been established from the bone marrow of a patient with bi-phenotypic leukaemia. Proliferation assays using a variety of cytokines demonstrated that HSM-2 proliferated in response to recombinant interleukin-6 (rIL-6), but did not respond to ...

journal_title：British journal of haematology

authors： Kobayashi M,Miyagishima T,Imamura M,Maeda S,Gotohda Y,Iwasaki H,Sakurada K,Miyazaki T

更新日期：1991-06-01 00:00:00

abstract：:We describe two British families with similar, dominantly-inherited, temperature-related variants of hereditary stomatocytosis, consistent with the original description of 'cryohydrocytosis'. The cells show a 5-6-fold increase in passive permeability at 37 degrees C with abnormal intracellular Na and K levels at 15-20...

journal_title：British journal of haematology

authors： Coles SE,Chetty MC,Ho MM,Nicolaou A,Kearney JW,Wright SD,Stewart GW

更新日期：1999-06-01 00:00:00

abstract：:We report a patient with congenital homozygous factor V deficiency in whom a large pseudotumour in the right upper leg was successfully surgically excised under continuous substitution with fresh-frozen plasma. ...

journal_title：British journal of haematology

authors： Tanis BC,van der Meer FJ,Bloem RM,Vlasveld LT

更新日期：1998-02-01 00:00:00

abstract：:Molecular genetic studies of lymphoma have led to refinements in disease classification in the most recent World Health Organization update. Nevertheless, a 'one-size-fits-most' treatment strategy based on morphology remains widely used for lymphoma despite significant molecular heterogeneity within histopathologicall...

journal_title：British journal of haematology

authors： El-Galaly TC,Cheah CY,Villa D

更新日期：2019-08-01 00:00:00

abstract：:Human erythrocytes from healthy male donors were fractionated with respect to in vivo age by simple centrifugation in order to characterize changes in the functional integrity of the membrane during the life-span of the cell. The three enzymes, Na/K-ATPase, glyceraldehyde-3-phosphate dehydrogenase and NADH-ferricyanid...

journal_title：British journal of haematology

authors： Kadlubowski M,Agutter PS

更新日期：1977-09-01 00:00:00

abstract：:Paroxysmal nocturnal haemoglobinuria (PNH) is a serious form of acquired haemolytic anaemia with several features that make it unique, including the fact that it is caused by clonal expansion, in the context of bone marrow failure, of a haematopoietic stem cell that has a somatic mutation in a gene crucial for the syn...

journal_title：British journal of haematology

authors： Luzzatto L,Gianfaldoni G,Notaro R

更新日期：2011-06-01 00:00:00

abstract：:Serum concentrations of the thrombopoiesis-enhancing cytokines thrombopoietin (TPO), erythropoietin (EPO), interleukin (IL)-6 and IL-11 were determined in 119 healthy whole-blood (WBD) and 101 platelet donors (PD) prior to donation. The 90% TPO reference interval in WBD of 64-867 pg/ml (median 163, 100% range 45-7572)...

journal_title：British journal of haematology

authors： Tacke F,Schöffski P,Trautwein C,Martin MU,Stangel W,Seifried E,Manns MP,Ganser A,Petersen D

更新日期：1999-05-01 00:00:00

abstract：:Minimal residual disease (MRD) assessment is a powerful prognostic factor for determining the risk of relapse in childhood acute lymphoblastic leukaemia (ALL). In this Swedish multi-centre study of childhood ALL diagnosed between 2002 and 2006, the MRD levels were analysed in 726 follow-up samples in 228 children usin...

journal_title：British journal of haematology

authors： Thörn I,Forestier E,Botling J,Thuresson B,Wasslavik C,Björklund E,Li A,Lindström-Eriksson E,Malec M,Grönlund E,Torikka K,Heldrup J,Abrahamsson J,Behrendtz M,Söderhäll S,Jacobsson S,Olofsson T,Porwit A,Lönnerholm G,R

更新日期：2011-03-01 00:00:00

abstract：:Acute promyelocytic leukaemia (APL) is a rare subtype of acute myeloid leukaemia. The outcome of paediatric APL has improved substantially over the past 20 years; cure rates above 80% are expected when all-trans retinoic acid (ATRA) is given with anthracycline-based regimens. The presenting features of paediatric APL ...

journal_title：British journal of haematology

authors： Abla O,Ribeiro RC

更新日期：2014-01-01 00:00:00

abstract：:Genomic DNA from 106 cases of adult de novo acute myeloid leukaemia (AML) was screened by polymerase chain reaction (PCR) and gel electrophoresis for FLT3 internal tandem duplication (ITD) mutations within the juxtamembrane (JM) domain. FLT3 mutations were detected in 14 cases (13.2%) and occurred in FAB types M1 (4 o...

journal_title：British journal of haematology

authors： Abu-Duhier FM,Goodeve AC,Wilson GA,Gari MA,Peake IR,Rees DC,Vandenberghe EA,Winship PR,Reilly JT

更新日期：2000-10-01 00:00:00

abstract：:Peripheral blood globin synthesis studies were done in 11 patients with delta beta-thalassaemia trait, Hb S-delta beta-thalassaemia or delta beta/betao-thalassaemia from two black and two Caucasian families. All patients had elevated Hb F and normal or decreased Hb A2 levels and 10 had family studies confirming the di...

journal_title：British journal of haematology

authors： Kinney TR,Friedman S,Cifuentes E,Kim HC,Schwartz E

更新日期：1978-01-01 00:00:00

abstract：:Previously described platelet-aggregating antibodies associated with thrombosis and thrombocytopenia required heparin for their in vivo and in vitro expression. We have observed a patient with thrombosis who became thrombocytopenic during heparin treatment, but who suffered further thrombotic events and continued thro...

journal_title：British journal of haematology

authors： Pfueller SL,David R,Firkin BG,Bilston RA,Cortizo WF,Raines G

更新日期：1990-03-01 00:00:00

abstract：:Knowledge of the absolute and relative risk of venous thromboembolism (VTE) in and around pregnancy would be crucial in identifying when to commence and cease thromboprophylaxis in women who would benefit from such intervention. We addressed this hypothesis using a large prospective primary care database from the Unit...

journal_title：British journal of haematology

authors： Sultan AA,West J,Tata LJ,Fleming KM,Nelson-Piercy C,Grainge MJ

更新日期：2012-02-01 00:00:00

abstract：:After T-cell depleted marrow transplantation, there is a rapid recovery of cytotoxic effector cells, with activity against targets not susceptible to killing by 'resting' natural killer cells. These targets include Epstein-Barr virus transformed B cells and leukaemic cell lines. Activated killer cell function declines...

journal_title：British journal of haematology

authors： Leger O,Drexler HG,Reittie JE,Secker-Walker L,Prentice HG,Brenner MK

更新日期：1987-11-01 00:00:00

abstract：:Although haematopoietic cell transplantation (HCT) is curative for sickle cell anaemia (SCA), concerns about its short- and long-term toxicities limit its application. A potential toxicity is an adverse effect on growth. To identify an HCT growth effect, serial height and weight measurements from 53 children and adole...

journal_title：British journal of haematology

authors： Eggleston B,Patience M,Edwards S,Adamkiewicz T,Buchanan GR,Davies SC,Dickerhoff R,Donfield S,Feig SA,Giller RH,Haight A,Horan J,Hsu LL,Kamani N,Lane P,Levine JE,Margolis D,Moore TB,Ohene-Frempong K,Redding-Lallinger

更新日期：2007-02-01 00:00:00

abstract：:Monoclonal antibody (mAb) drugs are desirable for the improvement of multiple myeloma (MM) treatment. In this study, we found for the first time that CD48 was highly expressed on MM plasma cells. In 22 out of 24 MM patients, CD48 was expressed on more than 90% of MM plasma cells at significantly higher levels than it ...

journal_title：British journal of haematology

authors： Hosen N,Ichihara H,Mugitani A,Aoyama Y,Fukuda Y,Kishida S,Matsuoka Y,Nakajima H,Kawakami M,Yamagami T,Fuji S,Tamaki H,Nakao T,Nishida S,Tsuboi A,Iida S,Hino M,Oka Y,Oji Y,Sugiyama H

更新日期：2012-01-01 00:00:00

abstract：:The sera of 14 patients with quinine/quinidine-dependent thrombocytopenia were studied in the platelet suspension immunofluorescence test (PSIFT), the 51Cr-lysis assay and the complement fixation test (CFT). When anti-Ig or anti-IgG reagents were used, the PSIFT proved to be a little more sensitive than the 51Cr-lysis...

journal_title：British journal of haematology

authors： van Leeuwen EF,Engelfriet CP,von dem Borne AE

更新日期：1982-08-01 00:00:00

abstract：:In a retrospective study, we examined the association between cytomegalovirus (CMV) infection and non-neutropenic fever immediately following autologous peripheral blood stem cell transplantation for a variety of haematological malignancies and solid tumours. Sixty non-neutropenic febrile episodes (41 in CMV-seroposit...

journal_title：British journal of haematology

authors： Fassas AB,Bolaños-Meade J,Buddharaju LN,Rapoport A,Cottler-Fox M,Chen T,Lovchik JC,Cross A,Tricot G

更新日期：2001-01-01 00:00:00

abstract：:Platelet function was investigated in three patients with the Lesch-Nyhan syndrome. Platelet count, morphology and size distribution was normal in all patients. Platelet turnover was normal. Electron microscopy did not reveal any ultrastructural abnormality. Template bleeding times were normal and prolonged after aspi...

journal_title：British journal of haematology

authors： Rivard GE,Izadi P,Lazerson J,McLaren JD,Parker C,Fish CH

更新日期：1975-10-01 00:00:00